AU2001244692B2 - Novel crystal form of pyrrolidylthiocarbapenem derivative - Google Patents

Novel crystal form of pyrrolidylthiocarbapenem derivative Download PDF

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Publication number
AU2001244692B2
AU2001244692B2 AU2001244692A AU2001244692A AU2001244692B2 AU 2001244692 B2 AU2001244692 B2 AU 2001244692B2 AU 2001244692 A AU2001244692 A AU 2001244692A AU 2001244692 A AU2001244692 A AU 2001244692A AU 2001244692 B2 AU2001244692 B2 AU 2001244692B2
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AU
Australia
Prior art keywords
crystal
type
diffraction
powder
ray diffraction
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AU2001244692A
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AU2001244692A1 (en
Inventor
Toshio Kawakita
Izumi Saitoh
Masayuki Takahira
Yasuyuki Yoshioka
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Shionogi and Co Ltd
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Shionogi and Co Ltd
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Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Publication of AU2001244692A1 publication Critical patent/AU2001244692A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
AU2001244692A 2000-03-31 2001-03-30 Novel crystal form of pyrrolidylthiocarbapenem derivative Ceased AU2001244692B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2000099868 2000-03-31
JP2000-99868 2000-03-31
PCT/JP2001/002834 WO2001072750A1 (en) 2000-03-31 2001-03-30 Novel crystal form of pyrrolidylthiocarbapenem derivative

Publications (2)

Publication Number Publication Date
AU2001244692A1 AU2001244692A1 (en) 2001-12-20
AU2001244692B2 true AU2001244692B2 (en) 2004-10-14

Family

ID=18614158

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001244692A Ceased AU2001244692B2 (en) 2000-03-31 2001-03-30 Novel crystal form of pyrrolidylthiocarbapenem derivative
AU4469201A Pending AU4469201A (en) 2000-03-31 2001-03-30 Novel crystal form of pyrrolidylthiocarbapenem derivative

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU4469201A Pending AU4469201A (en) 2000-03-31 2001-03-30 Novel crystal form of pyrrolidylthiocarbapenem derivative

Country Status (17)

Country Link
US (5) US20030153191A1 (enFirst)
EP (1) EP1270575B1 (enFirst)
JP (1) JP3375084B2 (enFirst)
KR (1) KR100472842B1 (enFirst)
CN (1) CN1192030C (enFirst)
AT (1) ATE304014T1 (enFirst)
AU (2) AU2001244692B2 (enFirst)
BR (1) BRPI0109712B8 (enFirst)
CA (1) CA2404703C (enFirst)
CY (2) CY1105674T1 (enFirst)
DE (1) DE60113243T2 (enFirst)
DK (1) DK1270575T3 (enFirst)
ES (1) ES2252205T3 (enFirst)
MX (1) MXPA02009592A (enFirst)
TW (1) TWI293631B (enFirst)
WO (1) WO2001072750A1 (enFirst)
ZA (1) ZA200207675B (enFirst)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1192030C (zh) * 2000-03-31 2005-03-09 盐野义制药株式会社 吡咯烷硫卡培南衍生物的新型结晶
JP5004355B2 (ja) * 2001-05-10 2012-08-22 塩野義製薬株式会社 アセチルチオピロリジン誘導体の製法
BR0214209A (pt) * 2001-11-16 2004-10-26 Ranbaxy Lab Ltd Processo para a preparação de imipenem cristalino e composto preparado pelo dito processo
TWI353855B (en) * 2005-05-26 2011-12-11 Shionogi & Co Method for preparing an aqueous solution of doripe
US8093378B2 (en) * 2006-04-28 2012-01-10 Kaneka Corporation Crystallization method for intermediates of carbapenem antibiotics
CN101466713A (zh) * 2006-07-03 2009-06-24 成都地奥九泓制药厂 多尼培南的新结晶及其制备方法和用途
CN101191787B (zh) * 2006-11-21 2011-07-27 上海医药工业研究院 高效液相色谱法测定多利培南含量的方法
US8445673B2 (en) * 2008-03-24 2013-05-21 Ranbaxy Laboratories Limited Process for the preparation of sterile doripenem
CN103025733B (zh) * 2010-06-03 2015-11-25 山东轩竹医药科技有限公司 碳青霉烯类衍生物或其水合物的晶型及其制备方法与用途
CN102977101A (zh) * 2011-09-07 2013-03-20 中国人民解放军军事医学科学院毒物药物研究所 多尼培南一水合物、其药物组合物、其制备方法和用途
CN102285988B (zh) * 2011-09-08 2012-09-05 上海希迈医药科技有限公司 一种多尼培南水合物晶体及其制备方法
WO2013068910A1 (en) * 2011-11-08 2013-05-16 Ranbaxy Laboratories Limited Process for the preparation of polymorphs of doripenem
CN104072497B (zh) * 2013-03-29 2017-10-03 石药集团中奇制药技术（石家庄）有限公司 一种多尼培南新结晶及其制备方法
CN103389347B (zh) * 2013-07-26 2015-12-09 深圳市海滨制药有限公司 高效液相色谱法测定多尼培南的方法
WO2015167148A1 (ko) * 2014-04-28 2015-11-05 제이더블유중외제약 주식회사 도리페넴의 신규한 결정 및 이의 제조방법
KR20160007679A (ko) 2016-01-04 2016-01-20 제일약품주식회사 도리페넴의 신규한 결정형

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5317016A (en) * 1991-08-20 1994-05-31 Shionogi Seiyaku Kabushiki Kaisha Pyrrolidylthiocarbapenem derivative
US5539102A (en) * 1992-02-21 1996-07-23 Shionogi Seiyaku Kabushiki Kaisha Production method for sulfamide
US6111098A (en) * 1994-05-02 2000-08-29 Shionogi & Co., Ltd. Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same
JP3558684B2 (ja) * 1994-06-28 2004-08-25 塩野義製薬株式会社 ピロリジルチオカルバペネム誘導体の乾燥方法
CN1192030C (zh) * 2000-03-31 2005-03-09 盐野义制药株式会社 吡咯烷硫卡培南衍生物的新型结晶
BRPI0407480A (pt) * 2003-02-14 2006-02-07 Shionogi & Co Cristal de intermediário sintético de carbapenem
US20120035357A1 (en) 2009-02-26 2012-02-09 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of carbapenem antibiotic

Also Published As

Publication number Publication date
KR100472842B1 (ko) 2005-03-10
US8247402B2 (en) 2012-08-21
US20030153191A1 (en) 2003-08-14
US20150031664A1 (en) 2015-01-29
KR20020087446A (ko) 2002-11-22
CA2404703C (en) 2007-06-05
ES2252205T3 (es) 2006-05-16
BRPI0109712B8 (pt) 2021-05-25
ZA200207675B (en) 2003-09-25
ATE304014T1 (de) 2005-09-15
CN1432016A (zh) 2003-07-23
EP1270575B1 (en) 2005-09-07
WO2001072750A1 (en) 2001-10-04
DK1270575T3 (da) 2006-01-16
AU4469201A (en) 2001-10-08
JP3375084B2 (ja) 2003-02-10
US9221823B2 (en) 2015-12-29
CA2404703A1 (en) 2002-09-26
DE60113243T2 (de) 2006-02-16
BRPI0109712B1 (pt) 2017-10-24
EP1270575A4 (en) 2004-02-18
US20130059831A1 (en) 2013-03-07
US20070060562A1 (en) 2007-03-15
BR0109712A (pt) 2003-04-29
US20080207586A1 (en) 2008-08-28
TWI293631B (enFirst) 2008-02-21
EP1270575A1 (en) 2003-01-02
CY2009001I2 (el) 2009-11-04
CY2009001I1 (el) 2009-11-04
MXPA02009592A (es) 2003-03-12
DE60113243D1 (de) 2005-10-13
CN1192030C (zh) 2005-03-09
CY1105674T1 (el) 2010-07-28

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NC Extension of term for standard patent requested (sect. 70)
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Free format text: FORMER OWNER WAS: SHIONOGI & CO., LTD. THE EARLIEST FIRST REGULATORY APPROVAL DATE PROVIDED BY THE PATENTEE 20 APR 2009 FOR THE GOODS DORIBAX DORIPENEM EXTENSION OF TERM OF PATENT PURSUANT TO SECTION 77 EXPIRES ON 20 APR

MK14 Patent ceased section 143(a) (annual fees not paid) or expired