EA200401358A1 - 2,5-бис-диамин-[1,4]бензохиноновые производные для лечения болезни альцгеймера, способ их получения и промежуточные продукты - Google Patents

2,5-бис-диамин-[1,4]бензохиноновые производные для лечения болезни альцгеймера, способ их получения и промежуточные продукты

Info

Publication number
EA200401358A1
EA200401358A1 EA200401358A EA200401358A EA200401358A1 EA 200401358 A1 EA200401358 A1 EA 200401358A1 EA 200401358 A EA200401358 A EA 200401358A EA 200401358 A EA200401358 A EA 200401358A EA 200401358 A1 EA200401358 A1 EA 200401358A1
Authority
EA
Eurasian Patent Office
Prior art keywords
bis
disease
treatment
derivatives
petrochinone
Prior art date
Application number
EA200401358A
Other languages
English (en)
Other versions
EA007909B1 (ru
Inventor
Винченца Андризано
Мануэла Бартолини
Мария Лаура Болоньези
Андреа Кавалли
Карло Мелькиорре
Маурицио Реканатини
Original Assignee
Альма Матер Студиорум - Университа' Ди Болонья
Лей Лайн Дженомикс С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Альма Матер Студиорум - Университа' Ди Болонья, Лей Лайн Дженомикс С. П. А. filed Critical Альма Матер Студиорум - Университа' Ди Болонья
Publication of EA200401358A1 publication Critical patent/EA200401358A1/ru
Publication of EA007909B1 publication Critical patent/EA007909B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/24—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings
    • C07C225/26—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings
    • C07C225/28—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones the carbon skeleton containing carbon atoms of quinone rings having amino groups bound to carbon atoms of quinone rings or of condensed ring systems containing quinone rings of non-condensed quinone rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

2,5-бис-Диамин-[1,4]бензохиноновые производные, имеющие общую формулу (I), имеют доказанную полезность для лечения болезни Альцгеймера; способ получения их и промежуточных продуктов, используемых в указанном способе также описаны.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401358A 2002-04-12 2003-04-11 2,5-бис-диамин-[1,4] бензохиноновые производные для лечения болезни альцгеймера, способ их получения и промежуточные продукты EA007909B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2002BO000198A ITBO20020198A1 (it) 2002-04-12 2002-04-12 Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed
PCT/IT2003/000227 WO2003087035A1 (en) 2002-04-12 2003-04-11 2,5-bis-diamine-'1,4! benzoquinone derivatives for the treatment of alzheimer's disease a process for their preparation and intermediates therefor

Publications (2)

Publication Number Publication Date
EA200401358A1 true EA200401358A1 (ru) 2005-06-30
EA007909B1 EA007909B1 (ru) 2007-02-27

Family

ID=11440044

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401358A EA007909B1 (ru) 2002-04-12 2003-04-11 2,5-бис-диамин-[1,4] бензохиноновые производные для лечения болезни альцгеймера, способ их получения и промежуточные продукты

Country Status (9)

Country Link
US (1) US7589219B2 (ru)
EP (1) EP1497257A1 (ru)
JP (1) JP2005522502A (ru)
CN (1) CN100358862C (ru)
AU (1) AU2003224449B8 (ru)
CA (1) CA2482391A1 (ru)
EA (1) EA007909B1 (ru)
IT (1) ITBO20020198A1 (ru)
WO (1) WO2003087035A1 (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101146800A (zh) 2005-01-27 2008-03-19 生物工程大学精神物质实验室 用于治疗阿尔茨海默病的有机化合物，它们的用途和制备方法
US20090093521A1 (en) * 2005-06-14 2009-04-09 Maria Laura Bolognesi 2, 5-Bis-Diamine [1,4] Benzoquinone-Derivatives
ITBO20070618A1 (it) * 2007-09-12 2009-03-13 Univ Bologna Alma Mater Composti organici utili per il trattamento di malattie neurodegenerative, loro utilizzazioni e metodo per la loro preparazione

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2317757A (en) * 1940-04-12 1943-04-27 Graf Roderich Alkylene-polyamines and a process of preparing them
US2813904A (en) * 1955-05-12 1957-11-19 Olin Mathieson Acid-addition quaternary salts and methods of preparing same
US2844585A (en) 1955-12-21 1958-07-22 Sterling Drug Inc Quaternary ammonium alkylamino-benzoquinones
DE2515146A1 (de) * 1975-04-08 1976-10-21 Bayer Ag Carbonsaeureamide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
US5459255A (en) * 1990-01-11 1995-10-17 Isis Pharmaceuticals, Inc. N-2 substituted purines
US5189088A (en) 1992-03-30 1993-02-23 Eastman Kodak Company Bis(phenolic-amine)quinone compounds and polyolefin compositions stabilized therewith
US5736539A (en) * 1993-06-18 1998-04-07 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
JPH08193026A (ja) 1995-01-12 1996-07-30 Teijin Ltd アミロイドβ蛋白凝集・沈着阻害剤
AU700635B2 (en) * 1995-07-28 1999-01-07 Dainippon Pharmaceutical Co. Ltd. (R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6-Y L)-2-methoxy-6-methylamino-3-pyridinecarboxamide, process for preparation thereof and pharmaceutical composition containing said compound.
DE19824865A1 (de) * 1997-08-27 1999-03-04 Solvay Pharm Gmbh Neue Harnstoffderivate
WO2001005783A1 (en) * 1999-07-15 2001-01-25 Pharmacopeia, Inc. Bradykinin b1 receptor antagonists
UA75054C2 (ru) * 1999-10-13 2006-03-15 Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг Замещенные в положении 6 индолиноны, их получение и их применение как лекарственного средства
WO2002000631A2 (en) * 2000-06-29 2002-01-03 Fujisawa Pharmaceutical Co., Ltd. Benzhydryl derivatives

Also Published As

Publication number Publication date
EP1497257A1 (en) 2005-01-19
WO2003087035A1 (en) 2003-10-23
AU2003224449B8 (en) 2009-03-05
ITBO20020198A0 (it) 2002-04-12
AU2003224449A1 (en) 2003-10-27
WO2003087035A8 (en) 2004-01-08
CA2482391A1 (en) 2003-10-23
US20050261345A1 (en) 2005-11-24
EA007909B1 (ru) 2007-02-27
JP2005522502A (ja) 2005-07-28
CN1659133A (zh) 2005-08-24
US7589219B2 (en) 2009-09-15
CN100358862C (zh) 2008-01-02
AU2003224449B2 (en) 2009-02-12
ITBO20020198A1 (it) 2003-10-13

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU