US20030176357A1
(en)
*
|
1998-10-06 |
2003-09-18 |
Pospisilik Andrew J. |
Dipeptidyl peptidase IV inhibitors and their uses for lowering blood pressure levels
|
TWI249401B
(en)
*
|
1999-04-14 |
2006-02-21 |
Takeda Chemical Industries Ltd |
Agent for improving ketosis
|
AR030379A1
(es)
*
|
2000-08-22 |
2003-08-20 |
Novartis Ag |
Combinaciones
|
US7199102B2
(en)
*
|
2000-08-24 |
2007-04-03 |
The Regents Of The University Of California |
Orally administered peptides synergize statin activity
|
US7166578B2
(en)
|
2000-08-24 |
2007-01-23 |
The Regents Of The University Of California |
Orally administered peptides synergize statin activity
|
US7723303B2
(en)
*
|
2000-08-24 |
2010-05-25 |
The Regents Of The University Of California |
Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
|
US7144862B2
(en)
*
|
2000-08-24 |
2006-12-05 |
The Regents Of The University Of California |
Orally administered peptides to ameliorate atherosclerosis
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
US7148197B2
(en)
*
|
2000-08-24 |
2006-12-12 |
The Regents Of The University Of California |
Orally administered small peptides synergize statin activity
|
DK1345895T3
(da)
*
|
2000-12-21 |
2007-05-07 |
Sanofi Aventis Deutschland |
Hidtil ukendt diphenylazetidioner, fremgangsmåde til deres fremstilling, lægemidler indeholdende disse forbindelser og deres anvendelse til behandling af lipidstofskifteforstyrrelser
|
WO2002096399A1
(fr)
*
|
2001-05-28 |
2002-12-05 |
Kanebo, Limited |
Accelerateur de lipolyse, preparation dermatologique cosmetique pour reduction de masse corporelle, et composition d'aliment ou de boisson contenant cet accelerateur, et procede de reduction de masse corporelle et utilisation medicinale sur la base de l'activite de cet accelerateur
|
US7025985B2
(en)
*
|
2001-05-28 |
2006-04-11 |
Kanebo, Ltd. |
Dihydroxyphenyl compounds and glucoside compounds thereof
|
US6987123B2
(en)
*
|
2001-07-26 |
2006-01-17 |
Cadila Healthcare Limited |
Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
|
MXPA04002330A
(es)
|
2001-09-14 |
2005-04-08 |
Japan Tobacco Inc |
Compuestos biarilo ligados.
|
US20030220374A1
(en)
*
|
2002-01-14 |
2003-11-27 |
Pharmacia Corporation |
Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
|
AR039090A1
(es)
*
|
2002-03-22 |
2005-02-09 |
Novartis Ag |
Combinacion de compuestos organicos
|
US6716842B2
(en)
|
2002-04-05 |
2004-04-06 |
Warner-Lambert Company, Llc |
Antidiabetic agents
|
AU2003225027A1
(en)
*
|
2002-04-16 |
2003-11-03 |
Merck And Co., Inc. |
Combination therapy using a ppar alpha/gamma agonist
|
ITMI20021012A1
(it)
*
|
2002-05-13 |
2003-11-13 |
Giovanni Scaramuzzino |
Combinazione di un inibitore dell'enzima hmg-coa reduttasi e di un estere nitrato
|
EP1388352A1
(en)
*
|
2002-08-08 |
2004-02-11 |
Laboratoires Fournier S.A. |
Use of a ppar-alpha agonist to treat patients suffering from weight gain associated with a ppar-gamma agonist treatment
|
US7393960B2
(en)
|
2002-08-29 |
2008-07-01 |
Merck & Co., Inc. |
Indoles having anti-diabetic activity
|
ES2342596T3
(es)
*
|
2002-08-29 |
2010-07-09 |
MERCK SHARP & DOHME CORP. |
Indoles con actividad anti-diabetica.
|
CN100577660C
(zh)
*
|
2002-09-12 |
2010-01-06 |
霍夫曼-拉罗奇有限公司 |
作为ppar激动剂用于治疗糖尿病的n-取代-1h-吲哚-5-丙酸化合物
|
DE10300099A1
(de)
*
|
2003-01-07 |
2004-07-15 |
Bayer Healthcare Ag |
Indol-Phenylsulfonamid-Derivate
|
DK1599468T3
(da)
|
2003-01-14 |
2008-02-04 |
Arena Pharm Inc |
1,2,3-trisubstituerede aryl- og heteroarylderivater som modulatorer af metabolisme og forebyggelse og behandling af forstyrrelser forbundet dermed såsom diabetes og hyperglykæmi
|
AU2004210127B2
(en)
|
2003-01-27 |
2009-10-01 |
Merck Sharp & Dohme Corp. |
Substituted pyrazoles, compositions containing such compounds and methods of use
|
BRPI0409447A
(pt)
*
|
2003-04-14 |
2006-04-18 |
Inst For Pharm Discovery Inc |
ácidos fenilalcanóicos substituìdos
|
WO2004098510A2
(en)
*
|
2003-04-30 |
2004-11-18 |
Beth Israel Deaconess Medical Center |
Cystic fibrosis therapy
|
US7981915B2
(en)
*
|
2003-04-30 |
2011-07-19 |
Beth Israel Deaconess Medical Center |
Methods for modulating PPAR biological activity for the treatment of diseases caused by mutations in the CFTR gene
|
US7358364B2
(en)
|
2003-04-30 |
2008-04-15 |
The Institute For Pharmaceutical Discovery Llc |
Substituted carboxylic acids
|
US20050107387A1
(en)
*
|
2003-05-13 |
2005-05-19 |
Pharmacia Corporation |
Compositions of a cyclooxygenase-2 selective inhibitor and a peroxisome proliferator activated receptor agonist for the treatment of ischemic mediated central nervous system disorders
|
WO2004108126A1
(en)
*
|
2003-06-06 |
2004-12-16 |
Snowden Pharmaceuticals, Llc |
Fibric acid derivatives for the treatment of irritable bowel syndrome
|
WO2004110368A2
(en)
*
|
2003-06-06 |
2004-12-23 |
Merck & Co., Inc. |
Combination therapy for the treatment of hypertension
|
EP2287166A3
(en)
|
2003-07-14 |
2011-06-22 |
Arena Pharmaceuticals, Inc. |
Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto
|
DE10335449A1
(de)
*
|
2003-08-02 |
2005-02-17 |
Bayer Healthcare Ag |
Bicyclische Indolinsulfonamid-Derivate
|
DE10337839A1
(de)
*
|
2003-08-18 |
2005-03-17 |
Bayer Healthcare Ag |
Indolin-Derivate
|
US20050074443A1
(en)
*
|
2003-10-03 |
2005-04-07 |
Treadwell Benjamin V. |
Methods of attenuating autoimmune disease and compositions useful therefor
|
CN1875002B
(zh)
*
|
2003-11-05 |
2011-08-03 |
霍夫曼-拉罗奇有限公司 |
作为ppar激动剂的苯基衍生物
|
JP2007509998A
(ja)
|
2003-11-05 |
2007-04-19 |
エフ.ホフマン−ラ ロシュ アーゲー |
Ppar活性化剤としてのベンズ環付加された化合物
|
MXPA06004642A
(es)
|
2003-11-05 |
2006-06-27 |
Hoffmann La Roche |
Derivados de heteroaril como activadores de los receptores activados de proliferadores de peroxisoma (ppar).
|
CN1886133B
(zh)
|
2003-12-04 |
2010-12-01 |
财团法人卫生研究院 |
吲哚化合物
|
TWI297606B
(en)
*
|
2004-01-16 |
2008-06-11 |
Nat Health Research Institutes |
Cancer therapy
|
EP1744747A4
(en)
*
|
2004-04-26 |
2009-12-02 |
Univ Vanderbilt |
INDIC ACID AND INDULECTIC ACID DERIVATIVES AS THERAPEUTIC ACTIVITIES WITH REDUCED GASTROINTESTINAL TOXICITY
|
US20080076810A1
(en)
*
|
2004-05-28 |
2008-03-27 |
Weiguo Lui |
Benzoureas Having Anti-Diabetic Activity
|
US8022063B2
(en)
*
|
2004-05-29 |
2011-09-20 |
7Tm Pharma A/S |
CRTH2 receptor ligands for medicinal uses
|
ES2306165T3
(es)
*
|
2004-06-04 |
2008-11-01 |
MERCK & CO., INC. |
Derivados de pirazol, composiciones que contienen dichos compuestos y procedimientos de uso.
|
CN1980659A
(zh)
|
2004-07-02 |
2007-06-13 |
默克公司 |
具有抗糖尿病活性的吲哚类
|
ATE468853T1
(de)
|
2004-07-22 |
2010-06-15 |
Merck Sharp & Dohme |
Substituierte pyrazole, derartige verbindungen enthaltende zusammensetzungen und verfahren zu ihrer verwendung
|
CN101048367A
(zh)
|
2004-07-30 |
2007-10-03 |
萨尔瓦特实验室股份有限公司 |
作为PPARγ调节剂的新的酪氨酸衍生物
|
CA2580501A1
(en)
*
|
2004-09-16 |
2006-03-30 |
The Regents Of The University Of California |
G-type peptides and other agents to ameliorate atherosclerosis and other pathologies
|
JP2008019169A
(ja)
*
|
2004-10-25 |
2008-01-31 |
Osaka Univ |
新規ppar調節剤およびそのスクリーニング方法
|
JP2008520692A
(ja)
*
|
2004-11-18 |
2008-06-19 |
ジ インスチチュート フォー ファーマシューティカル ディスカバリー、エルエルシー |
複素環置換カルボン酸
|
EP1827472A4
(en)
|
2004-12-06 |
2012-09-05 |
Univ California |
METHOD FOR IMPROVING THE STRUCTURE AND FUNCTION OF ARTERIOLS
|
DOP2006000008A
(es)
*
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
FR2880887B1
(fr)
*
|
2005-01-14 |
2009-01-30 |
Merck Sante Soc Par Actions Si |
Derives d'hydroxyphenols, procedes pour leur preparation, compositions pharmaceutiques les contenant et applications en therapeutique
|
WO2006096564A1
(en)
|
2005-03-04 |
2006-09-14 |
Merck & Co., Inc. |
Fused aromatic compounds having anti-diabetic activity
|
US20080293639A1
(en)
*
|
2005-04-29 |
2008-11-27 |
The Regents Of The University Of California |
Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response
|
MX2007013430A
(es)
*
|
2005-04-29 |
2008-03-19 |
Univ California |
Peptidos y peptidos mimeticos para tratar patologias caracterizadas por una respuesta inflamatoria.
|
ES2375302T3
(es)
*
|
2005-05-24 |
2012-02-28 |
Dsm Ip Assets B.V. |
Derivados de ligustilida para el tratamiento de trastornos inflamatorios.
|
US7807692B2
(en)
|
2005-07-06 |
2010-10-05 |
Merck Sharp & Dohme Corp. |
Antidiabetic oxazolidinediones and thiazolidinediones
|
US7709658B2
(en)
|
2005-07-26 |
2010-05-04 |
Merck Sharp & Dohme Corp. |
Process for synthesizing a substituted pyrazole
|
US20070161006A1
(en)
*
|
2006-01-10 |
2007-07-12 |
Vita Genomics, Inc. |
Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
|
CL2007001011A1
(es)
*
|
2006-04-11 |
2008-05-16 |
Arena Pharm Inc |
Metodo para la identificacion de secretagogos de gip, polipeptido inhibidor gastrico; y uso de un receptor acoplado a proteina g para clasificar compuestos de prueba como secretagogos de gip.
|
PE20071221A1
(es)
*
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
WO2007149456A2
(en)
|
2006-06-19 |
2007-12-27 |
Vanderbilt University |
Methods and compositions for diagnostic and therapeutic targeting of cox-2
|
JP2010502719A
(ja)
|
2006-09-08 |
2010-01-28 |
ロード アイランド ホスピタル |
アルコール誘発性脳疾患の治療、予防および回復
|
JP5570223B2
(ja)
|
2007-01-26 |
2014-08-13 |
カネック ファーマ インコーポレイテッド |
タンパク質チロシンホスファターゼ1b(ptp−1b)阻害剤としての縮合芳香族ジフルオロメタンホスホネート
|
AU2008221194B2
(en)
|
2007-02-26 |
2013-06-27 |
Merck Canada Inc. |
Indole and indoline cyclopropyl amide derivatives as EP4 receptor antagonists
|
US8338458B2
(en)
|
2007-05-07 |
2012-12-25 |
Merck Sharp & Dohme Corp. |
Method of treatment using fused aromatic compounds having anti-diabetic activity
|
US20080319218A1
(en)
*
|
2007-06-22 |
2008-12-25 |
Andreas Haubrich |
Processes for Making and Using Benzyl Pentahydroxyhexylcarbamoylundecanoate
|
US20080319221A1
(en)
*
|
2007-06-22 |
2008-12-25 |
Bernd Junker |
Esters of Pentahydroxyhexylcarbamoyl Alkanoic Acids
|
DK2682400T5
(da)
|
2007-08-28 |
2017-11-27 |
Uab Research Foundation |
Syntetiske apolipoprotein E-efterlignende polypeptider og fremgangsmåder til anvendelse
|
CA2697957A1
(en)
|
2007-08-28 |
2009-03-12 |
Uab Research Foundation |
Synthetic apolipoprotein e mimicking polypeptides and methods of use
|
FR2921366B1
(fr)
*
|
2007-09-26 |
2009-12-04 |
Servier Lab |
Nouveaux derives heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
DE102007054497B3
(de)
*
|
2007-11-13 |
2009-07-23 |
Sanofi-Aventis Deutschland Gmbh |
Neue kristalline Diphenylazetidinonhydrate und Verfahren zu deren Herstellung
|
EP2146210A1
(en)
*
|
2008-04-07 |
2010-01-20 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY
|
JO2870B1
(en)
|
2008-11-13 |
2015-03-15 |
ميرك شارب اند دوهم كورب |
Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
|
CA2743489A1
(en)
|
2008-11-17 |
2010-05-20 |
Merck Sharp & Dohme Corp. |
Substituted bicyclic amines for the treatment of diabetes
|
TW201028414A
(en)
|
2009-01-16 |
2010-08-01 |
Merck Sharp & Dohme |
Oxadiazole beta carboline derivatives as antidiabetic compounds
|
JP2012515782A
(ja)
|
2009-01-23 |
2012-07-12 |
シェーリング コーポレイション |
抗糖尿病性架橋および縮合化合物
|
CA2749930A1
(en)
|
2009-01-23 |
2010-07-29 |
Schering Corporation |
Bridged and fused heterocyclic antidiabetic compounds
|
US8575166B2
(en)
|
2009-02-05 |
2013-11-05 |
Merck Sharp & Dohme Corp. |
Phthalazine-containing antidiabetic compounds
|
US20120220567A1
(en)
|
2009-07-23 |
2012-08-30 |
Shipps Jr Gerald W |
Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
WO2011011506A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
US8552022B2
(en)
|
2009-08-13 |
2013-10-08 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
CA2771352A1
(en)
|
2009-09-02 |
2011-03-10 |
Merck Sharp & Dohme Corp. |
Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
CN102695414A
(zh)
|
2010-01-15 |
2012-09-26 |
默沙东公司 |
作为抗糖尿病化合物的噁二唑β-咔啉衍生物
|
WO2011103256A1
(en)
|
2010-02-22 |
2011-08-25 |
Merck Sharp & Dohme Corp. |
Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
EP2563764B1
(en)
|
2010-04-26 |
2015-02-25 |
Merck Sharp & Dohme Corp. |
Novel spiropiperidine prolylcarboxypeptidase inhibitors
|
WO2011143057A1
(en)
|
2010-05-11 |
2011-11-17 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
WO2011146358A1
(en)
|
2010-05-21 |
2011-11-24 |
Merck Sharp & Dohme Corp. |
Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
WO2011156246A1
(en)
|
2010-06-11 |
2011-12-15 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
WO2012024183A1
(en)
|
2010-08-18 |
2012-02-23 |
Merck Sharp & Dohme Corp. |
Spiroxazolidinone compounds
|
SG188548A1
(en)
|
2010-09-22 |
2013-04-30 |
Arena Pharm Inc |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
KR20130143042A
(ko)
|
2010-10-29 |
2013-12-30 |
머크 샤프 앤드 돔 코포레이션 |
디아제늄디올레이트 헤테로시클릭 유도체
|
RU2598842C2
(ru)
|
2011-01-20 |
2016-09-27 |
Мерк Шарп Энд Домэ Корп. |
Антагонисты рецептора минералокортикоидов
|
JO3350B1
(ar)
|
2011-03-07 |
2019-03-13 |
Merck Sharp & Dohme |
مشتقات حلقية غير متجانسة محتوية على مجموعات أمينو أولية ومركبات داي أزينيومديولات
|
CA2831334A1
(en)
|
2011-04-08 |
2012-10-11 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
WO2012139495A1
(en)
|
2011-04-13 |
2012-10-18 |
Merck Sharp & Dohme Corp. |
Mineralocorticoid receptor antagonists
|
EP2704568B1
(en)
|
2011-05-02 |
2018-01-24 |
Merck Sharp & Dohme Corp. |
Diazeniumdiolate cyclohexyl derivatives
|
BR112013030883A2
(pt)
|
2011-06-02 |
2017-10-10 |
Intervet Int Bv |
composto, composição farmacêutica, uso do composto, e, método para o tratamento de uma condição selecionada do grupo consistindo em obesidade e diabete
|
US9006228B2
(en)
|
2011-06-16 |
2015-04-14 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment
|
WO2012178142A1
(en)
*
|
2011-06-23 |
2012-12-27 |
Metabolic Solutions Development Company, Llc |
Ppar-sparing compounds and combinations fort the treatment of diabetes and other metabolic diseases
|
WO2013048916A1
(en)
|
2011-09-30 |
2013-04-04 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment
|
WO2013055606A1
(en)
|
2011-10-13 |
2013-04-18 |
Merck Sharp & Dohme Corp. |
Mineralocorticoid receptor antagonists
|
WO2013059245A1
(en)
|
2011-10-17 |
2013-04-25 |
Vanderbilt University |
Indomethacin analogs for the treatment of castrate-resistant prostate cancer
|
WO2013062838A1
(en)
|
2011-10-24 |
2013-05-02 |
Merck Sharp & Dohme Corp. |
Substituted piperidinyl compounds useful as gpr119 agonists
|
JO3210B1
(ar)
|
2011-10-28 |
2018-03-08 |
Merck Sharp & Dohme |
مثبط منصهر لبروتين نقل الكوليسترليستير اوكسازوليدينون ثمائي الحلقة
|
WO2013068328A1
(en)
|
2011-11-07 |
2013-05-16 |
Intervet International B.V. |
Bicyclo [2.2.2] octan-1-ylcarboxylic acid compounds as dgat-1 inhibitors
|
WO2013068439A1
(en)
|
2011-11-09 |
2013-05-16 |
Intervet International B.V. |
4-amino-5-oxo-7,8-dihydropyrimido[5, 4 -f] [1, 4] oxazepine compounds as dgat1 inhibitors
|
AU2012339870B2
(en)
|
2011-11-15 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
Substituted cyclopropyl compounds useful as GPR119 agonists
|
US9073930B2
(en)
|
2012-02-17 |
2015-07-07 |
Merck Sharp & Dohme |
Dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
CN104411710A
(zh)
|
2012-04-16 |
2015-03-11 |
卡内克制药公司 |
作为ptp-1b抑制剂前体的稠合的芳族膦酸酯衍生物
|
EP2874622A4
(en)
|
2012-07-23 |
2015-12-30 |
Merck Sharp & Dohme |
TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS
|
US9453038B2
(en)
|
2012-12-17 |
2016-09-27 |
Merck Sharp & Dohme Corp. |
Glucokinase activator compounds, compositions containing such compounds, and methods of treatment
|
US9717714B2
(en)
|
2012-12-19 |
2017-08-01 |
Merck Sharp & Dohme Corp. |
Spirocyclic CETP inhibitors
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
WO2015089809A1
(en)
|
2013-12-19 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Antidiabetic substituted heteroaryl compounds
|
US10065945B2
(en)
|
2014-01-24 |
2018-09-04 |
Merck Sharp & Dohme Corp. |
Isoquinoline derivatives as MGAT2 inhibitors
|
WO2016018729A1
(en)
|
2014-07-29 |
2016-02-04 |
Merck Sharp & Dohme Corp. |
Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
|
WO2016018665A1
(en)
|
2014-07-31 |
2016-02-04 |
Uab Research Foundation |
Apoe mimetic peptides and higher potency to clear plasma cholesterol
|
US10100042B2
(en)
|
2014-08-08 |
2018-10-16 |
Merck Sharp & Dohme Corp. |
[5,6]—fused bicyclic antidiabetic compounds
|
US10662171B2
(en)
|
2014-08-08 |
2020-05-26 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
EP3177287B1
(en)
|
2014-08-08 |
2022-02-23 |
Merck Sharp & Dohme Corp. |
Antidiabetic bicyclic compounds
|
EP3209682B1
(en)
|
2014-10-24 |
2020-12-30 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
TW201625635A
(zh)
|
2014-11-21 |
2016-07-16 |
默沙東藥廠 |
作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物
|
EP3242666A1
(en)
|
2015-01-06 |
2017-11-15 |
Arena Pharmaceuticals, Inc. |
Methods of treating conditions related to the s1p1 receptor
|
US10245264B2
(en)
|
2015-05-27 |
2019-04-02 |
Merck Sharp & Dohme Corp. |
Substituted imidazo[1,2-a]pyrazines as soluble guanylate cyclase activators
|
WO2016191335A1
(en)
|
2015-05-28 |
2016-12-01 |
Merck Sharp & Dohme Corp. |
Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators
|
JP6838744B2
(ja)
|
2015-06-22 |
2021-03-03 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
S1P1レセプター関連障害における使用のための(R)−2−(7−(4−シクロペンチル−3−(トリフルオロメチル)ベンジルオキシ)−1,2,3,4−テトラヒドロシクロペンタ[b]インドール−3−イル)酢酸(化合物1)の結晶性L−アルギニン塩
|
EP3322420B1
(en)
|
2015-07-13 |
2021-12-29 |
Merck Sharp & Dohme Corp. |
Bicyclic heterocycles as inhibitors of cholesterol ester transfer protein
|
US10800826B2
(en)
|
2015-10-05 |
2020-10-13 |
Merck Sharp & Dohme Corp. |
Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
|
WO2017095725A1
(en)
|
2015-11-30 |
2017-06-08 |
Merck Sharp & Dohme Corp. |
Aryl sulfonamides as blt1 antagonists
|
EP3383868B1
(en)
|
2015-11-30 |
2022-10-05 |
Merck Sharp & Dohme LLC |
Aryl sulfonamides as blt1 antagonists
|
WO2017107052A1
(en)
|
2015-12-22 |
2017-06-29 |
Merck Sharp & Dohme Corp. |
Soluble guanylate cyclase stimulators
|
WO2017197555A1
(en)
|
2016-05-16 |
2017-11-23 |
Merck Sharp & Dohme Corp. |
Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators
|
WO2017201683A1
(en)
|
2016-05-25 |
2017-11-30 |
Merck Sharp & Dohme Corp. |
Substituted tetrahydroisoquinoline compounds useful as gpr120 agonists
|
WO2018034917A1
(en)
|
2016-08-15 |
2018-02-22 |
Merck Sharp & Dohme Corp. |
Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
|
EP3496716B1
(en)
|
2016-08-15 |
2021-11-03 |
Merck Sharp & Dohme Corp. |
Compounds useful for altering the levels of bile acids for the treatment of diabetes and cardiometabolic disease
|
US11008313B2
(en)
|
2016-09-20 |
2021-05-18 |
Merck Sharp & Dohme Corp. |
Substituted 1-methyl-1,2,3,4-tetrahydroisoquinoline molecules as PCSK9 allosteric binders
|
WO2018093698A1
(en)
|
2016-11-18 |
2018-05-24 |
Merck Sharp & Dohme Corp. |
Indole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
|
WO2018107415A1
(en)
|
2016-12-15 |
2018-06-21 |
Merck Sharp & Dohme Corp. |
Hydroxy isoxazole compounds useful as gpr120 agonists
|
KR20190116416A
(ko)
|
2017-02-16 |
2019-10-14 |
아레나 파마슈티칼스, 인크. |
원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
|
JOP20190150A1
(ar)
|
2018-06-21 |
2019-12-21 |
Merck Sharp & Dohme |
مركبات مناهضة لـ pcsk9
|
US20220177465A1
(en)
|
2019-04-04 |
2022-06-09 |
Merck Sharp & Dohme Corp. |
Inhibitors of histone deacetylase-3 useful for the treatment of cancer, inflammation, neurodegeneration diseases and diabetes
|
WO2020236690A1
(en)
|
2019-05-22 |
2020-11-26 |
Merck Sharp & Dohme Corp. |
Natriuretic peptide receptor a agonists useful for the treatment of cardiometabolic diseases, kidney disease and diabetes
|
EP3972590A4
(en)
|
2019-05-22 |
2023-06-14 |
Merck Sharp & Dohme LLC |
NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USED TO TREAT CARDIOMETABOLIC DISEASES, KIDNEY DISEASES AND DIABETES
|
WO2021041770A1
(en)
|
2019-08-30 |
2021-03-04 |
Merck Sharp & Dohme Corp. |
Pcsk9 antagonist compounds
|
EP3842061A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled triazole co-agonists of the glucagon and glp-1 receptors
|
EP3842449A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled olefin co-agonists of the glucagon and glp-1 receptors
|
EP3842060A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled lactam co-agonists of the glucagon and glp-1 receptors
|
WO2021236401A1
(en)
|
2020-05-18 |
2021-11-25 |
Merck Sharp & Dohme Corp. |
Novel diacylglyceride o-acyltransferase 2 inhibitors
|
KR20240050369A
(ko)
|
2021-08-19 |
2024-04-18 |
머크 샤프 앤드 돔 엘엘씨 |
Pcsk9 활성과 관련된 상태를 치료하기 위한 화합물
|
TW202404574A
(zh)
|
2022-06-15 |
2024-02-01 |
美商默沙東有限責任公司 |
用於捕捉介白素-1 β之環狀肽
|