ES2133139T3 - Hetero anticuerpos biespecificos con funciones efectoras dobles. - Google Patents

Hetero anticuerpos biespecificos con funciones efectoras dobles.

Info

Publication number
ES2133139T3
ES2133139T3 ES90917241T ES90917241T ES2133139T3 ES 2133139 T3 ES2133139 T3 ES 2133139T3 ES 90917241 T ES90917241 T ES 90917241T ES 90917241 T ES90917241 T ES 90917241T ES 2133139 T3 ES2133139 T3 ES 2133139T3
Authority
ES
Spain
Prior art keywords
effector cells
molecules
hetero
bispecific antibodies
target
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90917241T
Other languages
English (en)
Inventor
Michael W Fanger
Paul M Guyre
Edward D Ball
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
Medarex LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medarex LLC filed Critical Medarex LLC
Application granted granted Critical
Publication of ES2133139T3 publication Critical patent/ES2133139T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3023—Lung
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

Abstract

SE HAN DESCUBIERTO MOLECULAS BIESPECIFICAS QUE REACCIONAN TANTO CON EL RECEPTOR FCGAMMA DE ALTA AFINIDAD DE LAS CELULAS EFECTORAS HUMANAS COMO CON UN ANTIGENO SUPERFICIAL DE UNA CELULA CONCRETA. LA UNION DE LAS MOLECULAS A LOS RECEPTORES FC HALLADOS SOBRE LAS CELULAS EFECTORAS NO SE BLOQUEA MEDIANTE LA INMUNOGLOBULINA HUMANA G. LAS MOLECULAS SON UTILES PARA OBJETIVAR CELULAS EFECTORAS HUMANAS (POR EJEMPLO MACROFAGOS) CONTRA CELULAS QUE SOPORTAN EL ANTIGENO OBJETIVADO. PARA ESTE PROPOSITO, PUEDEN CONSTRUIRSE MOLECULAS BIESPECIFICAS QUE CONTENGAN LA REGION DE UNION DERIVADA DEL ANTICUERPO RECEPTOR DE ANTI-FCGAMMA Y LA REGION DE UNION DERIVADA DE UN ANTICUERPO ESPECIFICO PARA EL ANTIGENO OBJETIVADO. LAS CELULAS EFECTORAS OBJETIVADAS PUEDEN UTILIZARSE PARA DESTRUIR CELULAS QUE SOPORTEN EL ANTIGENO SUPERFICIAL DE LA CELULA MEDIANTE CITOLISIS DEPENDIENTE DE LOS ANTICUERPOS INTERMEDIADA POR LA CELULA Y MEDIANTE FIJACION DE COMPLEMENTO.
ES90917241T 1989-10-20 1990-10-18 Hetero anticuerpos biespecificos con funciones efectoras dobles. Expired - Lifetime ES2133139T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42454089A 1989-10-20 1989-10-20

Publications (1)

Publication Number Publication Date
ES2133139T3 true ES2133139T3 (es) 1999-09-01

Family

ID=23682977

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90917241T Expired - Lifetime ES2133139T3 (es) 1989-10-20 1990-10-18 Hetero anticuerpos biespecificos con funciones efectoras dobles.

Country Status (9)

Country Link
EP (1) EP0595798B1 (es)
JP (1) JP3360108B2 (es)
AT (1) ATE177152T1 (es)
CA (1) CA2069960C (es)
DE (1) DE69032979T2 (es)
DK (1) DK0595798T3 (es)
ES (1) ES2133139T3 (es)
GR (1) GR3030415T3 (es)
WO (1) WO1991005871A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5582996A (en) * 1990-12-04 1996-12-10 The Wistar Institute Of Anatomy & Biology Bifunctional antibodies and method of preparing same
WO1994008038A1 (en) * 1992-10-02 1994-04-14 Trustees Of Dartmouth College Bispecific reagents for redirected targeting of low density lipoprotein
DE4337197C1 (de) * 1993-10-30 1994-08-25 Biotest Pharma Gmbh Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US6540994B1 (en) * 1997-07-18 2003-04-01 I.D.M. Immuno-Designed Molecules Macrophages, process for preparing the same and their use as active substances of pharmaceutical compositions
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US6365161B1 (en) 1995-06-07 2002-04-02 Medarex, Inc. Therapeutic compounds comprised of anti-FC receptor binding agents
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US6783980B2 (en) 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
CA2311574A1 (en) 1997-12-02 1999-06-10 Medarex, Inc. Cells expressing anti-fc receptor binding components
AU3601299A (en) * 1998-04-09 1999-11-01 I.D.M. Immuno-Designed Molecules Use of monocytes derived cells and antibodies in a synergic way for optimal induction of immunotherapeutic efficiency
US20020168347A1 (en) * 1998-04-09 2002-11-14 Jacques Bartholeyns Use of monocytes derived cells, antigens and antibodies for optimal induction of immunotherapeutic efficiency
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
WO2003104467A1 (en) 2002-04-25 2003-12-18 Crucell Holland B.V. Means and methods for the production of adenovirus vectors
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
DE60138403D1 (de) 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
CA2833477A1 (en) 2011-04-21 2012-10-26 Seattle Genetics, Inc. Novel binder-drug conjugates (adcs) and their use
BR112016014830A2 (pt) 2013-12-23 2017-09-19 Bayer Pharma AG Conjugados de fármaco de anticorpo (adcs) com inibidores de ksp
AU2016282723B2 (en) 2015-06-22 2021-09-23 Bayer Pharma Aktiengesellschaft Antibody drug conjugates (ADCs) and antibody prodrug conjugates (APDCs) with enzymatically cleavable groups
WO2017060322A2 (en) 2015-10-10 2017-04-13 Bayer Pharma Aktiengesellschaft Ptefb-inhibitor-adc
JP7251981B2 (ja) 2016-03-24 2023-04-04 バイエル ファーマ アクチエンゲゼルシャフト 酵素開裂基を有する細胞毒性活性剤のプロドラッグ
EP3471776B1 (en) 2016-06-15 2022-05-04 Bayer Pharma Aktiengesellschaft Specific antibody-drug-conjugates with ksp inhibitors and anti-cd123-antibodies
JP7066714B2 (ja) 2016-12-21 2022-05-13 バイエル・ファルマ・アクティエンゲゼルシャフト 酵素的に切断可能な基を有する抗体薬物コンジュゲート（ａｄｃ）
US20190351066A1 (en) 2016-12-21 2019-11-21 Bayer Aktiengesellschaft Prodrugs of cytotoxic active agents having enzymatically cleavable groups
JP7030811B2 (ja) 2016-12-21 2022-03-07 バイエル・ファルマ・アクティエンゲゼルシャフト Ｋｓｐ阻害剤を有する特異的抗体－薬物コンジュゲート（ａｄｃ）

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954617A (en) * 1986-07-07 1990-09-04 Trustees Of Dartmouth College Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
GB8802108D0 (en) 1988-01-30 1988-02-24 Univ Dundee Diagnosis & grading of cervical intraepithelial neoplasia(cin)

Also Published As

Publication number Publication date
GR3030415T3 (en) 1999-09-30
ATE177152T1 (de) 1999-03-15
CA2069960C (en) 2004-03-02
DE69032979D1 (de) 1999-04-08
EP0595798A1 (en) 1994-05-11
EP0595798B1 (en) 1999-03-03
DK0595798T3 (da) 1999-09-27
JPH05505595A (ja) 1993-08-19
WO1991005871A1 (en) 1991-05-02
DE69032979T2 (de) 1999-11-04
CA2069960A1 (en) 1991-04-21
JP3360108B2 (ja) 2002-12-24

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