AU2005250233B2 - Recombinase polymerase amplification - Google Patents

Recombinase polymerase amplification Download PDF

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Publication number
AU2005250233B2
AU2005250233B2 AU2005250233A AU2005250233A AU2005250233B2 AU 2005250233 B2 AU2005250233 B2 AU 2005250233B2 AU 2005250233 A AU2005250233 A AU 2005250233A AU 2005250233 A AU2005250233 A AU 2005250233A AU 2005250233 B2 AU2005250233 B2 AU 2005250233B2
Authority
AU
Australia
Prior art keywords
dna
polymerase
amplification
recombinase
rpa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2005250233A
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English (en)
Other versions
AU2005250233A1 (en
Inventor
Niall A. Armes
Olaf Piepenburg
Derek L. Stemple
Colin H. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Diagnostics Scarborough Inc
Original Assignee
Abbott Diagnostics Scarborough Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/931,916 external-priority patent/US7399590B2/en
Application filed by Abbott Diagnostics Scarborough Inc filed Critical Abbott Diagnostics Scarborough Inc
Publication of AU2005250233A1 publication Critical patent/AU2005250233A1/en
Assigned to ALERE SAN DIEGO, INC. reassignment ALERE SAN DIEGO, INC. Amend patent request/document other than specification (104) Assignors: ASM SCIENTIFIC, INC.
Application granted granted Critical
Publication of AU2005250233B2 publication Critical patent/AU2005250233B2/en
Priority to AU2011202896A priority Critical patent/AU2011202896B2/en
Assigned to ABBOTT DIAGNOSTICS SCARBOROUGH, INC. reassignment ABBOTT DIAGNOSTICS SCARBOROUGH, INC. Request for Assignment Assignors: ALERE SAN DIEGO, INC.
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AU2005250233A 2004-06-01 2005-04-11 Recombinase polymerase amplification Expired AU2005250233B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2011202896A AU2011202896B2 (en) 2004-06-01 2011-06-16 Recombinase Polymerase Amplification

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US57614804P 2004-06-01 2004-06-01
US57616204P 2004-06-01 2004-06-01
US60/576,148 2004-06-01
US60/576,162 2004-06-01
US10/931,916 2004-09-01
US10/931,916 US7399590B2 (en) 2002-02-21 2004-09-01 Recombinase polymerase amplification
US62229104P 2004-10-26 2004-10-26
US60/622,291 2004-10-26
US63274604P 2004-12-02 2004-12-02
US60/632,746 2004-12-02
PCT/IB2005/001560 WO2005118853A2 (en) 2004-06-01 2005-04-11 Recombinase polymerase amplification

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2011202896A Division AU2011202896B2 (en) 2004-06-01 2011-06-16 Recombinase Polymerase Amplification

Publications (2)

Publication Number Publication Date
AU2005250233A1 AU2005250233A1 (en) 2005-12-15
AU2005250233B2 true AU2005250233B2 (en) 2011-03-17

Family

ID=35463460

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2005250233A Expired AU2005250233B2 (en) 2004-06-01 2005-04-11 Recombinase polymerase amplification

Country Status (6)

Country Link
EP (4) EP1759012B1 (enExample)
JP (4) JP5026958B2 (enExample)
AU (1) AU2005250233B2 (enExample)
CA (1) CA2569512C (enExample)
ES (2) ES2718482T3 (enExample)
WO (1) WO2005118853A2 (enExample)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537762A (ja) 1999-01-05 2002-11-12 トラスティーズ オブ ボストン ユニバーシティ 改良型核酸クローニング
US7435562B2 (en) 2000-07-21 2008-10-14 Modular Genetics, Inc. Modular vector systems
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
DK1499738T3 (da) 2002-02-21 2008-11-17 Asm Scient Inc Recombinase-polymerease-amplifikation
WO2005118608A2 (en) 2004-06-02 2005-12-15 Asm Scientific, Inc. 2’-nitrobenzyl-modified ribonucleotides
ATE540110T1 (de) 2004-11-11 2012-01-15 Modular Genetics Inc Oligonukleotid-leiterkonstruktion und system zur erzeugung von molekularer vielfalt
EP2829615B1 (en) 2005-07-25 2018-05-09 Alere San Diego, Inc. Kit for multiplexing recombinase polymerase amplification
EP2029782B1 (en) * 2006-05-04 2014-11-26 Alere San Diego, Inc. Recombinase polymerase amplification
AU2016204451B2 (en) * 2006-05-04 2017-05-11 Abbott Diagnostics Scarborough, Inc. Recombinase Polymerase Amplification
US7501254B2 (en) 2006-07-20 2009-03-10 Ghc Technologies, Inc. Methods and compositions for amplification and capture of nucleic acid sequences
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
DE102006054562A1 (de) * 2006-11-20 2008-05-21 Bayer Healthcare Ag Verfahren zum Nachweis von Pyrophosphat mit Biolumineszenz Detektion
US9689031B2 (en) 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
CN104862385B (zh) 2008-06-11 2018-11-23 基因排列技术有限公司 等温核酸扩增
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
US9309557B2 (en) 2010-12-17 2016-04-12 Life Technologies Corporation Nucleic acid amplification
US9334531B2 (en) 2010-12-17 2016-05-10 Life Technologies Corporation Nucleic acid amplification
JP5847076B2 (ja) 2009-05-20 2016-01-20 バイオサイト インコーポレイテッド Ｄｎａグリコシラーゼ／リアーゼおよびａｐエンドヌクレアーゼ基質
WO2010141940A1 (en) * 2009-06-05 2010-12-09 Alere San Diego, Inc. Recombinase polymerase amplification reagents and kits
WO2011038197A1 (en) * 2009-09-25 2011-03-31 Alere San Diego, Inc. Detection of nucleic acids in crude matrices
US9399217B2 (en) 2010-10-04 2016-07-26 Genapsys, Inc. Chamber free nanoreactor system
US9184099B2 (en) 2010-10-04 2015-11-10 The Board Of Trustees Of The Leland Stanford Junior University Biosensor devices, systems and methods therefor
EP2625526B1 (en) 2010-10-04 2017-03-15 Genapsys Inc. Systems and methods for automated reusable parallel biological reactions
EP3978620A1 (en) 2011-04-07 2022-04-06 Abbott Diagnostics Scarborough, Inc. Monitoring recombinase polymerase amplification mixtures
US9926596B2 (en) 2011-05-27 2018-03-27 Genapsys, Inc. Systems and methods for genetic and biological analysis
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
CN104105797B (zh) 2011-12-01 2016-08-31 吉纳普赛斯股份有限公司 用于高效电子测序与检测的系统和方法
JP5958034B2 (ja) * 2012-04-11 2016-07-27 富士レビオ株式会社 分子ビーコン型プローブを用いた標的核酸の検出方法
US10030262B2 (en) 2012-04-19 2018-07-24 Life Technologies Corporation Method of performing digital PCR
WO2014007289A1 (ja) * 2012-07-05 2014-01-09 日本碍子株式会社 核酸クロマトグラフィー法、核酸クロマトグラフィー用組成物及びこれを含むキット
CN102816756B (zh) * 2012-09-07 2014-04-16 江苏奇天基因生物科技有限公司 等温核酸扩增反应试剂及等温核酸扩增方法
EP2971141B1 (en) 2013-03-15 2018-11-28 Genapsys, Inc. Systems for biological analysis
JP5904153B2 (ja) * 2013-03-29 2016-04-13 ソニー株式会社 核酸増幅反応用試料の調製方法、核酸増幅方法、固相状核酸増幅反応用試薬及びマイクロチップ
EP3008177B1 (en) * 2013-06-11 2020-06-03 Biocartis NV Biomolecule drying process for long-term storage
EP3080300B1 (en) 2013-12-11 2020-09-02 Genapsys Inc. Systems and methods for biological analysis and computation
EP3132060B1 (en) 2014-04-18 2019-03-13 Genapsys Inc. Methods and systems for nucleic acid amplification
EP2966177A1 (en) 2014-07-09 2016-01-13 Vetgenomics, S.L. Methods for detecting target DNA sequences
CN104232622B (zh) * 2014-09-24 2016-09-14 中国人民解放军疾病预防控制所 一种用聚合酶螺旋反应恒温扩增核酸的方法及其应用
WO2016156529A1 (en) * 2015-03-31 2016-10-06 Qiagen Gmbh Efficiency improving ligation methods
GB201519565D0 (en) 2015-11-05 2015-12-23 Alere San Diego Inc Sample preparation device
CN114645100A (zh) * 2016-01-29 2022-06-21 中国动物卫生与流行病学中心 一种检测h7亚型禽流感病毒的引物对及其引用、检测h7亚型禽流感病毒的方法
EP4155397B1 (en) * 2016-02-10 2024-06-26 The Regents of The University of Michigan Detection of nucleic acids
CN105543402B (zh) * 2016-03-02 2019-07-02 刘国宪 等温核酸扩增反应试剂及等温核酸扩增方法
KR20220167397A (ko) 2016-03-04 2022-12-20 애보트 다이어그노스틱스 스카보로, 인크. 자동화된 네스티드 재조합효소 중합효소 증폭
US11299777B2 (en) 2016-04-04 2022-04-12 Nat Diagnostics, Inc. Isothermal amplification components and processes
US9617587B1 (en) 2016-04-04 2017-04-11 Nat Diagnostics, Inc. Isothermal amplification components and processes
DE102016108115B4 (de) 2016-05-02 2019-05-09 Agilent Technologies, Inc. - A Delaware Corporation - Probenpuffer mit niedermolekularem Farbstoffstabilisator für Gelelektrophorese
GB201611469D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Improvements in or relating to nucleic acid amplification processes
EP3488017A4 (en) 2016-07-20 2020-02-26 Genapsys Inc. SYSTEMS AND METHODS FOR SEQUENCING NUCLEIC ACIDS
CN106399590B (zh) * 2016-10-31 2019-12-13 中国人民解放军军事医学科学院微生物流行病研究所 呼吸道感染相关腺病毒的通用型核酸等温检测试剂
US10632464B2 (en) * 2017-02-28 2020-04-28 Alere San Diego, Inc. Microfluidic devices and related methods
EP3592768B1 (en) 2017-03-08 2024-12-25 The Regents of The University of Michigan Analyte detection
EP3684951A4 (en) 2017-09-21 2021-06-16 Genapsys, Inc. NUCLEIC ACID SEQUENCING SYSTEMS AND METHODS
CN108130369A (zh) * 2017-12-29 2018-06-08 博迪泰（厦门）生物科技有限公司 一种检测乳牛短脊椎综合症的引物、试剂盒及检测方法
GB2569965A (en) 2018-01-04 2019-07-10 Lumiradx Uk Ltd Improvements in or relating to amplification of nucleic acids
EP3743209A1 (en) 2018-01-24 2020-12-02 Perkinelmer Health Sciences Inc. Purification of nucleic acids in a microfluidic chip by separation
AU2019287163B2 (en) 2018-06-12 2025-08-21 Keygene N.V. Nucleic acid amplification method
DE102018222357A1 (de) * 2018-12-19 2020-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. In-vitro-Verfahren zum Nachweis von mindestens einer Nukleinsäure, die sich bei einem Lebewesen im Vollblut außerhalb der Blutzellen befindet und Vorrichtung und Kit hierzu
KR20220083700A (ko) 2019-10-18 2022-06-20 에피제네론, 인크. 표적 핵산의 검출 방법, 핵산 결합 분자의 검출 방법 및 핵산 결합능의 평가 방법
CN111197110A (zh) * 2020-01-16 2020-05-26 浙江农林大学 用于检测猫泛白细胞减少症病毒的rpa-fld方法
CN111518669A (zh) * 2020-05-07 2020-08-11 安徽科技学院 一种核酸检测微流控芯片及其应用
WO2021226754A1 (zh) * 2020-05-09 2021-11-18 杭州梓晶生物有限公司 一种病毒重组酶-聚合酶扩增检测方法
US20240279751A1 (en) 2020-06-10 2024-08-22 King Abdullah University Of Science And Technology A rapid multiplex rpa based nanopore sequencing method for real-time detection and sequencing of multiple viral pathogens
CN111979303A (zh) * 2020-08-11 2020-11-24 上海奕谱生物科技有限公司 一种核酸检测试剂盒、方法及其应用
EP3985128A1 (en) 2020-10-14 2022-04-20 midge medical GmbH Isothermal nucleic acid amplification methods for point-of-need diagnosis of emerging infectious diseases
CN116323000A (zh) * 2020-10-14 2023-06-23 迈德格医疗有限公司 用于即时需求诊断的等温核酸扩增方法
EP3995592A1 (en) 2020-11-09 2022-05-11 midge medical GmbH Multimeric isothermal nucleic acid amplification methods for point-of-need diagnosis
CN112501262A (zh) * 2020-12-15 2021-03-16 苏州点晶生物科技有限公司 一种基于双重多酶介导的核酸扩增检测方法及试剂
CN112708662B (zh) * 2020-12-28 2021-08-31 阅尔基因技术（苏州）有限公司 抑制生物dna样本中非目标区域的核苷酸组合物及其应用
EP4053293A1 (en) 2021-03-03 2022-09-07 midge medical GmbH Protected isothermal nucleic acid amplification (pina) methods for point-of-need diagnosis of emerging infectious diseases
CN114085891A (zh) * 2021-11-23 2022-02-25 广州达安基因股份有限公司 基于重组酶聚合酶扩增技术的逆转录扩增系统和方法
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EP4477663A1 (en) 2023-06-14 2024-12-18 midge medical GmbH Proteins for isothermal amplification
CN119534585B (zh) * 2024-12-06 2025-11-28 安徽工业大学 用于检测微囊藻毒素mc-lr的ecl生物传感器
GB202500508D0 (en) * 2025-01-15 2025-02-26 Biocrucible Ltd Molecular diagnostic device
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CN121674356B (zh) * 2026-02-11 2026-05-26 简达生物技术(南京)有限公司 一种连接酶缓冲液及其产品和在mRNA加尾中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
WO2002086167A1 (en) * 2001-04-20 2002-10-31 The Penn State Research Foundation Methods for nucleic acid manipulation
WO2003072805A2 (en) * 2002-02-21 2003-09-04 Asm Scientific, Inc. Recombinase polymerase amplification

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100245284B1 (ko) * 1990-05-07 2000-03-02 이노우에 노리유끼 이중 d-루프 형성의 진단학적 응용
US5273881A (en) 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
CA2095624C (en) 1990-11-09 2000-06-13 Rafael D. Camerini-Otero Method of targeting dna
US6117679A (en) * 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5705366A (en) * 1994-09-15 1998-01-06 Johnson & Johnson Clinical Diagnostics, Inc. Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor
US20040110167A1 (en) * 1995-07-13 2004-06-10 Gerdes John C. Lateral flow system for nucleic acid detection
WO2001066688A1 (en) * 2000-03-08 2001-09-13 Imagene Technology, Inc. Lateral flow pcr with amplicon concentration and detection
EP1446502A4 (en) * 2001-09-28 2005-02-09 Univ Delaware DETECTION AND SEPARATION OF POLYMORPHISMS
US7244562B2 (en) * 2001-11-01 2007-07-17 Gene Check, Inc. RecA assisted detection of mutations, single nucleotide polymorphisms and specific sequences
EP1525055A1 (en) * 2002-07-12 2005-04-27 British Biocell International Limited Lateral flow assay device and method
AU2003272438B2 (en) * 2002-09-20 2009-04-02 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
EP1403379A1 (en) * 2002-09-24 2004-03-31 QIAGEN GmbH Enhanced coamplification of nucleic acids
JP2008018820A (ja) * 2006-07-12 2008-01-31 Nsk Ltd 衝撃吸収式ステアリングコラム装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223414A (en) * 1990-05-07 1993-06-29 Sri International Process for nucleic acid hybridization and amplification
WO2002086167A1 (en) * 2001-04-20 2002-10-31 The Penn State Research Foundation Methods for nucleic acid manipulation
WO2003072805A2 (en) * 2002-02-21 2003-09-04 Asm Scientific, Inc. Recombinase polymerase amplification

Also Published As

Publication number Publication date
EP3540073B1 (en) 2021-08-25
JP2013102769A (ja) 2013-05-30
EP2336361A3 (en) 2011-07-06
EP1759012B1 (en) 2013-05-22
JP2008500831A (ja) 2008-01-17
JP2008188020A (ja) 2008-08-21
EP1759012A2 (en) 2007-03-07
ES2425354T3 (es) 2013-10-14
JP2011103900A (ja) 2011-06-02
ES2718482T3 (es) 2019-07-02
WO2005118853A3 (en) 2006-06-15
CA2569512C (en) 2016-05-31
JP5089466B2 (ja) 2012-12-05
WO2005118853A2 (en) 2005-12-15
AU2005250233A1 (en) 2005-12-15
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Class et al. Patent application title: Recombinase Polymerase Amplification Inventors: Olaf Piepenburg (Essex, GB) Colin H. Williams (Waltham, MA, US) Niall A. Armes (Suffolk, GB) Derek L. Stemple (Hertfordshire, GB)

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