AU649277B2 - Improvements in or relating to organic compounds - Google Patents

Improvements in or relating to organic compounds Download PDF

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Publication number
AU649277B2
AU649277B2 AU86923/91A AU8692391A AU649277B2 AU 649277 B2 AU649277 B2 AU 649277B2 AU 86923/91 A AU86923/91 A AU 86923/91A AU 8692391 A AU8692391 A AU 8692391A AU 649277 B2 AU649277 B2 AU 649277B2
Authority
AU
Australia
Prior art keywords
meleu
ciclosporin
hydroxy
mebmt
meval
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU86923/91A
Other languages
English (en)
Other versions
AU8692391A (en
Inventor
Pietro Bollinger
Soo Young Ko
Hans Kobel
Brigitte Rosenwirth
Dieter Seebach
Rene P. Traber
Roland Wenger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27517009&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU649277(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909023859A external-priority patent/GB9023859D0/en
Priority claimed from GB909023972A external-priority patent/GB9023972D0/en
Priority claimed from GB909023971A external-priority patent/GB9023971D0/en
Priority claimed from GB909023970A external-priority patent/GB9023970D0/en
Priority claimed from GB919116836A external-priority patent/GB9116836D0/en
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of AU8692391A publication Critical patent/AU8692391A/en
Publication of AU649277B2 publication Critical patent/AU649277B2/en
Application granted granted Critical
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request to Amend Deed and Register Assignors: SANDOZ LTD.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU86923/91A 1990-11-02 1991-10-31 Improvements in or relating to organic compounds Expired AU649277B2 (en)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB9023859 1990-11-02
GB909023859A GB9023859D0 (en) 1990-11-02 1990-11-02 Chemical products
GB909023972A GB9023972D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB909023971A GB9023971D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB9023972 1990-11-05
GB9023971 1990-11-05
GB9023970 1990-11-05
GB909023970A GB9023970D0 (en) 1990-11-05 1990-11-05 New use of a cyclosporin derivative
GB919116836A GB9116836D0 (en) 1991-08-05 1991-08-05 Organic compounds
GB9116836 1991-08-05

Publications (2)

Publication Number Publication Date
AU8692391A AU8692391A (en) 1992-05-07
AU649277B2 true AU649277B2 (en) 1994-05-19

Family

ID=27517009

Family Applications (1)

Application Number Title Priority Date Filing Date
AU86923/91A Expired AU649277B2 (en) 1990-11-02 1991-10-31 Improvements in or relating to organic compounds

Country Status (25)

Country Link
US (3) US5767069A (enExample)
EP (1) EP0484281B2 (enExample)
JP (1) JP2740775B2 (enExample)
KR (1) KR100203556B1 (enExample)
AT (1) ATE148469T1 (enExample)
AU (1) AU649277B2 (enExample)
CA (1) CA2054590C (enExample)
CY (1) CY2159B1 (enExample)
CZ (1) CZ280909B6 (enExample)
DE (1) DE69124459T3 (enExample)
DK (1) DK0484281T4 (enExample)
ES (1) ES2095926T5 (enExample)
FI (1) FI111730B (enExample)
GR (2) GR3022592T3 (enExample)
HK (1) HK1005741A1 (enExample)
HU (1) HU212674B (enExample)
IE (1) IE913824A1 (enExample)
IL (1) IL99912A (enExample)
MX (1) MX9101869A (enExample)
MY (1) MY134806A (enExample)
NZ (1) NZ240421A (enExample)
PL (1) PL168609B1 (enExample)
PT (1) PT99410B (enExample)
SA (1) SA92120344B1 (enExample)
SK (1) SK278808B6 (enExample)

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ES2065273B1 (es) * 1993-05-25 1995-09-16 Biogal Gyogyszergyar Procedimiento para la purificacion de ciclosporina a.
US5639852A (en) * 1994-09-01 1997-06-17 Wisconsin Alumni Research Foundation Immunostimulatory agents
US5948693A (en) * 1994-09-01 1999-09-07 Wisconsin Alumni Research Foundation Solid phase synthesis of immunosuppressive agents
US6696413B2 (en) 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
US5948884A (en) * 1995-07-17 1999-09-07 C-Chem Ag Cyclosporin derivatives with anti-HIV effect
JP3089350B2 (ja) * 1995-11-20 2000-09-18 ギルフォード ファーマシューティカルズ インコーポレイテッド シクロフィリンロタマーゼ活性の阻害剤
WO1997033604A1 (en) * 1996-03-12 1997-09-18 Picower Institute For Medical Research Treatment of hiv-infection by interfering with host cell cyclophilin receptor activity
CN1130373C (zh) * 1996-09-13 2003-12-10 诺瓦蒂斯有限公司 [3'－脱氧－3'－氧代－MeBmt]'环孢菌素制备方法
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757522B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757520B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
AU750245B2 (en) 1997-10-08 2002-07-11 Aurinia Phamaceuticals Inc. Deuterated cyclosporine analogs and their use as immunomodulating agents
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
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EP0484281B1 (en) 1997-01-29
DE69124459T2 (de) 1997-07-10
JPH05208996A (ja) 1993-08-20
HK1005741A1 (en) 1999-01-22
GR3022592T3 (en) 1997-05-31
ATE148469T1 (de) 1997-02-15
EP0484281A3 (en) 1993-02-24
HU212674B (en) 1996-09-30
HU913446D0 (en) 1992-01-28
DE69124459D1 (de) 1997-03-13
IL99912A0 (en) 1992-08-18
GR3035323T3 (en) 2001-04-30
PT99410B (pt) 1999-04-30
PL292248A1 (en) 1992-07-27
NZ240421A (en) 1993-04-28
DE69124459T3 (de) 2001-05-31
IL99912A (en) 1996-09-12
DK0484281T3 (enExample) 1997-02-17
MX9101869A (es) 1993-04-01
MY134806A (en) 2007-12-31
PL168609B1 (pl) 1996-03-29
ES2095926T5 (es) 2001-02-16
SA92120344B1 (ar) 2004-01-24
US5767069A (en) 1998-06-16
US6255100B1 (en) 2001-07-03
DK0484281T4 (da) 2001-02-05
IE913824A1 (en) 1992-05-22
JP2740775B2 (ja) 1998-04-15
KR920009390A (ko) 1992-06-25
KR100203556B1 (ko) 1999-06-15
CA2054590A1 (en) 1992-05-03
CY2159B1 (en) 2002-08-23
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US5981479A (en) 1999-11-09
AU8692391A (en) 1992-05-07
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FI915135L (fi) 1992-05-03
HUT62337A (en) 1993-04-28
FI915135A0 (fi) 1991-10-30
CZ280909B6 (cs) 1996-05-15
SK278808B6 (sk) 1998-03-04
CS329791A3 (en) 1992-05-13
PT99410A (pt) 1992-09-30
ES2095926T3 (es) 1997-03-01
FI111730B (fi) 2003-09-15
EP0484281B2 (en) 2000-11-22

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