AU2003237365B2 - Non-gelatin capsule shell formulation comprising iota-carrageenan and kappa-carrageenan - Google Patents
Non-gelatin capsule shell formulation comprising iota-carrageenan and kappa-carrageenan Download PDFInfo
- Publication number
- AU2003237365B2 AU2003237365B2 AU2003237365A AU2003237365A AU2003237365B2 AU 2003237365 B2 AU2003237365 B2 AU 2003237365B2 AU 2003237365 A AU2003237365 A AU 2003237365A AU 2003237365 A AU2003237365 A AU 2003237365A AU 2003237365 B2 AU2003237365 B2 AU 2003237365B2
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- Australia
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- composition
- carrageenan
- weight
- film
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- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 230
- 229920001525 carrageenan Polymers 0.000 title claims abstract description 104
- 239000000679 carrageenan Substances 0.000 title claims abstract description 101
- 229940113118 carrageenan Drugs 0.000 title claims abstract description 101
- ZNOZWUKQPJXOIG-XSBHQQIPSA-L [(2r,3s,4r,5r,6s)-6-[[(1r,3s,4r,5r,8s)-3,4-dihydroxy-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-[[(1r,3r,4r,5r,8s)-8-[(2s,3r,4r,5r,6r)-3,4-dihydroxy-6-(hydroxymethyl)-5-sulfonatooxyoxan-2-yl]oxy-4-hydroxy-2,6-dioxabicyclo[3.2.1]octan-3-yl]oxy]-5-hydroxy-2-( Chemical compound O[C@@H]1[C@@H](O)[C@@H](OS([O-])(=O)=O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H]2OC[C@H]1O[C@H](O[C@H]1[C@H]([C@@H](CO)O[C@@H](O[C@@H]3[C@@H]4OC[C@H]3O[C@H](O)[C@@H]4O)[C@@H]1O)OS([O-])(=O)=O)[C@@H]2O ZNOZWUKQPJXOIG-XSBHQQIPSA-L 0.000 title claims abstract description 65
- 238000009472 formulation Methods 0.000 title description 4
- 239000007903 gelatin capsule Substances 0.000 title description 4
- 235000010418 carrageenan Nutrition 0.000 claims abstract description 102
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims abstract description 99
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 47
- 239000002552 dosage form Substances 0.000 claims abstract description 42
- 239000004067 bulking agent Substances 0.000 claims abstract description 36
- 239000004014 plasticizer Substances 0.000 claims abstract description 20
- 229920000881 Modified starch Polymers 0.000 claims description 26
- 239000002775 capsule Substances 0.000 claims description 26
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 24
- 239000000600 sorbitol Substances 0.000 claims description 24
- 235000010356 sorbitol Nutrition 0.000 claims description 24
- 229920002472 Starch Polymers 0.000 claims description 22
- 235000019698 starch Nutrition 0.000 claims description 22
- 239000004368 Modified starch Substances 0.000 claims description 21
- 235000019426 modified starch Nutrition 0.000 claims description 21
- 239000008107 starch Substances 0.000 claims description 21
- 239000006185 dispersion Substances 0.000 claims description 18
- 239000007787 solid Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- 235000010449 maltitol Nutrition 0.000 claims description 13
- 239000000845 maltitol Substances 0.000 claims description 11
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 11
- 229940035436 maltitol Drugs 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000007894 caplet Substances 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 239000000499 gel Substances 0.000 abstract description 32
- 239000000416 hydrocolloid Substances 0.000 abstract description 15
- 239000000463 material Substances 0.000 abstract description 12
- 239000002537 cosmetic Substances 0.000 abstract description 7
- 239000003973 paint Substances 0.000 abstract description 5
- 239000003921 oil Substances 0.000 abstract description 4
- 235000015872 dietary supplement Nutrition 0.000 abstract description 3
- 239000011874 heated mixture Substances 0.000 abstract 1
- 239000011344 liquid material Substances 0.000 abstract 1
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- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 22
- 238000005538 encapsulation Methods 0.000 description 17
- 239000007788 liquid Substances 0.000 description 17
- 239000012153 distilled water Substances 0.000 description 15
- 108010010803 Gelatin Proteins 0.000 description 14
- 239000008273 gelatin Substances 0.000 description 14
- 229920000159 gelatin Polymers 0.000 description 14
- 235000019322 gelatine Nutrition 0.000 description 14
- 235000011852 gelatine desserts Nutrition 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 11
- 239000004408 titanium dioxide Substances 0.000 description 11
- 241001465754 Metazoa Species 0.000 description 7
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- 239000000084 colloidal system Substances 0.000 description 6
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- 229940079593 drug Drugs 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 235000013826 starch sodium octenyl succinate Nutrition 0.000 description 5
- 239000001334 starch sodium octenyl succinate Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 240000008042 Zea mays Species 0.000 description 4
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 3
- 239000003086 colorant Substances 0.000 description 3
- 235000005822 corn Nutrition 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 239000003826 tablet Substances 0.000 description 3
- 244000247812 Amorphophallus rivieri Species 0.000 description 2
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 244000024675 Eruca sativa Species 0.000 description 2
- 235000014755 Eruca sativa Nutrition 0.000 description 2
- 229920002581 Glucomannan Polymers 0.000 description 2
- 229920002752 Konjac Polymers 0.000 description 2
- 229920000161 Locust bean gum Polymers 0.000 description 2
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 2
- 239000006227 byproduct Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 239000000252 konjac Substances 0.000 description 2
- 235000010485 konjac Nutrition 0.000 description 2
- 235000010420 locust bean gum Nutrition 0.000 description 2
- 239000000711 locust bean gum Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000003605 opacifier Substances 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- -1 potassium cations Chemical class 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- IBZYPBGPOGJMBF-UHFFFAOYSA-N 3,6 anhydrogalactose Natural products CCC=CCC1C(CC(=O)NC(C(C)CC)C(O)=O)CCC1=O IBZYPBGPOGJMBF-UHFFFAOYSA-N 0.000 description 1
- WZYRMLAWNVOIEX-BGPJRJDNSA-N 3,6-anhydro-D-galactose Chemical compound O=C[C@H](O)[C@H]1OC[C@@H](O)[C@@H]1O WZYRMLAWNVOIEX-BGPJRJDNSA-N 0.000 description 1
- DCQFFOLNJVGHLW-UHFFFAOYSA-N 4'-Me ether-Punctatin+ Natural products O1C(O)C(O)C2OCC1C2O DCQFFOLNJVGHLW-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 244000303965 Cyamopsis psoralioides Species 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 235000019759 Maize starch Nutrition 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 208000018756 Variant Creutzfeldt-Jakob disease Diseases 0.000 description 1
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229920001222 biopolymer Polymers 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 208000005881 bovine spongiform encephalopathy Diseases 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- WZYRMLAWNVOIEX-UHFFFAOYSA-N cinnamtannin B-2 Natural products O=CC(O)C1OCC(O)C1O WZYRMLAWNVOIEX-UHFFFAOYSA-N 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
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- 230000001627 detrimental effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229940099371 diacetylated monoglycerides Drugs 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 239000007897 gelcap Substances 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
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- 239000012535 impurity Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
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- 230000002335 preservative effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
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- 239000002562 thickening agent Substances 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/051,201 US6949256B2 (en) | 2002-01-18 | 2002-01-18 | Non-gelatin capsule shell formulation |
| US10/051,201 | 2002-01-18 | ||
| PCT/US2003/001134 WO2003061633A1 (en) | 2002-01-18 | 2003-01-15 | Non-gelatin capsule shell formulation comprising iota-carrageenan and kappa-carrageenan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003237365A1 AU2003237365A1 (en) | 2003-09-18 |
| AU2003237365B2 true AU2003237365B2 (en) | 2007-05-31 |
Family
ID=21969929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003237365A Expired - Fee Related AU2003237365B2 (en) | 2002-01-18 | 2003-01-15 | Non-gelatin capsule shell formulation comprising iota-carrageenan and kappa-carrageenan |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6949256B2 (enExample) |
| EP (1) | EP1474115B1 (enExample) |
| JP (1) | JP2005529066A (enExample) |
| CN (1) | CN100467065C (enExample) |
| AT (1) | ATE459344T1 (enExample) |
| AU (1) | AU2003237365B2 (enExample) |
| CA (1) | CA2473312C (enExample) |
| DE (1) | DE60331524D1 (enExample) |
| MX (1) | MXPA04006914A (enExample) |
| WO (1) | WO2003061633A1 (enExample) |
Families Citing this family (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1249219B1 (de) * | 2000-12-29 | 2009-10-21 | Swiss Caps Rechte und Lizenzen AG | Verfahren und Vorrichtung zum Herstellen von Formkörpern aus einem biopolymeren Material |
| US7887838B2 (en) * | 2002-01-18 | 2011-02-15 | Banner Pharmacaps, Inc. | Non-gelatin film and method and apparatus for producing same |
| ES2195774B1 (es) * | 2002-03-11 | 2004-11-01 | Premium Ingredients, S.L. | Aditivo alimentario. |
| US7713551B2 (en) * | 2002-09-11 | 2010-05-11 | Elan Pharma International Ltd. | Gel stabilized nanoparticulate active agent compositions |
| JP4414670B2 (ja) * | 2003-04-10 | 2010-02-10 | 松谷化学工業株式会社 | イオン交換能力を有するグルコースポリマーの製造法及びそれを含有する組成物 |
| US20050008677A1 (en) * | 2003-04-14 | 2005-01-13 | Fmc Corporation | Delivery system of homogeneous, thermoreversible gel film containing kappa-2 carrageenan |
| US20050019294A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible alginate films and soft capsules made therefrom |
| JP2007526209A (ja) * | 2003-04-14 | 2007-09-13 | エフ エム シー コーポレーション | 均一かつ熱可逆性低粘度ポリマンナンフィルムの伝達システム |
| US20050048185A1 (en) * | 2003-04-14 | 2005-03-03 | Fmc Corporation | Delivery systems of homogeneous, thermoreversible low viscosity polymannan gum films |
| US20050013847A1 (en) * | 2003-04-14 | 2005-01-20 | Fmc Corporation | Delivery systems of homogeneous, thermoreversible alginate films |
| US20050019295A1 (en) * | 2003-04-14 | 2005-01-27 | Fmc Corporation | Homogeneous, thermoreversible low viscosity polymannan gum films and soft capsules made therefrom |
| US7816341B2 (en) * | 2003-04-14 | 2010-10-19 | Fmc Corporation | Homogeneous, thermoreversible gel containing reduced viscosity carrageenan and products made therefrom |
| WO2005104674A2 (en) * | 2003-11-12 | 2005-11-10 | National Paintball Supply, Inc. | Projectile, projectile core, and method of making |
| US20060088590A1 (en) * | 2004-10-22 | 2006-04-27 | Banner Pharmacaps, Inc. | Non-blooming gelatin and non-gelatin formulations |
| AU2005314021B2 (en) * | 2004-12-09 | 2010-02-11 | Insys Therapeutics, Inc. | Room-temperature stable dronabinol formulations |
| US7905181B2 (en) * | 2005-02-05 | 2011-03-15 | Ciesiun Paul M | Bioluminescent paintball |
| US8479656B2 (en) * | 2005-02-05 | 2013-07-09 | Hydro-Caps, Llc | Water based paintball and method for fabricating water based paintballs |
| CN1276779C (zh) * | 2005-07-01 | 2006-09-27 | 唐连德 | 一种植物多糖空心胶囊原料组合物及空心胶囊的制备方法 |
| US7861728B2 (en) * | 2006-02-10 | 2011-01-04 | R.J. Reynolds Tobacco Company | Smokeless tobacco composition having an outer and inner pouch |
| US8920918B2 (en) * | 2005-10-31 | 2014-12-30 | Kee Action Sports Technology Holdings, Llc | Oil and polyethylene glycol fill material for use in paintball shells |
| WO2007063084A1 (en) * | 2005-12-02 | 2007-06-07 | Cargill, Incorporated | Low calorie fat substitute |
| CA2882048C (en) | 2006-02-03 | 2020-03-24 | Opko Renal, Llc | Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3 |
| US7810507B2 (en) * | 2006-02-10 | 2010-10-12 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| HUE037309T2 (hu) | 2006-06-21 | 2018-08-28 | Opko Ireland Global Holdings Ltd | Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer |
| CN100411614C (zh) * | 2006-06-29 | 2008-08-20 | 郑建璋 | 银耳多糖胶囊壳生产方法 |
| EP2046290A4 (en) * | 2006-08-04 | 2011-08-17 | Insys Therapeutics Inc | AQUEOUS DRONABINOL FORMULATIONS |
| JP5021263B2 (ja) * | 2006-10-02 | 2012-09-05 | 中日本カプセル 株式会社 | 皮膜用組成物 |
| US8574624B2 (en) * | 2006-11-17 | 2013-11-05 | Corn Products Development, Inc. | Highly inhibited starch fillers for films and capsules |
| WO2009047644A2 (en) | 2007-04-25 | 2009-04-16 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| ES2401205T3 (es) | 2007-04-25 | 2013-04-17 | Cytochroma Inc. | Composiciones de orales de liberación controlada que comprende un compuesto de vitamina D y un soporte céreo |
| CA2683514C (en) | 2007-04-25 | 2019-07-09 | Proventiv Therapeutics, Llc | Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease |
| US20090004231A1 (en) | 2007-06-30 | 2009-01-01 | Popp Shane M | Pharmaceutical dosage forms fabricated with nanomaterials for quality monitoring |
| CN101873809B (zh) | 2007-07-23 | 2014-11-12 | R.J.雷诺兹烟草公司 | 无烟烟草组合物 |
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| US6745546B2 (en) * | 2001-11-02 | 2004-06-08 | R.P. Scherer Technologies, Inc. | Encapsulation machine with valved injection wedge |
| US6884060B2 (en) * | 2001-11-02 | 2005-04-26 | R.P. Scherer Technologies, Inc. | Apparatus for manufacturing encapsulated products |
-
2002
- 2002-01-18 US US10/051,201 patent/US6949256B2/en not_active Expired - Fee Related
-
2003
- 2003-01-15 DE DE60331524T patent/DE60331524D1/de not_active Expired - Lifetime
- 2003-01-15 AT AT03731918T patent/ATE459344T1/de not_active IP Right Cessation
- 2003-01-15 AU AU2003237365A patent/AU2003237365B2/en not_active Expired - Fee Related
- 2003-01-15 MX MXPA04006914A patent/MXPA04006914A/es unknown
- 2003-01-15 WO PCT/US2003/001134 patent/WO2003061633A1/en not_active Ceased
- 2003-01-15 CN CNB038062461A patent/CN100467065C/zh not_active Expired - Fee Related
- 2003-01-15 JP JP2003561578A patent/JP2005529066A/ja active Pending
- 2003-01-15 EP EP03731918A patent/EP1474115B1/en not_active Expired - Lifetime
- 2003-01-15 CA CA2473312A patent/CA2473312C/en not_active Expired - Fee Related
-
2005
- 2005-08-02 US US11/195,372 patent/US20060029660A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2473312C (en) | 2010-02-23 |
| CN100467065C (zh) | 2009-03-11 |
| WO2003061633A1 (en) | 2003-07-31 |
| WO2003061633B1 (en) | 2003-12-18 |
| JP2005529066A (ja) | 2005-09-29 |
| US20030138482A1 (en) | 2003-07-24 |
| MXPA04006914A (es) | 2006-03-16 |
| CA2473312A1 (en) | 2003-07-31 |
| US6949256B2 (en) | 2005-09-27 |
| US20060029660A1 (en) | 2006-02-09 |
| CN1649572A (zh) | 2005-08-03 |
| EP1474115B1 (en) | 2010-03-03 |
| EP1474115A1 (en) | 2004-11-10 |
| DE60331524D1 (de) | 2010-04-15 |
| ATE459344T1 (de) | 2010-03-15 |
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| Date | Code | Title | Description |
|---|---|---|---|
| MK25 | Application lapsed reg. 22.2i(2) - failure to pay acceptance fee |