US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
ES2330052T3
(es)
|
1991-03-01 |
2009-12-03 |
Dyax Corporation |
Proteina quimerica que comprende micro-proteinas que tienen dos o mas puentes disulfuro y relaizaciones de las mismas.
|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
US20050084885A1
(en)
*
|
1994-01-18 |
2005-04-21 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
AU726759B2
(en)
*
|
1994-08-20 |
2000-11-23 |
Gendaq Limited |
Improvements in or relating to binding proteins for recognition of DNA
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
US7262055B2
(en)
|
1998-08-25 |
2007-08-28 |
Gendaq Limited |
Regulated gene expression in plants
|
US7285416B2
(en)
|
2000-01-24 |
2007-10-23 |
Gendaq Limited |
Regulated gene expression in plants
|
USRE45795E1
(en)
|
1994-08-20 |
2015-11-10 |
Gendaq, Ltd. |
Binding proteins for recognition of DNA
|
GB9710809D0
(en)
*
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
GB9710807D0
(en)
*
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
WO1999021991A1
(en)
*
|
1997-10-29 |
1999-05-06 |
Shanghai Second Medical University |
Bmzf12: a zinc finger gene cloned from bone marrow
|
US6410248B1
(en)
|
1998-01-30 |
2002-06-25 |
Massachusetts Institute Of Technology |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
|
AU746454B2
(en)
|
1998-03-02 |
2002-05-02 |
Massachusetts Institute Of Technology |
Poly zinc finger proteins with improved linkers
|
WO1999045127A2
(en)
*
|
1998-03-06 |
1999-09-10 |
Oxford Biomedica (Uk) Limited |
Enhanced prodrug activation
|
JP2002506640A
(ja)
*
|
1998-03-17 |
2002-03-05 |
ジェンダック・リミテッド |
核酸結合タンパク質
|
EP1112355A1
(de)
*
|
1998-09-14 |
2001-07-04 |
Aston University |
Gen- und proteinbibliotheken, und damit in zusammenhang stehende verfahren
|
US20050086718A1
(en)
|
1999-03-23 |
2005-04-21 |
Mendel Biotechnology, Inc. |
Plant transcriptional regulators of abiotic stress
|
US7897843B2
(en)
|
1999-03-23 |
2011-03-01 |
Mendel Biotechnology, Inc. |
Transcriptional regulation of plant biomass and abiotic stress tolerance
|
US6806062B1
(en)
*
|
1998-10-05 |
2004-10-19 |
Novozymes A/S |
Fungal transcriptional activator useful in methods for producing polypeptides
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
US7070934B2
(en)
|
1999-01-12 |
2006-07-04 |
Sangamo Biosciences, Inc. |
Ligand-controlled regulation of endogenous gene expression
|
US7013219B2
(en)
*
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
US7030215B2
(en)
|
1999-03-24 |
2006-04-18 |
Sangamo Biosciences, Inc. |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
US20030104526A1
(en)
|
1999-03-24 |
2003-06-05 |
Qiang Liu |
Position dependent recognition of GNN nucleotide triplets by zinc fingers
|
EP1181359A1
(de)
|
1999-05-28 |
2002-02-27 |
Sangamo Biosciences Inc. |
Molekulare schalter
|
CA2369855A1
(en)
*
|
1999-05-28 |
2001-01-04 |
Sangamo Biosciences, Inc. |
Molecular switches
|
GB9915126D0
(en)
|
1999-06-30 |
1999-09-01 |
Imp College Innovations Ltd |
Control of gene expression
|
WO2001002856A1
(en)
*
|
1999-07-02 |
2001-01-11 |
The Scripps Research Institute |
Method for determination of peptide-binding agent interaction
|
EP1230355A2
(de)
*
|
1999-10-01 |
2002-08-14 |
Sangamo Biosciences Inc. |
Dna bibliothek und methoden zu deren verwendung für die selektion und das design von polypeptiden
|
EP1229781B1
(de)
|
1999-11-17 |
2013-01-02 |
Mendel Biotechnology, Inc. |
Saatmerkmal bestimmende Gene
|
EP1950306A1
(de)
|
1999-11-17 |
2008-07-30 |
Mendel Biotechnology, Inc. |
Umweltstress-Toleranzgene
|
ATE309536T1
(de)
|
1999-12-06 |
2005-11-15 |
Sangamo Biosciences Inc |
Methoden zur verwendung von randomisierten zinkfingerprotein-bibliotheken zur identifizierung von genfunktionen
|
CA2398155C
(en)
*
|
2000-01-24 |
2011-07-19 |
Sangamo Biosciences, Inc. |
Methods and compositions for linking binding domains in nucleic acid binding proteins
|
WO2001059450A2
(en)
*
|
2000-02-08 |
2001-08-16 |
Sangamo Biosciences, Inc. |
Cells expressing zinc finger protein for drug discovery
|
US20020061512A1
(en)
*
|
2000-02-18 |
2002-05-23 |
Kim Jin-Soo |
Zinc finger domains and methods of identifying same
|
US20020064802A1
(en)
*
|
2000-04-28 |
2002-05-30 |
Eva Raschke |
Methods for binding an exogenous molecule to cellular chromatin
|
WO2001083819A2
(en)
|
2000-04-28 |
2001-11-08 |
Sangamo Biosciences, Inc. |
Methods for designing exogenous regulatory molecules
|
AU2001257421A1
(en)
*
|
2000-04-28 |
2001-11-12 |
Sangamo Biosciences, Inc. |
Pharmacogenomics and identification of drug targets by reconstruction of signal transduction pathways based on sequences of accessible regions
|
EP1276860B1
(de)
*
|
2000-04-28 |
2007-09-26 |
Sangamo Biosciences Inc. |
Datenbanken von regulatorischen sequenzen, methoden zu ihrer herstellung und verwendung
|
US7923542B2
(en)
|
2000-04-28 |
2011-04-12 |
Sangamo Biosciences, Inc. |
Libraries of regulatory sequences, methods of making and using same
|
US20040039175A1
(en)
*
|
2000-05-08 |
2004-02-26 |
Yen Choo |
Modulation of viral gene expression by engineered zinc finger proteins
|
US6492117B1
(en)
*
|
2000-07-12 |
2002-12-10 |
Gendaq Limited |
Zinc finger polypeptides capable of binding DNA quadruplexes
|
US20030082561A1
(en)
*
|
2000-07-21 |
2003-05-01 |
Takashi Sera |
Zinc finger domain recognition code and uses thereof
|
AU2001278496A1
(en)
*
|
2000-07-21 |
2002-02-05 |
Syngenta Participations Ag |
Zinc finger domain recognition code and uses thereof
|
EP2410060A1
(de)
|
2000-08-22 |
2012-01-25 |
Mendel Biotechnology, Inc. |
Gene zum Verändern der Eigenschaften von Pflanzen IV
|
AU2001285252A1
(en)
*
|
2000-08-25 |
2002-03-13 |
Gendaq, Ltd. |
Analysis of binding interactions
|
ATE448301T1
(de)
|
2000-09-08 |
2009-11-15 |
Univ Zuerich |
Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten
|
US6905816B2
(en)
*
|
2000-11-27 |
2005-06-14 |
Intelligent Medical Devices, Inc. |
Clinically intelligent diagnostic devices and methods
|
US7026462B2
(en)
|
2000-12-07 |
2006-04-11 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
US7067317B2
(en)
*
|
2000-12-07 |
2006-06-27 |
Sangamo Biosciences, Inc. |
Regulation of angiogenesis with zinc finger proteins
|
EP1353941B1
(de)
|
2001-01-22 |
2013-03-13 |
Sangamo BioSciences, Inc. |
Modifizierte zinkfinger-bindungsproteine
|
US7947469B2
(en)
|
2001-01-22 |
2011-05-24 |
Gendaq, Ltd. |
Modulation of HIV infection
|
US6872548B2
(en)
*
|
2001-01-31 |
2005-03-29 |
Human Genome Sciences, Inc. |
Scaffolded fusion polypeptides and compositions and methods for making the same
|
US7067617B2
(en)
|
2001-02-21 |
2006-06-27 |
The Scripps Research Institute |
Zinc finger binding domains for nucleotide sequence ANN
|
CA2457095A1
(en)
*
|
2001-08-17 |
2003-02-27 |
Toolgen, Inc. |
Zinc finger domain libraries
|
WO2003027247A2
(en)
|
2001-09-24 |
2003-04-03 |
Sangamo Biosciences, Inc. |
Modulation of stem cells using zinc finger proteins
|
US20040259258A1
(en)
*
|
2001-12-07 |
2004-12-23 |
Kim Jin-Soo |
Regulation of prokaryotic gene expression with zinc finger proteins
|
WO2003048345A1
(en)
*
|
2001-12-07 |
2003-06-12 |
Toolgen, Inc. |
Phenotypic screen of chimeric proteins
|
US6899892B2
(en)
*
|
2001-12-19 |
2005-05-31 |
Regents Of The University Of Minnesota |
Methods to reduce body fat
|
US7262054B2
(en)
|
2002-01-22 |
2007-08-28 |
Sangamo Biosciences, Inc. |
Zinc finger proteins for DNA binding and gene regulation in plants
|
CA2474486C
(en)
|
2002-01-23 |
2013-05-14 |
The University Of Utah Research Foundation |
Targeted chromosomal mutagenesis using zinc finger nucleases
|
US20030232410A1
(en)
*
|
2002-03-21 |
2003-12-18 |
Monika Liljedahl |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
|
EP1532178A4
(de)
*
|
2002-06-11 |
2006-10-25 |
Scripps Research Inst |
Synthetische transkriptionsfaktoren
|
DE50310378D1
(de)
|
2002-07-26 |
2008-10-02 |
Basf Plant Science Gmbh |
Neue selektionsverfahren
|
CA2494626A1
(en)
|
2002-08-07 |
2004-03-04 |
Basf Plant Science Gmbh |
Nucleic acid sequences encoding proteins associated with abiotic stress response
|
US7361635B2
(en)
|
2002-08-29 |
2008-04-22 |
Sangamo Biosciences, Inc. |
Simultaneous modulation of multiple genes
|
EP2806025B1
(de)
|
2002-09-05 |
2019-04-03 |
California Institute of Technology |
Verwendung von Zinkfingernukleasen zur Stimulierung von Gentargeting
|
ES2380017T3
(es)
|
2002-09-18 |
2012-05-07 |
Mendel Biotechnology, Inc. |
Polinucleótidos y polipéptidos en plantas
|
US20070178454A1
(en)
*
|
2002-10-21 |
2007-08-02 |
Joung J K |
Context sensitive paralell optimization of zinc finger dna binding domains
|
US20060246440A1
(en)
*
|
2002-10-23 |
2006-11-02 |
Joung J K |
Methods for producing zinc finger proteins that bind to extended dna target sequences
|
AU2003295692A1
(en)
*
|
2002-11-15 |
2004-06-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for analysis of regulatory sequences
|
US7696334B1
(en)
*
|
2002-12-05 |
2010-04-13 |
Rosetta Genomics, Ltd. |
Bioinformatically detectable human herpesvirus 5 regulatory gene
|
CN100398652C
(zh)
*
|
2002-12-09 |
2008-07-02 |
图尔金株式会社 |
调节性锌指蛋白
|
AU2003303589B2
(en)
|
2002-12-26 |
2008-04-24 |
Syngenta Participations Ag |
Cell proliferation-related polypeptides and uses therefor
|
US20070042433A1
(en)
*
|
2003-03-26 |
2007-02-22 |
Jianxin Bao |
Neuregulin protein regulation of synaptic proteins
|
EP1641930B1
(de)
|
2003-04-15 |
2011-06-29 |
BASF Plant Science GmbH |
Nukleinsäuresequenzen, die für proteine in zusammenhang mit abiotischer stressreaktion kodieren, sowie pflanzenzellen und pflanzen mit erhöhter umweltstressverträglichkeit
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US11311574B2
(en)
|
2003-08-08 |
2022-04-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
US20120196370A1
(en)
|
2010-12-03 |
2012-08-02 |
Fyodor Urnov |
Methods and compositions for targeted genomic deletion
|
EP3222715A1
(de)
|
2003-08-08 |
2017-09-27 |
Sangamo BioSciences, Inc. |
Verfahren und zusammensetzungen für gezielte spaltung und rekombination
|
US7216038B2
(en)
|
2003-09-11 |
2007-05-08 |
Franco Vitaliano |
Quantum information processing elements and quantum information processing platforms using such elements
|
US7219018B2
(en)
*
|
2003-09-11 |
2007-05-15 |
Franco Vitaliano |
Quantum information processing elements and quantum information processing platforms using such elements
|
US7219017B2
(en)
|
2003-09-11 |
2007-05-15 |
Franco Vitaliano |
Quantum information processing elements and quantum information processing platforms using such elements
|
WO2005028630A2
(en)
|
2003-09-19 |
2005-03-31 |
Sangamo Biosciences, Inc. |
Engineered zinc finger proteins for regulation of gene expression
|
US7972854B2
(en)
|
2004-02-05 |
2011-07-05 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
CA2561565C
(en)
*
|
2004-04-08 |
2013-11-26 |
Sangamo Biosciences, Inc. |
Methods for repression of phospholamban gene and modulating cardiac contractility
|
CA2561714A1
(en)
*
|
2004-04-08 |
2005-10-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating neuropathic and neurodegenerative conditions
|
CA2579677A1
(en)
*
|
2004-09-16 |
2006-03-30 |
Sangamo Biosciences, Inc. |
Compositions and methods for protein production
|
CN103289961A
(zh)
|
2004-09-24 |
2013-09-11 |
巴斯福植物科学有限公司 |
编码与非生物性胁迫反应相关的蛋白质的核酸序列和环境胁迫抗性增加的植物细胞和植物
|
WO2006078431A2
(en)
|
2004-12-22 |
2006-07-27 |
The University Of Iowa Research Foundation |
Compositions and methods related to modified retroviral vectors for restricted, site specific integration
|
CA2594572A1
(en)
|
2005-01-14 |
2006-07-20 |
University Of Guelph |
Nitrogen-regulated sugar sensing gene and protein and modulation thereof
|
CA2599004C
(en)
|
2005-02-28 |
2015-05-26 |
Sangamo Biosciences, Inc. |
Anti-angiogenic methods and compositions
|
KR101419729B1
(ko)
*
|
2005-07-26 |
2014-07-17 |
상가모 바이오사이언스 인코포레이티드 |
외래 핵산 서열의 표적화된 통합 및 발현
|
EP1915452A2
(de)
|
2005-08-12 |
2008-04-30 |
BASF Plant Science GmbH |
Für mit einer reaktion auf abiotischen stress assoziierte proteine codierende nukleinsäuresequenzen sowie pflanzenzellen und pflanzen mit erhöhter toleranz gegenüber umweltstress
|
AU2006287553A1
(en)
|
2005-09-08 |
2007-03-15 |
Chromatin, Inc. |
Plants modified with mini-chromosomes
|
JP2009520463A
(ja)
|
2005-11-28 |
2009-05-28 |
ザ スクリプス リサーチ インスティテュート |
Tnnのための亜鉛フィンガー結合ドメイン
|
US20090172834A1
(en)
|
2006-03-24 |
2009-07-02 |
Basf Plant Science Gmbh |
Proteins Associated With Abiotic Stress Response And Homologs
|
US20080015164A1
(en)
*
|
2006-05-19 |
2008-01-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for inactivation of dihydrofolate reductase
|
WO2007139982A2
(en)
|
2006-05-25 |
2007-12-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene inactivation
|
WO2007139898A2
(en)
*
|
2006-05-25 |
2007-12-06 |
Sangamo Biosciences, Inc. |
Variant foki cleavage half-domains
|
ATE554096T1
(de)
|
2006-08-10 |
2012-05-15 |
Basf Plant Science Gmbh |
Verfahren zum erhöhen der resistenz gegen sojabohnenrost in transgenen pflanzen
|
PL2049663T3
(pl)
|
2006-08-11 |
2015-08-31 |
Dow Agrosciences Llc |
Homologiczna rekombinacja za pośrednictwem nukleazy z palcami cynkowymi
|
RU2428480C9
(ru)
|
2006-08-30 |
2012-03-20 |
Басф Плант Сайенс Гмбх |
Способ повышения резистентности трансгенных растений к патогенным воздействиям
|
CA2660861A1
(en)
|
2006-10-12 |
2008-04-17 |
Basf Plant Science Gmbh |
Method for increasing pathogen resistance in transgenic plants
|
CN101589148B
(zh)
|
2006-10-13 |
2014-07-02 |
巴斯福植物科学有限公司 |
产量提高的植物
|
US9217026B2
(en)
*
|
2006-11-13 |
2015-12-22 |
Sangamo Biosciences, Inc. |
Method of inactivating a glucocorticoid receptor gene in an isolated cell
|
WO2008067840A1
(en)
|
2006-12-08 |
2008-06-12 |
Swetree Technologies Ab |
Plants having improved growth characteristics and method for making the same
|
SI2415872T1
(sl)
*
|
2006-12-14 |
2016-09-30 |
Dow Agrosciences Llc |
Optimizirani nekanonični proteini s cinkovim prstom
|
BRPI0807760A2
(pt)
|
2007-02-19 |
2014-06-17 |
Evonik Degussa Gmbh |
Bactérias corineformes com atividade de formato-thf-sintetase e/ou atividade de clivagem de glicina
|
CA2584934A1
(en)
|
2007-04-17 |
2008-10-17 |
University Of Guelph |
Nitrogen-regulated sugar sensing gene and protein and modulation thereof
|
CN101679977B
(zh)
|
2007-04-26 |
2013-05-01 |
桑格摩生物科学股份有限公司 |
向ppp1r12c基因座的靶向整合
|
DE112008001452T5
(de)
|
2007-05-22 |
2010-12-16 |
Basf Plant Science Gmbh |
Pflanzen mit erhöhter Toleranz und/oder Resistenz gegen Umweltstress und erhöhter Biomasseproduktion
|
CN101772575B
(zh)
|
2007-05-23 |
2015-03-11 |
先正达参股股份有限公司 |
多核苷酸标志物
|
KR101510778B1
(ko)
|
2007-07-12 |
2015-04-10 |
상가모 바이오사이언스 인코포레이티드 |
알파 1,6 당전이효소(fut8) 유전자 발현을 비활성화시키기 위한 방법 및 조성물
|
MX2010002931A
(es)
|
2007-09-18 |
2010-06-01 |
Basf Plant Science Gmbh |
Plantas con rendimiento incrementado.
|
DE112008002456T5
(de)
|
2007-09-21 |
2011-01-13 |
Basf Plant Science Gmbh |
Pflanzen mit erhöhtem Ertrag
|
US11235026B2
(en)
|
2007-09-27 |
2022-02-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating PD1
|
EP2205749B1
(de)
*
|
2007-09-27 |
2016-05-18 |
Dow AgroSciences LLC |
Technisch konstruierte zinkfingerproteine mit genen für 5-enolpyruvylshikimat-3-phosphat-synthase als ziel
|
CA2700231C
(en)
*
|
2007-09-27 |
2018-09-18 |
Sangamo Biosciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
EP2597155B1
(de)
|
2007-10-25 |
2016-11-23 |
Sangamo BioSciences, Inc. |
Verfahren und Zusammensetzungen für gezielte Integration
|
BRPI0821748A2
(pt)
*
|
2007-12-19 |
2019-09-24 |
Basf Plant Science Gmbh |
método para produzir uma planta com rendimento aumentado, molécula isolada de ácido nucleico, construção de ácido nucleico, vetor, processo para produzir um polipeptídeo, polipeptídeo, anticorpo, núcleo de célula de planta, célula de planta, tecido de planta, material de propagação, semente, pólen, progênie, ou uma parte de planta, ou uma planta com rendimento aumento, processo para a indentificação de um composto, método para a produção de uma composição agrícola, composição, polipeptídeo ou molécula de ácido nucleico, uso dos ácidos nucléicos, e, método para a indentificação de uma planta com um rendimento aumentado
|
BR122017021070B1
(pt)
|
2007-12-28 |
2019-01-29 |
Swetree Technologies Ab |
método para produzir uma planta lenhosa perene transgênica apresentando um crescimento aumentado medido pela altura em comparação com seu tipo selvagem
|
MX2010009010A
(es)
*
|
2008-02-27 |
2010-09-09 |
Basf Plant Science Gmbh |
Plantas con mayor rendimiento.
|
EP2281050B1
(de)
|
2008-04-14 |
2014-04-02 |
Sangamo BioSciences, Inc. |
Lineare donorkonstrukte zur gezielten integration
|
ES2594229T3
(es)
|
2008-04-30 |
2016-12-16 |
Sanbio, Inc. |
Células de regeneración nerviosa con alteraciones en la metilación del ADN
|
WO2009137872A1
(en)
*
|
2008-05-14 |
2009-11-19 |
Simons Haplomics Limited |
Methods and compositions for the treatment of cancer
|
JP2011521643A
(ja)
|
2008-05-28 |
2011-07-28 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
Dna結合ドメインおよび切断ドメインを連結するための組成物
|
KR101802393B1
(ko)
*
|
2008-06-10 |
2017-11-28 |
상가모 테라퓨틱스, 인코포레이티드 |
Bax- 및 bak-결함 세포주들의 제조 방법 및 조성물
|
US8048307B2
(en)
*
|
2008-08-14 |
2011-11-01 |
Brent Lee |
Dynamic filtration device using centrifugal force
|
CN103923892A
(zh)
|
2008-08-19 |
2014-07-16 |
巴斯夫植物科学有限公司 |
通过在植物或其部分中提高或产生一种或更多活性具有提高产量的植物
|
CN102159722B
(zh)
|
2008-08-22 |
2014-09-03 |
桑格摩生物科学股份有限公司 |
用于靶向单链切割和靶向整合的方法和组合物
|
US20110195843A1
(en)
|
2008-09-23 |
2011-08-11 |
Basf Plant Science Gmbh |
Plants with Increased Yield (LT)
|
AU2009306369A1
(en)
|
2008-10-23 |
2010-04-29 |
Basf Plant Science Gmbh |
A method for producing a transgenic cell with increased gamma-aminobutyric acid (GABA) content
|
EP2350289A1
(de)
|
2008-10-23 |
2011-08-03 |
BASF Plant Science GmbH |
Pflanzen mit erhöhtem ertrag (nue)
|
AU2009311697B2
(en)
*
|
2008-10-29 |
2014-12-18 |
Sangamo Therapeutics, Inc. |
Methods and compositions for inactivating glutamine synthetase gene expression
|
EP2527454B1
(de)
|
2008-11-03 |
2017-05-03 |
Swetree Technologies AB |
Vegetabiles Material, Pflanzen und Verfahren zur Herstellung einer Pflanze mit veränderten Lignin-Eigenschaften
|
WO2010056808A2
(en)
*
|
2008-11-12 |
2010-05-20 |
The Regents Of The University Of California |
Compositions and methods for re-programming and re-differentiating cells
|
US20110023152A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of cognition related genes in animals
|
US20110016543A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in inflammation
|
US20110023148A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of addiction-related genes in animals
|
US20110023145A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in autism spectrum disorders
|
US20110023151A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of abc transporters
|
US20110016542A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Canine genome editing with zinc finger nucleases
|
US20110016546A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Porcine genome editing with zinc finger nucleases
|
US20110016540A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of genes associated with trinucleotide repeat expansion disorders in animals
|
US20110023149A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in tumor suppression in animals
|
US20110023139A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in cardiovascular disease
|
US20110023141A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved with parkinson's disease
|
US20110030072A1
(en)
*
|
2008-12-04 |
2011-02-03 |
Sigma-Aldrich Co. |
Genome editing of immunodeficiency genes in animals
|
US20110023153A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in alzheimer's disease
|
US20110016541A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of sensory-related genes in animals
|
US20110023150A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genome editing of genes associated with schizophrenia in animals
|
US20110016539A1
(en)
*
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of neurotransmission-related genes in animals
|
US20110023154A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Silkworm genome editing with zinc finger nucleases
|
US20110023147A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of prion disorder-related genes in animals
|
US20110023146A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in secretase-associated disorders
|
US20110023158A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Bovine genome editing with zinc finger nucleases
|
US20110023140A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Rabbit genome editing with zinc finger nucleases
|
US20110023144A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in amyotrophyic lateral sclerosis disease
|
US20110023143A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of neurodevelopmental genes in animals
|
US20110023156A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Feline genome editing with zinc finger nucleases
|
KR101803737B1
(ko)
|
2008-12-04 |
2017-12-01 |
상가모 테라퓨틱스, 인코포레이티드 |
징크 핑거 뉴클레아제를 이용한 랫트의 유전체 편집
|
US20110023159A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Ovine genome editing with zinc finger nucleases
|
US20110023157A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Equine genome editing with zinc finger nucleases
|
EP2199399A1
(de)
|
2008-12-17 |
2010-06-23 |
BASF Plant Science GmbH |
Ketokarotinoidproduktion in Pflanzen
|
AR074783A1
(es)
|
2008-12-17 |
2011-02-09 |
Dow Agrosciences Llc |
Metodos y composiciones para expresar uno o mas productos de un acido nucleico exogeno integrado al locus zp15 de una celula vegetal
|
CA2934285C
(en)
*
|
2009-02-04 |
2018-11-27 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating neuropathies
|
US11235062B2
(en)
*
|
2009-03-06 |
2022-02-01 |
Metaqor Llc |
Dynamic bio-nanoparticle elements
|
US11096901B2
(en)
|
2009-03-06 |
2021-08-24 |
Metaqor Llc |
Dynamic bio-nanoparticle platforms
|
CA2755192C
(en)
|
2009-03-20 |
2018-09-11 |
Sangamo Biosciences, Inc. |
Modification of cxcr4 using engineered zinc finger proteins
|
CA2756833C
(en)
*
|
2009-04-09 |
2019-11-19 |
Sangamo Biosciences, Inc. |
Targeted integration into stem cells
|
US8772008B2
(en)
*
|
2009-05-18 |
2014-07-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for increasing nuclease activity
|
AU2010266705B2
(en)
|
2009-06-30 |
2014-06-05 |
Sangamo Therapeutics, Inc. |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
|
CA2766123A1
(en)
|
2009-07-08 |
2011-01-13 |
Cellular Dynamics International, Inc. |
Modified ips cells having a mutant form of human immunodeficiency virus (hiv) cellular entry gene
|
AU2010275363A1
(en)
|
2009-07-23 |
2012-02-02 |
Basf Plant Science Company Gmbh |
Plants with increased yield
|
US9234016B2
(en)
*
|
2009-07-28 |
2016-01-12 |
Sangamo Biosciences, Inc. |
Engineered zinc finger proteins for treating trinucleotide repeat disorders
|
US20120178647A1
(en)
*
|
2009-08-03 |
2012-07-12 |
The General Hospital Corporation |
Engineering of zinc finger arrays by context-dependent assembly
|
DK2462230T3
(en)
*
|
2009-08-03 |
2015-10-19 |
Recombinetics Inc |
METHODS AND COMPOSITIONS FOR TARGETED RE-MODIFICATION
|
WO2011019385A1
(en)
|
2009-08-11 |
2011-02-17 |
Sangamo Biosciences, Inc. |
Organisms homozygous for targeted modification
|
MY174390A
(en)
*
|
2009-10-22 |
2020-04-15 |
Sangamo Biosciences Inc |
Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
EP2501816A4
(de)
|
2009-11-17 |
2013-07-03 |
Basf Plant Science Co Gmbh |
Pflanzen mit erhöhtem ertrag
|
AU2010325549B2
(en)
|
2009-11-27 |
2017-04-20 |
Basf Plant Science Company Gmbh |
Optimized endonucleases and uses thereof
|
EA031322B1
(ru)
|
2010-01-22 |
2018-12-28 |
Дау Агросайенсиз Ллс |
Клетка или клеточная линия для экспрессии экзогенных нуклеотидных последовательностей и применение клетки или клеточной линии
|
CA2788560A1
(en)
|
2010-02-08 |
2011-08-11 |
Sangamo Biosciences, Inc. |
Engineered cleavage half-domains
|
US9255259B2
(en)
|
2010-02-09 |
2016-02-09 |
Sangamo Biosciences, Inc. |
Targeted genomic modification with partially single-stranded donor molecules
|
CA2796600C
(en)
|
2010-04-26 |
2019-08-13 |
Sangamo Biosciences, Inc. |
Genome editing of a rosa locus using zinc-finger nucleases
|
WO2011139349A1
(en)
|
2010-05-03 |
2011-11-10 |
Sangamo Biosciences, Inc. |
Compositions for linking zinc finger modules
|
EP2571512B1
(de)
|
2010-05-17 |
2017-08-23 |
Sangamo BioSciences, Inc. |
Neue dna-bindende proteine und verwendungen davon
|
AU2011281062B2
(en)
|
2010-07-21 |
2015-01-22 |
Board Of Regents, The University Of Texas System |
Methods and compositions for modification of a HLA locus
|
JP2013537410A
(ja)
|
2010-07-23 |
2013-10-03 |
シグマ−アルドリッチ・カンパニー・リミテッド・ライアビリティ・カンパニー |
標的化エンドヌクレアーゼおよび一本鎖核酸を用いたゲノム編集
|
WO2012047598A1
(en)
|
2010-09-27 |
2012-04-12 |
Sangamo Biosciences, Inc. |
Methods and compositions for inhibiting viral entry into cells
|
CA2814143C
(en)
|
2010-10-12 |
2020-09-08 |
The Children's Hospital Of Philadelphia |
Methods and compositions for treating hemophilia b
|
EP2659404B1
(de)
|
2010-12-29 |
2018-08-08 |
Sigma-Aldrich Co., LLC |
Zellen mit gestörter expression von in adme und toxikologieverfahren involvierten proteinen
|
US9267123B2
(en)
|
2011-01-05 |
2016-02-23 |
Sangamo Biosciences, Inc. |
Methods and compositions for gene correction
|
EP2694554A1
(de)
|
2011-04-08 |
2014-02-12 |
Gilead Biologics, Inc. |
Verfahren und zusammensetzungen zur normalisierung einer tumorvaskulatur mittels loxl2-hemmung
|
ES2671733T3
(es)
|
2011-06-30 |
2018-06-08 |
Sigma Aldrich Co. Llc |
Células deficientes en ácido CMP-N-acetilneuramínico hidroxilasa y/o glucoproteína alfa-1,3-galactosil transferasa
|
EP2732038B1
(de)
|
2011-07-15 |
2018-09-05 |
The General Hospital Corporation |
Verfahren zur transkription einer aktivatorähnlichen effektoranordnung
|
JP6072788B2
(ja)
|
2011-07-25 |
2017-02-01 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
嚢胞性線維症膜コンダクタンス制御因子(cftr)遺伝子を改変するための方法および組成物
|
CN103917644A
(zh)
|
2011-09-21 |
2014-07-09 |
桑格摩生物科学股份有限公司 |
调控转基因表达的方法和组合物
|
WO2013050318A1
(en)
|
2011-10-07 |
2013-04-11 |
Basf Plant Science Company Gmbh |
Method of producing plants having increased resistance to pathogens
|
MA36970A1
(fr)
*
|
2011-10-11 |
2016-03-31 |
Aliophtha Ag |
Régulation de l'expression d'un récepteur par l'intermédiaire de l'administration de facteurs de transcription artificiels
|
EP2771457B1
(de)
|
2011-10-27 |
2017-11-22 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur veränderung des hprt-locus
|
CA2854819C
(en)
|
2011-11-16 |
2022-07-19 |
Sangamo Biosciences, Inc. |
Modified dna-binding proteins and uses thereof
|
CN104245932A
(zh)
|
2012-01-11 |
2014-12-24 |
西格马-奥尔德里奇有限责任公司 |
具有简单糖型的重组蛋白的产生
|
EP2806881A1
(de)
|
2012-01-27 |
2014-12-03 |
SanBio, Inc. |
Verfahren und zusammensetzungen zur modulation der angiogenese und vaskulogenese
|
CN105658792B
(zh)
|
2012-02-28 |
2020-11-10 |
西格马-奥尔德里奇有限责任公司 |
靶向组蛋白乙酰化
|
JP6490426B2
(ja)
|
2012-02-29 |
2019-03-27 |
サンガモ セラピューティクス, インコーポレイテッド |
ハンチントン病を治療するための方法および組成物
|
MX369788B
(es)
|
2012-05-02 |
2019-11-21 |
Dow Agrosciences Llc |
Modificacion dirigida de deshidrogenasa de malato.
|
EP3646880A1
(de)
|
2012-05-07 |
2020-05-06 |
Allergan, Inc. |
Verfahren zur behandlung von amd bei gegen eine anti-vegf-therapie unempfindlichen patienten
|
RU2650819C2
(ru)
|
2012-05-07 |
2018-04-17 |
Сангамо Терапьютикс, Инк. |
Способы и композиции для опосредованной нуклеазой направленной интеграции трансгенов
|
US9890364B2
(en)
|
2012-05-29 |
2018-02-13 |
The General Hospital Corporation |
TAL-Tet1 fusion proteins and methods of use thereof
|
CA2878037C
(en)
|
2012-07-11 |
2021-08-31 |
Sangamo Biosciences, Inc. |
Methods and compositions for delivery of biologics
|
US10648001B2
(en)
|
2012-07-11 |
2020-05-12 |
Sangamo Therapeutics, Inc. |
Method of treating mucopolysaccharidosis type I or II
|
HUE041553T2
(hu)
|
2012-07-11 |
2019-05-28 |
Sangamo Therapeutics Inc |
Lizoszomális tárolási betegségek (LSD) kezelése és génterápia
|
ES2812599T3
(es)
|
2012-08-29 |
2021-03-17 |
Sangamo Therapeutics Inc |
Procedimientos y composiciones para el tratamiento de una afección genética
|
WO2014039513A2
(en)
|
2012-09-04 |
2014-03-13 |
The Trustees Of The University Of Pennsylvania |
Inhibition of diacylglycerol kinase to augment adoptive t cell transfer
|
CN105264067B
(zh)
|
2012-09-07 |
2020-11-10 |
美国陶氏益农公司 |
Fad3性能基因座及相应的能够诱导靶向断裂的靶位点特异性结合蛋白
|
UA119135C2
(uk)
|
2012-09-07 |
2019-05-10 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб отримання трансгенної рослини
|
UA118090C2
(uk)
|
2012-09-07 |
2018-11-26 |
ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі |
Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив
|
ES2824024T3
(es)
|
2012-10-10 |
2021-05-11 |
Sangamo Therapeutics Inc |
Compuestos modificadores de células T y usos de los mismos
|
EP2906602B1
(de)
|
2012-10-12 |
2019-01-16 |
The General Hospital Corporation |
Transkriptionsaktivator-like-effektor-lysinspezifische demethylase-1 (lsd1)-fusionsproteine
|
US9255250B2
(en)
|
2012-12-05 |
2016-02-09 |
Sangamo Bioscience, Inc. |
Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene
|
KR20150096696A
(ko)
|
2012-12-13 |
2015-08-25 |
다우 아그로사이언시즈 엘엘씨 |
메이즈에서 특정 유전자좌로의 정밀 유전자 표적화
|
AU2014207618A1
(en)
|
2013-01-16 |
2015-08-06 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
EP3623463B1
(de)
|
2013-02-07 |
2021-10-20 |
The General Hospital Corporation |
Tale-transkriptionsaktivatoren
|
PT2963113T
(pt)
|
2013-02-14 |
2020-02-14 |
Univ Osaka |
Método para isolar região genómica específica utilizando molécula que se liga especificamente a sequência de adn endógena
|
AU2014218621B2
(en)
|
2013-02-25 |
2019-11-07 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing nuclease-mediated gene disruption
|
CA2906553C
(en)
|
2013-03-15 |
2022-08-02 |
The General Hospital Corporation |
Rna-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
US9937207B2
(en)
|
2013-03-21 |
2018-04-10 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell receptor genes using talens
|
CN105263312A
(zh)
|
2013-04-05 |
2016-01-20 |
美国陶氏益农公司 |
用于在植物基因组内整合外源序列的方法和组合物
|
CA2910427C
(en)
|
2013-05-10 |
2024-02-20 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
CA2910489A1
(en)
|
2013-05-15 |
2014-11-20 |
Sangamo Biosciences, Inc. |
Methods and compositions for treatment of a genetic condition
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
CA2920899C
(en)
|
2013-08-28 |
2023-02-28 |
Sangamo Biosciences, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
WO2015057976A1
(en)
|
2013-10-17 |
2015-04-23 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
|
CN105899665B
(zh)
|
2013-10-17 |
2019-10-22 |
桑格摩生物科学股份有限公司 |
用于核酸酶介导的基因组工程改造的递送方法和组合物
|
UA120503C2
(uk)
|
2013-11-04 |
2019-12-26 |
Дау Агросайєнсиз Елелсі |
Спосіб одержання трансгенної клітини рослини кукурудзи
|
UY35816A
(es)
|
2013-11-04 |
2015-05-29 |
Dow Agrosciences Llc |
?locus óptimos de la soja?.
|
WO2015066634A2
(en)
|
2013-11-04 |
2015-05-07 |
Dow Agrosciences Llc |
Optimal soybean loci
|
AU2014341929B2
(en)
|
2013-11-04 |
2017-11-30 |
Corteva Agriscience Llc |
Optimal maize loci
|
LT3066201T
(lt)
|
2013-11-07 |
2018-08-10 |
Editas Medicine, Inc. |
Su crispr susiję būdai ir kompozicijos su valdančiomis grnr
|
BR112016010175A2
(pt)
|
2013-11-11 |
2017-10-03 |
Sangamo Biosciences Inc |
Repressor genético, seus usos, e composição farmacêutica
|
EP3960856A1
(de)
|
2013-11-13 |
2022-03-02 |
Children's Medical Center Corporation |
Nukleasevermittelte regulierung der genexpression
|
EP3757116A1
(de)
|
2013-12-09 |
2020-12-30 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen für genom-engineering
|
PL3102673T3
(pl)
|
2014-02-03 |
2020-11-02 |
Sangamo Therapeutics, Inc. |
Sposoby i kompozycje do leczenia talasemii beta
|
US20150232578A1
(en)
|
2014-02-14 |
2015-08-20 |
Symvivo Corporation |
Hybrid proteins and uses thereof
|
JP6606088B2
(ja)
|
2014-02-24 |
2019-11-13 |
サンガモ セラピューティクス, インコーポレイテッド |
ヌクレアーゼ媒介性標的化組み込みのための方法および組成物
|
EP3736325A1
(de)
|
2014-03-04 |
2020-11-11 |
Sigma Aldrich Co. LLC |
Virenresistente zellen und deren verwendung
|
US9624498B2
(en)
|
2014-03-18 |
2017-04-18 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
CA2946514C
(en)
|
2014-04-22 |
2023-08-29 |
Q-State Biosciences, Inc. |
Optogenetic analysis of compounds
|
WO2015164748A1
(en)
|
2014-04-24 |
2015-10-29 |
Sangamo Biosciences, Inc. |
Engineered transcription activator like effector (tale) proteins
|
MX2016014565A
(es)
|
2014-05-08 |
2017-05-23 |
Sangamo Biosciences Inc |
Metodos y composiciones para tratar la enfermedad de huntington.
|
CA2947622A1
(en)
|
2014-05-13 |
2015-11-19 |
Sangamo Biosciences, Inc. |
Genome editing methods and compositions for prevention or treatment of a disease
|
CA2949710A1
(en)
|
2014-05-30 |
2015-12-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods to treat latent viral infections
|
US9970001B2
(en)
|
2014-06-05 |
2018-05-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for nuclease design
|
WO2015193653A1
(en)
|
2014-06-16 |
2015-12-23 |
Consejo Nacional De Investigaciones Cientificas Y Tecnicas |
Oxidative resistance chimeric genes and proteins, and transgenic plants including the same
|
IL286474B2
(en)
|
2014-06-23 |
2023-11-01 |
Massachusetts Gen Hospital |
Genome-wide random identification of DSBS assessed by sequencing (guide-sequence)
|
US20170159065A1
(en)
|
2014-07-08 |
2017-06-08 |
Vib Vzw |
Means and methods to increase plant yield
|
CA2955203C
(en)
|
2014-07-14 |
2022-01-04 |
Washington State University |
Nanos knock-out that ablates germline cells
|
US11278572B2
(en)
|
2014-07-18 |
2022-03-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
|
WO2016014837A1
(en)
|
2014-07-25 |
2016-01-28 |
Sangamo Biosciences, Inc. |
Gene editing for hiv gene therapy
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
US9616090B2
(en)
|
2014-07-30 |
2017-04-11 |
Sangamo Biosciences, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
ES2886012T3
(es)
|
2014-09-16 |
2021-12-16 |
Sangamo Therapeutics Inc |
Métodos y composiciones para la ingeniería y corrección de genomas mediadas por nucleasas en células madre hematopoyéticas
|
CA2963080A1
(en)
|
2014-10-01 |
2016-04-07 |
The General Hospital Corporation |
Methods for increasing efficiency of nuclease-induced homology-directed repair
|
US10889834B2
(en)
|
2014-12-15 |
2021-01-12 |
Sangamo Therapeutics, Inc. |
Methods and compositions for enhancing targeted transgene integration
|
EP3247366A4
(de)
|
2015-01-21 |
2018-10-31 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur identifizierung hochspezifischer nukleasen
|
BR112017016789A2
(pt)
|
2015-02-11 |
2018-05-08 |
Basf Se |
métodos para produzir uma planta transgênica, para controlar a vegetação indesejada e para o cultivo da planta, molécula de ácido nucleico, construção de ácido nucleico, vetor, polipeptídeo hppd mutado, núcleo de célula vegetal, núcleo de célula vegetal transgênica, planta transgênica, uso do ácido nucleico, combinação útil, processo para a preparação de uma combinação útil e uso de uma combinação útil
|
US10048275B2
(en)
|
2015-03-13 |
2018-08-14 |
Q-State Biosciences, Inc. |
Cardiotoxicity screening methods
|
ES2959608T3
(es)
|
2015-04-03 |
2024-02-27 |
Dana Farber Cancer Inst Inc |
Composición y métodos de edición del genoma de células B
|
US10179918B2
(en)
|
2015-05-07 |
2019-01-15 |
Sangamo Therapeutics, Inc. |
Methods and compositions for increasing transgene activity
|
US10808020B2
(en)
|
2015-05-12 |
2020-10-20 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
EP3298448A4
(de)
|
2015-05-21 |
2019-03-27 |
Q-State Biosciences, Inc. |
Optogenetisches mikroskop
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
GB2543873A
(en)
|
2015-05-29 |
2017-05-03 |
Agenovir Corp |
Compositions and methods for cell targeted HPV treatment
|
EP3302525A2
(de)
|
2015-06-05 |
2018-04-11 |
Novartis AG |
Verfahren und zusammensetzungen zur diagnose, behandlung und überwachung der behandlung von shank3-mangelbedingten erkrankungen
|
US9957501B2
(en)
|
2015-06-18 |
2018-05-01 |
Sangamo Therapeutics, Inc. |
Nuclease-mediated regulation of gene expression
|
AU2016291778B2
(en)
|
2015-07-13 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
WO2017023570A1
(en)
|
2015-08-06 |
2017-02-09 |
The Curators Of The University Of Missouri |
Pathogen-resistant animals having modified cd163 genes
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
JP2018530536A
(ja)
|
2015-09-11 |
2018-10-18 |
ザ ジェネラル ホスピタル コーポレイション |
ヌクレアーゼDSBの完全照合およびシーケンシング(FIND−seq)
|
EA037993B1
(ru)
|
2015-09-23 |
2021-06-21 |
Сангамо Терапьютикс, Инк. |
Репрессоры htt и их применение
|
JP2018529353A
(ja)
|
2015-09-30 |
2018-10-11 |
ザ ジェネラル ホスピタル コーポレイション |
配列決定法による切断事象の包括的生体外報告(CIRCLE−seq)
|
CA3004349A1
(en)
|
2015-11-23 |
2017-06-01 |
Sangamo Therapeutics, Inc. |
Methods and compositions for engineering immunity
|
AU2016369490C1
(en)
|
2015-12-18 |
2021-12-23 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
CN108699132B
(zh)
|
2015-12-18 |
2023-08-11 |
桑格摩生物治疗股份有限公司 |
Mhc细胞受体的靶向破坏
|
EP3402533B1
(de)
|
2016-01-15 |
2021-08-04 |
Sangamo Therapeutics, Inc. |
Verfahren und zusammensetzungen zur behandlung von neurologischer erkrankung
|
CN109069568B
(zh)
|
2016-02-02 |
2023-07-07 |
桑格摩生物治疗股份有限公司 |
用于连接dna结合结构域和切割结构域的组合物
|
AU2017238512B2
(en)
|
2016-03-23 |
2022-12-08 |
Dana-Farber Cancer Institute, Inc. |
Methods for enhancing the efficiency of gene editing
|
US11124805B2
(en)
|
2016-07-13 |
2021-09-21 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
US20190247436A1
(en)
|
2016-07-21 |
2019-08-15 |
Maxcyte, Inc. |
Methods and compositions for modifying genomic dna
|
US11344511B2
(en)
|
2016-07-27 |
2022-05-31 |
Case Western Reserve University |
Compounds and methods of promoting myelination
|
US11193136B2
(en)
|
2016-08-09 |
2021-12-07 |
Vib Vzw |
Cellulose synthase inhibitors and mutant plants
|
AU2017315414B2
(en)
|
2016-08-24 |
2024-02-15 |
Sangamo Therapeutics, Inc. |
Engineered target specific nucleases
|
WO2018039440A1
(en)
|
2016-08-24 |
2018-03-01 |
Sangamo Therapeutics, Inc. |
Regulation of gene expression using engineered nucleases
|
WO2018049009A2
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
MX2019003768A
(es)
|
2016-10-03 |
2019-06-24 |
Juno Therapeutics Inc |
Moleculas de enlace especificas de hpv.
|
EP3757120B8
(de)
|
2016-10-04 |
2022-06-15 |
Precision Biosciences, Inc. |
Co-stimulierende domänen zur verwendung bei genetisch veränderten zellen
|
CN110290813A
(zh)
|
2016-10-14 |
2019-09-27 |
通用医疗公司 |
表观遗传学调控的位点特异性核酸酶
|
CA3039673A1
(en)
|
2016-10-20 |
2018-04-26 |
Sangamo Therapeutics, Inc. |
Methods and compositions for the treatment of fabry disease
|
US11020492B2
(en)
|
2016-10-31 |
2021-06-01 |
Sangamo Therapeutics, Inc. |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
|
IL266862B2
(en)
|
2016-12-01 |
2024-01-01 |
Sangamo Therapeutics Inc |
Tau modulators and methods and preparations for their administration
|
JP7416406B2
(ja)
|
2016-12-08 |
2024-01-17 |
ケース ウェスタン リザーブ ユニバーシティ |
機能的ミエリン産生を増進させるための方法および組成物
|
US20190390241A1
(en)
|
2017-01-24 |
2019-12-26 |
Sigma-Aldrich Co. Llc |
Viral resistant cells and culture systems
|
SG11201906948UA
(en)
|
2017-04-20 |
2019-08-27 |
Univ Oregon Health & Science |
Human gene correction
|
CA3061612A1
(en)
|
2017-04-28 |
2018-11-01 |
Acuitas Therapeutics, Inc. |
Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
AU2018261366A1
(en)
|
2017-05-03 |
2019-10-31 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CTFR) gene
|
JP7170666B2
(ja)
|
2017-05-08 |
2022-11-14 |
プレシジョン バイオサイエンシズ,インク. |
操作された抗原受容体をコードする核酸分子及び阻害性核酸分子、並びにそれらの使用方法
|
WO2018218166A1
(en)
|
2017-05-25 |
2018-11-29 |
The General Hospital Corporation |
Using split deaminases to limit unwanted off-target base editor deamination
|
US11512287B2
(en)
|
2017-06-16 |
2022-11-29 |
Sangamo Therapeutics, Inc. |
Targeted disruption of T cell and/or HLA receptors
|
EP3645038A1
(de)
|
2017-06-30 |
2020-05-06 |
Precision Biosciences, Inc. |
Genetisch modifizierte t-zellen mit einem modifizierten intron im t-zell-rezeptor-alpha-gen
|
EP4215543A3
(de)
|
2017-10-03 |
2023-10-11 |
Juno Therapeutics, Inc. |
Hpv-spezifische bindungsmoleküle
|
US20200239544A1
(en)
|
2017-10-03 |
2020-07-30 |
Precision Biosciences, Inc. |
Modified epidermal growth factor receptor peptides for use in genetically-modified cells
|
US20200299658A1
(en)
|
2017-11-01 |
2020-09-24 |
Precision Biosciences, Inc. |
Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
|
US11661611B2
(en)
|
2017-11-09 |
2023-05-30 |
Sangamo Therapeutics, Inc. |
Genetic modification of cytokine inducible SH2-containing protein (CISH) gene
|
AU2019209293B2
(en)
|
2018-01-17 |
2023-07-27 |
Vertex Pharmaceuticals Incorporated |
DNA-PK inhibitors
|
BR112020014140A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
inibidores de dna-pk
|
WO2019143677A1
(en)
|
2018-01-17 |
2019-07-25 |
Vertex Pharmaceuticals Incorporated |
Quinoxalinone compounds, compositions, methods, and kits for increasing genome editing efficiency
|
BR112020015488A2
(pt)
|
2018-02-08 |
2020-12-08 |
Sangamo Therapeutics, Inc. |
Nucleases alvo-específicas modificadas
|
BR112020020245A2
(pt)
|
2018-04-05 |
2021-04-06 |
Editas Medicine, Inc. |
Métodos de produzir células expressando um receptor recombinante e composições relacionadas
|
EP3773908A1
(de)
|
2018-04-05 |
2021-02-17 |
Juno Therapeutics, Inc. |
T-zell-rezeptoren und gentechnisch veränderte zellen zur expression davon
|
RU2020136054A
(ru)
|
2018-04-05 |
2022-05-06 |
Джуно Терапьютикс, Инк. |
Т-клетки, экспрессирующие рекомбинантный рецептор, соответствующие полинуклеотиды и способы
|
EP3781587A4
(de)
|
2018-04-18 |
2022-03-30 |
Sangamo Therapeutics, Inc. |
Zinkfingerproteinzusammensetzungen zur modulation von huntingtin (htt)
|
US11690921B2
(en)
|
2018-05-18 |
2023-07-04 |
Sangamo Therapeutics, Inc. |
Delivery of target specific nucleases
|
CN108802357B
(zh)
*
|
2018-06-27 |
2021-03-30 |
中南民族大学 |
一种用于免疫印迹分析的生物发光探针及其应用
|
SG11202101801RA
(en)
|
2018-08-23 |
2021-03-30 |
Sangamo Therapeutics Inc |
Engineered target specific base editors
|
CN113015741A
(zh)
|
2018-09-18 |
2021-06-22 |
桑格摩生物治疗股份有限公司 |
程序性细胞死亡1(pd1)特异性核酸酶
|
WO2020132659A1
(en)
|
2018-12-21 |
2020-06-25 |
Precision Biosciences, Inc. |
Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
|
US11453639B2
(en)
|
2019-01-11 |
2022-09-27 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
WO2020159445A1
(en)
|
2019-01-31 |
2020-08-06 |
Agency For Science, Technology And Research |
Cnx/erp57 inhibitor for use in the treatment or prevention of cancer
|
US11946040B2
(en)
|
2019-02-04 |
2024-04-02 |
The General Hospital Corporation |
Adenine DNA base editor variants with reduced off-target RNA editing
|
EP3826664A4
(de)
|
2019-02-06 |
2022-10-26 |
Sangamo Therapeutics, Inc. |
Verfahren zur behandlung von mukopolysaccharidose typ i
|
EP3946384A1
(de)
|
2019-04-02 |
2022-02-09 |
Sangamo Therapeutics, Inc. |
Verfahren zur behandlung von beta-thalassämie
|
WO2020206248A1
(en)
|
2019-04-03 |
2020-10-08 |
Precision Biosciences, Inc. |
Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir)
|
US20220204994A1
(en)
|
2019-04-05 |
2022-06-30 |
Precision Biosciences, Inc. |
Methods of preparing populations of genetically-modified immune cells
|
EP3958871A1
(de)
|
2019-04-23 |
2022-03-02 |
Sangamo Therapeutics, Inc. |
Modulatoren der chromosom-9-open-reading-frame-72-genexpression und ihre verwendungen
|
KR20220016474A
(ko)
|
2019-05-01 |
2022-02-09 |
주노 쎄러퓨티크스 인코퍼레이티드 |
변형된 cd247 유전자 자리로부터 키메라 수용체를 발현하는 세포, 관련 폴리뉴클레오타이드 및 방법
|
AU2020265741A1
(en)
|
2019-05-01 |
2021-11-25 |
Editas Medicine, Inc. |
Cells expressing a recombinant receptor from a modified TGFBR2 Locus, related polynucleotides and methods
|
SG11202112553WA
(en)
|
2019-06-13 |
2021-12-30 |
Allogene Therapeutics Inc |
Anti-talen antibodies and uses thereof
|
EP4004216A1
(de)
|
2019-07-25 |
2022-06-01 |
Precision BioSciences, Inc. |
Zusammensetzungen und verfahren zum sequenziellen stapeln von nukleinsäuresequenzen in einen genomischen locus
|
WO2021035054A1
(en)
|
2019-08-20 |
2021-02-25 |
Precision Biosciences, Inc. |
Lymphodepletion dosing regimens for cellular immunotherapies
|
WO2021035170A1
(en)
|
2019-08-21 |
2021-02-25 |
Precision Biosciences, Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
WO2021067864A1
(en)
|
2019-10-02 |
2021-04-08 |
Sangamo Therapeutics, Inc. |
Zinc finger protein transcription factors for treatment of prion disease
|
KR20220071248A
(ko)
|
2019-10-02 |
2022-05-31 |
상가모 테라퓨틱스, 인코포레이티드 |
알파-시누클레인 발현을 억제시키기 위한 아연 핑거 단백질 전사 인자
|
DK3812472T3
(da)
|
2019-10-21 |
2023-02-20 |
Univ Freiburg Albert Ludwigs |
Virkelig uvildig in vitro-undersøgelse til profilering af off-target-aktivitet af en eller flere målspecifikke programmerbare nukleaser i celler (abnoba-seq)
|
US20220411479A1
(en)
|
2019-10-30 |
2022-12-29 |
Precision Biosciences, Inc. |
Cd20 chimeric antigen receptors and methods of use for immunotherapy
|
TW202132566A
(zh)
|
2019-11-01 |
2021-09-01 |
美商聖加莫治療股份有限公司 |
用於治療或預防溶體貯積病之鋅指核酸酶變異體
|
WO2021087358A1
(en)
|
2019-11-01 |
2021-05-06 |
Sangamo Therapeutics, Inc. |
Gin recombinase variants
|
EP4069285A1
(de)
|
2019-12-06 |
2022-10-12 |
Precision BioSciences, Inc. |
Methoden zur krebsimmuntherapie unter verwendung von lymphodepletionsregimen und allogenen cd19-, cd20- oder bcma-car-t-zellen
|
CN115210251A
(zh)
|
2020-01-22 |
2022-10-18 |
桑格摩生物治疗股份有限公司 |
用于阻遏tau表达的锌指蛋白转录因子
|
WO2021158915A1
(en)
|
2020-02-06 |
2021-08-12 |
Precision Biosciences, Inc. |
Recombinant adeno-associated virus compositions and methods for producing and using the same
|
US20230263121A1
(en)
|
2020-03-31 |
2023-08-24 |
Elo Life Systems |
Modulation of endogenous mogroside pathway genes in watermelon and other cucurbits
|
JP2023525513A
(ja)
|
2020-05-06 |
2023-06-16 |
セレクティス ソシエテ アノニム |
細胞ゲノムにおける外因性配列の標的化挿入のための方法
|
JP2023525510A
(ja)
|
2020-05-06 |
2023-06-16 |
セレクティス ソシエテ アノニム |
治療用タンパク質の送達のために細胞を遺伝子改変する方法
|
WO2021231259A1
(en)
|
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Self-limiting viral vectors encoding nucleases
|
WO2021231661A2
(en)
|
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|
EP4171616A1
(de)
|
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2023-05-03 |
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|
JP2023535365A
(ja)
|
2020-07-16 |
2023-08-17 |
アクイタス セラピューティクス インコーポレイテッド |
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|
EP4192875A1
(de)
|
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Precision BioSciences, Inc. |
Antikörper und fragmente spezifisch für b-zellreifungsantigen und verwendungen davon
|
WO2022046760A2
(en)
|
2020-08-25 |
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Kite Pharma, Inc. |
T cells with improved functionality
|
AU2021350099A1
(en)
|
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Sangamo Therapeutics, Inc. |
Zinc finger fusion proteins for nucleobase editing
|
US20240018203A1
(en)
|
2020-10-02 |
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Sangamo Therapeutics, Inc. |
Novel zinc finger protein transcription factors for repressing alpha-synuclein expression
|
US20230365995A1
(en)
|
2020-10-07 |
2023-11-16 |
Precision Biosciences, Inc. |
Lipid nanoparticle compositions
|
US20240060079A1
(en)
|
2020-10-23 |
2024-02-22 |
Elo Life Systems |
Methods for producing vanilla plants with improved flavor and agronomic production
|
CN116802203A
(zh)
|
2020-11-04 |
2023-09-22 |
朱诺治疗学股份有限公司 |
从经修饰的恒定cd3免疫球蛋白超家族链基因座表达嵌合受体的细胞、相关多核苷酸和方法
|
CA3200855A1
(en)
|
2020-11-16 |
2022-05-19 |
Pig Improvement Company Uk Limited |
Influenza a-resistant animals having edited anp32 genes
|
WO2022165111A1
(en)
|
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2022-08-04 |
Precision Biosciences, Inc. |
Modulation of tgf beta signaling in genetically-modified eukaryotic cells
|
WO2022226316A1
(en)
|
2021-04-22 |
2022-10-27 |
Precision Biosciences, Inc. |
Compositions and methods for generating male sterile plants
|
WO2023064872A1
(en)
|
2021-10-14 |
2023-04-20 |
Precision Biosciences, Inc. |
Combinations of anti-bcma car t cells and gamma secretase inhibitors
|
WO2023070003A1
(en)
|
2021-10-19 |
2023-04-27 |
Precision Biosciences, Inc. |
Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
|
WO2023081900A1
(en)
|
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2023-05-11 |
Juno Therapeutics, Inc. |
Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
|
WO2023086790A1
(en)
|
2021-11-09 |
2023-05-19 |
Amgen Inc. |
Method for producing an antibody peptide conjugate
|
WO2023091910A1
(en)
|
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2023-05-25 |
Precision Biosciences, Inc. |
Methods for cancer immunotherapy
|
WO2023105244A1
(en)
|
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|
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(en)
|
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|
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(en)
|
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2023-07-13 |
Vib Vzw |
Means and methods to increase abiotic stress tolerance in plants
|
WO2023131637A1
(en)
|
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Improved silage grasses
|
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(en)
|
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2023-08-03 |
Vib Vzw |
Plants having reduced levels of bitter taste metabolites
|
WO2023168397A1
(en)
|
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2023-09-07 |
Sigma-Aldrich Co. Llc |
Metabolic selection via the asparagine biosynthesis pathway
|
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(en)
|
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Gene edited livestock animals having coronavirus resistance
|
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(en)
|
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|
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(en)
|
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|