ATE364092T1 - Reinigung von polypeptiden - Google Patents

Reinigung von polypeptiden

Info

Publication number
ATE364092T1
ATE364092T1 AT04700878T AT04700878T ATE364092T1 AT E364092 T1 ATE364092 T1 AT E364092T1 AT 04700878 T AT04700878 T AT 04700878T AT 04700878 T AT04700878 T AT 04700878T AT E364092 T1 ATE364092 T1 AT E364092T1
Authority
AT
Austria
Prior art keywords
homogenate
broth
polypeptide
lactate
polypeptides
Prior art date
Application number
AT04700878T
Other languages
German (de)
English (en)
Inventor
Philip Lester
Josefine Persson
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE364092T1 publication Critical patent/ATE364092T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT04700878T 2003-01-09 2004-01-08 Reinigung von polypeptiden ATE364092T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43941803P 2003-01-09 2003-01-09

Publications (1)

Publication Number Publication Date
ATE364092T1 true ATE364092T1 (de) 2007-06-15

Family

ID=33299572

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04700878T ATE364092T1 (de) 2003-01-09 2004-01-08 Reinigung von polypeptiden

Country Status (18)

Country Link
US (2) US7169908B2 (https=)
EP (1) EP1581644B1 (https=)
JP (1) JP2006517415A (https=)
KR (1) KR20050095605A (https=)
CN (1) CN100467611C (https=)
AT (1) ATE364092T1 (https=)
AU (1) AU2004230670B2 (https=)
BR (1) BRPI0406470A (https=)
CA (1) CA2511946A1 (https=)
DE (1) DE602004006831T2 (https=)
DK (1) DK1581644T3 (https=)
ES (1) ES2287687T3 (https=)
MX (1) MXPA05007378A (https=)
NZ (1) NZ540895A (https=)
PL (1) PL377653A1 (https=)
RU (1) RU2337968C2 (https=)
WO (1) WO2004092393A1 (https=)
ZA (1) ZA200504990B (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE498409T1 (de) 1998-08-06 2011-03-15 Mountain View Pharmaceuticals Peg-uricase konjugate und verwendung davon
AU2003270380B2 (en) * 2002-09-06 2010-07-01 Genentech, Inc. Process for protein extraction
TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
SG161247A1 (en) 2005-04-11 2010-05-27 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
JP5033177B2 (ja) * 2006-04-12 2012-09-26 サビエント ファーマセウティカルズ インク． 陽イオン界面活性剤によるタンパク質の精製
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
AR062069A1 (es) 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
WO2008079302A2 (en) * 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
WO2008140615A2 (en) * 2006-12-21 2008-11-20 Novozymes, Inc. Modified messenger rna stabilizing sequences for expressing genes in bacterial cells
RU2474585C2 (ru) * 2007-01-22 2013-02-10 Дженентек, Инк. Осаждение и очистка белков полиэлектролитами
KR102055873B1 (ko) 2007-07-09 2019-12-13 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
US7887821B2 (en) * 2007-12-20 2011-02-15 Alk-Abello A/S Process for producing an allergen extract
US8999702B2 (en) 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
GB0818228D0 (en) * 2008-10-06 2008-11-12 Avecia Biolog Ltd Purification process
WO2010043701A1 (en) * 2008-10-17 2010-04-22 Dsm Ip Assets B.V. Clarification process
JP2012511929A (ja) 2008-12-16 2012-05-31 イー・エム・デイー・ミリポア・コーポレイシヨン 攪拌タンク反応器及び方法
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN102869767B (zh) * 2010-02-01 2016-03-09 迪格纳生物技术公司 干扰素α5的制备方法
MX2012009267A (es) * 2010-02-12 2013-02-07 Leti Sl Lab Proceso para producir un extracto alergenico.
WO2011110598A1 (en) * 2010-03-10 2011-09-15 F. Hoffmann-La Roche Ag Method for purifying immunoglobulin solutions
JO3131B1 (ar) 2010-04-27 2017-09-20 Glaxosmithkline Llc مركبات كيميائية
WO2011146394A1 (en) 2010-05-17 2011-11-24 Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
DE102011001743A1 (de) * 2011-04-01 2012-10-04 Technische Universität Dortmund Verfahren zur Trennung/Reinigung von Biomolekühlen
RU2654567C2 (ru) 2011-10-11 2018-05-21 Дженентек, Инк. Улучшенная сборка биспецифических антител
CN102443055B (zh) * 2011-10-26 2017-07-28 浙江海正药业股份有限公司 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺
WO2013180648A1 (en) 2012-05-31 2013-12-05 Agency For Science, Technology And Research Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations
CN102701501A (zh) * 2012-06-26 2012-10-03 天津市津华盛生物科技有限公司 工业乳酸链球菌素废水综合利用的方法
CN105026418B (zh) * 2013-02-06 2019-01-11 新加坡科技研究局 蛋白质纯化方法
WO2014133458A1 (en) * 2013-02-26 2014-09-04 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers and electropositive surfaces
CN105008384A (zh) * 2013-02-28 2015-10-28 新加坡科技研究局 在高电导率下在非离子性有机聚合物的存在下的蛋白质纯化
JP2016509068A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ クロマチン欠損細胞培養採取物からの抗体のクロマトグラフィー精製
EP2992021B1 (en) * 2013-04-30 2020-07-22 Intas Pharmaceuticals Limited Novel cloning, expression & purification method for the preparation of ranibizumab
DK3137483T3 (en) 2014-04-30 2019-04-23 Novozymes As Method of reducing the DNA content of a fermentation broth
CN116637177A (zh) 2016-11-11 2023-08-25 好利恩治疗美国公司 泼尼松和尿酸酶分子的组合疗法及其用途
CN108333263A (zh) * 2017-01-20 2018-07-27 北京蛋白质组研究中心 一种尿蛋白制备方法及尿蛋白质组的检测方法
TW201927335A (zh) * 2017-10-02 2019-07-16 美商拜耳保健有限責任公司 防止雙硫鍵於細胞培養收集物中還原之方法
MX2020006639A (es) * 2017-12-22 2020-09-14 Regeneron Pharma Sistema y metodo para caracterizar las impurezas de un producto farmaceutico.
CN111363024A (zh) * 2018-12-26 2020-07-03 深圳翰宇药业股份有限公司 多肽的纯化方法
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
EP3980349A4 (en) * 2019-06-05 2023-07-12 Viome Life Sciences, Inc. SAMPLE COLLECTION METHODS AND DEVICES
WO2021211493A1 (en) 2020-04-15 2021-10-21 Genentech, Inc. Copper loss mitigation
CN112708566A (zh) * 2021-01-25 2021-04-27 西南林业大学 一种黑曲霉生产胞外多聚物的优化培养基及培养方法
CN114774500A (zh) * 2022-04-26 2022-07-22 成都蜀星饲料有限公司 多肽及制备方法、有机复合微量元素及制备方法
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL34079A (en) * 1969-04-01 1973-02-28 Upjohn Co Purification of ypsilon-globulins
US3607857A (en) * 1970-03-03 1971-09-21 Upjohn Co Process of removing acrinol from gamma globulin using siliceous material such as silica gel
US3903254A (en) * 1971-07-23 1975-09-02 Upjohn Co Separation of erythrocyte stroma from lysing medium and hemoglobin with acrinol
DE2308013A1 (de) * 1973-02-17 1974-09-12 Behringwerke Ag Katalasearme glucoseoxidase und verfahren zu ihrer gewinnung
JPS519035B2 (https=) * 1973-10-31 1976-03-23
SU944580A1 (ru) 1980-02-07 1982-07-23 Кировский научно-исследовательский институт переливания крови Способ получени поверхностного антигена гепатита В
US4563303A (en) * 1984-04-14 1986-01-07 Judicial Foundation The Chemosero-Therapeutic Research Institute Method for purification of filamentous hemagglutinin
JPS60258127A (ja) * 1984-06-04 1985-12-20 Green Cross Corp:The Ｂ型肝炎ワクチンの製造方法
EP0226639B1 (en) * 1985-05-29 1990-11-14 The Green Cross Corporation Process for preparing heterogenic protein
EP0227833B1 (en) * 1985-07-16 1991-01-16 Green Cross Corporation Process for preparing hetero-protein
DE3604947A1 (de) 1986-02-17 1987-08-20 Biotest Pharma Gmbh Verfahren zur herstellung eines immunglobulinhaltigen praeparates und dessen verwendung zur prophylaxe und therapie von aids
FR2600078B1 (fr) 1986-06-12 1989-07-13 Merieux Inst Procede de preparation de facteur xiii a partir du placenta
DE3929504A1 (de) * 1989-09-06 1991-03-07 Behringwerke Ag Verfahren zur reinigung von plasminogen-aktivator-inhibitor 2 (pai-2)
DE4030264A1 (de) * 1990-09-25 1992-04-23 Hoechst Ag Verfahren zur herstellung gereinigter glycolipide durch membrantrennverfahren
GB9215540D0 (en) 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
US5861263A (en) * 1992-10-20 1999-01-19 Universidad Autonoma De Nuevo Leon Preparation of preserved entamoeba histolytica antigens without enzymatic inhibitors and their use in immunological methods
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5760189A (en) 1995-06-02 1998-06-02 Genetics Institute, Inc. Protein recovery & purification methods
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
CA2289665C (en) 1997-06-13 2005-08-09 Genentech, Inc. Protein recovery by chromatography followed by filtration upon a charged layer
JPH11341947A (ja) * 1998-06-02 1999-12-14 Yakult Honsha Co Ltd 発酵管理方法
US6156514A (en) * 1998-12-03 2000-12-05 Sunol Molecular Corporation Methods for making recombinant cells
EP1252181B1 (en) * 2000-01-20 2006-01-18 Regents Of The University Of Minnesota Peptides with antibacterial activity

Also Published As

Publication number Publication date
PL377653A1 (pl) 2006-02-06
MXPA05007378A (es) 2005-11-23
RU2337968C2 (ru) 2008-11-10
DE602004006831D1 (de) 2007-07-19
NZ540895A (en) 2007-03-30
ES2287687T3 (es) 2007-12-16
US7579448B2 (en) 2009-08-25
KR20050095605A (ko) 2005-09-29
BRPI0406470A (pt) 2005-12-06
CA2511946A1 (en) 2004-10-28
DK1581644T3 (da) 2007-10-08
ZA200504990B (en) 2006-08-30
RU2005125210A (ru) 2006-01-10
DE602004006831T2 (de) 2008-02-14
EP1581644A1 (en) 2005-10-05
WO2004092393A1 (en) 2004-10-28
JP2006517415A (ja) 2006-07-27
CN100467611C (zh) 2009-03-11
AU2004230670B2 (en) 2010-11-25
CN1759186A (zh) 2006-04-12
US20050037456A1 (en) 2005-02-17
AU2004230670A1 (en) 2004-10-28
US20070077625A1 (en) 2007-04-05
EP1581644B1 (en) 2007-06-06
US7169908B2 (en) 2007-01-30

Similar Documents

Publication Publication Date Title
ATE364092T1 (de) Reinigung von polypeptiden
ATE414162T1 (de) Verfahren und materialien zur herstellung von glucosamin
ATE374828T1 (de) Expressionsvektor zur antibiotikafreien expression
CY1108571T1 (el) Διεργασια για την παραγωγη και τον καθαρισμο ερυθροποιητινης
ATE323759T1 (de) Rückgewinnung eines proteins bei hohem ph-wert
DE50306845D1 (de) Disubstituierte thiazolylcarboxanilide und ihre verwendung als mikrobizide
BR0108711A (pt) Expressão heteróloga de proteìnas de neisseria
EP1236754A3 (en) Polyhydroxyalkanoate and method of producing same, and omega-(2-thienylsulfanyl) alkanoic acid and method of producing same
KR840002031A (ko) Dna, 재조합 dna, 이들을 갖는 숙주 및 폴리펩타이드를 제조하는 방법
PL1675956T3 (pl) Minimalna sekwencja DNA działająca jako insulator chromatyny i jej zastosowanie do wyrażania białek
ATE512230T1 (de) Proteinherstellungsverfahren unter nutzung von yebf
IN187721B (https=)
WO2000056903A3 (en) IMPROVED METHODS FOR PRODUCING PROTEINS IN TRANSFORMED $i(PICHIA)
Xiao et al. Fermentation of feathers with Bacillus sp. TC5 to simultaneous obtain keratinase and antioxidant-rich peptide products
EP1277831A3 (de) Verfahren und Vorrichtung zur Ernte mikrobieller Biomasse aus einem Kultivationssystem
ATE278781T1 (de) Tioredioxine h aus zwig und hart-weizen und ähnliche proteine, diese kodierende dna-fragmente und verfahren zu ihrer herstellung
ATE420161T1 (de) Monopropylenglykol als fermentationszusatz
KR927003623A (ko) 변성단백질의 활성회복 방법
SE9904247D0 (sv) Compositions and methods utilizing sequences for controlling nucleic acid expression in yeast
Payne et al. Peptidic Aldehydes Based on a-and ß-Amino Acids: Synthesis, Inhibition of m-Calpain, and Anti-Cataract Properties
ATE346921T1 (de) Menschliches, durch kalzium aktivierbares kaliumkanalpolypeptid aus leukozyten
Paberit et al. Isolation and properties of neutral metalloprotease from thermophilic bacteria Bacillus brevis.
ATE235509T1 (de) Peptide zur inhibition von hpv e7 proteinen
LEE et al. Removal of chromate by white rot fungus, Inonotus cuticularis
Cleveland JBC Centennial

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1581644

Country of ref document: EP