AU2019251223A1 - Cereblon ligands and bifunctional compounds comprising the same - Google Patents

Cereblon ligands and bifunctional compounds comprising the same Download PDF

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Publication number
AU2019251223A1
AU2019251223A1 AU2019251223A AU2019251223A AU2019251223A1 AU 2019251223 A1 AU2019251223 A1 AU 2019251223A1 AU 2019251223 A AU2019251223 A AU 2019251223A AU 2019251223 A AU2019251223 A AU 2019251223A AU 2019251223 A1 AU2019251223 A1 AU 2019251223A1
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Australia
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alkyl
syndrome
group
optionally substituted
disease
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AU2019251223A
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English (en)
Inventor
Michael Berlin
Andrew P. Crew
Craig M. Crews
Hanqing Dong
Keith R. Hornberger
Yimin Qian
Lawrence B. Snyder
Jing Wang
Kurt Zimmermann
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Arvinas Operations Inc
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Arvinas Operations Inc
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Priority claimed from US15/953,108 external-priority patent/US20180228907A1/en
Application filed by Arvinas Operations Inc filed Critical Arvinas Operations Inc
Publication of AU2019251223A1 publication Critical patent/AU2019251223A1/en
Priority to AU2023248067A priority Critical patent/AU2023248067B2/en
Priority to AU2025275145A priority patent/AU2025275145A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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AU2019251223A 2018-04-13 2019-04-09 Cereblon ligands and bifunctional compounds comprising the same Abandoned AU2019251223A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2023248067A AU2023248067B2 (en) 2018-04-13 2023-10-10 Cereblon ligands and bifunctional compounds comprising the same
AU2025275145A AU2025275145A1 (en) 2018-04-13 2025-12-03 Cereblon ligands and bifunctional compounds comprising the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/953,108 US20180228907A1 (en) 2014-04-14 2018-04-13 Cereblon ligands and bifunctional compounds comprising the same
US15/953,108 2018-04-13
PCT/US2019/026570 WO2019199816A1 (en) 2018-04-13 2019-04-09 Cereblon ligands and bifunctional compounds comprising the same

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AU2023248067A Active AU2023248067B2 (en) 2018-04-13 2023-10-10 Cereblon ligands and bifunctional compounds comprising the same
AU2025275145A Pending AU2025275145A1 (en) 2018-04-13 2025-12-03 Cereblon ligands and bifunctional compounds comprising the same

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EP (1) EP3774772A1 (https=)
JP (3) JP2021521192A (https=)
KR (1) KR20210003804A (https=)
CN (2) CN118480030A (https=)
AU (3) AU2019251223A1 (https=)
CA (1) CA3095912A1 (https=)
IL (3) IL302595A (https=)
MX (2) MX2020010571A (https=)
WO (1) WO2019199816A1 (https=)

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US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
IL290809B2 (en) 2016-11-01 2024-01-01 Arvinas Operations Inc Tau-protein targeting protacs and associated methods of use
EP4717317A2 (en) 2017-06-20 2026-04-01 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
EP3710002A4 (en) 2017-11-16 2021-07-07 C4 Therapeutics, Inc. DEGRADER AND DEGRONE FOR TARGETED PROTEIN DEGRADATION
JP2021519337A (ja) 2018-03-26 2021-08-10 シー４ セラピューティクス， インコーポレイテッド Ｉｋａｒｏｓの分解のためのセレブロン結合剤
CN119751456A (zh) 2018-04-16 2025-04-04 C4医药公司 螺环化合物
WO2019222272A1 (en) 2018-05-14 2019-11-21 Nuvation Bio Inc. Anti-cancer nuclear hormone receptor-targeting compounds
JP2021527137A (ja) 2018-06-13 2021-10-11 アンフィスタ セラピューティクス リミテッド Ｒｐｎ１１を標的化するための二機能性分子
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