AU2010289400B2 - Mutant smoothened and methods of using the same - Google Patents
Mutant smoothened and methods of using the same Download PDFInfo
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- AU2010289400B2 AU2010289400B2 AU2010289400A AU2010289400A AU2010289400B2 AU 2010289400 B2 AU2010289400 B2 AU 2010289400B2 AU 2010289400 A AU2010289400 A AU 2010289400A AU 2010289400 A AU2010289400 A AU 2010289400A AU 2010289400 B2 AU2010289400 B2 AU 2010289400B2
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Classifications
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23936409P | 2009-09-02 | 2009-09-02 | |
| US61/239,364 | 2009-09-02 | ||
| PCT/US2010/047739 WO2011028950A1 (en) | 2009-09-02 | 2010-09-02 | Mutant smoothened and methods of using the same |
Publications (2)
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| WO2015116902A1 (en) | 2014-01-31 | 2015-08-06 | Genentech, Inc. | G-protein coupled receptors in hedgehog signaling |
| WO2015120075A2 (en) | 2014-02-04 | 2015-08-13 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| EP3253784B1 (en) * | 2015-02-04 | 2020-05-06 | Genentech, Inc. | Mutant smoothened and methods of using the same |
| AU2016271432A1 (en) | 2015-06-05 | 2017-12-07 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| EP3411396A1 (en) | 2016-02-04 | 2018-12-12 | Curis, Inc. | Mutant smoothened and methods of using the same |
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2016
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| JP2016073276A (ja) | 2016-05-12 |
| CA2772715C (en) | 2019-03-26 |
| WO2011028950A1 (en) | 2011-03-10 |
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| EP2473522B1 (en) | 2016-08-17 |
| JP6279527B2 (ja) | 2018-02-14 |
| AU2010289400A1 (en) | 2012-04-12 |
| US20120282259A1 (en) | 2012-11-08 |
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| US9910050B2 (en) | 2018-03-06 |
| JP5887270B2 (ja) | 2016-03-16 |
| ES2599076T3 (es) | 2017-01-31 |
| JP2013503644A (ja) | 2013-02-04 |
| US20160313354A1 (en) | 2016-10-27 |
| US9321823B2 (en) | 2016-04-26 |
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