AU670270B2 - Acylaminoindole derivatives as 5-HT1 agonists - Google Patents

Acylaminoindole derivatives as 5-HT1 agonists Download PDF

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Publication number
AU670270B2
AU670270B2 AU37821/93A AU3782193A AU670270B2 AU 670270 B2 AU670270 B2 AU 670270B2 AU 37821/93 A AU37821/93 A AU 37821/93A AU 3782193 A AU3782193 A AU 3782193A AU 670270 B2 AU670270 B2 AU 670270B2
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AU
Australia
Prior art keywords
alkyl
aryl
compound
international
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU37821/93A
Other languages
English (en)
Other versions
AU3782193A (en
Inventor
John E Macor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Publication of AU3782193A publication Critical patent/AU3782193A/en
Application granted granted Critical
Publication of AU670270B2 publication Critical patent/AU670270B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Soft Magnetic Materials (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Materials For Photolithography (AREA)
AU37821/93A 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-HT1 agonists Ceased AU670270B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10
US866382 1992-04-10
PCT/US1993/001807 WO1993021180A1 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-ht1 agonists

Publications (2)

Publication Number Publication Date
AU3782193A AU3782193A (en) 1993-11-18
AU670270B2 true AU670270B2 (en) 1996-07-11

Family

ID=25347493

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37821/93A Ceased AU670270B2 (en) 1992-04-10 1993-03-04 Acylaminoindole derivatives as 5-HT1 agonists

Country Status (31)

Country Link
US (1) US5498626A (cs)
EP (1) EP0635015B1 (cs)
JP (1) JP2544704B2 (cs)
KR (1) KR0179074B1 (cs)
CN (1) CN1038506C (cs)
AT (1) ATE148465T1 (cs)
AU (1) AU670270B2 (cs)
BR (1) BR9306221A (cs)
CA (1) CA2132706C (cs)
CZ (1) CZ282653B6 (cs)
DE (1) DE69307875T2 (cs)
DK (1) DK0635015T3 (cs)
EG (1) EG20466A (cs)
ES (1) ES2097496T3 (cs)
FI (2) FI111256B (cs)
GR (1) GR3022767T3 (cs)
HR (1) HRP930753B1 (cs)
HU (1) HUT64060A (cs)
IL (1) IL105309A0 (cs)
MX (1) MX9301996A (cs)
MY (1) MY115278A (cs)
NO (1) NO309860B1 (cs)
NZ (1) NZ251047A (cs)
PL (1) PL172232B1 (cs)
RU (1) RU2110516C1 (cs)
SK (1) SK278182B6 (cs)
TW (1) TW394769B (cs)
UA (1) UA34452C2 (cs)
WO (1) WO1993021180A1 (cs)
YU (1) YU48916B (cs)
ZA (1) ZA932536B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
CZ281763B6 (cs) 1992-04-07 1997-01-15 Pfizer Inc. Indolové deriváty představující 5-HT1 agonisty, způsob jejich přípravy, farmaceutické prostředky obsahující tyto látky, jejich použití a meziprodukty postupu přípravy
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
WO1995006636A1 (en) * 1993-08-31 1995-03-09 Pfizer Inc. 5-arylindole derivatives
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
CA2195850A1 (en) * 1994-08-03 1996-02-15 Guillaume Lebaut Substituted indoles
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
AU3170099A (en) * 1998-04-16 1999-11-08 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
CN1771031A (zh) * 2003-01-22 2006-05-10 Gtx公司 用sarms治疗与女性雄激素缺乏(ad if)相关的疾病
NZ585671A (en) * 2007-12-07 2012-06-29 Pfizer Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-fluoro-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8950491A (en) * 1990-10-15 1992-05-20 Pfizer Inc. Indole derivatives
AU2896192A (en) * 1991-11-25 1993-06-28 Pfizer Inc. Indole derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
NZ197998A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 5-amino(methyl)-1h-indol-3-ylalkaneamines
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
CA2282890C (en) * 1990-06-07 2001-07-31 The Wellcome Foundation Limited Therapeutic heterocyclic compounds
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8950491A (en) * 1990-10-15 1992-05-20 Pfizer Inc. Indole derivatives
AU2896192A (en) * 1991-11-25 1993-06-28 Pfizer Inc. Indole derivatives

Also Published As

Publication number Publication date
CZ282653B6 (cs) 1997-08-13
SK278182B6 (en) 1996-03-06
NO309860B1 (no) 2001-04-09
HUT64060A (en) 1993-11-29
WO1993021180A1 (en) 1993-10-28
RU2110516C1 (ru) 1998-05-10
PL172232B1 (pl) 1997-08-29
ES2097496T3 (es) 1997-04-01
ZA932536B (en) 1994-10-08
BR9306221A (pt) 1998-06-30
DE69307875T2 (de) 1997-05-22
CA2132706C (en) 1998-08-04
NO943803L (no) 1994-10-07
EP0635015A1 (en) 1995-01-25
MX9301996A (es) 1994-03-31
CZ247794A3 (en) 1995-07-12
CN1038506C (zh) 1998-05-27
IL105309A0 (en) 1993-08-18
HU9301048D0 (en) 1993-06-28
JP2544704B2 (ja) 1996-10-16
KR950700903A (ko) 1995-02-20
TW394769B (en) 2000-06-21
CN1080288A (zh) 1994-01-05
HRP930753B1 (en) 2000-10-31
NO943803D0 (no) 1994-10-07
KR0179074B1 (ko) 1999-03-20
EP0635015B1 (en) 1997-01-29
FI20010214L (fi) 2001-02-05
MY115278A (en) 2003-05-31
DK0635015T3 (da) 1997-03-17
EG20466A (en) 1999-05-31
HRP930753A2 (en) 1994-10-31
NZ251047A (en) 1996-09-25
ATE148465T1 (de) 1997-02-15
DE69307875D1 (de) 1997-03-13
YU25593A (sh) 1996-10-09
YU48916B (sh) 2002-11-15
US5498626A (en) 1996-03-12
UA34452C2 (uk) 2001-03-15
JPH07501831A (ja) 1995-02-23
RU94045902A (ru) 1996-08-27
CA2132706A1 (en) 1993-10-28
GR3022767T3 (en) 1997-06-30
FI931613A0 (fi) 1993-04-08
SK120794A3 (en) 1995-05-10
AU3782193A (en) 1993-11-18
FI111256B (fi) 2003-06-30
FI931613L (fi) 1993-10-11
FI20010214A7 (fi) 2001-02-05

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Legal Events

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired