DK0635015T3 - Acylaminoindolderivater som 5-Htl agonister - Google Patents

Acylaminoindolderivater som 5-Htl agonister

Info

Publication number
DK0635015T3
DK0635015T3 DK93907096.7T DK93907096T DK0635015T3 DK 0635015 T3 DK0635015 T3 DK 0635015T3 DK 93907096 T DK93907096 T DK 93907096T DK 0635015 T3 DK0635015 T3 DK 0635015T3
Authority
DK
Denmark
Prior art keywords
aryl
alkyl
alkylaryl
hydrogen
pct
Prior art date
Application number
DK93907096.7T
Other languages
Danish (da)
English (en)
Inventor
John E Macor
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0635015T3 publication Critical patent/DK0635015T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Soft Magnetic Materials (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Pyrrole Compounds (AREA)
DK93907096.7T 1992-04-10 1993-03-04 Acylaminoindolderivater som 5-Htl agonister DK0635015T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86638292A 1992-04-10 1992-04-10

Publications (1)

Publication Number Publication Date
DK0635015T3 true DK0635015T3 (da) 1997-03-17

Family

ID=25347493

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93907096.7T DK0635015T3 (da) 1992-04-10 1993-03-04 Acylaminoindolderivater som 5-Htl agonister

Country Status (31)

Country Link
US (1) US5498626A (cs)
EP (1) EP0635015B1 (cs)
JP (1) JP2544704B2 (cs)
KR (1) KR0179074B1 (cs)
CN (1) CN1038506C (cs)
AT (1) ATE148465T1 (cs)
AU (1) AU670270B2 (cs)
BR (1) BR9306221A (cs)
CA (1) CA2132706C (cs)
CZ (1) CZ282653B6 (cs)
DE (1) DE69307875T2 (cs)
DK (1) DK0635015T3 (cs)
EG (1) EG20466A (cs)
ES (1) ES2097496T3 (cs)
FI (2) FI111256B (cs)
GR (1) GR3022767T3 (cs)
HR (1) HRP930753B1 (cs)
HU (1) HUT64060A (cs)
IL (1) IL105309A0 (cs)
MX (1) MX9301996A (cs)
MY (1) MY115278A (cs)
NO (1) NO309860B1 (cs)
NZ (1) NZ251047A (cs)
PL (1) PL172232B1 (cs)
RU (1) RU2110516C1 (cs)
SK (1) SK278182B6 (cs)
TW (1) TW394769B (cs)
UA (1) UA34452C2 (cs)
WO (1) WO1993021180A1 (cs)
YU (1) YU48916B (cs)
ZA (1) ZA932536B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
BR9306201A (pt) 1992-04-07 1998-06-23 Pfizer Derivados de indol como agonistas 5-ht1
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
ES2070772B1 (es) * 1993-08-09 1996-02-16 Pfizer Derivados de acilaminoindol
KR100191973B1 (ko) * 1993-08-31 1999-06-15 디. 제이. 우드, 스피겔 알렌 제이 5-아릴인돌 유도체
GB9402011D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
GB9402016D0 (en) * 1994-02-02 1994-03-30 Merck Sharp & Dohme Therapeutic agents
WO1996004266A2 (de) * 1994-08-03 1996-02-15 Asta Medica Aktiengesellschaft Indol-, indazol-, pyridopyrrol- und pyridopyrazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung
GB9417310D0 (en) * 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9420503D0 (en) * 1994-10-11 1994-11-23 Pfizer Ltd Therapeutic agents
GB9420529D0 (en) 1994-10-12 1994-11-30 Pfizer Ltd Indoles
WO1999053956A1 (en) * 1998-04-16 1999-10-28 Yamanouchi Pharmaceutical Co., Ltd. Remedies for obesity
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
CA2514024A1 (en) * 2003-01-22 2004-08-05 Gtx Inc. Treating androgen deficiency in female (adif)-associated conditions with sarms
WO2009071988A1 (en) * 2007-12-07 2009-06-11 Pfizer Inc. Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-flu0r0-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
EP3610890A1 (en) 2012-11-14 2020-02-19 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN103408535B (zh) * 2013-08-13 2016-03-02 张家港威胜生物医药有限公司 一种依来曲普坦中间体-5-溴-3-(n-甲基吡咯啉-2-基甲基)-1h-吲哚合成工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
AU550010B2 (en) * 1980-08-12 1986-02-27 Glaxo Group Limited 5-tryptaminoacetamides, carbamates and ureas
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
IL96891A0 (en) * 1990-01-17 1992-03-29 Merck Sharp & Dohme Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
MC2210A1 (fr) * 1990-06-07 1992-11-26 Wellcome Found Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
DE10299004I2 (de) * 1990-10-15 2006-03-16 Pfizer Indolderivate
US5208248A (en) * 1991-01-11 1993-05-04 Merck Sharpe & Dohme, Ltd. Indazole-substituted five-membered heteroaromatic compounds
CZ283018B6 (cs) * 1991-02-01 1997-12-17 Merck Sharp And Dohme Limited Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi
RU2126399C1 (ru) * 1991-11-25 1999-02-20 Пфайзер Инк. Производные индола, замещенные индолы и способ ингибирования 5ht1 рецептора серотонина

Also Published As

Publication number Publication date
AU3782193A (en) 1993-11-18
YU48916B (sh) 2002-11-15
TW394769B (en) 2000-06-21
CN1080288A (zh) 1994-01-05
FI20010214L (fi) 2001-02-05
FI931613A0 (fi) 1993-04-08
NO309860B1 (no) 2001-04-09
RU94045902A (ru) 1996-08-27
SK278182B6 (en) 1996-03-06
NO943803D0 (no) 1994-10-07
CZ282653B6 (cs) 1997-08-13
ATE148465T1 (de) 1997-02-15
YU25593A (sh) 1996-10-09
MX9301996A (es) 1994-03-31
UA34452C2 (uk) 2001-03-15
NZ251047A (en) 1996-09-25
DE69307875T2 (de) 1997-05-22
NO943803L (no) 1994-10-07
JP2544704B2 (ja) 1996-10-16
ZA932536B (en) 1994-10-08
CA2132706C (en) 1998-08-04
IL105309A0 (en) 1993-08-18
HRP930753B1 (en) 2000-10-31
BR9306221A (pt) 1998-06-30
US5498626A (en) 1996-03-12
HUT64060A (en) 1993-11-29
EP0635015A1 (en) 1995-01-25
FI931613L (fi) 1993-10-11
SK120794A3 (en) 1995-05-10
GR3022767T3 (en) 1997-06-30
AU670270B2 (en) 1996-07-11
MY115278A (en) 2003-05-31
KR0179074B1 (ko) 1999-03-20
WO1993021180A1 (en) 1993-10-28
FI111256B (fi) 2003-06-30
EP0635015B1 (en) 1997-01-29
RU2110516C1 (ru) 1998-05-10
JPH07501831A (ja) 1995-02-23
HU9301048D0 (en) 1993-06-28
CA2132706A1 (en) 1993-10-28
FI20010214A7 (fi) 2001-02-05
PL172232B1 (pl) 1997-08-29
DE69307875D1 (de) 1997-03-13
CN1038506C (zh) 1998-05-27
CZ247794A3 (en) 1995-07-12
EG20466A (en) 1999-05-31
KR950700903A (ko) 1995-02-20
HRP930753A2 (en) 1994-10-31
ES2097496T3 (es) 1997-04-01

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