ATE397075T1 - Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendung - Google Patents
Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendungInfo
- Publication number
- ATE397075T1 ATE397075T1 AT96906417T AT96906417T ATE397075T1 AT E397075 T1 ATE397075 T1 AT E397075T1 AT 96906417 T AT96906417 T AT 96906417T AT 96906417 T AT96906417 T AT 96906417T AT E397075 T1 ATE397075 T1 AT E397075T1
- Authority
- AT
- Austria
- Prior art keywords
- adenoviral
- chimeric adenoviral
- chimeric
- fiber protein
- amino acid
- Prior art date
Links
- 102000034240 fibrous proteins Human genes 0.000 title 1
- 108091005899 fibrous proteins Proteins 0.000 title 1
- 101710145505 Fiber protein Proteins 0.000 abstract 4
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 3
- 241000701161 unidentified adenovirus Species 0.000 abstract 2
- CXURGFRDGROIKG-UHFFFAOYSA-N 3,3-bis(chloromethyl)oxetane Chemical compound ClCC1(CCl)COC1 CXURGFRDGROIKG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000835 fiber Substances 0.000 abstract 1
- 238000005829 trimerization reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/395,381 US5770442A (en) | 1995-02-21 | 1995-02-21 | Chimeric adenoviral fiber protein and methods of using same |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE397075T1 true ATE397075T1 (de) | 2008-06-15 |
Family
ID=23562798
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96906417T ATE397075T1 (de) | 1995-02-21 | 1996-02-13 | Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendung |
Country Status (8)
Country | Link |
---|---|
US (3) | US5770442A (de) |
EP (1) | EP0811069B1 (de) |
JP (1) | JPH11500315A (de) |
AT (1) | ATE397075T1 (de) |
AU (1) | AU698254B2 (de) |
CA (1) | CA2213343C (de) |
DE (1) | DE69637545D1 (de) |
WO (1) | WO1996026281A1 (de) |
Families Citing this family (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5820868A (en) | 1993-12-09 | 1998-10-13 | Veterinary Infectious Disease Organization | Recombinant protein production in bovine adenovirus expression vector system |
US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US6127525A (en) * | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US6783980B2 (en) * | 1995-06-15 | 2004-08-31 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
ATE278794T1 (de) * | 1995-06-15 | 2004-10-15 | Crucell Holland Bv | Verpackungssysteme für humane, menschliche adenoviren, zur verwendung in die gentherapie |
US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
AU716466B2 (en) * | 1995-09-27 | 2000-02-24 | Medical Research Council | Recombinant viruses incorporating a protease cleavable protein |
EE9800160A (et) * | 1995-11-28 | 1998-12-15 | Genvec, Inc. | Vektorid ja meetodid geenide ülekandmiseks rakkudesse |
AU742018B2 (en) * | 1996-08-21 | 2001-12-13 | Genvec, Inc. | Alternatively targeted adenovirus |
US6420629B1 (en) * | 1996-09-09 | 2002-07-16 | B.C. Research Inc. | Process of increasing plant growth and yield and modifying cellulose production in plants |
NZ508399A (en) * | 1996-09-25 | 2003-06-30 | Novartis Ag | Packaging cell lines for use in facilitating the development of high capacity adenoviral vectors |
US7232899B2 (en) * | 1996-09-25 | 2007-06-19 | The Scripps Research Institute | Adenovirus vectors, packaging cell lines, compositions, and methods for preparation and use |
WO1998017322A1 (en) * | 1996-10-24 | 1998-04-30 | Genzyme Corporation And President And Fellows Of Harvard College | Enhanced delivery of adenoviral vectors to lung tissue |
US5877011A (en) * | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
WO1998041618A1 (en) * | 1997-03-14 | 1998-09-24 | Uab Research Foundation | Method for the purification of virus |
US6432699B1 (en) * | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
FR2761688A1 (fr) * | 1997-04-02 | 1998-10-09 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
EP1015005A4 (de) * | 1997-05-08 | 2002-10-16 | Genetic Therapy Inc | Gentransfer mit hilfe von adenovirus enthaltend modifizierte faserproteine |
EP0988390A1 (de) * | 1997-05-28 | 2000-03-29 | Genvec, Inc. | Adenovirus mit veränderter zielzellenspezifität |
CA2294649C (en) | 1997-06-23 | 2007-09-25 | University Of Saskatchewan | Bovine adenovirus type 3 genome |
US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
US6348450B1 (en) * | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
CA2327545A1 (en) * | 1998-02-06 | 1999-08-12 | Uab Research Foundation | Adenovirus vector containing a heterologous peptide epitope in the hi loop of the fiber knob |
US20050095231A1 (en) * | 1998-02-17 | 2005-05-05 | Curiel David T. | Modified adenovirus containing a fiber replacement protein |
US6815200B1 (en) | 1998-02-17 | 2004-11-09 | The Uab Research Foundation | Modified adenovirus containing a fiber replacement protein |
EP1070118B1 (de) * | 1998-02-17 | 2006-10-11 | The Uab Research Foundation | Modifizierte adenoviren welche ein faserersatzprotein enthalten |
US6670188B1 (en) * | 1998-04-24 | 2003-12-30 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
AU4070499A (en) * | 1998-04-30 | 1999-11-16 | Cornell Research Foundation Inc. | Adenoviral vectors with tandem fiber proteins |
US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
US20040043489A1 (en) * | 1998-07-08 | 2004-03-04 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells and methods of use |
AU2003268608B2 (en) * | 1998-07-08 | 2007-01-04 | Crucell Holland B.V. | Chimaeric adenoviruses |
AU773202B2 (en) * | 1998-08-27 | 2004-05-20 | Aventis Pharma S.A. | Targeted adenovirus vectors for delivery of heterologous genes |
US6900049B2 (en) * | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
US6455314B1 (en) | 1998-09-11 | 2002-09-24 | Genvec, Inc. | Alternatively targeted adenovirus |
IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
AU776067B2 (en) * | 1999-03-04 | 2004-08-26 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6869936B1 (en) * | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
WO2000067576A1 (en) * | 1999-05-12 | 2000-11-16 | The Uab Research Foundation | Infectivity-enhanced conditionally-replicative adenovirus and uses thereof |
US20050232900A1 (en) * | 1999-05-18 | 2005-10-20 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6913922B1 (en) | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
CA2378324A1 (en) * | 1999-07-06 | 2001-01-11 | Leif Lindholm | Recombinant adenovirus |
CA2348158A1 (fr) * | 1999-08-27 | 2001-03-08 | Transgene S.A. | Fibre adenovirale modifiee et utilisations |
ES2183752T3 (es) * | 1999-09-17 | 2005-07-16 | Tgt Laboratories, S.A. De C.V. | Vectores adenovirales recombinantes y su utilizacion en el tratamiento de la cirrosis de higado. |
EP1276888A2 (de) * | 2000-04-26 | 2003-01-22 | Crucell Holland B.V. | Adenovirale vektoren ohne knob-domäne im fiber protein, und verwendungen davon |
EP1157999A1 (de) * | 2000-05-24 | 2001-11-28 | Introgene B.V. | Verfahren und Mitteln zur Verbesserung der Haut-Transplantation mittels Genabgabe-Vehikel mit Tropismus für primären Fibroblasten, sowie andere Verwendungsmöglichkeiten für diesen |
JP2003534806A (ja) * | 2000-05-31 | 2003-11-25 | ジェンベク、インコーポレイティッド | アデノウイルスベクターのターゲティングの方法および組成物 |
US6524572B1 (en) * | 2000-06-26 | 2003-02-25 | Rainbow Therapeutic Company | Targeting recombinant virus with a bispecific fusion protein ligand in coupling with an antibody to cells for gene therapy |
US20020164333A1 (en) * | 2000-07-10 | 2002-11-07 | The Scripps Research Institute | Bifunctional molecules and vectors complexed therewith for targeted gene delivery |
US20040033605A1 (en) * | 2000-09-20 | 2004-02-19 | Menzo Havenga | Gene delivery vectors provided with a tissue tropism for dendritic cells |
US7235233B2 (en) * | 2000-09-26 | 2007-06-26 | Crucell Holland B.V. | Serotype 5 adenoviral vectors with chimeric fibers for gene delivery in skeletal muscle cells or myoblasts |
US20030202963A1 (en) * | 2000-10-12 | 2003-10-30 | Cornell Research Foundation, Inc. | Method of treating cancer |
MXPA00011713A (es) * | 2000-11-28 | 2002-05-31 | Tgt Lab S A De C V | Vectores recombinantes virales y no virales conteniendo el gen humano del activador de plasminogeno derivado de urocinasa y su utilidad en el tratamiento de diversos tipos de fibrosis hepatica, renal, pulmonar, pancreatica, cardiaca y cicatrices hipe |
JP4399255B2 (ja) * | 2001-06-22 | 2010-01-13 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 細菌の形質転換体を迅速に選別する方法および新規なサルアデノウイルス蛋白質 |
US20040136963A1 (en) * | 2001-06-22 | 2004-07-15 | The Trustees Of The University Of Pennsylvania | Simian adenovirus vectors and methods of use |
US20060275262A1 (en) * | 2001-07-26 | 2006-12-07 | Mathis James M | Conditionally replicating viruses and methods for cancer virotherapy |
US9175309B2 (en) * | 2001-09-29 | 2015-11-03 | Industry-University Cooperation Foundation Hanyang University | Recombinant adenovirus with enhanced therapeutic effect and pharmaceutical composition comprising said recombinant adenovirus |
US7175983B2 (en) | 2001-11-02 | 2007-02-13 | Abmaxis, Inc. | Adapter-directed display systems |
HU230488B1 (hu) | 2001-11-21 | 2016-08-29 | The Trustees Of The University Of Pennsylvania | Simian adenovírus nukleinsav és aminosav-szekvencia, azt tartalmazó vektorok, és eljárások annak alkalmazására |
AU2006204656B2 (en) * | 2001-11-21 | 2008-01-24 | The Trustees Of The University Of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
CA2474763A1 (en) * | 2002-01-24 | 2003-07-31 | The Scripps Research Institute | Fiber shaft modifications for efficient targeting |
KR101006594B1 (ko) | 2002-04-25 | 2011-01-07 | 크루셀 홀란드 비.브이. | 안정한 아데노바이러스 벡터 및 그 증식 방법 |
ATE447037T1 (de) * | 2002-04-25 | 2009-11-15 | Crucell Holland Bv | Mittel und verfahren zur herstellung von adenovirusvektoren |
AU2003223775A1 (en) * | 2002-04-30 | 2003-11-17 | Duke University | Adeno-associated viral vectors and methods for their production from hybrid adenovirus and for their use |
WO2004007537A2 (en) * | 2002-07-10 | 2004-01-22 | Transgene S.A. | Modified adenoviral fiber with ablated to cellular receptors |
US20080153083A1 (en) | 2003-10-23 | 2008-06-26 | Crucell Holland B.V. | Settings for recombinant adenoviral-based vaccines |
EP1553983A2 (de) | 2002-10-23 | 2005-07-20 | Crucell Holland B.V. | Einstellung für rekombinante adenovirus-basierte impfstoffe |
CA2507915C (en) | 2002-12-17 | 2013-07-02 | Crucell Holland B.V. | Recombinant viral-based malaria vaccines |
ES2371913T3 (es) | 2003-01-22 | 2012-01-11 | Duke University | Constructos mejorados para expresar polipéptidos lisosomales. |
US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
AU2004238979B2 (en) | 2003-05-14 | 2008-12-18 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Broadening adenovirus tropism |
US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
CA2526120A1 (en) * | 2003-06-03 | 2005-02-24 | Cell Genesys, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
US7291498B2 (en) * | 2003-06-20 | 2007-11-06 | The Trustees Of The University Of Pennsylvania | Methods of generating chimeric adenoviruses and uses for such chimeric adenoviruses |
EP1636370B1 (de) * | 2003-06-20 | 2014-04-16 | The Trustees of The University of Pennsylvania | Methoden, chimärische adenoviren zu erzeugen und verwendung solcher adenoviren |
EP1649028B1 (de) * | 2003-07-25 | 2012-08-22 | Genvec, Inc. | Adenoviralevektoren-basierte impfstoffe |
US20050186178A1 (en) * | 2003-08-28 | 2005-08-25 | Ennist David L. | Oncolytic adenoviral vectors encoding GM-CSF |
US7482156B2 (en) * | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
EP1687032B1 (de) * | 2003-11-14 | 2010-02-24 | Genvec, Inc. | Pharmazeutische verbindung zur behandlung von lokal fortgeschrittenem primär inoperablen pankreaskarzinom (lapc). |
EP1718738A2 (de) | 2004-02-23 | 2006-11-08 | Crucell Holland B.V. | Verfahren zur reinigung von viren |
CA2563396A1 (en) | 2004-04-12 | 2005-11-24 | The Government Of The United States Of America, As Represented By The Se Cretary, Department Of Health And Human Services | Method of using adenoviral vectors to induce an immune response |
US20060062764A1 (en) * | 2004-08-25 | 2006-03-23 | Seshidar-Reddy Police | Fiber-modified adenoviral vectors for enhanced transduction of tumor cells |
EP1784493A2 (de) * | 2004-09-01 | 2007-05-16 | The Government of the United States of America as Represented by The Department of Health and Human Services | Adenovirale vektoren mit der fähigkeit zum umwandeln von apcs, mögliche verwendung bei immunantworterzeugung |
JP2008531581A (ja) * | 2005-02-23 | 2008-08-14 | ユーエービー リサーチ ファウンデーション | アルキル−グリコシドで増強されたワクチン接種 |
US20060205080A1 (en) * | 2005-03-01 | 2006-09-14 | David Frey | Formulations for therapeutic viruses having enhanced storage stability |
US20070010016A1 (en) * | 2005-03-11 | 2007-01-11 | Mccelland Alan | Gene transfer with adenoviruses having modified fiber proteins |
DK1869171T4 (en) | 2005-04-11 | 2016-01-18 | Crucell Holland Bv | Virus cleaning using ultrafiltration |
US20060234347A1 (en) * | 2005-04-13 | 2006-10-19 | Harding Thomas C | Targeting multiple angiogenic pathways for cancer therapy using soluble tyrosine kinase receptors |
US8765146B2 (en) * | 2005-08-31 | 2014-07-01 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
US9651543B2 (en) | 2005-08-31 | 2017-05-16 | The United States Of America As Represented By The Secretary Of The Navy | Malaria antigen screening method |
US8450055B2 (en) * | 2005-08-31 | 2013-05-28 | The United States Of America As Represented By The Secretary Of The Navy | Malaria antigen screening method |
BRPI0618441B8 (pt) * | 2005-11-10 | 2021-07-27 | Genvec Inc | vetor adenoviral |
CA2646671A1 (en) | 2006-03-30 | 2007-11-01 | University Of California | Methods and compositions for localized secretion of anti-ctla-4 antibodies |
US7919079B2 (en) | 2006-03-31 | 2011-04-05 | Biosante Pharmaceuticals, Inc. | Cancer immunotherapy compositions and methods of use |
US20080248060A1 (en) * | 2007-01-09 | 2008-10-09 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
US8629334B2 (en) * | 2008-07-16 | 2014-01-14 | University Of Florida Research Foundation, Inc. | Viral-based transient-expression vector system for trees |
DK2350268T3 (en) | 2008-11-03 | 2015-03-23 | Crucell Holland Bv | PROCEDURE FOR PRODUCING ADENOVIRUS VECTORS |
US9605844B2 (en) * | 2009-09-01 | 2017-03-28 | Cree, Inc. | Lighting device with heat dissipation elements |
CN102791852B (zh) | 2009-10-15 | 2014-05-07 | 克鲁塞尔荷兰公司 | 纯化腺病毒颗粒的方法 |
EA028875B1 (ru) | 2009-10-15 | 2018-01-31 | Янссен Вэксинс Энд Превеншн Б.В. | Способ очистки аденовирусных частиц из клеточной суспензии |
WO2011047316A1 (en) | 2009-10-16 | 2011-04-21 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Nucleic acid sequences encoding expandable hiv mosaic proteins |
WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
MX2012005181A (es) | 2009-11-09 | 2012-08-01 | Genvec Inc | Metodos para la propagacion de vectores adenovirales de monos. |
WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
AP3390A (en) | 2010-09-20 | 2015-08-31 | Crucell Holland Bv | Therapeutic vaccination against active tuberculosis |
US9512429B2 (en) | 2010-12-06 | 2016-12-06 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Pharmaceutical composition comprising Nanog shRNA, and method of using Nanog shRNA to treat cancer |
WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
US8920813B2 (en) | 2010-12-20 | 2014-12-30 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
WO2013181128A1 (en) | 2012-05-29 | 2013-12-05 | Genvec, Inc. | Modified serotype 28 adenoviral vectors |
WO2014153204A1 (en) | 2013-03-14 | 2014-09-25 | Salk Institute For Biological Studies | Oncolytic adenovirus compositions |
WO2014165349A1 (en) | 2013-04-04 | 2014-10-09 | Trustees Of Dartmouth College | Compositions and methods for in vivo excision of hiv-1 proviral dna |
ES2711115T3 (es) | 2013-09-19 | 2019-04-30 | Janssen Vaccines & Prevention Bv | Formulaciones de adenovirus mejoradas |
TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
BR112018006488B1 (pt) | 2015-10-06 | 2024-03-12 | Janssen Vaccines & Prevention B.V. | Métodos para prevenir a degradação induzida por plástico de biológicos |
WO2017070113A1 (en) | 2015-10-19 | 2017-04-27 | The United States of America, as represented by the Secretary, Department of Health and Human Sevices | Pharmaceutical composition comprising nanog shrna, and method of using nanog shrna to treat cancer |
JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
WO2018064523A1 (en) | 2016-09-30 | 2018-04-05 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into t cells |
WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
EP3927833A4 (de) | 2019-02-21 | 2022-11-30 | Unleash Immuno Oncolytics, Inc. | Onkolytischer adenoviraler vektor und verfahren zur verwendung |
EP4338727A1 (de) | 2022-09-14 | 2024-03-20 | Roquette Freres | Adenovirus-formulierungen |
Family Cites Families (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4593002A (en) * | 1982-01-11 | 1986-06-03 | Salk Institute Biotechnology/Industrial Associates, Inc. | Viruses with recombinant surface proteins |
US4487829A (en) * | 1982-03-23 | 1984-12-11 | Massachusetts Institute Of Technology | Production and use of monoclonal antibodies against adenoviruses |
US4517686A (en) * | 1982-08-04 | 1985-05-21 | La Jolla Cancer Research Foundation | Polypeptide |
US4792525A (en) * | 1982-08-04 | 1988-12-20 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4578079A (en) * | 1982-08-04 | 1986-03-25 | La Jolla Cancer Research Foundation | Tetrapeptide |
US4589881A (en) * | 1982-08-04 | 1986-05-20 | La Jolla Cancer Research Foundation | Polypeptide |
US4797368A (en) * | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
FR2602790B1 (fr) * | 1986-08-13 | 1990-06-01 | Transgene Sa | Expression d'un antigene specifique de tumeur par un virus vecteur recombinant et utilisation de celui-ci pour le traitement preventif ou curatif de la tumeur correspondante |
US4851341A (en) | 1986-12-19 | 1989-07-25 | Immunex Corporation | Immunoaffinity purification system |
EP0273085A1 (de) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | Verfahren zur Einführung fremder Nukleinsäuren in eukaryotische Zellen |
US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
US4956281A (en) * | 1987-06-03 | 1990-09-11 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing lymphocyte function associated antigen-3 |
US5024939A (en) * | 1987-07-09 | 1991-06-18 | Genentech, Inc. | Transient expression system for producing recombinant protein |
US5674722A (en) * | 1987-12-11 | 1997-10-07 | Somatix Therapy Corporation | Genetic modification of endothelial cells |
US5672344A (en) * | 1987-12-30 | 1997-09-30 | The Regents Of The University Of Michigan | Viral-mediated gene transfer system |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5204445A (en) * | 1988-10-03 | 1993-04-20 | The Scripps Research Institute | Peptides and antibodies that inhibit integrin-ligand binding |
US5198346A (en) * | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
US5096815A (en) * | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
WO1990012087A1 (en) | 1989-04-05 | 1990-10-18 | Novacell Corporation | Infectious targetted replication-defective virion |
US5223394A (en) * | 1989-04-10 | 1993-06-29 | Biogen, Inc. | Recombinant dna molecule comprising lymphocyte function-associated antigen 3 phosphatidylinositol linkage signal sequence |
ES2096590T3 (es) * | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
US5240846A (en) * | 1989-08-22 | 1993-08-31 | The Regents Of The University Of Michigan | Gene therapy vector for cystic fibrosis |
US5332567A (en) * | 1989-08-24 | 1994-07-26 | Immunomedics | Detection and treatment of infections with immunoconjugates |
US5436146A (en) * | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
JPH05504677A (ja) * | 1989-10-20 | 1993-07-22 | トラスティーズ オブ ダートマス カレッジ | IgAレセプターに特異的なモノクロナール抗体 |
EP0595798B1 (de) * | 1989-10-20 | 1999-03-03 | Medarex, Inc. | Bispezifische heteroantikörper mit zweifachen effektorfunktionen |
AU7906691A (en) * | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
US5349053A (en) * | 1990-06-01 | 1994-09-20 | Protein Design Labs, Inc. | Chimeric ligand/immunoglobulin molecules and their uses |
US5246921A (en) * | 1990-06-26 | 1993-09-21 | The Wistar Institute Of Anatomy And Biology | Method for treating leukemias |
GB2246779B (en) * | 1990-08-03 | 1994-08-17 | Delta Biotechnology Ltd | Tumour-associated protease inhibitors targeted to tumour cells |
AU660629B2 (en) | 1990-10-01 | 1995-07-06 | University Of Connecticut, The | Targeting viruses and cells for selective internalization by cells |
GB9101550D0 (en) * | 1991-01-24 | 1991-03-06 | Mastico Robert A | Antigen-presenting chimaeric protein |
JP3534749B2 (ja) * | 1991-08-20 | 2004-06-07 | アメリカ合衆国 | アデノウイルスが介在する胃腸管への遺伝子の輸送 |
FR2681786A1 (fr) * | 1991-09-27 | 1993-04-02 | Centre Nat Rech Scient | Vecteurs recombinants d'origine virale, leur procede d'obtention et leur utilisation pour l'expression de polypeptides dans des cellules musculaires. |
NZ244306A (en) * | 1991-09-30 | 1995-07-26 | Boehringer Ingelheim Int | Composition for introducing nucleic acid complexes into eucaryotic cells, complex containing nucleic acid and endosomolytic agent, peptide with endosomolytic domain and nucleic acid binding domain and preparation |
IL103059A0 (en) * | 1991-09-30 | 1993-02-21 | Boehringer Ingelheim Int | Conjugates for introducing nucleic acid into higher eucaryotic cells |
US5521291A (en) * | 1991-09-30 | 1996-05-28 | Boehringer Ingelheim International, Gmbh | Conjugates for introducing nucleic acid into higher eucaryotic cells |
SE503225C2 (sv) | 1991-10-30 | 1996-04-22 | Leif Lindholm Konsult Ab | Virus-antikroppskomplex för införing av virus i mammalieceller |
US5661133B1 (en) * | 1991-11-12 | 1999-06-01 | Univ Michigan | Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein |
JPH07507689A (ja) | 1992-06-08 | 1995-08-31 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 特定組織のターゲティング方法及び組成物 |
JPH08504091A (ja) | 1992-09-22 | 1996-05-07 | メディカル・リサーチ・カウンシル | 外部表面に非ウィルス性ポリペプチドを提示する組換えウィルス |
NZ256018A (en) * | 1992-09-25 | 1997-07-27 | Rhone Poulenc Rorer Sa | Recombinant adenoviral vectors and their use in directing expression and transcription of selected nucleotide sequences in cells of the central nervous system |
DE4232846A1 (de) * | 1992-09-30 | 1994-03-31 | Audi Ag | Querträger für das Armaturenbrett eines Kraftfahrzeuges |
GB9223084D0 (en) | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
ATE212665T1 (de) * | 1992-11-18 | 2002-02-15 | Arch Dev Corp | Adenovirus gelenkter gen-transfer zum herz- und glatten vaskularen muskel |
GB9300686D0 (en) | 1993-01-15 | 1993-03-03 | Imp Cancer Res Tech | Compounds for targeting |
WO1994017832A1 (en) * | 1993-02-09 | 1994-08-18 | The Scripps Research Institute | Targeting and delivery of genes and antiviral agents into cells by the adenovirus penton |
DE4311651A1 (de) | 1993-04-08 | 1994-10-13 | Boehringer Ingelheim Int | Virus für den Transport von Fremd-DNA in höhere eukaryotische Zellen |
JPH08509869A (ja) * | 1993-05-10 | 1996-10-22 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 膵臓および胆管の上皮細胞への遺伝子導入 |
US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
WO1995006745A1 (de) * | 1993-09-03 | 1995-03-09 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Vektor für leber-gentherapie |
US5552311A (en) * | 1993-09-14 | 1996-09-03 | University Of Alabama At Birmingham Research Foundation | Purine nucleoside phosphorylase gene therapy for human malignancy |
US5534423A (en) * | 1993-10-08 | 1996-07-09 | Regents Of The University Of Michigan | Methods of increasing rates of infection by directing motion of vectors |
FR2712812B1 (fr) * | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
IT1271461B (it) * | 1993-12-01 | 1997-05-28 | Menarini Ricerche Sud Spa | Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso. |
US5491565A (en) * | 1993-12-03 | 1996-02-13 | Telefonaktiebolaget Lm Ericsson | System and method for varying the transmission rate of facsimile data in a telecommunication system |
US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
US5928944A (en) * | 1994-02-04 | 1999-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Method of adenoviral-medicated cell transfection |
US6312699B1 (en) * | 1994-03-28 | 2001-11-06 | Uab Research Foundation | Ligands added to adenovirus fiber |
US7252989B1 (en) * | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
JPH09509329A (ja) * | 1994-05-13 | 1997-09-22 | チロン ビアジーン,インコーポレイティド | 遺伝子搬送媒体を標的とする組成物及び方法 |
US5571531A (en) * | 1994-05-18 | 1996-11-05 | Mcmaster University | Microparticle delivery system with a functionalized silicone bonded to the matrix |
FR2721943B1 (fr) * | 1994-06-29 | 1996-08-02 | Rhone Poulenc Rorer Sa | Adenovirus comprenant un gene codant pour une superoxyde dismutase |
US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
US5559099A (en) | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
CA2199609A1 (en) * | 1994-09-09 | 1996-03-14 | Errol B. Desouza | Interleukin-1 type 3 receptors |
FR2724846B1 (fr) * | 1994-09-27 | 1996-12-20 | Rhone Poulenc Rorer Sa | Methode de traitement des cancers par regulation de l'activite des proteines ras |
DE69534166T2 (de) * | 1994-10-28 | 2006-03-09 | Trustees Of The University Of Pennsylvania | Rekombinanter adenovirus und methoden zu dessen verwendung |
WO1996014837A1 (en) * | 1994-11-09 | 1996-05-23 | Genetic Therapy, Inc. | Gene therapy for hypercholesterolemia |
WO1996017073A1 (fr) * | 1994-11-29 | 1996-06-06 | Takara Shuzo Co., Ltd. | Procede pour la production de cellules transformees |
FR2727867B1 (fr) * | 1994-12-13 | 1997-01-31 | Rhone Poulenc Rorer Sa | Transfert de genes dans les motoneurones medullaires au moyen de vecteurs adenoviraux |
US6127525A (en) | 1995-02-21 | 2000-10-03 | Cornell Research Foundation, Inc. | Chimeric adenoviral coat protein and methods of using same |
US5770442A (en) | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
US5622699A (en) | 1995-09-11 | 1997-04-22 | La Jolla Cancer Research Foundation | Method of identifying molecules that home to a selected organ in vivo |
EE9800160A (et) * | 1995-11-28 | 1998-12-15 | Genvec, Inc. | Vektorid ja meetodid geenide ülekandmiseks rakkudesse |
WO1997024453A1 (en) | 1995-12-28 | 1997-07-10 | Chiron Corporation | Receptor specific chimeric viral surface polypeptides for viral and particle incorporation and internalization in target cells |
AU2678097A (en) | 1996-04-16 | 1997-11-07 | Immusol Incorporated | Targeted viral vectors |
WO1998011221A2 (en) | 1996-09-13 | 1998-03-19 | Dana-Farber Cancer Institute | Car, a novel coxsackievirus and adenovirus receptor |
NZ508399A (en) | 1996-09-25 | 2003-06-30 | Novartis Ag | Packaging cell lines for use in facilitating the development of high capacity adenoviral vectors |
US5877011A (en) | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
US5922315A (en) | 1997-01-24 | 1999-07-13 | Genetic Therapy, Inc. | Adenoviruses having altered hexon proteins |
-
1995
- 1995-02-21 US US08/395,381 patent/US5770442A/en not_active Expired - Lifetime
-
1996
- 1996-02-13 AT AT96906417T patent/ATE397075T1/de not_active IP Right Cessation
- 1996-02-13 JP JP8525732A patent/JPH11500315A/ja active Pending
- 1996-02-13 DE DE69637545T patent/DE69637545D1/de not_active Expired - Lifetime
- 1996-02-13 CA CA002213343A patent/CA2213343C/en not_active Expired - Fee Related
- 1996-02-13 AU AU49804/96A patent/AU698254B2/en not_active Ceased
- 1996-02-13 WO PCT/US1996/001957 patent/WO1996026281A1/en active Application Filing
- 1996-02-13 EP EP96906417A patent/EP0811069B1/de not_active Expired - Lifetime
-
1999
- 1999-06-04 US US09/326,447 patent/US6576456B2/en not_active Expired - Lifetime
-
2002
- 2002-06-17 US US10/173,930 patent/US20030166286A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2213343C (en) | 2009-09-01 |
AU698254B2 (en) | 1998-10-29 |
AU4980496A (en) | 1996-09-11 |
EP0811069B1 (de) | 2008-05-28 |
US5770442A (en) | 1998-06-23 |
EP0811069A1 (de) | 1997-12-10 |
US20030166286A1 (en) | 2003-09-04 |
US6576456B2 (en) | 2003-06-10 |
US20020099024A1 (en) | 2002-07-25 |
WO1996026281A1 (en) | 1996-08-29 |
DE69637545D1 (de) | 2008-07-10 |
JPH11500315A (ja) | 1999-01-12 |
CA2213343A1 (en) | 1996-08-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE397075T1 (de) | Chimärisches , adenovirales faserprotein und verfahren zu dessen verwendung | |
NZ323834A (en) | Chimeric adenovirus coat protein vectors and methods for gene transfer to cells | |
ATE382695T1 (de) | Targeting von adenoviren mit hilfe von konformationsbeschränkten peptidmotiven | |
FI951138A (fi) | Puuttellisia adenovirusvektoreita ja niiden käyttö geeniterapiassa | |
ATE332363T1 (de) | Rekombinanter adenovirus welcher eine chimäre penton-base aufweist | |
FI943389A (fi) | Bacillus-lajista saatu ksylanaasi, tällaisen ksylanaasin ja muiden proteiinien ekspressiovektori, niiden isäntäorganismit ja käyttö | |
NZ336829A (en) | Adenoviruses having altered hexon proteins which present epitopes that are not recognised by neutralizing antibodies to the unmodified adenovirus of another serotype | |
CA2321177A1 (en) | Recombinant fibronectin-based extracellular matrix for wound healing | |
TR199900666T2 (xx) | �nsan paratormonu ile ilgili peptidlere kar�� antikor. | |
DE69522385D1 (de) | Computersystem zur Ausführung von Verzweigungsbefehlen | |
DE69632827D1 (de) | Materialen und methoden im zusammenhang mit bindung und präsentation von substanzen auf zelloberflächen | |
ATA907698A (de) | Pipelineverteilungsnetzwerksysteme für den transport von flüssigerdgas | |
DK549188D0 (da) | Lymfocythaemmende hla-peptider | |
EP0871661A4 (de) | Neue proteindomäne, welche tyrosin-pharphoryliarte proteine bindet | |
ATE262537T1 (de) | Proliferationsinhibitor von endothellzellen und dessen verwendung | |
FI970097A (fi) | Proteiinit, jotka ovat peräisin nisäkkäiden maksasta ja niiden käyttö onkologiassa | |
FI971275A (fi) | Inaktivoidun IVa2-geenin käsittävät epätäydelliset yhdistelmä-DNA-tekniset adenovirukset | |
AU7423391A (en) | Dna constructs for the expression of proteins in the mammary gland of transgenetic mammals | |
ATE285474T1 (de) | Haemophilus adhäsionsproteinen | |
PT625157E (pt) | Epitopes p1a1 e p1a2 da gpiiia da plaqueta sua preparacao e utilizacao | |
WO2000018909A3 (en) | NUCLEIC ACIDS AND PROTEINS FROM $i(CENARCHAEUM SYMBIOSUM) | |
SE8502540L (sv) | Stabilt tandvardsmedel innehallande dextranas | |
NZ512596A (en) | Cell line expressing non-native cell surface receptors | |
SE9502595D0 (sv) | Novel DNA and peptide sequence and related expression vector | |
BR1101121A (pt) | Vetor adenovirótico recombinante e processos de uso |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |