ATE493407T1 - 3-(heteroaryloxy)-2-alkyl-1- azabicycloalkylderivate als alpha.7-nachr- liganden zur behandlung von zns-erkrankungen - Google Patents
3-(heteroaryloxy)-2-alkyl-1- azabicycloalkylderivate als alpha.7-nachr- liganden zur behandlung von zns-erkrankungenInfo
- Publication number
- ATE493407T1 ATE493407T1 AT05758825T AT05758825T ATE493407T1 AT E493407 T1 ATE493407 T1 AT E493407T1 AT 05758825 T AT05758825 T AT 05758825T AT 05758825 T AT05758825 T AT 05758825T AT E493407 T1 ATE493407 T1 AT E493407T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- heteroaryloxy
- alpha
- alkyl
- cns diseases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0415746.7A GB0415746D0 (en) | 2004-07-14 | 2004-07-14 | Organic compounds |
PCT/EP2005/007630 WO2006005608A1 (en) | 2004-07-14 | 2005-07-13 | 3-(heteroaryl-oxy)-2-alkyl-1-aza-bicycloalkyl derivatives as alpha.7-nachr ligands for the treatment of cns diseases |
Publications (1)
Publication Number | Publication Date |
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ATE493407T1 true ATE493407T1 (de) | 2011-01-15 |
Family
ID=32893550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05758825T ATE493407T1 (de) | 2004-07-14 | 2005-07-13 | 3-(heteroaryloxy)-2-alkyl-1- azabicycloalkylderivate als alpha.7-nachr- liganden zur behandlung von zns-erkrankungen |
Country Status (30)
Country | Link |
---|---|
US (3) | US20080194573A1 (de) |
EP (2) | EP1776360B1 (de) |
JP (1) | JP5122951B2 (de) |
KR (1) | KR101279201B1 (de) |
CN (2) | CN1984911A (de) |
AT (1) | ATE493407T1 (de) |
AU (1) | AU2005261866B8 (de) |
BR (1) | BRPI0513275A (de) |
CA (1) | CA2570155C (de) |
CY (1) | CY1111651T1 (de) |
DE (1) | DE602005025642D1 (de) |
DK (1) | DK1776360T3 (de) |
EC (1) | ECSP077166A (de) |
EG (1) | EG26020A (de) |
ES (1) | ES2357963T3 (de) |
GB (1) | GB0415746D0 (de) |
HK (1) | HK1101285A1 (de) |
HR (1) | HRP20110206T1 (de) |
IL (1) | IL180309A (de) |
MA (1) | MA28693B1 (de) |
MX (1) | MX2007000504A (de) |
NO (1) | NO338622B1 (de) |
NZ (1) | NZ551800A (de) |
PL (1) | PL1776360T3 (de) |
PT (1) | PT1776360E (de) |
RU (1) | RU2402551C2 (de) |
SI (1) | SI1776360T1 (de) |
TN (1) | TNSN07007A1 (de) |
WO (1) | WO2006005608A1 (de) |
ZA (1) | ZA200610122B (de) |
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JPS6262265A (ja) * | 1985-09-13 | 1987-03-18 | Hitachi Ltd | 復水器自動検査補修システム |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
AR049401A1 (es) | 2004-06-18 | 2006-07-26 | Novartis Ag | Aza-biciclononanos |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
EP1802616B1 (de) | 2004-10-15 | 2011-01-12 | NeuroSearch A/S | Neue azabizyklische arylderivate und medizinische verwendung damit |
GB0521508D0 (en) * | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
WO2007093601A1 (en) | 2006-02-14 | 2007-08-23 | Neurosearch A/S | 3, 9-diazabicyclo(3.3.1)non-3-yl-aryl methanone derivatives as nicotinic acetylcholine receptor agonists |
US8314119B2 (en) | 2006-11-06 | 2012-11-20 | Abbvie Inc. | Azaadamantane derivatives and methods of use |
EP2231657A1 (de) * | 2007-11-21 | 2010-09-29 | Abbott Laboratories | Biarylsubstituierte azabicyclische alkanderivate als modulatoren der aktivität des nicotinischen acetylcholinrezeptors |
JP2012533601A (ja) * | 2009-07-23 | 2012-12-27 | ノバルティス アーゲー | 運動失調症の処置または予防のための、アザビシクロアルキル誘導体またはピロリジン−2−オン誘導体の使用 |
TWI558398B (zh) * | 2009-09-22 | 2016-11-21 | 諾華公司 | 菸鹼乙醯膽鹼受體α7活化劑之用途 |
US8389536B2 (en) | 2009-10-27 | 2013-03-05 | Hoffmann-La Roche Inc. | Positive allosteric modulators (PAM) |
US8940762B2 (en) * | 2010-01-20 | 2015-01-27 | Abbvie Inc. | Methods for treating pain |
KR20130108586A (ko) | 2010-09-23 | 2013-10-04 | 애브비 인코포레이티드 | 아자아다만탄 유도체의 일수화물 |
EA201391091A1 (ru) | 2011-01-27 | 2013-12-30 | Новартис Аг | Применение активаторов никотиновых ацетилхолиновых рецепторов альфа-7 |
WO2012127393A1 (en) | 2011-03-18 | 2012-09-27 | Novartis Ag | COMBINATIONS OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATORS AND mGluR5 ANTAGONISTS FOR USE IN DOPAMINE INDUCED DYSKINESIA IN PARKINSON'S DISEASE |
TWI589576B (zh) * | 2011-07-15 | 2017-07-01 | 諾華公司 | 氮雜-雙環二芳基醚之鹽類及製造彼等或其前驅物之方法 |
CN103930112B (zh) | 2011-10-20 | 2018-11-09 | 诺华股份有限公司 | 预测对α7烟碱型乙酰胆碱受体激活剂疗法的响应的生物标志物 |
CA2890018A1 (en) * | 2012-11-05 | 2014-05-08 | Nant Holdings Ip, Llc | Substituted indol-5-ol derivatives and their therapeutical applications |
WO2014091388A2 (en) | 2012-12-11 | 2014-06-19 | Novartis Ag | Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment |
KR101879920B1 (ko) * | 2013-01-15 | 2018-07-18 | 노파르티스 아게 | 알파 7 니코틴성 아세틸콜린 수용체 작용물질의 용도 |
ES2865736T3 (es) | 2013-01-15 | 2021-10-15 | Novartis Ag | Uso de agonistas del receptor de acetilcolina nicotínico alfa 7 |
US20150313884A1 (en) | 2013-01-15 | 2015-11-05 | Novartis Ag | Use of alpha 7 nicotinic acetylcholine receptor agonists |
EP2945626B1 (de) * | 2013-01-15 | 2018-09-12 | Novartis AG | Verwendung von alpha-7-nikotinrezeptor-agonisten zur behandlung von narkolepsie |
EP3105225A1 (de) | 2014-02-12 | 2016-12-21 | iTeos Therapeutics | Neuartige 3-(indol-3-yl)-pyrazol-derivate, pharmazeutische zusammensetzungen und verfahren zur verwendung |
MX2016015005A (es) | 2014-05-15 | 2017-09-28 | Iteos Therapeutics | Derivados de pirrolidina-2,5-diona, composiciones farmaceuticas y metodos para usar como inhibidores ido1. |
EP3233087B1 (de) * | 2014-12-16 | 2019-10-02 | Axovant Sciences GmbH | Geminale substituierte chinuklidinamidverbindungen als agonisten von alpha-7-nikotinischen acetylcholinrezeptoren |
KR102013512B1 (ko) | 2015-03-17 | 2019-08-22 | 화이자 인코포레이티드 | 신규 3-인돌 치환 유도체, 제약 조성물 및 사용 방법 |
JP6643814B2 (ja) | 2015-05-14 | 2020-02-12 | 株式会社ジェイエスピー | 架橋発泡粒子及び発泡粒子成形体 |
EP3334733A1 (de) | 2015-08-10 | 2018-06-20 | Pfizer Inc | 3-indol-substituierte derivate, pharmazeutische zusammensetzungen und verfahren zur verwendung |
JP6836866B2 (ja) | 2016-09-16 | 2021-03-03 | 株式会社ジェイエスピー | 架橋発泡粒子とその成形体 |
JP6519813B2 (ja) | 2016-11-11 | 2019-05-29 | 株式会社ジェイエスピー | 発泡粒子とその成形体 |
RU2020105929A (ru) | 2017-08-04 | 2021-09-06 | Скайхоук Терапьютикс, Инк. | Способы и композиции для модулирования сплайсинга |
JP2022521467A (ja) | 2019-02-05 | 2022-04-08 | スカイホーク・セラピューティクス・インコーポレーテッド | スプライシングを調節するための方法および組成物 |
EP3920928A4 (de) | 2019-02-06 | 2022-09-28 | Skyhawk Therapeutics, Inc. | Verfahren und zusammensetzungen zur modulierung von spleissung |
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