MX2010003669A - Metodo para reducir la deposicion de amiloide, neurotoxicidad y microgliosis con el enantiomero (-)-nilvadipina. - Google Patents
Metodo para reducir la deposicion de amiloide, neurotoxicidad y microgliosis con el enantiomero (-)-nilvadipina.Info
- Publication number
- MX2010003669A MX2010003669A MX2010003669A MX2010003669A MX2010003669A MX 2010003669 A MX2010003669 A MX 2010003669A MX 2010003669 A MX2010003669 A MX 2010003669A MX 2010003669 A MX2010003669 A MX 2010003669A MX 2010003669 A MX2010003669 A MX 2010003669A
- Authority
- MX
- Mexico
- Prior art keywords
- nilvadipine
- human
- animal
- approximately
- enantiomerically enriched
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
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| US97795307P | 2007-10-05 | 2007-10-05 | |
| US4610908P | 2008-04-18 | 2008-04-18 | |
| PCT/US2008/078786 WO2009046323A1 (en) | 2007-10-05 | 2008-10-03 | Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer |
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| MX2010003669A true MX2010003669A (es) | 2010-11-25 |
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| BR (1) | BRPI0817516A2 (enExample) |
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| TW (1) | TWI500422B (enExample) |
| WO (1) | WO2009046323A1 (enExample) |
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| US20140286910A1 (en) * | 2013-03-19 | 2014-09-25 | Nikolai Tankovich | Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity |
| CN112826794B (zh) | 2019-11-06 | 2022-02-11 | 上海交通大学医学院 | 一种靶向修复神经血管病变的纳米复合物及其制备与应用 |
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| US4338322A (en) * | 1975-07-02 | 1982-07-06 | Fujisawa Pharmaceutical Co., Ltd. | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same |
| JPS6038322A (ja) * | 1983-08-11 | 1985-02-27 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンａ物質含有易溶性固形製剤 |
| JPS61129140A (ja) | 1984-11-27 | 1986-06-17 | Nitto Electric Ind Co Ltd | 医薬組成物 |
| GB8431119D0 (en) * | 1984-12-10 | 1985-01-16 | Fujisawa Pharmaceutical Co | Anti-arteriosclerotic composition |
| US4940556A (en) | 1986-01-30 | 1990-07-10 | Syntex (U.S.A.) Inc. | Method of preparing long acting formulation |
| DE3877630T2 (de) | 1987-06-12 | 1993-06-03 | American Cyanamid Co | Transkutane verabreichung von pharmazeutika. |
| US5114946A (en) * | 1987-06-12 | 1992-05-19 | American Cyanamid Company | Transdermal delivery of pharmaceuticals |
| US5001139A (en) * | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) * | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| US5045553A (en) * | 1987-06-24 | 1991-09-03 | Fujisawa Pharmaceutical Company, Ltd. | Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter |
| US4820720A (en) * | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
| US5508413A (en) * | 1987-08-27 | 1996-04-16 | Fujisawa Pharmaceutical Co., Ltd. | (+)-5-isopropyl 3-methyl 2-cyano-6 methyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate |
| US5160734A (en) * | 1987-11-25 | 1992-11-03 | American Cyanamid Company | Sustained release delivery system for substituted dihydropyridine calcium channel blockers |
| EP0317780B1 (en) | 1987-11-25 | 1992-05-20 | American Cyanamid Company | Sustained (controlled) release delivery system for substituted dihydropyridine calcium channel blockers |
| US4902514A (en) * | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
| JP2718105B2 (ja) | 1988-10-27 | 1998-02-25 | 藤沢薬品工業株式会社 | （＋）−２−シアノ−６−メチル−４−（３−ニトロフェニル）−１，４−ジヒドロピリジン−３，５−ジカルボン酸５−イソプロピル３−メチルの光安定性結晶 |
| JP3479532B2 (ja) * | 1989-03-31 | 2003-12-15 | ザ・チルドレンズ・メディカル・センター・コーポレーション | エイズの痴呆症、脊髄障害および失明の治療 |
| JPH0381262A (ja) | 1989-08-23 | 1991-04-05 | Yamanouchi Pharmaceut Co Ltd | ジヒドロピリジン系カルシウム拮抗薬の光学活性体の製造法 |
| JP2867462B2 (ja) | 1989-09-12 | 1999-03-08 | 藤沢薬品工業株式会社 | 経皮吸収用製剤 |
| JP2920956B2 (ja) | 1989-10-06 | 1999-07-19 | 藤沢薬品工業株式会社 | ニルバジピン含有持続性錠剤 |
| US5258393A (en) * | 1990-02-21 | 1993-11-02 | Fujisawa Pharmaceutical Co., Ltd. | Use of a dihydropyridine compound for improving inner ear microcirculation |
| WO1992003137A1 (en) | 1990-08-23 | 1992-03-05 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy, peripheral neuropathy, and vision loss |
| WO1993005770A1 (fr) | 1991-09-20 | 1993-04-01 | Fujisawa Pharmaceutical Co., Ltd. | Preparation a longue duree d'action |
| JPH05139974A (ja) | 1991-11-26 | 1993-06-08 | Fujisawa Pharmaceut Co Ltd | ジヒドロピリジンａ物質含有易溶性固体分散体の製造法 |
| US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
| DE4141646A1 (de) | 1991-12-17 | 1993-06-24 | Klinge Co Chem Pharm Fab | Arzneimittelkombination mit synergistischer wirkung, verfahren zu seiner herstellung und seine verwendung |
| US5340591A (en) * | 1992-01-24 | 1994-08-23 | Fujisawa Pharmaceutical Co., Ltd. | Method of producing a solid dispersion of the sparingly water-soluble drug, nilvadipine |
| DE4229805A1 (de) | 1992-09-07 | 1994-03-24 | Werner E G Prof Dr Mueller | Kalzium-Kanal-Antagonisten oder deren Derivate zur Herstellung eines Arzneimittels zur Bekämpfung von Erkrankungen, die durch Prion-Proteine oder Prion-analoge Proteine ausgelöst werden |
| CA2125251C (en) | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
| US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
| ATE204163T1 (de) * | 1993-06-30 | 2001-09-15 | Fujisawa Pharmaceutical Co | Verkapselter arzneistoff |
| US6334997B1 (en) * | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| JP3541389B2 (ja) * | 1996-04-26 | 2004-07-07 | 藤沢薬品工業株式会社 | ジヒドロピリジン化合物を含有する眼組織末梢循環改善剤 |
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| KR100222306B1 (ko) | 1996-11-20 | 1999-10-01 | 이병언 | 닐바디핀 속효성 고형제제 및 이의 제조방법 |
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-
2008
- 2008-10-03 BR BRPI0817516-0A patent/BRPI0817516A2/pt not_active Application Discontinuation
- 2008-10-03 PL PL08836256T patent/PL2214666T3/pl unknown
- 2008-10-03 TW TW097138351A patent/TWI500422B/zh not_active IP Right Cessation
- 2008-10-03 US US12/245,354 patent/US8236346B2/en not_active Expired - Fee Related
- 2008-10-03 NZ NZ584729A patent/NZ584729A/xx not_active IP Right Cessation
- 2008-10-03 KR KR1020107009874A patent/KR101417200B1/ko not_active Expired - Fee Related
- 2008-10-03 CN CN200880118761XA patent/CN101883564B/zh not_active Expired - Fee Related
- 2008-10-03 ES ES08836256.1T patent/ES2449594T3/es active Active
- 2008-10-03 JP JP2010528172A patent/JP5411145B2/ja not_active Expired - Fee Related
- 2008-10-03 CA CA2701620A patent/CA2701620C/en not_active Expired - Fee Related
- 2008-10-03 EP EP08836256.1A patent/EP2214666B1/en active Active
- 2008-10-03 DK DK08836256.1T patent/DK2214666T3/da active
- 2008-10-03 RU RU2010117634/15A patent/RU2490014C2/ru active
- 2008-10-03 AU AU2008308519A patent/AU2008308519B2/en not_active Ceased
- 2008-10-03 MX MX2010003669A patent/MX2010003669A/es active IP Right Grant
- 2008-10-03 WO PCT/US2008/078786 patent/WO2009046323A1/en not_active Ceased
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2010
- 2010-02-01 US US12/697,436 patent/US8236347B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010117634A (ru) | 2011-11-10 |
| US8236346B2 (en) | 2012-08-07 |
| DK2214666T3 (da) | 2014-01-27 |
| US20090092667A1 (en) | 2009-04-09 |
| KR20100067683A (ko) | 2010-06-21 |
| US8236347B2 (en) | 2012-08-07 |
| JP2010540661A (ja) | 2010-12-24 |
| TW200920364A (en) | 2009-05-16 |
| EP2214666A4 (en) | 2010-12-08 |
| AU2008308519A1 (en) | 2009-04-09 |
| TWI500422B (zh) | 2015-09-21 |
| EP2214666A1 (en) | 2010-08-11 |
| NZ584729A (en) | 2012-12-21 |
| AU2008308519A2 (en) | 2010-04-29 |
| US20100183711A1 (en) | 2010-07-22 |
| CN101883564B (zh) | 2013-10-16 |
| PL2214666T3 (pl) | 2014-06-30 |
| WO2009046323A1 (en) | 2009-04-09 |
| KR101417200B1 (ko) | 2014-08-01 |
| CN101883564A (zh) | 2010-11-10 |
| CA2701620A1 (en) | 2009-04-09 |
| CA2701620C (en) | 2014-12-09 |
| AU2008308519B2 (en) | 2014-09-11 |
| JP5411145B2 (ja) | 2014-02-12 |
| EP2214666B1 (en) | 2013-12-11 |
| RU2490014C2 (ru) | 2013-08-20 |
| BRPI0817516A2 (pt) | 2015-06-16 |
| ES2449594T3 (es) | 2014-03-20 |
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