AU2012258966C1 - Anti-CGRP compositions and use thereof - Google Patents

Anti-CGRP compositions and use thereof Download PDF

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Publication number
AU2012258966C1
AU2012258966C1 AU2012258966A AU2012258966A AU2012258966C1 AU 2012258966 C1 AU2012258966 C1 AU 2012258966C1 AU 2012258966 A AU2012258966 A AU 2012258966A AU 2012258966 A AU2012258966 A AU 2012258966A AU 2012258966 C1 AU2012258966 C1 AU 2012258966C1
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Australia
Prior art keywords
seq
cgrp
antibody
sequence
pain
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AU2012258966A1 (en
AU2012258966B2 (en
Inventor
Jens J. BILLGREN
Benjamin H. Dutzar
Leon F. Garcia-Martinez
Nicole M. JANSON
Brian Robert KOVACEVICH
John A. Latham
Maria-Cristina LOOMIS
Patricia Dianne Mcneill
Danielle M. Mitchell
Katie Olson
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H Lundbeck AS
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H Lundbeck AS
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Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of AU2012258966A1 publication Critical patent/AU2012258966A1/en
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Publication of AU2012258966B2 publication Critical patent/AU2012258966B2/en
Priority to AU2017203890A priority Critical patent/AU2017203890B2/en
Priority to AU2019226231A priority patent/AU2019226231B2/en
Assigned to H. LUNDBECK A/S reassignment H. LUNDBECK A/S Request for Assignment Assignors: ALDERBIO HOLDINGS LLC
Publication of AU2012258966C1 publication Critical patent/AU2012258966C1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2012258966A 2011-05-20 2012-05-21 Anti-CGRP compositions and use thereof Active 2036-06-16 AU2012258966C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017203890A AU2017203890B2 (en) 2011-05-20 2017-06-08 Anti-CGRP compositions and use thereof
AU2019226231A AU2019226231B2 (en) 2011-05-20 2019-09-06 Anti-CGRP compositions and use thereof

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161488660P 2011-05-20 2011-05-20
US61/488,660 2011-05-20
PCT/US2012/038844 WO2012162243A2 (en) 2011-05-20 2012-05-21 Anti-cgrp compositions and use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017203890A Division AU2017203890B2 (en) 2011-05-20 2017-06-08 Anti-CGRP compositions and use thereof

Publications (3)

Publication Number Publication Date
AU2012258966A1 AU2012258966A1 (en) 2013-12-05
AU2012258966B2 AU2012258966B2 (en) 2017-03-09
AU2012258966C1 true AU2012258966C1 (en) 2022-02-03

Family

ID=47175055

Family Applications (3)

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AU2012258966A Active 2036-06-16 AU2012258966C1 (en) 2011-05-20 2012-05-21 Anti-CGRP compositions and use thereof
AU2017203890A Active AU2017203890B2 (en) 2011-05-20 2017-06-08 Anti-CGRP compositions and use thereof
AU2019226231A Active AU2019226231B2 (en) 2011-05-20 2019-09-06 Anti-CGRP compositions and use thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017203890A Active AU2017203890B2 (en) 2011-05-20 2017-06-08 Anti-CGRP compositions and use thereof
AU2019226231A Active AU2019226231B2 (en) 2011-05-20 2019-09-06 Anti-CGRP compositions and use thereof

Country Status (38)

Country Link
US (10) US9745373B2 (enExample)
EP (5) EP2710039B1 (enExample)
JP (3) JP6282584B2 (enExample)
KR (1) KR102128627B1 (enExample)
CN (5) CN107602700B (enExample)
AP (1) AP2013007259A0 (enExample)
AR (3) AR086516A1 (enExample)
AU (3) AU2012258966C1 (enExample)
BR (2) BR112013029932A2 (enExample)
CA (3) CA2836649C (enExample)
CL (3) CL2013003336A1 (enExample)
CO (1) CO6870005A2 (enExample)
CY (2) CY1124209T1 (enExample)
DK (3) DK3662932T3 (enExample)
EA (3) EA201891284A1 (enExample)
ES (3) ES2873837T3 (enExample)
FR (1) FR22C1032I2 (enExample)
HR (3) HRP20190640T1 (enExample)
HU (4) HUE055505T2 (enExample)
IL (4) IL229431B (enExample)
LT (4) LT2710039T (enExample)
LU (1) LUC00270I2 (enExample)
MX (3) MX370749B (enExample)
NL (1) NL301181I2 (enExample)
NO (1) NO2022029I1 (enExample)
NZ (1) NZ733060A (enExample)
PE (2) PE20180502A1 (enExample)
PH (2) PH12013502405B1 (enExample)
PL (3) PL3495392T3 (enExample)
PT (3) PT3495392T (enExample)
RS (3) RS62306B1 (enExample)
SG (2) SG194938A1 (enExample)
SI (3) SI3495392T1 (enExample)
SM (3) SMT202100526T1 (enExample)
TR (1) TR201904088T4 (enExample)
TW (4) TWI646111B (enExample)
WO (1) WO2012162243A2 (enExample)
ZA (1) ZA201308637B (enExample)

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TR201904088T4 (tr) * 2011-05-20 2019-05-21 Alderbio Holdings Llc Anti-CGRP bileşimleri ve bunların kullanımları.
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US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
US20150017166A1 (en) * 2013-07-03 2015-01-15 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
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JP2021518748A (ja) * 2018-02-23 2021-08-05 アールイーエムディー バイオセラピューティクス，インコーポレイテッドＲＥＭＤ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ カルシトニン遺伝子関連ペプチド（ｃｇｒｐ）アンタゴニスト抗体
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US10899826B1 (en) * 2018-09-13 2021-01-26 Teva Pharmaceuticals International Gmbh Pharmaceutical compositions for an anti-CGRP antagonist antibody
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MA54709A (fr) * 2019-01-08 2022-04-13 H Lundbeck As Traitement de maux de tête dus à un usage abusif de médicaments à l'aide d'anticorps anti-cgrp ou anti-cgrp-r
BR112021016996A8 (pt) * 2019-02-28 2022-11-22 Dandi Bioscience Inc Polipeptídeo com atividade antibacteriana, composição para prevenir ou tratar sepsis compreendendo a mesma e composição antibacteriana
JP2022533030A (ja) * 2019-05-02 2022-07-21 ハー・ルンドベック・アクチエゼルスカベット 抗ｃｇｒｐ抗体を用いた頭痛の治療
WO2020239014A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 抗cgrp抗体及其应用
KR20210124867A (ko) 2020-04-06 2021-10-15 하. 룬드벡 아크티에셀스카브 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료
KR20230157986A (ko) 2021-03-02 2023-11-17 체게에르페 다이어그노스틱스 게엠베하 편투통 발생의 치료 및/또는 저감
US20250109188A1 (en) 2021-08-24 2025-04-03 Cgrp Diagnostics Gmbh Preventative treatment of migraine
IL310885A (en) 2021-08-27 2024-04-01 H Lundbeck As Treatment of cluster headache using anti-CGRP antibodies
CA3243636A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg CONJUGATED COMPRISING AT LEAST ONE β-GLUCANE OR ONE MANNANA
WO2024032750A1 (zh) * 2022-08-11 2024-02-15 上海君实生物医药科技股份有限公司 抗cgrp抗体及用途
IT202300010371A1 (it) * 2023-05-23 2024-11-23 Alberto Chiarugi Inibitori della crescita tumorale
CN120899912A (zh) * 2024-05-07 2025-11-07 中国人民解放军军事科学院军事医学研究院 一种治疗自身免疫性疾病的方法和应用
CN118271438B (zh) * 2024-05-27 2024-08-30 上海宏成药业有限公司 抗cgrp抗体或其抗原结合片段及其用途

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