AU2006263433B8 - Phosphoramidate alkylator prodrugs - Google Patents

Phosphoramidate alkylator prodrugs Download PDF

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Publication number
AU2006263433B8
AU2006263433B8 AU2006263433A AU2006263433A AU2006263433B8 AU 2006263433 B8 AU2006263433 B8 AU 2006263433B8 AU 2006263433 A AU2006263433 A AU 2006263433A AU 2006263433 A AU2006263433 A AU 2006263433A AU 2006263433 B8 AU2006263433 B8 AU 2006263433B8
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Australia
Prior art keywords
phosphoramidate alkylator
cancer
prodrug
phosphoramidate
pct
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AU2006263433A
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AU2006263433B2 (en
AU2006263433A1 (en
Inventor
Jian-Xin Duan
Hailong Jiao
Mark Matteucci
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Immunogenesis Inc
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Immunogenesis Inc
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Publication of AU2006263433A1 publication Critical patent/AU2006263433A1/en
Priority to AU2011202075A priority Critical patent/AU2011202075B8/en
Publication of AU2006263433B2 publication Critical patent/AU2006263433B2/en
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Publication of AU2006263433B8 publication Critical patent/AU2006263433B8/en
Assigned to MOLECULAR TEMPLATES, INC. reassignment MOLECULAR TEMPLATES, INC. Request to Amend Deed and Register Assignors: THRESHOLD PHARMACEUTICALS, INC.
Assigned to IMMUNOGENESIS, INC. reassignment IMMUNOGENESIS, INC. Request for Assignment Assignors: MOLECULAR TEMPLATES, INC.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
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    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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    • C07F9/65392—Five-membered rings containing two nitrogen atoms
    • C07F9/65397—Five-membered rings containing two nitrogen atoms having the two nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2006263433A 2005-06-29 2006-06-29 Phosphoramidate alkylator prodrugs Active AU2006263433B8 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011202075A AU2011202075B8 (en) 2005-06-29 2011-05-05 Phosphoramidate alkylator prodrugs

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69575505P 2005-06-29 2005-06-29
US60/695,755 2005-06-29
PCT/US2006/025881 WO2007002931A2 (en) 2005-06-29 2006-06-29 Phosphoramidate alkylator prodrugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011202075A Division AU2011202075B8 (en) 2005-06-29 2011-05-05 Phosphoramidate alkylator prodrugs

Publications (3)

Publication Number Publication Date
AU2006263433A1 AU2006263433A1 (en) 2007-01-04
AU2006263433B2 AU2006263433B2 (en) 2011-06-02
AU2006263433B8 true AU2006263433B8 (en) 2011-06-09

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AU2006263433A Active AU2006263433B8 (en) 2005-06-29 2006-06-29 Phosphoramidate alkylator prodrugs
AU2011202075A Active AU2011202075B8 (en) 2005-06-29 2011-05-05 Phosphoramidate alkylator prodrugs

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AU2011202075A Active AU2011202075B8 (en) 2005-06-29 2011-05-05 Phosphoramidate alkylator prodrugs

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US (4) US8003625B2 (cg-RX-API-DMAC10.html)
EP (2) EP1896040B1 (cg-RX-API-DMAC10.html)
JP (2) JP5180824B2 (cg-RX-API-DMAC10.html)
KR (1) KR101198571B1 (cg-RX-API-DMAC10.html)
CN (2) CN102746336B (cg-RX-API-DMAC10.html)
AU (2) AU2006263433B8 (cg-RX-API-DMAC10.html)
BR (1) BRPI0612845A8 (cg-RX-API-DMAC10.html)
CA (1) CA2613312C (cg-RX-API-DMAC10.html)
CY (1) CY1113250T1 (cg-RX-API-DMAC10.html)
DK (1) DK1896040T3 (cg-RX-API-DMAC10.html)
ES (2) ES2579235T3 (cg-RX-API-DMAC10.html)
HR (1) HRP20120803T1 (cg-RX-API-DMAC10.html)
IL (1) IL188236A (cg-RX-API-DMAC10.html)
NO (1) NO334420B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ565378A (cg-RX-API-DMAC10.html)
PL (1) PL1896040T3 (cg-RX-API-DMAC10.html)
PT (1) PT1896040E (cg-RX-API-DMAC10.html)
RS (1) RS52505B (cg-RX-API-DMAC10.html)
RU (1) RU2414475C2 (cg-RX-API-DMAC10.html)
SI (1) SI1896040T1 (cg-RX-API-DMAC10.html)
TW (1) TWI384989B (cg-RX-API-DMAC10.html)
WO (1) WO2007002931A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA200800314B (cg-RX-API-DMAC10.html)

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CA2613312C (en) 2005-06-29 2014-10-14 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs
US8552048B2 (en) 2006-12-26 2013-10-08 Threshold Pharmaceuticals, Inc. Phosphoramidate alkylator prodrugs for the treatment of cancer
WO2008124691A1 (en) 2007-04-05 2008-10-16 Threshold Pharmaceuticals, Inc. Glufosfamide combination therapy
WO2009018163A1 (en) * 2007-07-27 2009-02-05 Threshold Pharmaceuticals, Inc. Hypoxia activated prodrugs of anthracyclines
UA104579C2 (uk) * 2007-12-10 2014-02-25 Байокрист Фармасьютикалз, Инк. Спосіб лікування раку кровотворної системи із застосуванням фородезину у комбінації з ритуксимабом
CN102256966B (zh) 2008-10-17 2016-02-10 白头生物医学研究所 可溶性mTOR复合物和其调节剂
US8946275B2 (en) * 2008-10-21 2015-02-03 Threshold Pharmaceuticals, Inc. Treatment of cancer using hypoxia activated prodrugs
CA2803113A1 (en) * 2010-06-28 2012-01-12 Threshold Pharmaceuticals, Inc. Treatment of blood cancer
JP6066421B2 (ja) * 2010-07-12 2017-01-25 スレッショルド ファーマシューティカルズ、インク．Ｔｈｒｅｓｈｏｌｄ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 癌の治療のための低酸素活性化プロドラッグおよび血管新生阻害剤の投与方法
JP2014509658A (ja) * 2011-04-01 2014-04-21 スレッショルド ファーマシューティカルズ、インク． ガン処置方法
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CN102850397B (zh) * 2011-06-29 2015-02-18 北京大学 多靶点抗肿瘤化合物及其制备方法和应用
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US9254299B2 (en) 2011-12-22 2016-02-09 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with Chk1 inhibitors for treating cancer
US20150005262A1 (en) * 2011-12-22 2015-01-01 Threshold Pharmaceuticals, Inc. Hypoxia activated prodrugs and mtor inhibitors for treating cancer
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