AU2006324098C1 - Antiviral nucleosides - Google Patents

Antiviral nucleosides Download PDF

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Publication number
AU2006324098C1
AU2006324098C1 AU2006324098A AU2006324098A AU2006324098C1 AU 2006324098 C1 AU2006324098 C1 AU 2006324098C1 AU 2006324098 A AU2006324098 A AU 2006324098A AU 2006324098 A AU2006324098 A AU 2006324098A AU 2006324098 C1 AU2006324098 C1 AU 2006324098C1
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AU
Australia
Prior art keywords
hcv
compound
compound according
nucleoside
acid
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AU2006324098A
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English (en)
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AU2006324098B2 (en
AU2006324098A1 (en
Inventor
Byoung-Kwon Chun
Jeremy Clark
Keshab Sarma
Peiyuan Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Gilead Pharmasset LLC
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F Hoffmann La Roche AG
Gilead Pharmasset LLC
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Application filed by F Hoffmann La Roche AG, Gilead Pharmasset LLC filed Critical F Hoffmann La Roche AG
Publication of AU2006324098A1 publication Critical patent/AU2006324098A1/en
Publication of AU2006324098B2 publication Critical patent/AU2006324098B2/en
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Assigned to F. HOFFMANN-LA ROCHE AG, GILEAD PHARMASSET LLC reassignment F. HOFFMANN-LA ROCHE AG Request to Amend Deed and Register Assignors: F. HOFFMANN-LA ROCHE AG, PHARMASSET, INC.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/12—Triazine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AU2006324098A 2005-12-09 2006-11-29 Antiviral nucleosides Active AU2006324098C1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74931905P 2005-12-09 2005-12-09
US60/749,319 2005-12-09
PCT/EP2006/069060 WO2007065829A1 (en) 2005-12-09 2006-11-29 Antiviral nucleosides

Publications (3)

Publication Number Publication Date
AU2006324098A1 AU2006324098A1 (en) 2007-06-14
AU2006324098B2 AU2006324098B2 (en) 2011-02-24
AU2006324098C1 true AU2006324098C1 (en) 2011-12-08

Family

ID=37608355

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006324098A Active AU2006324098C1 (en) 2005-12-09 2006-11-29 Antiviral nucleosides

Country Status (25)

Country Link
US (1) US7754699B2 (enExample)
EP (1) EP1957510A1 (enExample)
JP (2) JP4979710B2 (enExample)
KR (1) KR101238461B1 (enExample)
CN (1) CN101336247B (enExample)
AR (1) AR056850A1 (enExample)
AU (1) AU2006324098C1 (enExample)
BR (1) BRPI0619563A2 (enExample)
CA (1) CA2632626C (enExample)
CR (1) CR10136A (enExample)
EC (1) ECSP088518A (enExample)
GT (1) GT200800095A (enExample)
HN (1) HN2006041184A (enExample)
IL (1) IL192002A0 (enExample)
MA (1) MA30057B1 (enExample)
MY (1) MY150667A (enExample)
NO (1) NO20082934L (enExample)
NZ (1) NZ568909A (enExample)
PE (1) PE20071131A1 (enExample)
RU (1) RU2422454C2 (enExample)
TW (1) TWI394759B (enExample)
UA (1) UA91255C2 (enExample)
UY (1) UY30004A1 (enExample)
WO (1) WO2007065829A1 (enExample)
ZA (1) ZA200804958B (enExample)

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