ES2095926T5 - Cyclosporins. - Google Patents
Cyclosporins.Info
- Publication number
- ES2095926T5 ES2095926T5 ES91810841T ES91810841T ES2095926T5 ES 2095926 T5 ES2095926 T5 ES 2095926T5 ES 91810841 T ES91810841 T ES 91810841T ES 91810841 T ES91810841 T ES 91810841T ES 2095926 T5 ES2095926 T5 ES 2095926T5
- Authority
- ES
- Spain
- Prior art keywords
- cyclosporins
- aids
- nonimmunosuppressive
- cyclophilin
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Cephalosporin Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE HA VISTO QUE CICLOSPORINAS DE UNION A CICLOPHILINAS, NOINMUNOSUPRESIVAS SON UTILES EN EL TRATAMIENTO Y PREVENCION DEL AIDS Y DESORDENES RELACIONADOS. TALES CICLOSPORINAS INCLUYEN DERIVADOS DE CICLOSPORINAS NOVEDOSOS MODIFICADOS EN LAS POSICIONES 4 Y/O 5.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909023859A GB9023859D0 (en) | 1990-11-02 | 1990-11-02 | Chemical products |
GB909023971A GB9023971D0 (en) | 1990-11-05 | 1990-11-05 | New use of a cyclosporin derivative |
GB909023970A GB9023970D0 (en) | 1990-11-05 | 1990-11-05 | New use of a cyclosporin derivative |
GB909023972A GB9023972D0 (en) | 1990-11-05 | 1990-11-05 | New use of a cyclosporin derivative |
GB919116836A GB9116836D0 (en) | 1991-08-05 | 1991-08-05 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2095926T3 ES2095926T3 (es) | 1997-03-01 |
ES2095926T5 true ES2095926T5 (es) | 2001-02-16 |
Family
ID=27517009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91810841T Expired - Lifetime ES2095926T5 (es) | 1990-11-02 | 1991-10-30 | Cyclosporins. |
Country Status (25)
Country | Link |
---|---|
US (3) | US5767069A (es) |
EP (1) | EP0484281B2 (es) |
JP (1) | JP2740775B2 (es) |
KR (1) | KR100203556B1 (es) |
AT (1) | ATE148469T1 (es) |
AU (1) | AU649277B2 (es) |
CA (1) | CA2054590C (es) |
CY (1) | CY2159B1 (es) |
CZ (1) | CZ280909B6 (es) |
DE (1) | DE69124459T3 (es) |
DK (1) | DK0484281T4 (es) |
ES (1) | ES2095926T5 (es) |
FI (1) | FI111730B (es) |
GR (2) | GR3022592T3 (es) |
HK (1) | HK1005741A1 (es) |
HU (1) | HU212674B (es) |
IE (1) | IE913824A1 (es) |
IL (1) | IL99912A (es) |
MX (1) | MX9101869A (es) |
MY (1) | MY134806A (es) |
NZ (1) | NZ240421A (es) |
PL (1) | PL168609B1 (es) |
PT (1) | PT99410B (es) |
SA (1) | SA92120344B1 (es) |
SK (1) | SK278808B6 (es) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993014780A1 (en) * | 1992-01-28 | 1993-08-05 | Abraham Karpas | The use of a compound for the manufacture of a medicament for the treatment of hiv infection |
GB9204466D0 (en) * | 1992-03-02 | 1992-04-15 | Sandoz Ltd | Improvements in or relating to organic compounds |
ES2065273B1 (es) * | 1993-05-25 | 1995-09-16 | Biogal Gyogyszergyar | Procedimiento para la purificacion de ciclosporina a. |
US5639852A (en) * | 1994-09-01 | 1997-06-17 | Wisconsin Alumni Research Foundation | Immunostimulatory agents |
US5948693A (en) * | 1994-09-01 | 1999-09-07 | Wisconsin Alumni Research Foundation | Solid phase synthesis of immunosuppressive agents |
US6696413B2 (en) | 1995-06-16 | 2004-02-24 | Hexal Ag | Pharmaceutical preparation with cyclosporin A |
JP3920919B2 (ja) * | 1995-07-17 | 2007-05-30 | シネクシス・インコーポレイテッド | 抗−hiv−作用を有するシクロスポリン誘導体 |
JP3089350B2 (ja) * | 1995-11-20 | 2000-09-18 | ギルフォード ファーマシューティカルズ インコーポレイテッド | シクロフィリンロタマーゼ活性の阻害剤 |
EP0944394A4 (en) * | 1996-03-12 | 2003-05-14 | Picower Inst Med Res | TREATING HIV INFECTION BY INFLUENCING CYCLOPHILIN RECEPTOR ACTIVITY IN THE HOST CELL |
CN1130373C (zh) * | 1996-09-13 | 2003-12-10 | 诺瓦蒂斯有限公司 | [3'-脱氧-3'-氧代-MeBmt]'环孢菌素制备方法 |
FR2757520B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derive de cyclosporine, sa preparation et les compositions pharmaceutiques qui le contiennent |
FR2757521B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2757522B1 (fr) * | 1996-12-24 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
FR2762843B1 (fr) * | 1997-04-30 | 1999-12-10 | Rhone Poulenc Rorer Sa | Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
US20030220234A1 (en) * | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
ATE314388T1 (de) | 1997-10-08 | 2006-01-15 | Isotechnika Inc | Deuterierte und undeuterierte cyclosporin-analoga und ihre verwendung als immunmodulierende agentien |
ZA99981B (en) * | 1998-02-17 | 2000-08-08 | Du Pont Pharm Co | Oral liquid formulations of benzoxazinones HIV reverse transcriptase inhibitors. |
GB9811854D0 (en) * | 1998-06-02 | 1998-07-29 | Ciba Geigy Ag | Organic compounds |
FR2780061B1 (fr) * | 1998-06-22 | 2001-09-07 | Rhone Poulenc Rorer Sa | Nouveau procede de preparation de derives de cyclosporine |
US6927208B1 (en) | 1998-07-01 | 2005-08-09 | Debiopharm S.A. | Cyclosporin with improved activity profile |
IL143604A0 (en) | 1998-12-30 | 2002-04-21 | Dexcel Ltd | Dispersable concentrate for the delivery of cyclosporin |
US6521595B1 (en) * | 1999-11-19 | 2003-02-18 | Lg Chemical, Ltd. | Nonimmunosuppressive [γ-hydroxy-methylleucine4] cyclosporin A, hair growth stimulator and external composition for skin using the same |
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
RU2290196C2 (ru) * | 2001-04-20 | 2006-12-27 | Дебиофарм С.А. | Модифицированный циклоспорин, который можно использовать в качестве пролекарства, и его применение |
KR100695611B1 (ko) * | 2001-05-17 | 2007-03-14 | 주식회사 엘지생활건강 | [감마 히드록시 엔-메틸 엘-루신4] 사이클로스포린유도체를 유효성분으로 하는 모발 성장 촉진제 |
MY145753A (en) * | 2001-10-19 | 2012-03-30 | Isotechnika Inc | Novel cyclosporin analog formulations |
SI1436321T1 (sl) | 2001-10-19 | 2006-12-31 | Isotechnika Inc | Sinteza analogov ciklosporina |
WO2003038032A2 (de) * | 2001-10-25 | 2003-05-08 | Viromics Gmbh | Mittel zur hemmung der synthese von virusproteinen |
US7108988B2 (en) * | 2001-11-02 | 2006-09-19 | The J. David Gladstone Institutes | Methods of identifying agents for inhibiting lentivirus replication |
EP1603512A2 (en) * | 2003-03-17 | 2005-12-14 | Albany Molecular Research, Inc. | Novel cyclosporins |
GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
US20080194470A1 (en) * | 2004-04-08 | 2008-08-14 | Novartis Ag | Nim811 In Cerebral Ischemia and Brain and Spinal Cord Injury |
CA2573400A1 (en) * | 2004-07-13 | 2006-01-19 | Novartis Ag | Cyclosporins to treat alzheimer's disease |
MX2007000503A (es) | 2004-07-14 | 2007-03-08 | Novartis Ag | Uso de una combinacion de ciclosporina e interferon pegilado para el tratamiento de hepatitis c(hcv). |
KR100597309B1 (ko) | 2004-09-17 | 2006-07-05 | 주식회사 핸슨바이오텍 | 세베키아 베니하나를 이용한 [감마 히드록실메틸루신4] 사이클로스포린 a의 제조방법 |
US7511013B2 (en) * | 2004-09-29 | 2009-03-31 | Amr Technology, Inc. | Cyclosporin analogues and their pharmaceutical uses |
JP2008514701A (ja) * | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキン類似体およびそれらの薬学的使用 |
US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
KR101309409B1 (ko) * | 2004-10-01 | 2013-09-23 | 싸이넥시스, 인크. | C형 간염 바이러스 감염의 치료 및 예방을 위한 3-에테르및 3-티오에테르 치환된 시클로스포린 유도체 |
JP2008515886A (ja) * | 2004-10-06 | 2008-05-15 | エーエムアール テクノロジー インコーポレイテッド | シクロスポリンアルキンおよびそれらの医用薬剤としての有用性 |
US7151085B2 (en) * | 2004-11-15 | 2006-12-19 | Allergan, Inc. | Therapeutic methods using cyclosporine components |
US7135455B2 (en) * | 2004-11-15 | 2006-11-14 | Allergan, Inc | Methods for the therapeutic use of cyclosporine components |
KR100777488B1 (ko) | 2004-12-15 | 2007-11-28 | 주식회사 핸슨바이오텍 | 세베키아 베니하나 (Sebekia benihana)배양물로부터 감마-히드록실메틸루신4 사이클로스포린 A를 효과적이고 선택적으로 회수하는 방법 |
MX2007007721A (es) * | 2004-12-23 | 2007-08-14 | Novartis Ag | Compuestos para el tratamiento de flaviviridae. |
EP1830871A1 (en) | 2004-12-23 | 2007-09-12 | Novartis AG | Compositions for hcv treatment |
WO2007041631A1 (en) * | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION |
US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
NZ571826A (en) | 2006-04-11 | 2012-01-12 | Novartis Ag | HCV/HIV inhibitors and their uses |
CA2652662C (en) | 2006-05-19 | 2015-11-03 | Scynexis, Inc. | Methods for the treatment and prevention of ocular disorders |
KR101089112B1 (ko) * | 2006-06-02 | 2011-12-06 | 피씨 제스띠옹 에스.아.에스. | 활성 전자 관리 |
WO2008069917A2 (en) * | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
US20080255038A1 (en) * | 2007-04-11 | 2008-10-16 | Samuel Earl Hopkins | Pharmaceutical compositions |
EP2195009B1 (en) * | 2007-09-26 | 2014-07-30 | Oregon Health and Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
WO2009148615A1 (en) * | 2008-06-06 | 2009-12-10 | Scynexis, Inc. | Cyclosporin analogs and their use in the treatment of hcv infections |
US9090671B2 (en) * | 2008-06-06 | 2015-07-28 | Scynexis, Inc. | Macrocyclic peptides |
AU2009276241A1 (en) | 2008-07-30 | 2010-02-04 | Ciclofilin Pharmaceuticals Corp. | Nonimmunosuppressive cyclosporine analogue molecules |
AU2009334790B2 (en) | 2008-12-31 | 2016-09-08 | Scynexis, Inc. | Derivatives of cyclosporin A |
US11304960B2 (en) | 2009-01-08 | 2022-04-19 | Chandrashekar Giliyar | Steroidal compositions |
US8481483B2 (en) * | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
GB0909754D0 (en) * | 2009-06-05 | 2009-07-22 | Magnani Mauro | Drug delivery systems |
WO2011076784A2 (en) | 2009-12-21 | 2011-06-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | New inhibitors of cyclophilins and uses thereof |
AU2010339460A1 (en) | 2009-12-30 | 2012-07-19 | Scynexis Inc. | Cyclosporine analogues |
CN103153329A (zh) | 2010-07-16 | 2013-06-12 | 美国科技环球有限公司 | 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用 |
US9573978B2 (en) | 2010-08-12 | 2017-02-21 | S&T Global, Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
WO2012048235A1 (en) | 2010-10-08 | 2012-04-12 | Novartis Ag | Vitamin e formulations of sulfamide ns3 inhibitors |
US9358241B2 (en) | 2010-11-30 | 2016-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US20180153904A1 (en) | 2010-11-30 | 2018-06-07 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9034858B2 (en) | 2010-11-30 | 2015-05-19 | Lipocine Inc. | High-strength testosterone undecanoate compositions |
US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
US20120148675A1 (en) | 2010-12-10 | 2012-06-14 | Basawaraj Chickmath | Testosterone undecanoate compositions |
US9200038B2 (en) | 2010-12-15 | 2015-12-01 | Ciclofilin Pharmaceuticals Corp. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
US20120253007A1 (en) * | 2011-03-28 | 2012-10-04 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Synthesis of Cyclosporin H |
US20140205566A1 (en) | 2012-11-30 | 2014-07-24 | Novartis Ag | Cyclic nucleuoside derivatives and uses thereof |
US9498485B2 (en) | 2014-08-28 | 2016-11-22 | Lipocine Inc. | Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters |
WO2016033549A2 (en) | 2014-08-28 | 2016-03-03 | Lipocine Inc. | (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE |
EP3544614A4 (en) | 2016-11-28 | 2020-08-05 | Lipocine Inc. | ORAL TESTOSTERONE UNDECANOATE THERAPY |
CN111449050A (zh) | 2019-01-20 | 2020-07-28 | 睿诺医疗科技(上海)有限公司 | 环孢菌素类似物及其用途 |
CN115298199A (zh) | 2020-03-26 | 2022-11-04 | 睿诺医疗科技(上海)有限公司 | 环孢菌素衍生物的制备 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2455859C2 (de) | 1973-12-06 | 1983-12-15 | Sandoz-Patent-GmbH, 7850 Lörrach | Das Antibiotikum Cyclosporin A (S 7481/F-1), seine Herstellung und Verwendung |
US4304855A (en) * | 1977-05-05 | 1981-12-08 | The Upjohn Company | Allylic methyl-hydroxylated novobiocins |
CH667274A5 (de) * | 1984-03-23 | 1988-09-30 | Sandoz Ag | Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
US4814323A (en) * | 1986-03-25 | 1989-03-21 | Andrieu J M | Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus |
EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
EP0373260B1 (en) * | 1987-06-22 | 1994-03-09 | Merck & Co. Inc. | Cyclosporin derivatives with modified "8-amino acid" |
GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
US4981799A (en) * | 1987-08-21 | 1991-01-01 | Takeda Chemical Industries, Ltd. | Acylamino acid racemase, production and use thereof |
US4914188A (en) † | 1987-11-16 | 1990-04-03 | Merck & Co., Inc. | Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin |
US5081024A (en) * | 1988-09-05 | 1992-01-14 | Nissan Chemical Industries, Ltd. | Process for producing optically active amino acids |
GB2227244A (en) * | 1989-01-19 | 1990-07-25 | Merck & Co Inc | Immunosuppressive fluorinated cyclosporin analogs |
US5122511A (en) * | 1990-02-27 | 1992-06-16 | Merck & Co., Inc. | Immunosuppressive cyclosporin analogs with modified amino acids at position-8 |
-
1991
- 1991-10-30 EP EP91810841A patent/EP0484281B2/en not_active Expired - Lifetime
- 1991-10-30 DE DE69124459T patent/DE69124459T3/de not_active Expired - Lifetime
- 1991-10-30 CZ CS913297A patent/CZ280909B6/cs not_active IP Right Cessation
- 1991-10-30 ES ES91810841T patent/ES2095926T5/es not_active Expired - Lifetime
- 1991-10-30 SK SK3297-91A patent/SK278808B6/sk not_active IP Right Cessation
- 1991-10-30 AT AT91810841T patent/ATE148469T1/de not_active IP Right Cessation
- 1991-10-30 FI FI915135A patent/FI111730B/fi not_active IP Right Cessation
- 1991-10-30 DK DK91810841T patent/DK0484281T4/da active
- 1991-10-31 CA CA002054590A patent/CA2054590C/en not_active Expired - Lifetime
- 1991-10-31 IL IL9991291A patent/IL99912A/en not_active IP Right Cessation
- 1991-10-31 NZ NZ240421A patent/NZ240421A/en not_active IP Right Cessation
- 1991-10-31 MX MX9101869A patent/MX9101869A/es unknown
- 1991-10-31 PL PL91292248A patent/PL168609B1/pl unknown
- 1991-10-31 AU AU86923/91A patent/AU649277B2/en not_active Expired
- 1991-10-31 PT PT99410A patent/PT99410B/pt not_active IP Right Cessation
- 1991-11-01 MY MYPI91002021A patent/MY134806A/en unknown
- 1991-11-01 KR KR1019910019402A patent/KR100203556B1/ko not_active IP Right Cessation
- 1991-11-01 JP JP3287501A patent/JP2740775B2/ja not_active Expired - Lifetime
- 1991-11-01 HU HU913446A patent/HU212674B/hu unknown
- 1991-11-01 IE IE382491A patent/IE913824A1/en not_active IP Right Cessation
-
1992
- 1992-01-19 SA SA92120344A patent/SA92120344B1/ar unknown
-
1995
- 1995-04-24 US US08/427,312 patent/US5767069A/en not_active Expired - Lifetime
-
1997
- 1997-02-19 GR GR970400277T patent/GR3022592T3/el unknown
-
1998
- 1998-05-26 US US09/084,709 patent/US5981479A/en not_active Expired - Lifetime
- 1998-06-03 HK HK98104804A patent/HK1005741A1/xx not_active IP Right Cessation
-
1999
- 1999-09-09 US US09/392,282 patent/US6255100B1/en not_active Expired - Fee Related
-
2000
- 2000-01-13 CY CY0000002A patent/CY2159B1/xx unknown
-
2001
- 2001-01-31 GR GR20010400150T patent/GR3035323T3/el not_active IP Right Cessation
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