AU2008308519B2 - Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer - Google Patents
Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer Download PDFInfo
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- AU2008308519B2 AU2008308519B2 AU2008308519A AU2008308519A AU2008308519B2 AU 2008308519 B2 AU2008308519 B2 AU 2008308519B2 AU 2008308519 A AU2008308519 A AU 2008308519A AU 2008308519 A AU2008308519 A AU 2008308519A AU 2008308519 B2 AU2008308519 B2 AU 2008308519B2
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
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| US60/977,953 | 2007-10-05 | ||
| US4610908P | 2008-04-18 | 2008-04-18 | |
| US61/046,109 | 2008-04-18 | ||
| PCT/US2008/078786 WO2009046323A1 (en) | 2007-10-05 | 2008-10-03 | Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer |
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| AU2008308519A1 AU2008308519A1 (en) | 2009-04-09 |
| AU2008308519A2 AU2008308519A2 (en) | 2010-04-29 |
| AU2008308519B2 true AU2008308519B2 (en) | 2014-09-11 |
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| EP (1) | EP2214666B1 (enExample) |
| JP (1) | JP5411145B2 (enExample) |
| KR (1) | KR101417200B1 (enExample) |
| CN (1) | CN101883564B (enExample) |
| AU (1) | AU2008308519B2 (enExample) |
| BR (1) | BRPI0817516A2 (enExample) |
| CA (1) | CA2701620C (enExample) |
| DK (1) | DK2214666T3 (enExample) |
| ES (1) | ES2449594T3 (enExample) |
| MX (1) | MX2010003669A (enExample) |
| NZ (1) | NZ584729A (enExample) |
| PL (1) | PL2214666T3 (enExample) |
| RU (1) | RU2490014C2 (enExample) |
| TW (1) | TWI500422B (enExample) |
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| US20140286910A1 (en) * | 2013-03-19 | 2014-09-25 | Nikolai Tankovich | Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity |
| CN112826794B (zh) | 2019-11-06 | 2022-02-11 | 上海交通大学医学院 | 一种靶向修复神经血管病变的纳米复合物及其制备与应用 |
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| US20050009885A1 (en) * | 2003-05-15 | 2005-01-13 | Mullan Michael J. | Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
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| EP1392287B8 (en) | 2001-05-25 | 2007-01-10 | Schering Corporation | Use of substituted azetidinone derivatives in the treatment of Alzheimer's disease |
| EP1426051B1 (en) * | 2001-09-11 | 2008-07-16 | Asahi Kasei Pharma Corporation | Medicinal composition for prevention of or treatment for cerebrovascular disorder |
| EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
| TW200306799A (en) | 2002-05-17 | 2003-12-01 | Novartis Ag | Combination of organic compounds |
| AU2003298514A1 (en) | 2002-05-17 | 2004-05-04 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| ES2369216T3 (es) | 2002-05-17 | 2011-11-28 | Novartis Pharma Ag | Composición farmacéutica que comprende un inhibidor de renina, un bloqueador del canal de calcio y un diurético. |
| JP2003146878A (ja) | 2002-11-22 | 2003-05-21 | Sawai Pharmaceutical Co Ltd | ニルバジピン含有易溶性固形製剤およびその製造法 |
| EA012325B1 (ru) | 2002-12-24 | 2009-08-28 | Беллус Хелс (Интернэшнл) Лимитед | Терапевтические составы для лечения болезней, связанных с наличием бета-амилоида |
| US20050031651A1 (en) * | 2002-12-24 | 2005-02-10 | Francine Gervais | Therapeutic formulations for the treatment of beta-amyloid related diseases |
| JP2004002460A (ja) | 2003-07-29 | 2004-01-08 | Towa Yakuhin Kk | 易吸収性ニルバジピン錠の製造法 |
| WO2009046338A1 (en) * | 2007-10-05 | 2009-04-09 | Roskamp Research Llc | Method for increasing cerebral blood flow with (+)-nilvadipine enantiomer |
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2008
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- 2008-10-03 PL PL08836256T patent/PL2214666T3/pl unknown
- 2008-10-03 TW TW097138351A patent/TWI500422B/zh not_active IP Right Cessation
- 2008-10-03 US US12/245,354 patent/US8236346B2/en not_active Expired - Fee Related
- 2008-10-03 NZ NZ584729A patent/NZ584729A/xx not_active IP Right Cessation
- 2008-10-03 KR KR1020107009874A patent/KR101417200B1/ko not_active Expired - Fee Related
- 2008-10-03 CN CN200880118761XA patent/CN101883564B/zh not_active Expired - Fee Related
- 2008-10-03 ES ES08836256.1T patent/ES2449594T3/es active Active
- 2008-10-03 JP JP2010528172A patent/JP5411145B2/ja not_active Expired - Fee Related
- 2008-10-03 CA CA2701620A patent/CA2701620C/en not_active Expired - Fee Related
- 2008-10-03 EP EP08836256.1A patent/EP2214666B1/en active Active
- 2008-10-03 DK DK08836256.1T patent/DK2214666T3/da active
- 2008-10-03 RU RU2010117634/15A patent/RU2490014C2/ru active
- 2008-10-03 AU AU2008308519A patent/AU2008308519B2/en not_active Ceased
- 2008-10-03 MX MX2010003669A patent/MX2010003669A/es active IP Right Grant
- 2008-10-03 WO PCT/US2008/078786 patent/WO2009046323A1/en not_active Ceased
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2010
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| EP0321636A2 (en) * | 1987-06-12 | 1989-06-28 | American Cyanamid Company | Enhancers for the transdermal flux of certain 1,4-Dihydropyridine derivatives |
| US5508413A (en) * | 1987-08-27 | 1996-04-16 | Fujisawa Pharmaceutical Co., Ltd. | (+)-5-isopropyl 3-methyl 2-cyano-6 methyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate |
| US20050009885A1 (en) * | 2003-05-15 | 2005-01-13 | Mullan Michael J. | Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010117634A (ru) | 2011-11-10 |
| MX2010003669A (es) | 2010-11-25 |
| US8236346B2 (en) | 2012-08-07 |
| DK2214666T3 (da) | 2014-01-27 |
| US20090092667A1 (en) | 2009-04-09 |
| KR20100067683A (ko) | 2010-06-21 |
| US8236347B2 (en) | 2012-08-07 |
| JP2010540661A (ja) | 2010-12-24 |
| TW200920364A (en) | 2009-05-16 |
| EP2214666A4 (en) | 2010-12-08 |
| AU2008308519A1 (en) | 2009-04-09 |
| TWI500422B (zh) | 2015-09-21 |
| EP2214666A1 (en) | 2010-08-11 |
| NZ584729A (en) | 2012-12-21 |
| AU2008308519A2 (en) | 2010-04-29 |
| US20100183711A1 (en) | 2010-07-22 |
| CN101883564B (zh) | 2013-10-16 |
| PL2214666T3 (pl) | 2014-06-30 |
| WO2009046323A1 (en) | 2009-04-09 |
| KR101417200B1 (ko) | 2014-08-01 |
| CN101883564A (zh) | 2010-11-10 |
| CA2701620A1 (en) | 2009-04-09 |
| CA2701620C (en) | 2014-12-09 |
| JP5411145B2 (ja) | 2014-02-12 |
| EP2214666B1 (en) | 2013-12-11 |
| RU2490014C2 (ru) | 2013-08-20 |
| BRPI0817516A2 (pt) | 2015-06-16 |
| ES2449594T3 (es) | 2014-03-20 |
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