JP5411145B2 - (−)−ニルバジピンエナンチオマーによってアミロイド沈着、アミロイド神経毒性、およびミクログリオーシスを減少させる方法 - Google Patents

(−)−ニルバジピンエナンチオマーによってアミロイド沈着、アミロイド神経毒性、およびミクログリオーシスを減少させる方法 Download PDF

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JP5411145B2
JP5411145B2 JP2010528172A JP2010528172A JP5411145B2 JP 5411145 B2 JP5411145 B2 JP 5411145B2 JP 2010528172 A JP2010528172 A JP 2010528172A JP 2010528172 A JP2010528172 A JP 2010528172A JP 5411145 B2 JP5411145 B2 JP 5411145B2
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nilvadipine
pharmaceutical composition
enantiomerically enriched
brain
day
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JP2010540661A5 (enExample
JP2010540661A (ja
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マイケル・ジェイ・ムラン
ダニエル・パリ
ロバート・エイ・アイビー・ザ・サード
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Alzheimers Institute of America Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/44221,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
JP2010528172A 2007-10-05 2008-10-03 (−)−ニルバジピンエナンチオマーによってアミロイド沈着、アミロイド神経毒性、およびミクログリオーシスを減少させる方法 Expired - Fee Related JP5411145B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97795307P 2007-10-05 2007-10-05
US60/977,953 2007-10-05
US4610908P 2008-04-18 2008-04-18
US61/046,109 2008-04-18
PCT/US2008/078786 WO2009046323A1 (en) 2007-10-05 2008-10-03 Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer

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JP2010540661A JP2010540661A (ja) 2010-12-24
JP2010540661A5 JP2010540661A5 (enExample) 2011-11-17
JP5411145B2 true JP5411145B2 (ja) 2014-02-12

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US (2) US8236346B2 (enExample)
EP (1) EP2214666B1 (enExample)
JP (1) JP5411145B2 (enExample)
KR (1) KR101417200B1 (enExample)
CN (1) CN101883564B (enExample)
AU (1) AU2008308519B2 (enExample)
BR (1) BRPI0817516A2 (enExample)
CA (1) CA2701620C (enExample)
DK (1) DK2214666T3 (enExample)
ES (1) ES2449594T3 (enExample)
MX (1) MX2010003669A (enExample)
NZ (1) NZ584729A (enExample)
PL (1) PL2214666T3 (enExample)
RU (1) RU2490014C2 (enExample)
TW (1) TWI500422B (enExample)
WO (1) WO2009046323A1 (enExample)

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US20140286910A1 (en) * 2013-03-19 2014-09-25 Nikolai Tankovich Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity
CN112826794B (zh) 2019-11-06 2022-02-11 上海交通大学医学院 一种靶向修复神经血管病变的纳米复合物及其制备与应用

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RU2010117634A (ru) 2011-11-10
MX2010003669A (es) 2010-11-25
US8236346B2 (en) 2012-08-07
DK2214666T3 (da) 2014-01-27
US20090092667A1 (en) 2009-04-09
KR20100067683A (ko) 2010-06-21
US8236347B2 (en) 2012-08-07
JP2010540661A (ja) 2010-12-24
TW200920364A (en) 2009-05-16
EP2214666A4 (en) 2010-12-08
AU2008308519A1 (en) 2009-04-09
TWI500422B (zh) 2015-09-21
EP2214666A1 (en) 2010-08-11
NZ584729A (en) 2012-12-21
AU2008308519A2 (en) 2010-04-29
US20100183711A1 (en) 2010-07-22
CN101883564B (zh) 2013-10-16
PL2214666T3 (pl) 2014-06-30
WO2009046323A1 (en) 2009-04-09
KR101417200B1 (ko) 2014-08-01
CN101883564A (zh) 2010-11-10
CA2701620A1 (en) 2009-04-09
CA2701620C (en) 2014-12-09
AU2008308519B2 (en) 2014-09-11
EP2214666B1 (en) 2013-12-11
RU2490014C2 (ru) 2013-08-20
BRPI0817516A2 (pt) 2015-06-16
ES2449594T3 (es) 2014-03-20

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