KR101417200B1 - (-)-닐바디핀 거울상이성질체를 사용하여 아밀로이드 침착, 아밀로이드 신경독성 및 소교세포증을 감소시키는 방법 - Google Patents

(-)-닐바디핀 거울상이성질체를 사용하여 아밀로이드 침착, 아밀로이드 신경독성 및 소교세포증을 감소시키는 방법 Download PDF

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KR101417200B1
KR101417200B1 KR1020107009874A KR20107009874A KR101417200B1 KR 101417200 B1 KR101417200 B1 KR 101417200B1 KR 1020107009874 A KR1020107009874 A KR 1020107009874A KR 20107009874 A KR20107009874 A KR 20107009874A KR 101417200 B1 KR101417200 B1 KR 101417200B1
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enriched
enantiomerically
beta
enantiomerically enriched
brain
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KR20100067683A (ko
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마이클 제이. 뮬런
다니엘 파리
로버트 에이. 3세 아이비
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알츠하이머즈 인스티튜트 오브 아메리카, 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020107009874A 2007-10-05 2008-10-03 (-)-닐바디핀 거울상이성질체를 사용하여 아밀로이드 침착, 아밀로이드 신경독성 및 소교세포증을 감소시키는 방법 Expired - Fee Related KR101417200B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97795307P 2007-10-05 2007-10-05
US60/977,953 2007-10-05
US4610908P 2008-04-18 2008-04-18
US61/046,109 2008-04-18
PCT/US2008/078786 WO2009046323A1 (en) 2007-10-05 2008-10-03 Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer

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KR20100067683A KR20100067683A (ko) 2010-06-21
KR101417200B1 true KR101417200B1 (ko) 2014-08-01

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EP (1) EP2214666B1 (enExample)
JP (1) JP5411145B2 (enExample)
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CN (1) CN101883564B (enExample)
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BR (1) BRPI0817516A2 (enExample)
CA (1) CA2701620C (enExample)
DK (1) DK2214666T3 (enExample)
ES (1) ES2449594T3 (enExample)
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NZ (1) NZ584729A (enExample)
PL (1) PL2214666T3 (enExample)
RU (1) RU2490014C2 (enExample)
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US20140286910A1 (en) * 2013-03-19 2014-09-25 Nikolai Tankovich Stem cells and methods incorporating environmental factors as a means for enhancing stem cell proliferation and plasticity
CN112826794B (zh) 2019-11-06 2022-02-11 上海交通大学医学院 一种靶向修复神经血管病变的纳米复合物及其制备与应用

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Also Published As

Publication number Publication date
KR20100067683A (ko) 2010-06-21
US8236346B2 (en) 2012-08-07
US8236347B2 (en) 2012-08-07
EP2214666B1 (en) 2013-12-11
AU2008308519A1 (en) 2009-04-09
TWI500422B (zh) 2015-09-21
TW200920364A (en) 2009-05-16
MX2010003669A (es) 2010-11-25
JP2010540661A (ja) 2010-12-24
WO2009046323A1 (en) 2009-04-09
CA2701620A1 (en) 2009-04-09
CA2701620C (en) 2014-12-09
BRPI0817516A2 (pt) 2015-06-16
RU2010117634A (ru) 2011-11-10
PL2214666T3 (pl) 2014-06-30
AU2008308519A2 (en) 2010-04-29
EP2214666A4 (en) 2010-12-08
CN101883564A (zh) 2010-11-10
CN101883564B (zh) 2013-10-16
US20090092667A1 (en) 2009-04-09
ES2449594T3 (es) 2014-03-20
JP5411145B2 (ja) 2014-02-12
AU2008308519B2 (en) 2014-09-11
NZ584729A (en) 2012-12-21
DK2214666T3 (da) 2014-01-27
RU2490014C2 (ru) 2013-08-20
EP2214666A1 (en) 2010-08-11
US20100183711A1 (en) 2010-07-22

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