AU2001268958B2 - Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv - Google Patents

Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv Download PDF

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Publication number
AU2001268958B2
AU2001268958B2 AU2001268958A AU2001268958A AU2001268958B2 AU 2001268958 B2 AU2001268958 B2 AU 2001268958B2 AU 2001268958 A AU2001268958 A AU 2001268958A AU 2001268958 A AU2001268958 A AU 2001268958A AU 2001268958 B2 AU2001268958 B2 AU 2001268958B2
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AU
Australia
Prior art keywords
alkyl
dione
dihydro
benzyl
purine
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Expired - Fee Related
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AU2001268958A
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AU2001268958A1 (en
Inventor
Lise Brown Christiansen
Anders Bendtz Kanstrup
Marit Kristiansen
Jane Marie Lundbeck
Christian K. Sams
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Novo Nordisk AS
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Novo Nordisk AS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2001268958A 2000-07-04 2001-07-04 Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv Expired - Fee Related AU2001268958B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200001040 2000-07-04
DKPA200001040 2000-07-04
US60223240 2000-07-04
US22324000P 2000-08-04 2000-08-04
PCT/DK2001/000467 WO2002002560A2 (en) 2000-07-04 2001-07-04 Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)

Publications (2)

Publication Number Publication Date
AU2001268958A1 AU2001268958A1 (en) 2002-04-11
AU2001268958B2 true AU2001268958B2 (en) 2006-03-09

Family

ID=26068848

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001268958A Expired - Fee Related AU2001268958B2 (en) 2000-07-04 2001-07-04 Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv
AU6895801A Pending AU6895801A (en) 2000-07-04 2001-07-04 Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU6895801A Pending AU6895801A (en) 2000-07-04 2001-07-04 Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv

Country Status (8)

Country Link
US (2) US20020161001A1 (https=)
EP (1) EP1301187B1 (https=)
JP (1) JP2004502690A (https=)
AU (2) AU2001268958B2 (https=)
HU (1) HUP0301622A3 (https=)
MX (1) MXPA02012272A (https=)
PL (1) PL360856A1 (https=)
WO (1) WO2002002560A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002234640B2 (en) * 2001-02-24 2009-10-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivative, production and use thereof as a medicament

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