ATE420161T1 - Monopropylenglykol als fermentationszusatz - Google Patents

Monopropylenglykol als fermentationszusatz

Info

Publication number
ATE420161T1
ATE420161T1 AT03761447T AT03761447T ATE420161T1 AT E420161 T1 ATE420161 T1 AT E420161T1 AT 03761447 T AT03761447 T AT 03761447T AT 03761447 T AT03761447 T AT 03761447T AT E420161 T1 ATE420161 T1 AT E420161T1
Authority
AT
Austria
Prior art keywords
sub
monopropylene glycol
fermentation additive
fermentation
additive
Prior art date
Application number
AT03761447T
Other languages
English (en)
Inventor
Svend Kaasgaard
Niels Banke
Kim Hansen
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE420161T1 publication Critical patent/ATE420161T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2405—Glucanases
    • C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
    • C12N9/2411—Amylases
    • C12N9/2414—Alpha-amylase (3.2.1.1.)
    • C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Processing Of Solid Wastes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03761447T 2002-07-01 2003-07-01 Monopropylenglykol als fermentationszusatz ATE420161T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200201021 2002-07-01

Publications (1)

Publication Number Publication Date
ATE420161T1 true ATE420161T1 (de) 2009-01-15

Family

ID=29797022

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03761447T ATE420161T1 (de) 2002-07-01 2003-07-01 Monopropylenglykol als fermentationszusatz

Country Status (8)

Country Link
US (1) US20060127974A1 (de)
EP (1) EP1520012B1 (de)
CN (1) CN100529066C (de)
AT (1) ATE420161T1 (de)
AU (1) AU2003243925A1 (de)
DE (1) DE60325731D1 (de)
DK (1) DK1520012T3 (de)
WO (1) WO2004003187A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006136164A1 (en) * 2005-06-24 2006-12-28 Novozymes A/S Mutant cells suitable for recombinant polypeptide production
CN100999742B (zh) * 2007-01-09 2011-05-11 清华大学 一种发酵生产1，3-丙二醇的高产工艺
JP2011523562A (ja) 2008-06-09 2011-08-18 ダニスコ・ユーエス・インク 発酵培養液からの不溶性酵素の回収及び不溶性酵素の製剤
CN104480152B (zh) * 2014-11-20 2017-09-01 武汉华士特工业生物技术开发有限公司 一种提高裂殖壶菌油脂中二十二碳六烯酸含量的方法
CA3083390A1 (en) * 2017-11-29 2019-06-06 Basf Se Storage-stable enzyme preparations, their production and use
DK3983425T3 (da) 2019-06-13 2025-12-15 Basf Se Fremgangsmåde til udvinding af et protein fra en fermenteringsbouillon ved hjælp af en divalent kation

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3111459A (en) * 1959-10-19 1963-11-19 Ajinomoto Kk Method for preparation of inosine
US3222257A (en) * 1961-04-19 1965-12-07 Ajinomoto Kk Process for producing nucleosides by microorganisms
GB1001173A (en) * 1962-10-22 1965-08-11 Miles Lab Process for the production of galactose oxidase
GB1296839A (de) 1969-05-29 1972-11-22
GB1372034A (en) 1970-12-31 1974-10-30 Unilever Ltd Detergent compositions
US3951937A (en) * 1973-12-20 1976-04-20 The Community Blood Council Of Greater New York, Inc. Large scale purification of hepatitis type B antigen using polyethylene glycol
DE2512735A1 (de) * 1975-03-22 1976-09-30 Henkel & Cie Gmbh Verfahren zur gewinnung von proteinen aus waessrigen protein- loesungen
US4069216A (en) * 1975-06-16 1978-01-17 Edward Shanbrom, Inc. Simplified methods for preparation of very high purity Factor VIII concentrate
JPS5953038B2 (ja) * 1979-04-07 1984-12-22 メルシャン株式会社 サイクロデキストリンの製造法
DD153495A3 (de) * 1979-07-03 1982-01-13 Petrolchemisches Kombinat Hilfsstoffkombination zur verbesserung mikrobiologischer verfahren
DK187280A (da) 1980-04-30 1981-10-31 Novo Industri As Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode
JPS6030682A (ja) * 1983-07-30 1985-02-16 Amano Pharmaceut Co Ltd β−アミラ−ゼの製造法
US4588691A (en) * 1984-02-29 1986-05-13 Johal Sarjit S Method for preparation of Fraction I protein and by-products thereof
US4673647A (en) * 1985-05-06 1987-06-16 Miles Laboratories, Inc. Process to solubilize enzymes and an enzyme liquid product produced thereby
US4933287A (en) 1985-08-09 1990-06-12 Gist-Brocades N.V. Novel lipolytic enzymes and their use in detergent compositions
US4728613A (en) * 1985-09-04 1988-03-01 Miles Laboratories, Inc. Method for the recovery of extracellular enzymes from whole fermentation beer
ATE110768T1 (de) 1986-08-29 1994-09-15 Novo Nordisk As Enzymhaltiger reinigungsmittelzusatz.
NZ221627A (en) 1986-09-09 1993-04-28 Genencor Inc Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios
DE3854249T2 (de) 1987-08-28 1996-02-29 Novonordisk As Rekombinante Humicola-Lipase und Verfahren zur Herstellung von rekombinanten Humicola-Lipasen.
JPS6474992A (en) 1987-09-16 1989-03-20 Fuji Oil Co Ltd Dna sequence, plasmid and production of lipase
DE68924654T2 (de) 1988-01-07 1996-04-04 Novonordisk As Spezifische Protease.
DK6488D0 (da) 1988-01-07 1988-01-07 Novo Industri As Enzymer
CH667673A5 (en) * 1988-01-22 1988-10-31 Eidgenoess Tech Hochschule Prodn. of fermentation broth with lignolytic activity - by growing fungi under nutrient limited conditions in stirred reactor and in presence of cell wall stabiliser
JP3079276B2 (ja) 1988-02-28 2000-08-21 天野製薬株式会社 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
DE68911131T2 (de) 1988-03-24 1994-03-31 Novonordisk As Cellulosezubereitung.
US5776757A (en) 1988-03-24 1998-07-07 Novo Nordisk A/S Fungal cellulase composition containing alkaline CMC-endoglucanase and essentially no cellobiohydrolase and method of making thereof
US5260202A (en) * 1988-09-07 1993-11-09 Delta Biotechnology Limited Fermentation method
GB8915658D0 (en) 1989-07-07 1989-08-23 Unilever Plc Enzymes,their production and use
DE4111321A1 (de) 1990-04-14 1991-10-17 Kali Chemie Ag Alkalische bacillus-lipasen, hierfuer codierende dna-sequenzen sowie bacilli, die diese lipasen produzieren
DK115890D0 (da) 1990-05-09 1990-05-09 Novo Nordisk As Enzym
DE69107455T3 (de) 1990-05-09 2004-09-23 Novozymes A/S Eine ein endoglucanase enzym enthaltende zellulasezubereitung.
WO1992005249A1 (en) 1990-09-13 1992-04-02 Novo Nordisk A/S Lipase variants
ATE219136T1 (de) 1991-01-16 2002-06-15 Procter & Gamble Kompakte waschmittelzusammensetzungen mit hochaktiven cellulasen
US5858757A (en) 1991-05-01 1999-01-12 Novo Nordisk A/S Stabilized enzymes and detergent compositions
US5371198A (en) * 1991-12-16 1994-12-06 Novo Nordisk A/S Method for protection of proteolysis-susceptible protein during protein production in a fluid medium
EP0571014B1 (de) * 1992-05-18 2004-03-31 Genencor International, Inc. Alkalische Proteasen produzierende Bakterien, und Verfahren zur Herstellung dieser alkalischen Proteasen
DK88892D0 (da) 1992-07-06 1992-07-06 Novo Nordisk As Forbindelse
EP0651794B1 (de) 1992-07-23 2009-09-30 Novozymes A/S MUTIERTE -g(a)-AMYLASE, WASCHMITTEL UND GESCHIRRSPÜLMITTEL
JP3254457B2 (ja) * 1992-09-18 2002-02-04 株式会社日立製作所 無給油式スクリュー圧縮機のロータ形成方法およびそのロータを用いた無給油式スクリュー圧縮機
JP3681750B2 (ja) 1992-10-06 2005-08-10 ノボザイムス アクティーゼルスカブ セルラーゼ変異体
JPH08506491A (ja) 1993-02-11 1996-07-16 ジェネンカー インターナショナル，インコーポレイティド 酸化安定性アルファ−アミラーゼ
KR950702240A (ko) 1993-04-27 1995-06-19 한스 발터 라벤 세제로의 이용을 위한 새로운 리파제 변형체
DK52393D0 (de) 1993-05-05 1993-05-05 Novo Nordisk As
US5443981A (en) * 1993-06-09 1995-08-22 Rutgers, The State University Acremonium typhinum ATCC 74228 which exhibits endoproteolytic activity
JP2859520B2 (ja) 1993-08-30 1999-02-17 ノボ ノルディスク アクティーゼルスカブ リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物
JPH07143883A (ja) 1993-11-24 1995-06-06 Showa Denko Kk リパーゼ遺伝子及び変異体リパーゼ
JP3553958B2 (ja) 1994-02-22 2004-08-11 ノボザイムス アクティーゼルスカブ 脂質分解酵素の変異体の製造方法
DK1632557T3 (da) 1994-03-08 2011-05-16 Novozymes As Hidtil ukendte alkaliske cellulaser
ATE510010T1 (de) 1994-03-29 2011-06-15 Novozymes As Alkaline amylase aus bacillus
WO1995030744A2 (en) 1994-05-04 1995-11-16 Genencor International Inc. Lipases with improved surfactant resistance
AU2884595A (en) 1994-06-20 1996-01-15 Unilever Plc Modified pseudomonas lipases and their use
AU2884695A (en) 1994-06-23 1996-01-19 Unilever Plc Modified pseudomonas lipases and their use
US5919691A (en) 1994-10-06 1999-07-06 Novo Nordisk A/S Enzyme and enzyme preparation with endoglucanase activity
BE1008998A3 (fr) 1994-10-14 1996-10-01 Solvay Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci.
AU3697995A (en) 1994-10-26 1996-05-23 Novo Nordisk A/S An enzyme with lipolytic activity
AR000862A1 (es) 1995-02-03 1997-08-06 Novozymes As Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del
JPH08228778A (ja) 1995-02-27 1996-09-10 Showa Denko Kk 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法
CN101955921A (zh) 1995-03-17 2011-01-26 诺沃奇梅兹有限公司 新的内切葡聚糖酶
JP4307549B2 (ja) 1995-07-14 2009-08-05 ノボザイムス アクティーゼルスカブ 脂肪分解活性を有する修飾された酵素
WO1997007202A1 (en) 1995-08-11 1997-02-27 Novo Nordisk A/S Novel lipolytic enzymes
US5763385A (en) 1996-05-14 1998-06-09 Genencor International, Inc. Modified α-amylases having altered calcium binding properties
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
AU3938997A (en) 1996-08-26 1998-03-19 Novo Nordisk A/S A novel endoglucanase
DE69735767T2 (de) 1996-09-17 2007-04-05 Novozymes A/S Cellulasevarianten
BR9712473B1 (pt) 1996-11-04 2009-08-11 variantes de subtilase e composições.
ATE409743T1 (de) 1996-11-04 2008-10-15 Novozymes As Subtilase varianten und verbindungen
WO1998034946A1 (en) 1997-02-12 1998-08-13 Massachusetts Institute Of Technology Daxx, a novel fas-binding protein that activates jnk and apoptosis
WO1998037179A2 (en) 1997-02-20 1998-08-27 Dsm N.V. Fermentative production of valuable compounds on an industrial scale using chemically defined media
AU7908898A (en) 1997-07-04 1999-01-25 Novo Nordisk A/S Family 6 endo-1,4-beta-glucanase variants and cleaning composit ions containing them
CN101532001A (zh) 2000-03-08 2009-09-16 诺维信公司 具有改变的特性的变体
EP1417301B1 (de) * 2001-08-07 2006-11-02 Novozymes A/S Kohlhydrate und polyole zum lösen der proteinkristalle

Also Published As

Publication number Publication date
CN1665923A (zh) 2005-09-07
EP1520012A2 (de) 2005-04-06
AU2003243925A1 (en) 2004-01-19
EP1520012B1 (de) 2009-01-07
DE60325731D1 (en) 2009-02-26
DK1520012T3 (da) 2009-04-27
WO2004003187A2 (en) 2004-01-08
AU2003243925A8 (en) 2004-01-19
WO2004003187A3 (en) 2004-03-18
CN100529066C (zh) 2009-08-19
US20060127974A1 (en) 2006-06-15

Similar Documents

Publication Publication Date Title
DK1581644T3 (da) Oprensning af polypeptider
ATE323759T1 (de) Rückgewinnung eines proteins bei hohem ph-wert
ATE340857T1 (de) Verfahren zur herstellung von l-aminosäuren durch erhöhung des zellulären nadph
CA2405486A1 (fr) Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
DK1422237T3 (da) Fremgangsmåder til rekombinant frembringelse af antifusogene peptider
EA200100809A1 (ru) 2,3,4,5-тетрагидро-1h-[1,4]бензодиазепин-3-гидроксамовые кислоты как ингибиторы матриксных металлопротеиназ
DE60306667D1 (de) Cefdinir salze als zwischenprodukte
DK1077218T3 (da) Peptidomimetiske forbindelser omfattende RGD-sekvenser, som er nyttige som integrininhibitorer
CY1108804T1 (el) Μεθοδος παρασκευης της 4β-αμινο-4'-δεμεθυλ-4- δεσοξυποδοφυλλοτοξινης.
ATE420161T1 (de) Monopropylenglykol als fermentationszusatz
NO20002600D0 (no) Mellomprodukter og fremgangsmÕter for anvendelse ved semisyntesen av paclitaxel og analoger
ATE496907T1 (de) Verfahren zur herstellung von cilostazol
EP1262536A3 (de) Carbodiimidverbindung, enthaltend eine fluroreszente Gruppe und Verfahren zur Herstellung dieser Verbindung
EP1420029A3 (de) Verfahren für die Synthese von Perindopril und seiner pharmazeutisch annehmbaren Salzen
DE50311388D1 (de) Nicht-peptidische brs-3-agonisten
AU2002331306A1 (en) Carbohydrates and polyols for dissolving protein crystals
LU90993I2 (fr) Xigris-drotrécogine alfa(activée) et ses dérivés pharmaceutiquement acceptables
DK0710290T3 (da) Fremgangsmåde til præcipitering af naturlige avermectiner og fermentativ fremstilling af samme
WO2002033093A3 (en) Aggrecanase molecules
BRPI0409737A (pt) tratamento de pigmentos de alto desempenho, composição do mesmo; sal de fórmula; processo de sintetização e método de obtenção
Jeyaraj et al. Synthesis of nucleopeptides by an enzyme labile urethane protecting group
EA200401358A1 (ru) 2,5-бис-диамин-[1,4]бензохиноновые производные для лечения болезни альцгеймера, способ их получения и промежуточные продукты
WO2002034895A3 (en) Novel aggrecanase molecules
DE602004018276D1 (de) Nitratester von phenylaminothiophen-essigsäurederivaten
SG145574A1 (en) Intermediates useful in the synthesis of hiv-protease inhibitors and methods for preparing the same

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties