AU2017345399B2 - Oxysterols and methods of use thereof - Google Patents

Oxysterols and methods of use thereof Download PDF

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Publication number
AU2017345399B2
AU2017345399B2 AU2017345399A AU2017345399A AU2017345399B2 AU 2017345399 B2 AU2017345399 B2 AU 2017345399B2 AU 2017345399 A AU2017345399 A AU 2017345399A AU 2017345399 A AU2017345399 A AU 2017345399A AU 2017345399 B2 AU2017345399 B2 AU 2017345399B2
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compound
pharmaceutically acceptable
acceptable salt
substituted
unsubstituted
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AU2017345399A1 (en
Inventor
Andrew Griffin
Boyd L. Harrison
Daniel La
Gabriel Martinez Botella
Albert J. Robichaud
Francesco G. Salituro
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Sage Therapeutics Inc
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Sage Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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    • C—CHEMISTRY; METALLURGY
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    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
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  • Rheumatology (AREA)
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  • Vascular Medicine (AREA)
  • Cardiology (AREA)
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AU2017345399A 2016-10-18 2017-10-18 Oxysterols and methods of use thereof Active AU2017345399B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2022200810A AU2022200810B2 (en) 2016-10-18 2022-02-08 Oxysterols and methods of use thereof
AU2024202773A AU2024202773A1 (en) 2016-10-18 2024-04-29 Oxysterols and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662409768P 2016-10-18 2016-10-18
US201662409756P 2016-10-18 2016-10-18
US62/409,768 2016-10-18
US62/409,756 2016-10-18
PCT/US2017/057276 WO2018075698A1 (en) 2016-10-18 2017-10-18 Oxysterols and methods of use thereof

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AU2022200810A Division AU2022200810B2 (en) 2016-10-18 2022-02-08 Oxysterols and methods of use thereof

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AU2017345399A1 AU2017345399A1 (en) 2019-05-09
AU2017345399B2 true AU2017345399B2 (en) 2022-02-24

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AU2022200810A Active AU2022200810B2 (en) 2016-10-18 2022-02-08 Oxysterols and methods of use thereof
AU2024202773A Pending AU2024202773A1 (en) 2016-10-18 2024-04-29 Oxysterols and methods of use thereof

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AU2024202773A Pending AU2024202773A1 (en) 2016-10-18 2024-04-29 Oxysterols and methods of use thereof

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US (4) US11111266B2 (cg-RX-API-DMAC7.html)
EP (3) EP3529256B1 (cg-RX-API-DMAC7.html)
JP (4) JP2019532079A (cg-RX-API-DMAC7.html)
KR (3) KR102521573B1 (cg-RX-API-DMAC7.html)
CN (3) CN115322238A (cg-RX-API-DMAC7.html)
AU (3) AU2017345399B2 (cg-RX-API-DMAC7.html)
DK (1) DK4105223T3 (cg-RX-API-DMAC7.html)
ES (2) ES3038660T3 (cg-RX-API-DMAC7.html)
IL (3) IL320521A (cg-RX-API-DMAC7.html)
MA (1) MA46565A (cg-RX-API-DMAC7.html)
MX (2) MX2019004679A (cg-RX-API-DMAC7.html)
RU (1) RU2019115112A (cg-RX-API-DMAC7.html)
TW (3) TW202446399A (cg-RX-API-DMAC7.html)
WO (1) WO2018075698A1 (cg-RX-API-DMAC7.html)

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AU2014243773B2 (en) 2013-03-13 2018-12-13 Sage Therapeutics, Inc. Neuroactive steroids and methods of use thereof
WO2015195967A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
BR122021005552B1 (pt) 2015-07-06 2024-01-02 Sage Therapeutics, Inc Compostos oxiesteróis, seus usos e composição farmacêutica
AU2016289971C1 (en) 2015-07-06 2022-12-08 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3436022B1 (en) 2016-04-01 2022-03-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
PT3481846T (pt) 2016-07-07 2021-08-13 Sage Therapeutics Inc 24-hidroxiesteroides 11-substituídos para utilização no tratamento de afeções relacionadas com nmda
WO2018064649A1 (en) 2016-09-30 2018-04-05 Sage Therapeutics, Inc. C7 substituted oxysterols and methods as nmda modulators
RU2019115112A (ru) * 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
RU2019115113A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CN111560045A (zh) * 2020-06-23 2020-08-21 江苏佳尔科药业集团股份有限公司 一种以ba为原料合成石胆酸的方法
CN112375117A (zh) * 2020-11-14 2021-02-19 湖南科瑞生物制药股份有限公司 石胆酸及其中间体的制备方法
CN113651866B (zh) * 2021-08-02 2023-07-04 王涛 一种以21-羟基-20-甲基孕甾-4-烯-3-酮为原料合成胆固醇的新方法
EP4430056A1 (en) * 2021-11-10 2024-09-18 Umecrine AB 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor
US20250375459A1 (en) * 2022-07-01 2025-12-11 Intercept Pharmaceuticals, Inc. Methods for ameliorating cognitive impairment using bile acid derivatives
TW202430133A (zh) * 2022-11-21 2024-08-01 美商賽吉醫療公司 負ｎｍｄａ調節化合物及其使用方法
CN115974950A (zh) * 2022-12-23 2023-04-18 上海彩迩文生化科技有限公司 一种3-烷基化的甾体中间体及其制备和应用
WO2025020191A1 (zh) * 2023-07-27 2025-01-30 珂阑(上海)医药科技有限公司 甾类化合物、其制备方法和应用
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