ES2176285T3 - Amidas y esteres de peptidos inhibidoras del cancer de seres humanos. - Google Patents

Amidas y esteres de peptidos inhibidoras del cancer de seres humanos.

Info

Publication number
ES2176285T3
ES2176285T3 ES95305129T ES95305129T ES2176285T3 ES 2176285 T3 ES2176285 T3 ES 2176285T3 ES 95305129 T ES95305129 T ES 95305129T ES 95305129 T ES95305129 T ES 95305129T ES 2176285 T3 ES2176285 T3 ES 2176285T3
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Spain
Prior art keywords
sub
esteres
amidas
cancer
human beings
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Expired - Lifetime
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ES95305129T
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English (en)
Inventor
George R Pettit
Jayaram K Srirangam
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University of Arizona
Arizona's Public Universities
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University of Arizona
Arizona's Public Universities
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Publication of ES2176285T3 publication Critical patent/ES2176285T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

SE DESCRIBEN LA SEPARACION, ELUCIDACION Y REPRODUCCION SINTETICA DE NUEVAS AMIDAS Y ESTERES DE PENTAPEPTIDOS. LOS COMPUESTOS TIENEN LA ESTRUCTURA GENERAL EN LA QUE R{SUB,1} Y R{SUB,2} SE SELECCIONAN COMO SE MUESTRA A CONTINUACION: 12) R{SUB,1} = -CH{SUB,2}-CH{SUB,3}; 14) R{SUB,1} = -CH{SUB,2}-CH{SUB,3}; 16A) R{SUB,1} = CH{SUB,3}; R{SUB,2} = -OCH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,3} 16B) R{SUB,1} = CH{SUB,3}; R{SUB,2} = -OCH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2} CH{SUB,3} 16C) R{SUB,1} = CH{SUB,3}; R{SUB,2} = -NHCH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,2}CH{SUB,3}
ES95305129T 1994-08-01 1995-07-21 Amidas y esteres de peptidos inhibidoras del cancer de seres humanos. Expired - Lifetime ES2176285T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/283,806 US5521284A (en) 1994-08-01 1994-08-01 Human cancer inhibitory pentapeptide amides and esters

Publications (1)

Publication Number Publication Date
ES2176285T3 true ES2176285T3 (es) 2002-12-01

Family

ID=23087626

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95305129T Expired - Lifetime ES2176285T3 (es) 1994-08-01 1995-07-21 Amidas y esteres de peptidos inhibidoras del cancer de seres humanos.

Country Status (9)

Country Link
US (1) US5521284A (es)
EP (1) EP0695758B1 (es)
JP (1) JP3579751B2 (es)
AT (1) ATE217883T1 (es)
CA (1) CA2154206A1 (es)
DE (1) DE69526756T2 (es)
DK (1) DK0695758T3 (es)
ES (1) ES2176285T3 (es)
PT (1) PT695758E (es)

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US5521284A (en) 1996-05-28
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JPH0881493A (ja) 1996-03-26
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PT695758E (pt) 2002-09-30

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