AU2017214134B2 - Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof - Google Patents

Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof Download PDF

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Publication number
AU2017214134B2
AU2017214134B2 AU2017214134A AU2017214134A AU2017214134B2 AU 2017214134 B2 AU2017214134 B2 AU 2017214134B2 AU 2017214134 A AU2017214134 A AU 2017214134A AU 2017214134 A AU2017214134 A AU 2017214134A AU 2017214134 B2 AU2017214134 B2 AU 2017214134B2
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compound
formula
acid
process according
sodium
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AU2017214134A1 (en
Inventor
Zhaozhong DING
Yinghu HU
Fei Sun
Ling Yang
Rui Zhao
Yilong ZHOU
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2017214134A 2016-02-05 2017-02-04 Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof Active AU2017214134B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610082028.3A CN107043378A (zh) 2016-02-05 2016-02-05 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体
CN201610082028.3 2016-02-05
PCT/CN2017/072893 WO2017133686A1 (zh) 2016-02-05 2017-02-04 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

Publications (2)

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AU2017214134A1 AU2017214134A1 (en) 2018-08-23
AU2017214134B2 true AU2017214134B2 (en) 2020-08-27

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AU2017214134A Active AU2017214134B2 (en) 2016-02-05 2017-02-04 Method for preparing pyrrolo[3,2-d]pyrimidine compound, and intermediates thereof

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US (2) US10654856B2 (OSRAM)
EP (1) EP3412673B1 (OSRAM)
JP (1) JP6877449B2 (OSRAM)
KR (1) KR102371500B1 (OSRAM)
CN (2) CN107043378A (OSRAM)
AR (1) AR107549A1 (OSRAM)
AU (1) AU2017214134B2 (OSRAM)
BR (1) BR112018015879B1 (OSRAM)
CA (1) CA3013520C (OSRAM)
CL (1) CL2018002094A1 (OSRAM)
DK (1) DK3412673T3 (OSRAM)
EA (1) EA034581B1 (OSRAM)
ES (1) ES2852323T3 (OSRAM)
HR (1) HRP20210103T1 (OSRAM)
HU (1) HUE053455T2 (OSRAM)
IL (1) IL260999B (OSRAM)
LT (1) LT3412673T (OSRAM)
MX (1) MX374298B (OSRAM)
MY (1) MY190551A (OSRAM)
NZ (1) NZ744885A (OSRAM)
PH (1) PH12018501642B1 (OSRAM)
PL (1) PL3412673T3 (OSRAM)
PT (1) PT3412673T (OSRAM)
SG (1) SG11201806685VA (OSRAM)
SI (1) SI3412673T1 (OSRAM)
TW (1) TW201728590A (OSRAM)
UA (1) UA124100C2 (OSRAM)
WO (1) WO2017133686A1 (OSRAM)

Families Citing this family (8)

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CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
KR102808827B1 (ko) 2016-02-05 2025-05-19 데날리 테라퓨틱스 인크. 수용체-상호작용 단백질 키나제 1의 억제제
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
WO2021177679A1 (ko) 2020-03-02 2021-09-10 성균관대학교산학협력단 병원균 외벽 성분 기반 생병원체 모방 나노 입자 및 그 제조 방법
EP4194010A4 (en) 2020-08-04 2025-03-26 Progeneer Inc. Conjugate of a functional drug and a toll-like receptor 7 or 8 agonist with a temporarily inactivated drug site, and use thereof
JP7690221B2 (ja) 2020-08-04 2025-06-10 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
CN116322751A (zh) 2020-08-04 2023-06-23 蛋白科技先锋 包含能够动力学控制的佐剂的mRNA疫苗
JP2025503642A (ja) 2022-01-12 2025-02-04 デナリ セラピューティクス インコーポレイテッド （ｓ）－５－ベンジル－ｎ－（５－メチル－４－オキソ－２，３，４，５－テトラヒドロピリド［３，２－ｂ］［１，４］オキサゼピン－３－イル）－４ｈ－１，２，４－トリアゾール－３－カルボキサミドの結晶性形態

Citations (1)

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WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

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WO2009082247A1 (en) * 2007-12-21 2009-07-02 Industrial Research Limited Process for preparing immucillins having a methylene link
PE20120106A1 (es) 2008-12-09 2012-02-20 Gilead Sciences Inc Moduladores de receptores tipo toll
DK2906563T3 (en) * 2012-10-10 2018-06-06 Janssen Sciences Ireland Uc PYRROLO [3,2-D] PYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS AND OTHER DISEASES
PT2922549T (pt) * 2012-11-20 2017-09-01 Glaxosmithkline Llc Novos compostos
CR20160512A (es) * 2014-05-01 2016-12-21 Novartis Ag Compuestos y composiciones como agonistas del receptor tipo toll 7
CN105367576A (zh) 2014-08-15 2016-03-02 正大天晴药业集团股份有限公司 作为tlr7激动剂的吡咯并嘧啶化合物
BR112017002811B1 (pt) * 2014-08-15 2022-09-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Compostos de pirrolopirimidina usados como agonista de tlr7 e seu uso, composição farmacêutica e kit
JP6524355B2 (ja) * 2015-11-05 2019-06-05 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. Ｔｌｒ７アゴニストとしての７−（チアゾール−５−イル）ピロロピリミジン化合物
CN107043380A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043377A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds

Also Published As

Publication number Publication date
EP3412673B1 (en) 2020-11-25
SI3412673T1 (sl) 2021-04-30
CA3013520C (en) 2022-07-19
HUE053455T2 (hu) 2021-06-28
KR102371500B1 (ko) 2022-03-07
AR107549A1 (es) 2018-05-09
EA034581B1 (ru) 2020-02-21
EA201891769A1 (ru) 2019-04-30
JP2019505531A (ja) 2019-02-28
CL2018002094A1 (es) 2018-12-07
WO2017133686A1 (zh) 2017-08-10
BR112018015879A2 (pt) 2018-12-26
MY190551A (en) 2022-04-27
EP3412673A1 (en) 2018-12-12
KR20180104724A (ko) 2018-09-21
PL3412673T3 (pl) 2021-07-26
PT3412673T (pt) 2021-02-15
PH12018501642A1 (en) 2019-06-03
MX2018009502A (es) 2018-12-11
JP6877449B2 (ja) 2021-05-26
IL260999B (en) 2021-02-28
CN108602832B (zh) 2020-10-09
CN107043378A (zh) 2017-08-15
US20190040072A1 (en) 2019-02-07
US10654856B2 (en) 2020-05-19
CN108602832A (zh) 2018-09-28
ES2852323T3 (es) 2021-09-13
PH12018501642B1 (en) 2019-06-03
NZ744885A (en) 2022-07-01
LT3412673T (lt) 2021-03-10
DK3412673T3 (da) 2021-01-18
HK1259183A1 (zh) 2019-11-29
UA124100C2 (uk) 2021-07-21
HRP20210103T1 (hr) 2021-03-05
BR112018015879B1 (pt) 2024-02-15
SG11201806685VA (en) 2018-09-27
AU2017214134A1 (en) 2018-08-23
US20200239484A1 (en) 2020-07-30
TW201728590A (zh) 2017-08-16
CA3013520A1 (en) 2017-08-10
MX374298B (es) 2025-03-06
EP3412673A4 (en) 2019-07-03

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