AU656859B2 - Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent - Google Patents

Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent Download PDF

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Publication number
AU656859B2
AU656859B2 AU39815/93A AU3981593A AU656859B2 AU 656859 B2 AU656859 B2 AU 656859B2 AU 39815/93 A AU39815/93 A AU 39815/93A AU 3981593 A AU3981593 A AU 3981593A AU 656859 B2 AU656859 B2 AU 656859B2
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AU
Australia
Prior art keywords
group
substituted
formula
ethyl
difluoromethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU39815/93A
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English (en)
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AU3981593A (en
Inventor
Tetsushi Katsube
Tomio Kimura
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Ube Corp
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Ube Industries Ltd
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Filing date
Publication date
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Publication of AU3981593A publication Critical patent/AU3981593A/en
Application granted granted Critical
Publication of AU656859B2 publication Critical patent/AU656859B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU39815/93A 1992-05-27 1993-05-26 Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent Ceased AU656859B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4-158912 1992-05-27
JP15891292 1992-05-27

Publications (2)

Publication Number Publication Date
AU3981593A AU3981593A (en) 1993-12-02
AU656859B2 true AU656859B2 (en) 1995-02-16

Family

ID=15682065

Family Applications (1)

Application Number Title Priority Date Filing Date
AU39815/93A Ceased AU656859B2 (en) 1992-05-27 1993-05-26 Aryl group- or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-HIV agent

Country Status (18)

Country Link
US (2) US5519016A (en:Method)
EP (1) EP0572259A1 (en:Method)
KR (1) KR100266305B1 (en:Method)
CN (1) CN1042936C (en:Method)
AU (1) AU656859B2 (en:Method)
CA (1) CA2096998A1 (en:Method)
CZ (1) CZ99693A3 (en:Method)
FI (1) FI932412A7 (en:Method)
HU (1) HUT64051A (en:Method)
ID (1) ID20476A (en:Method)
IL (1) IL105806A (en:Method)
MX (1) MX9303158A (en:Method)
NO (1) NO304832B1 (en:Method)
NZ (1) NZ247720A (en:Method)
PH (1) PH31078A (en:Method)
RU (1) RU2124510C1 (en:Method)
TW (1) TW234121B (en:Method)
ZA (1) ZA933732B (en:Method)

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DE4329600A1 (de) * 1993-09-02 1995-03-09 Bayer Ag Pyrido [1,2,3-d,e] [1,3,4] benzoxadiazinderivate
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DE4425660A1 (de) * 1994-07-20 1996-01-25 Bayer Ag 7-substituierte 1-[4-(1H-1,2,4-triazol-1-yl-methyl)phenyl] substituierte Chinoloncarbonsäuren
DE4425647A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
DE4425649A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue 1-[4-(Aminomethyl)phenyl] substituierte Chinoloncarbonsäuren
BR9509768A (pt) * 1994-11-24 1998-07-07 Hoffmann La Roche Novas pirimidinas de benzila
US5620997A (en) * 1995-05-31 1997-04-15 Warner-Lambert Company Isothiazolones
CA2290709C (en) * 1995-09-22 2003-11-04 Yoshihiro Ohshita 2,6-diaminopyridine compounds as intermediates for producing antibacterial dihydropyridone carboxylic acid derivatives
US6001863A (en) * 1996-11-26 1999-12-14 Warner-Lambert Company Isothiazolones
CO4970702A1 (es) * 1997-09-15 2000-11-07 Procter & Gamble Quinolonas antimicrobianas, sus composiciones y sus usos
US6387928B1 (en) 1997-09-15 2002-05-14 The Procter & Gamble Co. Antimicrobial quinolones, their compositions and uses
DE19751948A1 (de) * 1997-11-24 1999-05-27 Bayer Ag Verfahren zur Herstellung von 8-Methoxy-Chinoloncarbonsäuren
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
ATE329896T1 (de) * 1998-08-12 2006-07-15 Ihara Chemical Ind Co N-cyclopropyl-2-difluormethoxy-3-bromanilin und ein zwischenprodukt zu seiner herstellung
JP2002533342A (ja) * 1998-12-21 2002-10-08 アベンテイス・フアルマ・ソシエテ・アノニム １，８−ベンゾナフチリジン誘導体
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EP0422485A2 (de) * 1989-10-12 1991-04-17 Bayer Ag Chinoloncarbonsäurederivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
AU1887292A (en) * 1991-05-28 1993-01-08 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative

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Patent Citations (2)

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EP0422485A2 (de) * 1989-10-12 1991-04-17 Bayer Ag Chinoloncarbonsäurederivate, Verfahren zu ihrer Herstellung sowie ihre Verwendung als antivirale Mittel
AU1887292A (en) * 1991-05-28 1993-01-08 Daiichi Pharmaceutical Co., Ltd. Pyridonecarboxylic acid derivative

Also Published As

Publication number Publication date
US5519016A (en) 1996-05-21
CN1042936C (zh) 1999-04-14
HU9301536D0 (en) 1993-09-28
IL105806A0 (en) 1993-09-22
TW234121B (en:Method) 1994-11-11
HUT64051A (en) 1993-11-29
RU2124510C1 (ru) 1999-01-10
AU3981593A (en) 1993-12-02
EP0572259A1 (en) 1993-12-01
ID20476A (id) 1998-12-24
CZ99693A3 (en) 1993-12-15
CN1086515A (zh) 1994-05-11
NZ247720A (en) 1994-09-27
NO931867L (no) 1993-11-29
KR930023360A (ko) 1993-12-18
IL105806A (en) 1998-02-22
CA2096998A1 (en) 1993-11-28
PH31078A (en) 1998-02-05
KR100266305B1 (ko) 2000-09-15
FI932412L (fi) 1993-11-28
ZA933732B (en) 1993-12-15
US5688791A (en) 1997-11-18
FI932412A7 (fi) 1993-11-28
FI932412A0 (fi) 1993-05-26
MX9303158A (es) 1994-04-29
NO304832B1 (no) 1999-02-22
NO931867D0 (no) 1993-05-24

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