ATE73653T1 - Polyenmakrolide enthaltende proliposomale pulver. - Google Patents

Polyenmakrolide enthaltende proliposomale pulver.

Info

Publication number
ATE73653T1
ATE73653T1 AT88909920T AT88909920T ATE73653T1 AT E73653 T1 ATE73653 T1 AT E73653T1 AT 88909920 T AT88909920 T AT 88909920T AT 88909920 T AT88909920 T AT 88909920T AT E73653 T1 ATE73653 T1 AT E73653T1
Authority
AT
Austria
Prior art keywords
solution
solvent
fine powder
dissolved
tertiary butanol
Prior art date
Application number
AT88909920T
Other languages
English (en)
Inventor
Reeta Mehta
Gabriel Lopez-Berestein
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE73653T1 publication Critical patent/ATE73653T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
AT88909920T 1987-10-16 1988-10-17 Polyenmakrolide enthaltende proliposomale pulver. ATE73653T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/109,813 US4950432A (en) 1987-10-16 1987-10-16 Polyene microlide pre-liposomal powders
EP88909920A EP0380584B1 (de) 1987-10-16 1988-10-17 Polyenmakrolide enthaltende proliposomale pulver
PCT/US1988/003652 WO1989003208A1 (en) 1987-10-16 1988-10-17 Polyene macrolide pre-liposomal powders

Publications (1)

Publication Number Publication Date
ATE73653T1 true ATE73653T1 (de) 1992-04-15

Family

ID=22329695

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88909920T ATE73653T1 (de) 1987-10-16 1988-10-17 Polyenmakrolide enthaltende proliposomale pulver.

Country Status (7)

Country Link
US (1) US4950432A (de)
EP (1) EP0380584B1 (de)
JP (1) JPH03500650A (de)
AT (1) ATE73653T1 (de)
AU (1) AU609565B2 (de)
DE (1) DE3869424D1 (de)
WO (1) WO1989003208A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1338736C (fr) * 1986-12-05 1996-11-26 Roger Baurain Microcristaux comportant une substance active presentant une affinite pour les phospholipides, et au moins un phospholipide, procede de preparation
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4981690A (en) * 1987-10-27 1991-01-01 Board Of Regents, The University Of Texas System Liposome-incorporated mepartricin
AU598958B2 (en) * 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
US5096629A (en) * 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
FR2648056A1 (fr) * 1989-06-13 1990-12-14 Ire Celltarg Sa Procede de preparation de microparticules lipidiques d'aspect microcristallin
FR2651680B1 (fr) * 1989-09-14 1991-12-27 Medgenix Group Sa Nouveau procede de preparation de microparticules lipidiques.
DE4122744C2 (de) * 1990-08-06 1994-02-03 Nattermann A & Cie Wäßriges Liposomensystem und Verfahren zu seiner Herstellung
US5417978A (en) * 1993-07-29 1995-05-23 Board Of Regents, The University Of Texas System Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
US5878245A (en) 1993-10-29 1999-03-02 Advanced Micro Devices, Inc. High performance load/store functional unit and data cache
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
WO1998033482A1 (en) * 1997-02-04 1998-08-06 Abbott Laboratories Pain reducing parenteral liposome formulation
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
IL156580A0 (en) * 2001-01-25 2004-01-04 Bristol Myers Squibb Co A method for formulating an epothilone analog for parenteral use and pharmaceutical preparations including an epothilone analog
US6759058B1 (en) * 2001-04-25 2004-07-06 Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences Enteric-coated proliposomal formulations for poorly water soluble drugs
US20030113366A1 (en) * 2001-12-14 2003-06-19 Macgregor Alexander Reverse-micellar delivery system for controlled transportation and enhanced absorption of agents
KR20060021278A (ko) * 2002-08-15 2006-03-07 윤킹 리우 고체 나노미터 의약 및 이의 제조방법
ES2481167T3 (es) 2003-08-22 2014-07-29 Dupont Nutrition Biosciences Aps Composición que comprende una bacteriocina y un extracto de una planta de la familia Labiatae
WO2005018322A1 (en) 2003-08-22 2005-03-03 Danisco A/S Encapsulated antimicrobial material
EP1874793A4 (de) 2005-04-15 2008-12-24 Univ Texas Abgabe von sirna durch neutrale lipid-zusammensetzungen
US20070178147A1 (en) * 2005-12-08 2007-08-02 Desai Narendra R Liposomal compositions
US20070249546A1 (en) * 2006-04-22 2007-10-25 Sawaya Assad S Ophthalmic and related aqueous solutions containing antifungal agents, uses therefor and methods for preparing them
CN103118700A (zh) 2010-05-26 2013-05-22 西莱克塔生物科技公司 合成纳米载体联合疫苗
EA201390660A1 (ru) 2010-11-05 2013-11-29 Селекта Байосайенсиз, Инк. Модифицированные никотиновые соединения и связанные способы
US9987228B2 (en) 2014-11-18 2018-06-05 National Institute For Materials Science Method for producing porous particle

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1359473A (en) * 1970-11-03 1974-07-10 Prodotti Antibiotici Spa Polyenic antibiotic
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
GB1523965A (en) * 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
CH621479A5 (de) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4460577A (en) * 1977-09-30 1984-07-17 Farmitalia Carlo Erba S.P.A. Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4186183A (en) * 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
IT1111367B (it) * 1978-11-17 1986-01-13 Serono Ist Farm Processo per la preparazione estemporanea di liposomi e liposomi cosi' ottenuti
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US4610868A (en) * 1984-03-20 1986-09-09 The Liposome Company, Inc. Lipid matrix carriers for use in drug delivery systems
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
US4663167A (en) * 1984-04-16 1987-05-05 The Board Of Regents Of The University Of Texas System Composition and method for treatment of disseminated fungal infections in mammals
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
JPS6176414A (ja) * 1984-09-21 1986-04-18 Shionogi & Co Ltd リポソーム製剤の製法
US4622188A (en) * 1984-12-21 1986-11-11 E. I. Du Pont De Nemours And Company Method for manufacturing liposomes
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
US4766046A (en) * 1985-09-27 1988-08-23 Liposome Technology, Inc. Stabilized liposome/amphotericin composition and method
EP0238554A4 (de) * 1985-09-27 1987-10-27 Univ California Liposomensystem zur transdermalen arzneimittelverabreichung.
FR2593394A1 (fr) * 1986-01-30 1987-07-31 Ire Celltarg Sa Procede de preparation de liposomes contenant une subtance active lipophile, notamment de l'amphotericine, liposomes et nouveau medicament obtenus
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
FR2607403B1 (fr) * 1986-11-28 1991-02-22 Toulouse Inst Nal Sciences App Procede et dispositif de separation d'une phase dispersee en emulsion ou en suspension dans une phase continue
US4812312A (en) * 1987-03-03 1989-03-14 Board Of Regents Of The University Of Texas System Liposome-incorporated nystatin
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives

Also Published As

Publication number Publication date
EP0380584A1 (de) 1990-08-08
WO1989003208A1 (en) 1989-04-20
JPH03500650A (ja) 1991-02-14
AU609565B2 (en) 1991-05-02
EP0380584B1 (de) 1992-03-18
DE3869424D1 (de) 1992-04-23
AU2788689A (en) 1989-05-02
US4950432A (en) 1990-08-21

Similar Documents

Publication Publication Date Title
ATE73653T1 (de) Polyenmakrolide enthaltende proliposomale pulver.
DE69202559T2 (de) Proliposomales pulver für polyenliposomen sowie verfahren zu dessen herstellung.
DE60005241T2 (de) Verfahren zur Herstellung von Phosphatidylserinen
DE4345311C1 (de) Verfahren zur Herstellung und/oder Reinigung von Clavulansäure
DE3529529A1 (de) Verfahren zur herstellung einer stabilen modifikation von torasemid
DE3335701A1 (de) Verfahren zur herstellung grosser multilamellarer lipidblaeschen
IL135989A0 (en) Processes for the production of multivesicular liposomes
IE781574L (en) Preparation of liposomes
ATE121301T1 (de) Mikrokristalle, die eine aktive substanz mit phospholipidischer affinität enthalten und mindestens ein phospholipid, verfahren zur herstellung.
KR850003504A (ko) 포스파티딜세린 조성물의 제조방법 및 약제 조성물
DE68904999T3 (de) Verfahren zur Herstellung dispergierbarer kolloidaler Systeme aus amphiphilen Lipiden in Form von Liposomen in Submikrongrösse.
CH617710A5 (en) Process for the preparation of steroids of the pregnane or 19-norpregnane series with anaesthetic activity
IE56209B1 (en) Piperidinedione derivatives,processing anti-arrythmic activity,for protecting the myocardium,process for their preparation and pharmaceutical compositions containing said derivatives
HU9200235D0 (en) Process for the production of water soluble lipsome-suspensions containing qctive agents
EP0002062A1 (de) Phosphororganische Ringverbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung
CA1116518A (en) Method for purifying a liposomic suspension
DE3639084A1 (de) Phosphorsaeureester und verfahren zu deren herstellung
EP0305899A3 (de) Verfahren zum Reinigen von Celluloseethern
DE3044736C2 (de)
DE861562C (de) Verfahren zur Trennung und Reindarstellung von Lysergsaeure- und Isolysergsaeure-Derivaten
DE2504347C3 (de) Verfahren zur Herstellung von reinem Tetracyclinhydrochlorid
DE2745810A1 (de) Synthetische phosphatide, verfahren zu ihrer herstellung und ihre verwendung
DE717777C (de) Verfahren zur Darstellung von reaktionsfaehigen Estern von Oxyalkylamidinen
DE1958329A1 (de) Verfahren zur Reinigung von Cephaloglycinantibiotica
AT255882B (de) Verfahren zur Behandlung von Zellulosefasersuspensionen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties