AU2007276760B2 - Dimeric IAP antagonists - Google Patents

Dimeric IAP antagonists Download PDF

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Publication number
AU2007276760B2
AU2007276760B2 AU2007276760A AU2007276760A AU2007276760B2 AU 2007276760 B2 AU2007276760 B2 AU 2007276760B2 AU 2007276760 A AU2007276760 A AU 2007276760A AU 2007276760 A AU2007276760 A AU 2007276760A AU 2007276760 B2 AU2007276760 B2 AU 2007276760B2
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AU
Australia
Prior art keywords
carbon atoms
cycloalkyl
riob
independently
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2007276760A
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English (en)
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AU2007276760A1 (en
Inventor
Stephen M. Condon
Yijun Deng
Matthew G. Laporte
Susan R. Rippin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TetraLogic Pharmaceuticals Corp
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TetraLogic Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TetraLogic Pharmaceuticals Corp filed Critical TetraLogic Pharmaceuticals Corp
Publication of AU2007276760A1 publication Critical patent/AU2007276760A1/en
Application granted granted Critical
Publication of AU2007276760B2 publication Critical patent/AU2007276760B2/en
Priority to AU2012202098A priority Critical patent/AU2012202098A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2007276760A 2006-07-24 2007-07-24 Dimeric IAP antagonists Ceased AU2007276760B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2012202098A AU2012202098A1 (en) 2006-07-24 2012-04-12 Dimeric IAP antagonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82015606P 2006-07-24 2006-07-24
US60/820,156 2006-07-24
PCT/US2007/074225 WO2008014263A2 (en) 2006-07-24 2007-07-24 Dimeric iap antagonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2012202098A Division AU2012202098A1 (en) 2006-07-24 2012-04-12 Dimeric IAP antagonists

Publications (2)

Publication Number Publication Date
AU2007276760A1 AU2007276760A1 (en) 2008-01-31
AU2007276760B2 true AU2007276760B2 (en) 2012-01-19

Family

ID=38904713

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007276760A Ceased AU2007276760B2 (en) 2006-07-24 2007-07-24 Dimeric IAP antagonists

Country Status (15)

Country Link
US (2) US7985735B2 (https=)
EP (2) EP2049563B1 (https=)
JP (1) JP5228202B2 (https=)
KR (1) KR20090041391A (https=)
CN (1) CN101516904A (https=)
AR (1) AR063943A1 (https=)
AU (1) AU2007276760B2 (https=)
BR (1) BRPI0715195A2 (https=)
CA (1) CA2657706A1 (https=)
CL (1) CL2007002167A1 (https=)
IL (1) IL196423A0 (https=)
MX (1) MX2009000824A (https=)
NZ (1) NZ574311A (https=)
WO (1) WO2008014263A2 (https=)
ZA (1) ZA200900562B (https=)

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MX2007010371A (es) 2005-02-25 2008-01-11 Tetralogic Pharmaceuticals Inhibidores dimericos iap.
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WO2007048224A1 (en) 2005-10-25 2007-05-03 Aegera Therapeutics Inc. Iap bir domain binding compounds
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US8202902B2 (en) * 2006-05-05 2012-06-19 The Regents Of The University Of Michigan Bivalent SMAC mimetics and the uses thereof
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CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
US8445473B2 (en) 2008-04-11 2013-05-21 The Regents Of The University Of Michigan Heteroaryl-substituted bicyclic Smac mimetics and the uses thereof
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US20100317593A1 (en) * 2009-06-12 2010-12-16 Astrazeneca Ab 2,3-dihydro-1h-indene compounds
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
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UY33236A (es) 2010-02-25 2011-09-30 Novartis Ag Inhibidores dimericos de las iap
WO2012044993A1 (en) * 2010-09-30 2012-04-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compounds, pharmaceutical compositions, and methods of treating or preventing neurodegenerative diseases or disorders
UY33794A (es) 2010-12-13 2012-07-31 Novartis Ag Inhibidores diméricos de las iap
US20130196927A1 (en) * 2012-01-27 2013-08-01 Christopher BENETATOS Smac Mimetic Therapy
JP6280546B2 (ja) 2012-06-26 2018-02-14 デル マー ファーマシューティカルズ ジアンヒドロガラクチトール、ジアセチルジアンヒドロガラクチトール、ジブロモズルシトール、又はこれらの類似体若しくは誘導体を用いた、遺伝子多型又はａｈｉ１の調節不全若しくは変異を有する患者におけるチロシンキナーゼインヒビター抵抗性悪性腫瘍を処置するための方法
US20150190470A1 (en) * 2012-08-01 2015-07-09 Tetralogic Pharmaceuticals Corporation Combination therapy
KR20160061911A (ko) 2013-04-08 2016-06-01 데니스 엠. 브라운 최적하 투여된 화학 화합물의 치료 효과
WO2015109391A1 (en) * 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
CN105585583B (zh) * 2016-01-20 2018-04-13 广东工业大学 一种非肽类凋亡抑制蛋白拮抗剂及其合成方法与应用
CN105566447B (zh) * 2016-01-20 2019-09-20 广东工业大学 一种凋亡抑制蛋白的类肽拮抗剂及其合成方法与应用
JP2019514900A (ja) 2016-04-27 2019-06-06 メッドシャイン ディスカバリー インコーポレイテッド 新規な二価のｉａｐアンタゴニストとしてのベンズイミダゾール結合インドール化合物
CN106188098B (zh) * 2016-07-06 2017-11-03 广东工业大学 一种杂化抗癌药物及其制备方法与应用
CN106265764B (zh) * 2016-08-18 2018-03-16 广州威溶特医药科技有限公司 Iap抑制剂和溶瘤病毒在制备抗肿瘤药物中的应用
CN108440507B (zh) * 2017-02-16 2022-10-18 南京圣和药物研发有限公司 作为细胞凋亡蛋白抑制剂的化合物及其应用
JP7140781B2 (ja) * 2017-05-17 2022-09-21 デナリ セラピューティクス インコーポレイテッド 化合物、組成物および方法
WO2019080928A1 (zh) * 2017-10-27 2019-05-02 南京明德新药研发股份有限公司 一种iap拮抗剂的晶型及其制备方法
CN111655713B (zh) * 2018-02-09 2023-06-27 广东东阳光药业有限公司 Iap抑制剂及其在药物中的应用
JP2021038192A (ja) * 2019-05-31 2021-03-11 均 石井 Ｄｎａ変性剤を使用する成長促進剤。
CN112521372B (zh) * 2019-09-18 2022-07-08 南京华威医药科技集团有限公司 一种细胞凋亡蛋白抑制剂及其制备方法和用途

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Also Published As

Publication number Publication date
IL196423A0 (en) 2011-08-01
CN101516904A (zh) 2009-08-26
BRPI0715195A2 (pt) 2013-06-11
CL2007002167A1 (es) 2009-01-23
EP2409984A1 (en) 2012-01-25
ZA200900562B (en) 2010-06-30
CA2657706A1 (en) 2008-01-31
US20110305777A1 (en) 2011-12-15
JP5228202B2 (ja) 2013-07-03
WO2008014263A3 (en) 2008-03-13
WO2008014263A2 (en) 2008-01-31
AR063943A1 (es) 2009-03-04
AU2007276760A1 (en) 2008-01-31
EP2049563B1 (en) 2014-03-12
US20080020986A1 (en) 2008-01-24
US7985735B2 (en) 2011-07-26
NZ574311A (en) 2011-12-22
JP2009544728A (ja) 2009-12-17
MX2009000824A (es) 2009-02-04
KR20090041391A (ko) 2009-04-28
EP2049563A2 (en) 2009-04-22

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