AU2012245971A1 - A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation - Google Patents
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation Download PDFInfo
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- AU2012245971A1 AU2012245971A1 AU2012245971A AU2012245971A AU2012245971A1 AU 2012245971 A1 AU2012245971 A1 AU 2012245971A1 AU 2012245971 A AU2012245971 A AU 2012245971A AU 2012245971 A AU2012245971 A AU 2012245971A AU 2012245971 A1 AU2012245971 A1 AU 2012245971A1
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- Prior art keywords
- compound
- cancer
- crystalline form
- solvent
- process according
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- 150000003839 salts Chemical class 0.000 title abstract description 10
- CZWPOIYWNZYKCD-UHFFFAOYSA-N 4-(1h-indol-2-ylsulfonyl)morpholine Chemical class C=1C2=CC=CC=C2NC=1S(=O)(=O)N1CCOCC1 CZWPOIYWNZYKCD-UHFFFAOYSA-N 0.000 title abstract description 7
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 59
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 57
- 239000002904 solvent Substances 0.000 claims description 52
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
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| PCT/IB2012/051967 WO2012143879A1 (en) | 2011-04-21 | 2012-04-19 | A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation |
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| JP2014514321A (ja) * | 2011-04-21 | 2014-06-19 | メルク・シャープ・アンド・ドーム・コーポレーション | インスリン様増殖因子１受容体阻害剤 |
| WO2014002007A1 (en) * | 2012-06-26 | 2014-01-03 | Piramal Enterprises Limited | Method of predicting or monitoring response to igf-1r and ir inhibitors using biomarkers |
| KR102196374B1 (ko) | 2012-11-29 | 2020-12-31 | 케모센트릭스, 인크. | Cxcr7 길항제 |
| WO2014177915A1 (en) | 2013-05-01 | 2014-11-06 | Piramal Enterprises Limited | Cancer combination therapy using imidazo[4,5-c]quinoline derivatives |
| CN104098498A (zh) * | 2014-07-30 | 2014-10-15 | 天津市斯芬克司药物研发有限公司 | 一种吲唑类化合物及其制备方法 |
| WO2016041953A1 (en) | 2014-09-15 | 2016-03-24 | Dmitry Gorilovsky | A system comprising multiple digital cameras viewing a large scene |
| CN105218475A (zh) * | 2015-10-15 | 2016-01-06 | 湖南华腾制药有限公司 | 1,2-吗啉盐酸盐的合成方法 |
| CA3085481A1 (en) | 2017-12-15 | 2019-06-20 | Inthera Bioscience AG | 1 -(piperidinocarbonylmethyl)-2-oxopiperazine derivatives for treating cancer |
| BR112021011222A2 (pt) | 2018-12-12 | 2021-08-24 | Chemocentryx, Inc. | Inibidores de cxcr7 para o tratamento de câncer |
| CN113149941A (zh) * | 2020-01-22 | 2021-07-23 | 中国科学院上海药物研究所 | 醚类化合物及其在防治糖尿病及代谢综合征中的药学用途 |
| WO2025014774A1 (en) | 2023-07-07 | 2025-01-16 | Viridian Therapeutics, Inc. | Methods of treating active and chronic thyroid eye disease |
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-
2012
- 2012-04-19 JP JP2014506536A patent/JP2014514321A/ja active Pending
- 2012-04-19 US US14/112,743 patent/US20140046059A1/en not_active Abandoned
- 2012-04-19 AU AU2012245455A patent/AU2012245455A1/en not_active Abandoned
- 2012-04-19 US US14/112,671 patent/US20140045847A1/en not_active Abandoned
- 2012-04-19 US US14/113,166 patent/US20140045832A1/en not_active Abandoned
- 2012-04-19 EP EP12723912.7A patent/EP2699568A1/en not_active Withdrawn
- 2012-04-19 CN CN201280030276.3A patent/CN103732592A/zh active Pending
- 2012-04-19 WO PCT/US2012/034188 patent/WO2012145471A1/en not_active Ceased
- 2012-04-19 AU AU2012245971A patent/AU2012245971A1/en not_active Abandoned
- 2012-04-19 WO PCT/IB2012/051967 patent/WO2012143879A1/en not_active Ceased
- 2012-04-19 CA CA2833009A patent/CA2833009A1/en not_active Abandoned
- 2012-04-19 EP EP12718823.3A patent/EP2699567A1/en not_active Withdrawn
- 2012-04-19 CA CA2831730A patent/CA2831730A1/en not_active Abandoned
- 2012-04-19 WO PCT/IB2012/051958 patent/WO2012143874A1/en not_active Ceased
- 2012-04-19 IN IN2170MUN2013 patent/IN2013MN02170A/en unknown
-
2013
- 2013-10-09 IL IL228810A patent/IL228810A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2699568A1 (en) | 2014-02-26 |
| CA2831730A1 (en) | 2012-10-26 |
| JP2014514321A (ja) | 2014-06-19 |
| WO2012145471A1 (en) | 2012-10-26 |
| US20140045832A1 (en) | 2014-02-13 |
| WO2012143874A1 (en) | 2012-10-26 |
| AU2012245455A8 (en) | 2013-11-07 |
| IN2013MN02170A (enExample) | 2015-06-12 |
| US20140045847A1 (en) | 2014-02-13 |
| AU2012245971A8 (en) | 2013-11-07 |
| IL228810A0 (en) | 2013-12-31 |
| CA2833009A1 (en) | 2012-10-26 |
| CN103732592A (zh) | 2014-04-16 |
| AU2012245455A1 (en) | 2013-10-31 |
| EP2699567A1 (en) | 2014-02-26 |
| US20140046059A1 (en) | 2014-02-13 |
| WO2012143879A1 (en) | 2012-10-26 |
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