AU2009317860B2 - Enzymes and methods for producing omega-3 fatty acids - Google Patents
Enzymes and methods for producing omega-3 fatty acids Download PDFInfo
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- AU2009317860B2 AU2009317860B2 AU2009317860A AU2009317860A AU2009317860B2 AU 2009317860 B2 AU2009317860 B2 AU 2009317860B2 AU 2009317860 A AU2009317860 A AU 2009317860A AU 2009317860 A AU2009317860 A AU 2009317860A AU 2009317860 B2 AU2009317860 B2 AU 2009317860B2
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Classifications
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| AU2023241326A AU2023241326A1 (en) | 2008-11-18 | 2023-10-05 | Enzymes and methods for producing omega-3 fatty acids |
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Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11952581B2 (en) | 2003-08-01 | 2024-04-09 | Basf Plant Science Gmbh | Process for the production of polyunsaturated fatty acids in transgenic organisms |
| PT2172536T (pt) | 2003-08-01 | 2016-08-17 | Basf Plant Science Gmbh | Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos |
| CA2558726C (en) | 2004-02-27 | 2017-11-07 | Basf Plant Science Gmbh | Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms |
| CN1930277B (zh) | 2004-02-27 | 2011-02-02 | 巴斯福植物科学有限公司 | 在转基因植物中产生多不饱和脂肪酸的方法 |
| PL1756280T3 (pl) | 2004-04-22 | 2015-04-30 | Commw Scient Ind Res Org | Synteza długołańcuchowych wielonienasyconych kwasów tłuszczowych w komórkach rekombinowanych |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| AR059376A1 (es) | 2006-02-21 | 2008-03-26 | Basf Plant Science Gmbh | Procedimiento para la produccion de acidos grasos poliinsaturados |
| EP2046108A4 (en) | 2006-07-14 | 2010-03-24 | Commw Scient Ind Res Org | CHANGE OF FATTY ACID COMPOSITION OF RICE |
| BRPI0716075A2 (pt) | 2006-08-29 | 2013-08-06 | Commw Scient Ind Res Org | sÍntese de Ácidos graxos |
| CA2722276A1 (en) * | 2008-04-25 | 2009-10-29 | Commonwealth Scientific Industrial Research Organisation | Recombinant cells and methods for hydroxylating fatty acids |
| US20110218348A1 (en) * | 2008-04-25 | 2011-09-08 | Commonwealth Scientific Industrial Research Organisation | Polypeptides and methods for producing triacylglycerols comprising modified fatty acids |
| ES2603530T3 (es) | 2008-07-21 | 2017-02-28 | Commonwealth Scientific And Industrial Research Organisation | Aceite de semilla de algodón mejorado y usos |
| CA2768737A1 (en) | 2008-07-21 | 2010-01-28 | Commonwealth Scientific And Industrial Research Organisation | Improved vegetable oils and uses therefor |
| CA3015426C (en) * | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| US9493520B2 (en) | 2009-07-17 | 2016-11-15 | Basf Plant Science Company Gmbh | Fatty acid desaturases and elongases and uses thereof |
| CA2804025C (en) | 2010-06-28 | 2023-02-21 | Commonwealth Scientific And Industrial Research Organisation | Methods of producing lipids |
| AU2011317632B2 (en) * | 2010-10-21 | 2016-08-18 | Basf Plant Science Company Gmbh | Novel fatty acid desaturases, elongases, elongation components and uses therof |
| DK2740797T3 (da) * | 2011-08-04 | 2017-02-20 | Suntory Holdings Ltd | Protein med aktivitet til at fremme fedtsyreforlængelse, derfor kodende gen samt anvendelse deraf |
| WO2013096992A1 (en) | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Reserach Organisation | Simultaneous gene silencing and supressing gene silencing in the same cell |
| WO2013096993A1 (en) | 2011-12-27 | 2013-07-04 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
| CA2860416C (en) | 2011-12-27 | 2024-04-30 | Commonwealth Scientific And Industrial Research Organisation | Production of dihydrosterculic acid and derivatives thereof |
| US11639507B2 (en) | 2011-12-27 | 2023-05-02 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
| US8809026B2 (en) | 2011-12-27 | 2014-08-19 | Commonwealth Scientific And Industrial Research Organisation | Processes for producing lipids |
| BR112014025265A2 (pt) * | 2012-04-12 | 2017-07-11 | Rothamsted Res Ltd | produção de ácidos graxos poli-insaturados ômega-3 de cadeia longa |
| CN104619164B (zh) | 2012-04-25 | 2018-11-16 | 联邦科学技术研究组织 | 高油酸油 |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| US20140090108A1 (en) * | 2012-09-18 | 2014-03-27 | Freydoun Garabagi | Vectors and Methods For Enhancing Recombinant Protein Expression in Plants |
| GB201217524D0 (en) * | 2012-10-01 | 2012-11-14 | Rothamsted Res Ltd | Recombinant organisms |
| CN102978177B (zh) * | 2012-11-09 | 2015-06-03 | 浙江工业大学 | 冬虫夏草合成代谢二十碳五烯酸的△-5-脱氢酶、基因及应用 |
| CN103173445B (zh) * | 2013-04-15 | 2014-07-30 | 南京江辉生物科技有限公司 | 一种欧米伽3的合成基因、含有合成基因的大肠菌及其构建方法 |
| KR20160023703A (ko) | 2013-06-14 | 2016-03-03 | 제이.알.심프롯캄패니 | 식물에서의 단백질 생산 |
| EA037817B1 (ru) * | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
| US11718577B2 (en) | 2013-12-18 | 2023-08-08 | Commonwealth Scientific And Industrial Research Organisation | Lipid compositions comprising triacylglycerol with long-chain polyunsaturated fatty acids |
| CN117305343A (zh) * | 2014-06-27 | 2023-12-29 | 联邦科学技术研究组织 | 包含二十二碳五烯酸的提取的植物脂质 |
| CA2953008C (en) * | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
| EA037184B1 (ru) * | 2014-06-27 | 2021-02-16 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Липид, содержащий докозапентаеновую кислоту |
| PH12016502588B1 (en) | 2014-07-07 | 2024-01-17 | Commw Scient Ind Res Org | Processes for producing industrial products from plant lipids |
| US11484560B2 (en) | 2014-11-14 | 2022-11-01 | Basf Plant Science Company Gmbh | Stabilising fatty acid compositions |
| US20180122021A1 (en) * | 2015-03-03 | 2018-05-03 | Uop Llc | Chemical refinery performance optimization |
| JP2019129705A (ja) | 2016-03-31 | 2019-08-08 | 日本たばこ産業株式会社 | 植物に物質を導入する方法 |
| JP6959942B2 (ja) * | 2016-05-03 | 2021-11-05 | ロンザ リミテッドLonza Limited | タンパク質生成のための脂質代謝のモジュレーション |
| AR109245A1 (es) * | 2016-05-12 | 2018-11-14 | Basf Plant Science Co Gmbh | Métodos para optimizar la producción de metabolitos en plantas genéticamente modificadas y para procesar estas plantas |
| CA3026079C (en) | 2016-06-01 | 2024-10-01 | Cargill Inc | FISH FOOD PREPARED FROM OILSEED PLANTS PRODUCING OMEGA-3 FATTY ACIDS |
| KR102420456B1 (ko) * | 2016-06-16 | 2022-07-14 | 누시드 뉴트리셔널 오스트레일리아 피티와이 엘티디. | 근친교배 형질전환 카놀라 계통 ns-b50027-4 및 이의 종자 |
| WO2018039740A1 (en) | 2016-09-02 | 2018-03-08 | Commonwealth Scientific And Industrial Research Organisation | Plants with modified traits |
| WO2018057879A1 (en) | 2016-09-23 | 2018-03-29 | Wake Forest University | Modified microorganisms as sustainable sources of omega-3 polyunsaturated fatty acid production |
| US11913006B2 (en) | 2018-03-16 | 2024-02-27 | Nuseed Global Innovation Ltd. | Plants producing modified levels of medium chain fatty acids |
| CN108220167A (zh) * | 2018-04-10 | 2018-06-29 | 中盐工程技术研究院有限公司 | 盐藻纯化分离方法及微藻纯化分离方法 |
| CN112367971A (zh) | 2018-06-11 | 2021-02-12 | 加利福尼亚大学董事会 | 用以治疗眼睛疾病的脱甲基化 |
| EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586642A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala enriched polyunsaturated fatty acid compositions |
| AU2020236396A1 (en) | 2019-03-08 | 2021-10-14 | Commonwealth Scientific And Industrial Research Organisation | Expression of nitrogenase polypeptides in plant cells |
| US10916099B2 (en) * | 2019-06-04 | 2021-02-09 | Igt | Gaming system and method with guaranteed symbol generation |
| US10896579B2 (en) * | 2019-06-04 | 2021-01-19 | Igt | Gaming system and method with dynamically determined guaranteed awards |
| CN110218777B (zh) * | 2019-06-14 | 2023-05-16 | 苏州天合优才生物科技有限公司 | Pcr预混液 |
| PE20230178A1 (es) * | 2019-10-25 | 2023-02-01 | Nuseed Nutritional Us Inc | Composiciones enriquecidas de acidos grasos poliinsaturados |
| WO2022015699A1 (en) * | 2020-07-14 | 2022-01-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods to produce very long chain fatty acids |
| JPWO2022168958A1 (enExample) | 2021-02-05 | 2022-08-11 | ||
| AU2022419399A1 (en) * | 2021-12-20 | 2024-06-27 | Commonwealth Scientific And Industrial Research Organisation | Plants for producing cannabinoids |
| JP2023102179A (ja) * | 2022-01-11 | 2023-07-24 | 花王株式会社 | 脂質の製造方法 |
| CN119614625A (zh) * | 2025-02-17 | 2025-03-14 | 中国热带农业科学院三亚研究院 | 芜菁皱缩病毒蛋白p38在调控拟南芥双链结合蛋白上的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005103253A1 (en) * | 2004-04-22 | 2005-11-03 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| WO2007096387A1 (de) * | 2006-02-21 | 2007-08-30 | Basf Plant Science Gmbh | Verfahren zur herstellung von mehrfach ungesättigten fettsäuren |
Family Cites Families (256)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| DE3484215D1 (de) | 1983-01-17 | 1991-04-11 | Monsanto Co | Chimaerische gene geeignet zur expression in pflanzenzellen. |
| US5504200A (en) | 1983-04-15 | 1996-04-02 | Mycogen Plant Science, Inc. | Plant gene expression |
| DE3587718T2 (de) | 1984-03-06 | 1994-08-04 | Mgi Pharma Inc | Herbizide Resistenz in Pflanzen. |
| US5420034A (en) | 1986-07-31 | 1995-05-30 | Calgene, Inc. | Seed-specific transcriptional regulation |
| ZA871352B (en) | 1986-02-27 | 1987-08-12 | The General Hospital Corporation | Plant cells resistant to herbicidal glutamine synthetase inhibitors |
| MA20977A1 (fr) | 1986-05-19 | 1987-12-31 | Ciba Geigy Ag | Plantes tolerant les herbicides contenant le gene de gluthathione S-Transferase |
| US5188958A (en) | 1986-05-29 | 1993-02-23 | Calgene, Inc. | Transformation and foreign gene expression in brassica species |
| US5177010A (en) | 1986-06-30 | 1993-01-05 | University Of Toledo | Process for transforming corn and the products thereof |
| SE455438B (sv) | 1986-11-24 | 1988-07-11 | Aga Ab | Sett att senka en brennares flamtemperatur samt brennare med munstycken for oxygen resp brensle |
| US5004863B2 (en) | 1986-12-03 | 2000-10-17 | Agracetus | Genetic engineering of cotton plants and lines |
| CN87100603A (zh) | 1987-01-21 | 1988-08-10 | 昂科公司 | 抗黑素瘤疫苗 |
| US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
| US5932479A (en) | 1988-09-26 | 1999-08-03 | Auburn University | Genetic engineering of plant chloroplasts |
| ATE160174T1 (de) | 1989-08-09 | 1997-11-15 | Dekalb Genetics Corp | Methoden und zusammensetzungen für die herstellung von stabil transformierten, fruchtbaren mais pflanzen und zellen dafür |
| DK0472712T3 (da) | 1990-03-16 | 2002-01-14 | Calgene Llc | Sekvenser, der præferentielt eksprimeres i tidlig frøudvikling og dertil relaterede fremgangsmåder |
| US5451513A (en) | 1990-05-01 | 1995-09-19 | The State University of New Jersey Rutgers | Method for stably transforming plastids of multicellular plants |
| US5877402A (en) | 1990-05-01 | 1999-03-02 | Rutgers, The State University Of New Jersey | DNA constructs and methods for stably transforming plastids of multicellular plants and expressing recombinant proteins therein |
| US5861187A (en) | 1990-08-30 | 1999-01-19 | Cargill, Incorporated | Oil from canola seed with altered fatty acid profiles and a method of producing oil |
| US7135614B1 (en) | 1990-08-30 | 2006-11-14 | Cargill, Incorporated | Brassica or helianthus plants having mutant delta-12 or delta-15 sequences |
| US5518908A (en) | 1991-09-23 | 1996-05-21 | Monsanto Company | Method of controlling insects |
| US6355861B1 (en) | 1991-10-10 | 2002-03-12 | Rhone-Poulenc Agrochimie | Production of gamma linolenic acid by a Δ6-desaturase |
| US6683232B1 (en) | 1991-10-10 | 2004-01-27 | Rhone-Poulenc Agrochimie | Production of γ linolenic acid by a Δ6-desaturase |
| US5614393A (en) | 1991-10-10 | 1997-03-25 | Rhone-Poulenc Agrochimie | Production of γ-linolenic acid by a Δ6-desaturase |
| PH31293A (en) | 1991-10-10 | 1998-07-06 | Rhone Poulenc Agrochimie | Production of y-linolenic acid by a delta6-desaturage. |
| CA2124673C (en) | 1991-12-04 | 2008-08-05 | John Browse | Fatty acid desaturase genes from plants |
| US5593874A (en) | 1992-03-19 | 1997-01-14 | Monsanto Company | Enhanced expression in plants |
| US5798259A (en) | 1992-05-15 | 1998-08-25 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| US5683898A (en) | 1992-05-15 | 1997-11-04 | Sagami Chemical Research Center | Gene coding for eicosapentaenoic acid synthesizing enzymes and process for production of eicosapentaenoic acid |
| FI940203L (fi) | 1992-05-15 | 1994-03-14 | Sagami Chem Res | Geeni, joka koodaa eikosapeutaanihappoa syntetisoivia entsyymejä, ja menetelmä eikospentaanihapon valmistamiseksi |
| US6372965B1 (en) | 1992-11-17 | 2002-04-16 | E.I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and hydroxylases from plants |
| US6872872B1 (en) | 1992-11-17 | 2005-03-29 | E. I. Du Pont De Nemours And Company | Genes for microsomal delta-12 fatty acid desaturases and related enzymes from plants |
| EP0688160B1 (en) | 1993-03-11 | 1998-05-13 | National Research Council Of Canada | Enhanced regeneration system for cereals |
| CA2092588C (en) | 1993-03-26 | 2008-07-08 | Narender S. Nehra | Enhanced regeneration system for cereals |
| US5362865A (en) | 1993-09-02 | 1994-11-08 | Monsanto Company | Enhanced expression in plants using non-translated leader sequences |
| GB9324707D0 (en) | 1993-12-02 | 1994-01-19 | Olsen Odd Arne | Promoter |
| GB9403512D0 (en) | 1994-02-24 | 1994-04-13 | Olsen Odd Arne | Promoter |
| US5545818A (en) | 1994-03-11 | 1996-08-13 | Calgene Inc. | Expression of Bacillus thuringiensis cry proteins in plant plastids |
| GB9515941D0 (en) | 1995-08-03 | 1995-10-04 | Zeneca Ltd | DNA constructs |
| US5939288A (en) | 1995-06-07 | 1999-08-17 | Iowa State University Research Foundation, Inc. | Plant secretory signal peptides and nectarins |
| EP0880312B1 (en) | 1995-12-14 | 2006-03-08 | Cargill Incorporated | Plants having mutant sequences that confer altered fatty acid profiles |
| US7541519B2 (en) | 1995-12-14 | 2009-06-02 | Cargill, Incorporated | Fatty acid desaturases and mutant sequences thereof |
| US6342658B1 (en) | 1995-12-14 | 2002-01-29 | Cargill, Incorporated | Fatty acid desaturases and mutant sequences thereof |
| TR199800294T1 (xx) | 1996-06-21 | 1999-10-21 | Monsanto Company | Sabit transforme edilen verimli bu�day �retim y�ntemleri. |
| AU727694B2 (en) | 1996-07-10 | 2000-12-21 | Sagami Chemical Research Center | Process for producing icosapentaenoic acid by genetic recombination |
| US7109392B1 (en) | 1996-10-09 | 2006-09-19 | Cargill, Incorporated | Methods for increasing oleic acid content in seeds from transgenic plants containing a mutant delta 12 desaturase |
| WO1998018952A1 (en) | 1996-10-30 | 1998-05-07 | Nippon Suisan Kaisha, Ltd. | Process for producing fats containing highly unsaturated fatty acids containing selectively concentrated docosahexaenoic acid |
| US6194167B1 (en) | 1997-02-18 | 2001-02-27 | Washington State University Research Foundation | ω-3 fatty acid desaturase |
| DE69840022D1 (de) | 1997-03-04 | 2008-10-30 | Suntory Ltd | Verfahren zur herstellung von hochungesättigten fettsäuren und hochungesättigte fettsäuren enthaltendes lipid |
| US5977436A (en) | 1997-04-09 | 1999-11-02 | Rhone Poulenc Agrochimie | Oleosin 5' regulatory region for the modification of plant seed lipid composition |
| US6432684B1 (en) | 1997-04-11 | 2002-08-13 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6428990B1 (en) | 1997-04-11 | 2002-08-06 | Abbott Laboratories | Human desaturase gene and uses thereof |
| US6051754A (en) | 1997-04-11 | 2000-04-18 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US5968809A (en) * | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| ATE297994T1 (de) | 1997-04-11 | 2005-07-15 | Calgene Llc | Verfahren und zusammensetzungen für die synthese von langkettigen, mehrfach ungesättigten fettsäuren in pflanzen. |
| US5972664A (en) | 1997-04-11 | 1999-10-26 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| US6075183A (en) | 1997-04-11 | 2000-06-13 | Abbott Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids in plants |
| US7589253B2 (en) | 1997-04-15 | 2009-09-15 | Commonwealth Scientific And Industrial Research Organisation | Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism |
| US6235529B1 (en) | 1997-04-29 | 2001-05-22 | The Regents Of The University Of California | Compositions and methods for plant transformation and regeneration |
| US6566583B1 (en) | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| IL133272A0 (en) | 1997-06-04 | 2001-04-30 | Calgene Llc | Production of polyunsaturated fatty acid by expression of polyketide-like synthesis genes in plants |
| EP0987936A4 (en) | 1997-06-12 | 2001-03-14 | Cargill Inc | FATTY ACID DESATURASES AND MUTED SEQUENCES THEREOF |
| AU8583798A (en) | 1997-07-23 | 1999-02-16 | Centro De Investigacion Y De Estudios Avanzados Del I.P.N. | Improved plastid transformation of higher plants and production of trans genic plants with herbicide resistance |
| DE69840362D1 (de) | 1997-09-12 | 2009-01-29 | Commw Scient Ind Res Org | Regulation der genexpression in pflanzen |
| AU746032B2 (en) | 1997-09-30 | 2002-04-11 | Regents Of The University Of California, The | Production of proteins in plant seeds |
| CA2305570A1 (en) | 1997-10-01 | 1999-04-08 | Brian E. Busse | Container handling system |
| GB9724783D0 (en) | 1997-11-24 | 1998-01-21 | Inst Arable Crops Research | Novel polypeptides |
| EP1042485A2 (en) | 1997-12-23 | 2000-10-11 | University Of Bristol | Desaturase |
| US20030152983A1 (en) | 1997-12-23 | 2003-08-14 | University Of Bristol | Desaturase |
| US6100447A (en) | 1998-02-12 | 2000-08-08 | Applied Phytologics, Inc. | Method of barley transformation |
| AU763296B2 (en) | 1998-03-20 | 2003-07-17 | E.I. Du Pont De Nemours And Company | Limanthes oil genes |
| US6838594B1 (en) | 1998-03-20 | 2005-01-04 | E. I. Du Pont De Nemours And Company | Limnanthes oil genes |
| US6492108B1 (en) | 1998-03-26 | 2002-12-10 | Incyte Genomics, Inc. | Delta-6 desaturase homologs |
| EP1080189A4 (en) | 1998-05-29 | 2003-01-08 | Univ Ohio | COMPOSITIONS AND METHODS FOR THE PRODUCTION OF FATTY ACIDS, THEIR DERIVATIVES AND SUBSEQUENT PRODUCTS |
| EP1086236B1 (en) | 1998-06-12 | 2007-09-05 | Calgene LLC | Polyunsaturated fatty acids in plants |
| AU4564399A (en) | 1998-06-12 | 1999-12-30 | Abbott Laboratories | Polyunsaturated fatty acids in plants |
| WO2000011176A2 (en) | 1998-08-20 | 2000-03-02 | E.I. Du Pont De Nemours And Company | Genes for plant fatty acid modifying enzymes associated with conjugated double bond formation |
| WO2000011012A1 (en) | 1998-08-24 | 2000-03-02 | Rutgers, The State University Of New Jersey | Synthetic fatty acid desaturase gene for expression in plants |
| US6913916B1 (en) | 1998-09-02 | 2005-07-05 | Abbott Laboratories | Elongase genes and uses thereof |
| US20030163845A1 (en) | 1998-09-02 | 2003-08-28 | Pradip Mukerji | Elongase genes and uses thereof |
| US6403349B1 (en) | 1998-09-02 | 2002-06-11 | Abbott Laboratories | Elongase gene and uses thereof |
| US6677145B2 (en) | 1998-09-02 | 2004-01-13 | Abbott Laboratories | Elongase genes and uses thereof |
| WO2000020603A1 (en) | 1998-10-05 | 2000-04-13 | Abbott Laboratories | Altered fatty acid biosynthesis in insect cells using delta five desaturase |
| AU1097900A (en) | 1998-10-05 | 2000-04-26 | Abbott Laboratories | Delta 6 and delta 12 desaturases and modified fatty acid biosynthesis and products produced therefrom |
| JP2002527051A (ja) | 1998-10-09 | 2002-08-27 | メルク エンド カムパニー インコーポレーテッド | デルタ6脂肪酸デサチュラーゼ |
| JP4182192B2 (ja) | 1998-11-26 | 2008-11-19 | 独立行政法人産業技術総合研究所 | イコサペンタエン酸及び/又はドコサヘキサエン酸の生合成に関与する酵素群をコードする遺伝子 |
| US6864077B1 (en) | 1998-12-03 | 2005-03-08 | Edgar B. Cahoon | Membrane-bound desaturases |
| JP2001095588A (ja) | 1998-12-04 | 2001-04-10 | Research Institute Of Innovative Technology For The Earth | 緑藻のω3脂肪酸不飽和化酵素遺伝子及びその利用 |
| US6825017B1 (en) | 1998-12-07 | 2004-11-30 | Washington State University Research Foundation | Desaturases and methods of using them for synthesis of polyunsaturated fatty acids |
| US8003772B2 (en) | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7217856B2 (en) | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7247461B2 (en) | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US7271315B2 (en) | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US6448473B1 (en) * | 1999-03-05 | 2002-09-10 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| EP1035207A1 (en) | 1999-03-09 | 2000-09-13 | MultiGene Biotech GmbH | cDNA molecules of the members of gene family encoding human fatty acid desaturases and their use in diagnosis and therapy |
| WO2000055330A1 (en) | 1999-03-18 | 2000-09-21 | The University Of Bristol | Polysaturated fatty acid (pufa) elongase from caenorhabditis elegans |
| IL146782A0 (en) | 1999-06-07 | 2002-07-25 | Basf Plant Science Gmbh | 6-acetylenase and 6-desaturase from ceratodon purpureus |
| EP1190080A1 (de) | 1999-07-06 | 2002-03-27 | BASF Plant Science GmbH | $g(D)6-DESATURASEGENE EXPRIMIERENDE PFLANZEN UND PUFAS ENTHALTENDE ÖLE AUS DIESEN PFLANZEN UND EIN VERFAHREN ZUR HERSTELLUNG UNGESÄTTIGTER FETTSÄUREN |
| AU6091600A (en) | 1999-07-12 | 2001-01-30 | Ohio University | Mammalian cells expressing desaturases and elongases |
| US7070970B2 (en) | 1999-08-23 | 2006-07-04 | Abbott Laboratories | Elongase genes and uses thereof |
| CN1378602A (zh) | 1999-08-26 | 2002-11-06 | 卡尔根尼有限公司 | 含修饰的多不饱和脂肪酸的植物 |
| US7067722B2 (en) | 1999-08-26 | 2006-06-27 | Monsanto Technology Llc | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| US7531718B2 (en) | 1999-08-26 | 2009-05-12 | Monsanto Technology, L.L.C. | Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids |
| DE10044468A1 (de) | 1999-09-10 | 2001-03-15 | Axiva Gmbh | Neue Nukleinsäure aus Tetrahymena kodierend für eine delta-6Desaturase, ihre Herstellung und ihre Verwendung |
| FR2798391B1 (fr) | 1999-09-15 | 2001-12-14 | Inst Nat Sante Rech Med | Enzyme thyroidienne nadph oxydase, acide nucleique codant pour cette enzyme et leurs applications |
| DE19950589A1 (de) | 1999-10-20 | 2001-05-23 | Gvs Ges Fuer Erwerb Und Verwer | Elongasepromotoren für gewebespezifische Expression von Transgenen in Pflanzen |
| JP4221476B2 (ja) | 1999-11-19 | 2009-02-12 | 独立行政法人産業技術総合研究所 | イコサペンタエン酸生合成遺伝子群をクローニングしたプラスミド及びイコサペンタエン酸を産生するラン藻 |
| WO2001038512A2 (en) * | 1999-11-22 | 2001-05-31 | Plant Bioscience Limited | Enhanced transgene expression by co-expression with a suppressor of post-transcriptional gene silencing (ptgs) |
| AU1499601A (en) | 1999-11-25 | 2001-06-04 | Basf Plant Science Gmbh | Moss genes from physcomitrella patents encoding proteins involved in the synthesis of polyunsaturated fatty acids and lipids |
| JP2001169780A (ja) | 1999-12-15 | 2001-06-26 | Natl Inst Of Advanced Industrial Science & Technology Meti | ドコサヘキサエン酸生産細菌の遺伝子 |
| GB9929897D0 (en) | 1999-12-18 | 2000-02-09 | Slabas Antoni R | Improvements in or relating to conjugated fatty acids and related compounds |
| US20030172398A1 (en) | 1999-12-21 | 2003-09-11 | Browse John A. | Novel delta-12 desaturase and methods of using it for synthesis of polyunsaturated fatty acids |
| PL207026B1 (pl) | 2000-02-09 | 2010-10-29 | Basf Ag | Wyizolowany kwas nukleinowy, konstrukt genowy zawierający ten kwas, sekwencja aminokwasowa kodowana przez wyizolowaną sekwencję tego kwasu nukleinowego, wektor zawierający kwas nukleinowy lub konstrukt genowy, roślina transgeniczna lub mikroorganizm transgeniczny zawierający kwas nukleinowy, konstrukt genowy lub wektor, przeciwciało specyficznie wiążące się z polipeptydem kodowanym przez kwas nukleinowy, cząsteczka antysensownego kwasu nukleinowego oraz sposób wytwarzania wielonienasyconych kwasów tłuszczowych (PUFA) |
| US6686185B1 (en) | 2000-03-07 | 2004-02-03 | Millennium Pharmaceuticals, Inc. | 25934, a novel fatty acid desaturase and uses therefor |
| US20020111307A1 (en) | 2000-06-23 | 2002-08-15 | Glucksmann Maria Alexandra | 46508, a novel human peptidyl-tRNA hydrolase family member and uses thereof |
| US7411054B2 (en) | 2000-03-07 | 2008-08-12 | Millennium Pharmaceuticals, Inc. | 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor |
| US20040157221A9 (en) | 2000-03-07 | 2004-08-12 | Millennium Pharmaceuticals, Inc. | Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor |
| US6492577B1 (en) | 2000-03-16 | 2002-12-10 | The Regents Of The University Of California | Leafy cotyledon2 genes and their uses |
| WO2001073060A2 (en) | 2000-03-24 | 2001-10-04 | Millennium Pharmaceuticals, Inc. | 18221, dual specificity phosphatase and uses thereof |
| CA2301158A1 (en) | 2000-03-24 | 2001-09-24 | Stephen J. Allen | Screening methods for compounds useful for modulating lipid metabolism in disease |
| WO2001075069A1 (en) | 2000-03-31 | 2001-10-11 | Idemitsu Petrochemical Co., Ltd. | Process for producing lipids and lipid-secreting microorganisms |
| DE60142734D1 (de) | 2000-04-18 | 2010-09-16 | Commw Scient Ind Res Org | Verfahren zur modifizierung des baumwollölgehaltes |
| WO2001087140A2 (en) | 2000-05-16 | 2001-11-22 | Crosetto Dario B | Method and apparatus for anatomical and functional medical imaging |
| US7091005B2 (en) | 2000-05-16 | 2006-08-15 | Merck & Co., Inc. | Gene responsible for Stargardt-like dominant macular dystrophy |
| EP1404820A2 (en) | 2000-05-19 | 2004-04-07 | Millennium Pharmaceuticals, Inc. | 50365, a hexokinase family member and uses therefor |
| WO2001092489A2 (en) | 2000-05-26 | 2001-12-06 | Washington State University Research Foundation | Palmitate desaturase gene |
| WO2001096363A1 (en) | 2000-06-12 | 2001-12-20 | Boyce Thompson Institute For Plant Research | Fatty acid desaturase gene and protein for modulating activation of defense signaling pathways in plants |
| EP1297155A2 (en) | 2000-06-29 | 2003-04-02 | Millennium Pharmaceuticals, Inc. | 25869, a human carboxylesterase and uses thereof |
| WO2002006302A2 (en) | 2000-07-17 | 2002-01-24 | Millennium Pharmaceuticals, Inc. | 16816 and 16839, novel human phospholipase c molecules and uses therefor |
| GB0316629D0 (en) | 2003-07-16 | 2003-08-20 | Univ York | Transgenic cell |
| EP1339839A2 (en) | 2000-08-21 | 2003-09-03 | Millennium Pharmaceuticals, Inc. | Human transporter family members and uses thereof |
| CA2430987A1 (en) | 2000-09-26 | 2002-04-04 | Xenon Genetics, Inc. | Methods and compositions employing a novel stearoyl-coa desaturase-hscd5 |
| ES2343106T3 (es) | 2000-09-28 | 2010-07-23 | BIORIGINAL FOOD & SCIENCE CORP. | Fad4, fad5, fad5-2 y fad6, miembros de la familia de desaturasas de acidos grasos y usos de los mismos. |
| US7297523B2 (en) | 2000-11-29 | 2007-11-20 | Xenon Pharmaceuticals Inc. | Human elongase genes and uses thereof |
| DE10102337A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren, neue Biosynthesegene sowie neue pflanzliche Expressionskonstrukte |
| DE10102338A1 (de) | 2001-01-19 | 2002-07-25 | Basf Plant Science Gmbh | Verfahren zur Expression von Biosynthesegenen in pflanzlichen Samen unter Verwendung von neuen multiplen Expressionskonstrukten |
| EP1392823B1 (en) | 2001-01-25 | 2011-11-30 | Abbott Laboratories | Desaturase genes and uses thereof |
| US6635451B2 (en) | 2001-01-25 | 2003-10-21 | Abbott Laboratories | Desaturase genes and uses thereof |
| DE10106660A1 (de) | 2001-02-12 | 2002-08-29 | Celanese Ventures Gmbh | Verfahren zur Herstellung von gamma-Linolensäure aus einer Ciliaten-Kultur durch Zusatz geeigneter Vorläufermoleküle zu dem Kulturmedium |
| GB0107510D0 (en) | 2001-03-26 | 2001-05-16 | Univ Bristol | New elongase gene and a process for the production of -9-polyunsaturated fatty acids |
| WO2002081702A1 (fr) | 2001-04-05 | 2002-10-17 | Idemitsu Technofine Co., Ltd. | Genes de desaturase en position $g(d)6 d'acide gras, plasmides et transformants contenant ces genes |
| CN1273271C (zh) | 2001-04-11 | 2006-09-06 | 罗伯特·博施有限公司 | 具有减振手把的手持式工具机 |
| TWI426126B (zh) | 2001-04-16 | 2014-02-11 | Dsm Ip Assets Bv | 多不飽和脂肪酸(pufa)聚乙醯合成酶系統及其用途(二) |
| TWI324181B (en) | 2001-04-16 | 2010-05-01 | Martek Biosciences Corp | Product and process for transformation of thraustochytriales microorganisms |
| US20030082754A1 (en) | 2001-05-04 | 2003-05-01 | Pradip Mukerji | Delta4 - desaturase genes and uses thereof |
| US7045683B2 (en) | 2001-05-04 | 2006-05-16 | Abbott Laboratories | Δ4-desaturase genes and uses thereof |
| EP2255668A3 (en) * | 2001-05-14 | 2012-04-04 | Martek Biosciences Corporation | Production and Use of a Polar Lipid-Rich Fraction Containing Omega-3 and/or Omega-6 Highly Unsaturated Fatty Acids from Microbes, Genetically Modified Plant Seeds and Marine Organisms |
| WO2002102970A2 (en) | 2001-06-06 | 2002-12-27 | Bioriginal Food & Science Corporation | Flax (linum usitatissimim l.) seed-specific promoters |
| DE10134660A1 (de) | 2001-07-20 | 2003-02-06 | Basf Plant Science Gmbh | Fettsäure-Desaturase-Gene aus Granatapfel und Verfahren zur Herstellung von ungesättigten Fettsäuren |
| US20050089879A1 (en) | 2001-07-31 | 2005-04-28 | Ivo Feussner | Method for producing arachidonic acid in transgenic organisms |
| US6875595B2 (en) | 2001-09-13 | 2005-04-05 | Divergence, Inc. | Nematode fatty acid desaturase-like sequences |
| JP2003116566A (ja) | 2001-10-12 | 2003-04-22 | Osamu Suzuki | n−3系ドコサペンタエン酸の製造方法 |
| EP1472357B1 (de) | 2002-01-30 | 2009-12-16 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren mittels eines neuen elongase-gens |
| US7211656B2 (en) | 2002-01-30 | 2007-05-01 | Abbott Laboratories | Desaturase genes, enzymes encoded thereby, and uses thereof |
| GB2385852A (en) | 2002-02-27 | 2003-09-03 | Rothamsted Ex Station | Delta 6-desaturases from Primulaceae |
| US7700833B2 (en) | 2002-03-01 | 2010-04-20 | Cornell University | Process for the production of unsaturated fatty acids |
| EP2302060B1 (en) | 2002-03-16 | 2012-07-25 | The University of York | Desaturases |
| DE10219203A1 (de) | 2002-04-29 | 2003-11-13 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in Pflanzen |
| CA2883729C (en) | 2002-05-22 | 2017-03-07 | Virginia M. Ursin | Fatty acid desaturases from fungi |
| WO2004005442A1 (de) | 2002-07-03 | 2004-01-15 | Basf Plant Science Gmbh | Verfahren zur herstellung von konjugierten mehrfach ungesättigten fettsäuren mit mindestens zwei doppelbindungen in pflanzen |
| CN1675802A (zh) | 2002-08-19 | 2005-09-28 | 安德森电工产品公司 | 用于电连接器的手柄锁定系统及其方法 |
| GB0229578D0 (en) * | 2002-12-19 | 2003-01-22 | Univ Bristol | Novel method for the production of polyunsaturated fatty acids |
| BR0317304A (pt) | 2002-12-19 | 2005-11-08 | Univ Bristol | Processo para a produção de compostos, sequência de ácido nucleico isolada, sequência de aminoácidos, construção gênica, vetor, e, organismo |
| US20040172682A1 (en) | 2003-02-12 | 2004-09-02 | Kinney Anthony J. | Production of very long chain polyunsaturated fatty acids in oilseed plants |
| US8084074B2 (en) | 2003-02-12 | 2011-12-27 | E. I. Du Pont De Nemours And Company | Production of very long chain polyunsaturated fatty acids in oil seed plants |
| ATE517984T1 (de) * | 2003-02-27 | 2011-08-15 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren |
| EP3121269A1 (de) | 2003-03-31 | 2017-01-25 | University Of Bristol | Neue pflanzliche acyltransferase spezifisch für langkettige mehrfach ungesättigte fettsäuren |
| DE10315026A1 (de) | 2003-04-02 | 2004-10-14 | Bioplanta Arzneimittel Gmbh | Zusammensetzungen enthaltend omega-3-fettsäurehaltige Öle und Pflanzenextrakte |
| JP4732333B2 (ja) | 2003-04-08 | 2011-07-27 | ビーエーエスエフ プラント サイエンス ゲーエムベーハー | ミドリムシ(Euglenagracilis)由来のΔ−4−デサチュラーゼを発現する植物およびPUFA含有油 |
| ATE394483T1 (de) | 2003-04-16 | 2008-05-15 | Basf Plant Science Gmbh | Verwendung von genen zur erhöhung des ölgehaltes in pflanzen |
| US8313911B2 (en) | 2003-05-07 | 2012-11-20 | E I Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7238482B2 (en) | 2003-05-07 | 2007-07-03 | E. I. Du Pont De Nemours And Company | Production of polyunsaturated fatty acids in oleaginous yeasts |
| US7125672B2 (en) | 2003-05-07 | 2006-10-24 | E. I. Du Pont De Nemours And Company | Codon-optimized genes for the production of polyunsaturated fatty acids in oleaginous yeasts |
| US20110059496A1 (en) | 2003-06-25 | 2011-03-10 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| US7267976B2 (en) | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| PT2172536T (pt) * | 2003-08-01 | 2016-08-17 | Basf Plant Science Gmbh | Processo para a produção de ácidos gordos poli-insaturados em organismos transgénicos |
| AU2004268196B2 (en) | 2003-08-21 | 2010-03-04 | Monsanto Technology Llc | Fatty acid desaturases from primula |
| US20050132441A1 (en) * | 2003-11-12 | 2005-06-16 | Damude Howard G. | Delta15 desaturases suitable for altering levels of polyunsaturated fatty acids in oilseed plants and oleaginous yeast |
| US7504259B2 (en) | 2003-11-12 | 2009-03-17 | E. I. Du Pont De Nemours And Company | Δ12 desaturases suitable for altering levels of polyunsaturated fatty acids in oleaginous yeast |
| MY140210A (en) | 2003-12-22 | 2009-11-30 | Suntory Holdings Ltd | Marchantiales-derived unsaturated fatty acid synthetase genes and use of the same |
| WO2005080578A2 (en) * | 2004-02-17 | 2005-09-01 | The University Of York | Desaturase enzymes |
| CN1930277B (zh) * | 2004-02-27 | 2011-02-02 | 巴斯福植物科学有限公司 | 在转基因植物中产生多不饱和脂肪酸的方法 |
| CA2558726C (en) | 2004-02-27 | 2017-11-07 | Basf Plant Science Gmbh | Method for producing unsaturated .omega.-3-fatty acids in transgenic organisms |
| EP4219670A3 (de) | 2004-02-27 | 2023-08-09 | BASF Plant Science GmbH | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen pflanzen |
| US7217956B2 (en) | 2004-03-29 | 2007-05-15 | Articulated Technologies, Llc. | Light active sheet material |
| DE102004017370A1 (de) | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| DE102004017369A1 (de) | 2004-04-08 | 2005-11-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Screeningverfahren zur Identifizierung von PUFA-PKS in Proben |
| JP2007533310A (ja) | 2004-04-16 | 2007-11-22 | モンサント テクノロジー エルエルシー | トウモロコシにおける脂肪酸デサチュラーゼの発現 |
| ES2529572T3 (es) | 2004-04-22 | 2015-02-23 | Commonwealth Scientific And Industrial Research Organisation | Síntesis de ácidos grasos poliinsaturados de cadena larga por células recombinantes |
| AU2005235627B2 (en) | 2004-04-22 | 2011-07-07 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| CN101018862B (zh) * | 2004-04-22 | 2013-10-09 | 联邦科学技术研究组织 | 用重组细胞合成长链多不饱和脂肪酸 |
| AU2005250074B2 (en) | 2004-06-04 | 2011-04-14 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US7550651B2 (en) | 2004-06-25 | 2009-06-23 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| DE102004060340A1 (de) | 2004-07-16 | 2006-02-09 | Basf Plant Science Gmbh | Verfahren zur Erhöhung des Gehalts an mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| US7270315B2 (en) | 2004-09-28 | 2007-09-18 | Amt International, Inc. | Exchange column, perforated tray assembly |
| GB0421937D0 (en) | 2004-10-02 | 2004-11-03 | Univ York | Acyl CoA synthetases |
| US7198937B2 (en) | 2004-11-04 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US8685679B2 (en) | 2004-11-04 | 2014-04-01 | E I Du Pont De Nemours And Company | Acyltransferase regulation to increase the percent of polyunsaturated fatty acids in total lipids and oils of oleaginous organisms |
| US7189559B2 (en) | 2004-11-04 | 2007-03-13 | E. I. Du Pont De Nemours And Company | Mortierella alpina lysophosphatidic acid acyltransferase homolog for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7273746B2 (en) | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7192762B2 (en) | 2004-11-04 | 2007-03-20 | E. I. Du Pont De Nemours And Company | Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7550286B2 (en) | 2004-11-04 | 2009-06-23 | E. I. Du Pont De Nemours And Company | Docosahexaenoic acid producing strains of Yarrowia lipolytica |
| US20060094102A1 (en) | 2004-11-04 | 2006-05-04 | Zhixiong Xue | Ammonium transporter promoter for gene expression in oleaginous yeast |
| US20100120103A1 (en) | 2004-12-14 | 2010-05-13 | Avesthagen Limited | Recombinant Production Docosahexaenoic Acid (DHA) in Yeast |
| DE102004062294A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten langkettigen Fettsäuren in transgenen Organismen |
| DE102004063326A1 (de) | 2004-12-23 | 2006-07-06 | Basf Plant Science Gmbh | Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenen Organismen |
| DE102005013779A1 (de) | 2005-03-22 | 2006-09-28 | Basf Plant Science Gmbh | Verfahren zur Herstellung von mehrfach ungesättigten C20- und C22-Fettsäuren mit mindestens vier Doppelbindungen in transgenen Pflanzen |
| WO2006135866A2 (en) | 2005-06-10 | 2006-12-21 | Martek Biosciences Corporation | Pufa polyketide synthase systems and uses thereof |
| US20110138495A1 (en) * | 2005-07-05 | 2011-06-09 | Arthur Weissinger | Methods and Compositions for Expressing Proteins In Plants |
| DE102005038036A1 (de) | 2005-08-09 | 2007-02-15 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure in transgenen Nutzpflanzen |
| GB2431158A (en) | 2005-10-13 | 2007-04-18 | Rothamsted Res Ltd | Process for the production of arachidonic and/or eicosapentaenoic acid |
| DE102005052551A1 (de) | 2005-11-02 | 2007-05-16 | Rothamsted Res Harpenden | Verfahren zur Herstellung von y-Linolensäure und/oder Stearidonsäure in transgenen Brassicaceae und Linaceae |
| WO2007061742A1 (en) | 2005-11-23 | 2007-05-31 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| WO2007092460A2 (en) * | 2006-02-03 | 2007-08-16 | The Texas A & M University System | Enhancing expression of value-added genes by transgenic expression of tombusvirus-based p19 gene mutants |
| GB0603160D0 (en) | 2006-02-16 | 2006-03-29 | Rothamsted Res Ltd | Nucleic acid |
| MX340759B (es) | 2006-03-15 | 2015-03-11 | Dsm Ip Assets B V * | Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados. |
| US7943823B2 (en) | 2006-04-28 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Delta-8 desaturase and its use in making polyunsaturated fatty acids |
| EP2029751B1 (en) | 2006-05-29 | 2012-02-22 | Icon Genetics GmbH | Plant virus-based inducible expression system |
| JP4230494B2 (ja) | 2006-06-06 | 2009-02-25 | 日立建機株式会社 | 電気駆動ダンプトラックの駆動システム |
| JP2009542231A (ja) * | 2006-07-11 | 2009-12-03 | バイオリジナル フード アンド サイエンス コーポレーション | 脂肪酸デサチュラーゼおよびその用途 |
| DE102006034313A1 (de) | 2006-07-21 | 2008-01-24 | Basf Plant Science Gmbh | Verfahren zur Herstellung von Arachidonsäure und/oder Eicosapentaensäure |
| CA2659993C (en) | 2006-08-24 | 2016-01-05 | Basf Plant Science Gmbh | Isolation and characterization of a novel pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains |
| BRPI0716075A2 (pt) | 2006-08-29 | 2013-08-06 | Commw Scient Ind Res Org | sÍntese de Ácidos graxos |
| WO2008040787A2 (de) | 2006-10-06 | 2008-04-10 | Basf Plant Science Gmbh | Verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
| US8916361B2 (en) | 2006-11-17 | 2014-12-23 | Abbott Laboratories | Elongase gene and uses thereof |
| US7709239B2 (en) | 2006-12-07 | 2010-05-04 | E.I. Du Pont De Nemours And Company | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids |
| WO2008104559A1 (de) * | 2007-02-27 | 2008-09-04 | Norddeutsche Pflanzenzucht | Verfahren zur herstellung von mehrfach ungesättigten fettsäuren in transgenen organismen |
| DK2129777T3 (en) | 2007-04-03 | 2016-01-25 | Du Pont | MULTIZYMER AND USE THEREOF FOR THE PRODUCTION OF polyunsaturated fatty acids |
| US8119860B2 (en) | 2007-04-16 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-9 elongases and their use in making polyunsaturated fatty acids |
| US7943365B2 (en) | 2007-05-03 | 2011-05-17 | E.I. Du Pont De Nemours And Company | Δ-5 desaturases and their use in making polyunsaturated fatty acids |
| CA2694661C (en) | 2007-07-31 | 2017-10-03 | Basf Plant Science Gmbh | Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms |
| WO2009016208A2 (de) | 2007-07-31 | 2009-02-05 | Basf Plant Science Gmbh | Elongasen und verfahren zur herstellung mehrfach ungesättigter fettsäuren in transgenen organismen |
| US8119784B2 (en) | 2008-04-02 | 2012-02-21 | E. I. Du Pont De Nemours And Company | Delta-4 desaturase and its use in making polyunsaturated fatty acids |
| US20110218348A1 (en) | 2008-04-25 | 2011-09-08 | Commonwealth Scientific Industrial Research Organisation | Polypeptides and methods for producing triacylglycerols comprising modified fatty acids |
| CA2721879A1 (en) | 2008-04-25 | 2009-10-29 | Basf Plant Science Gmbh | Plant seed oil |
| US8785727B2 (en) | 2008-04-30 | 2014-07-22 | Rothamsted Research Ltd. | Desaturase and method for the production of polyunsaturated fatty acids in transgenic organisms |
| CA2726489A1 (en) | 2008-06-03 | 2009-12-10 | Basf Plant Science Gmbh | Fatiy acid dehydratases and uses thereof |
| US8168858B2 (en) | 2008-06-20 | 2012-05-01 | E. I. Du Pont De Nemours And Company | Delta-9 fatty acid elongase genes and their use in making polyunsaturated fatty acids |
| WO2010000708A2 (en) | 2008-07-01 | 2010-01-07 | Basf Plant Science Gmbh | Promoters from brassica napus for seed specific gene expression |
| CA2768737A1 (en) | 2008-07-21 | 2010-01-28 | Commonwealth Scientific And Industrial Research Organisation | Improved vegetable oils and uses therefor |
| ES2603530T3 (es) | 2008-07-21 | 2017-02-28 | Commonwealth Scientific And Industrial Research Organisation | Aceite de semilla de algodón mejorado y usos |
| EP2331695B1 (en) | 2008-08-26 | 2014-07-23 | BASF Plant Science GmbH | Nucleic acids encoding desaturases and modified plant oil |
| EP2337791B1 (en) | 2008-10-14 | 2013-07-24 | Monsanto Technology LLC | Utilization of fatty acid desaturases from hemiselmis spp |
| CA3015426C (en) | 2008-11-18 | 2020-01-14 | Commonwealth Scientific And Industrial Research Organisation | Recombinant cells comprising exogenous .delta.5 and .delta.6 desaturases, .delta.5 and .delta.6 elongases, and .delta.4 desaturases |
| DE112009003708T5 (de) | 2008-12-12 | 2012-09-13 | Basf Plant Science Gmbh | Desaturasen und Verfahren zur Herstellung mehrfach ungesättigter Fettsäuren in transgenenOrganismen |
| CA2760326A1 (en) | 2009-05-13 | 2010-11-18 | Basf Plant Science Company Gmbh | Acyltransferases and uses thereof in fatty acid production |
| US8188335B2 (en) | 2009-07-17 | 2012-05-29 | Abbott Laboratories | Δ9-elongase for production of polyunsaturated fatty acid-enriched oils |
| US9493520B2 (en) | 2009-07-17 | 2016-11-15 | Basf Plant Science Company Gmbh | Fatty acid desaturases and elongases and uses thereof |
| US9428757B2 (en) | 2009-08-31 | 2016-08-30 | Basf Plant Science Company Gmbh | Regulatory nucleic acid molecules for enhancing seed-specific gene expression in plants promoting enhanced polyunsaturated fatty acid synthesis |
| CA2804025C (en) | 2010-06-28 | 2023-02-21 | Commonwealth Scientific And Industrial Research Organisation | Methods of producing lipids |
| US9311457B1 (en) | 2011-11-02 | 2016-04-12 | Google Inc. | Platform for cloud application software |
| HUE033766T2 (en) | 2012-06-15 | 2018-01-29 | Commw Scient Ind Res Org | Production of long chain polyunsaturated fatty acids in plant cells |
| EA037817B1 (ru) | 2013-12-18 | 2021-05-25 | Коммонвелт Сайнтифик Энд Индастриэл Рисерч Организэйшн | Экстрагированный растительный липид, содержащий длинноцепочечные полиненасыщенные жирные кислоты |
| CA2953008C (en) | 2014-06-27 | 2024-03-19 | Nuseed Pty Ltd | Lipid comprising docosapentaenoic acid |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005103253A1 (en) * | 2004-04-22 | 2005-11-03 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| WO2007096387A1 (de) * | 2006-02-21 | 2007-08-30 | Basf Plant Science Gmbh | Verfahren zur herstellung von mehrfach ungesättigten fettsäuren |
Non-Patent Citations (1)
| Title |
|---|
| Robert S et al, Marine Biotechnology, 2009, 11(3):410-418 * |
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