JP2006517415A - ポリペプチドの精製 - Google Patents

ポリペプチドの精製 Download PDF

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Publication number
JP2006517415A
JP2006517415A JP2006508590A JP2006508590A JP2006517415A JP 2006517415 A JP2006517415 A JP 2006517415A JP 2006508590 A JP2006508590 A JP 2006508590A JP 2006508590 A JP2006508590 A JP 2006508590A JP 2006517415 A JP2006517415 A JP 2006517415A
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JP
Japan
Prior art keywords
polypeptide
homogenate
lactate
broth
antibody
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JP2006508590A
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English (en)
Japanese (ja)
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JP2006517415A5 (https=
Inventor
レスター，フィリップ，エム．
パーソン，ジョセフィン
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Genentech Inc
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2006517415A publication Critical patent/JP2006517415A/ja
Publication of JP2006517415A5 publication Critical patent/JP2006517415A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006508590A 2003-01-09 2004-01-08 ポリペプチドの精製 Withdrawn JP2006517415A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43941803P 2003-01-09 2003-01-09
PCT/US2004/000499 WO2004092393A1 (en) 2003-01-09 2004-01-08 Purification of polypeptides

Publications (2)

Publication Number Publication Date
JP2006517415A true JP2006517415A (ja) 2006-07-27
JP2006517415A5 JP2006517415A5 (https=) 2006-11-16

Family

ID=33299572

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006508590A Withdrawn JP2006517415A (ja) 2003-01-09 2004-01-08 ポリペプチドの精製

Country Status (18)

Country Link
US (2) US7169908B2 (https=)
EP (1) EP1581644B1 (https=)
JP (1) JP2006517415A (https=)
KR (1) KR20050095605A (https=)
CN (1) CN100467611C (https=)
AT (1) ATE364092T1 (https=)
AU (1) AU2004230670B2 (https=)
BR (1) BRPI0406470A (https=)
CA (1) CA2511946A1 (https=)
DE (1) DE602004006831T2 (https=)
DK (1) DK1581644T3 (https=)
ES (1) ES2287687T3 (https=)
MX (1) MXPA05007378A (https=)
NZ (1) NZ540895A (https=)
PL (1) PL377653A1 (https=)
RU (1) RU2337968C2 (https=)
WO (1) WO2004092393A1 (https=)
ZA (1) ZA200504990B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
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JP2012504586A (ja) * 2008-10-06 2012-02-23 フジフィルム・ダイオシンス・バイオテクノロジーズ ・ユーケイ・リミテッド 断片抗体のための精製方法
JP2015525213A (ja) * 2012-05-31 2015-09-03 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
JP2016506953A (ja) * 2013-02-06 2016-03-07 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ タンパク質精製方法
JP2016507588A (ja) * 2013-02-26 2016-03-10 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマーおよび電気陽性表面の存在下でのタンパク質精製
JP2016509069A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマー存在下、高導電率でのタンパク質精製
JP2016509068A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ クロマチン欠損細胞培養採取物からの抗体のクロマトグラフィー精製

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TWI418564B (zh) * 2005-04-11 2013-12-11 Savient Pharmaceuticals Inc 利用陽離子界面活性劑之蛋白質純化
SG161247A1 (en) 2005-04-11 2010-05-27 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
JP5033177B2 (ja) * 2006-04-12 2012-09-26 サビエント ファーマセウティカルズ インク． 陽イオン界面活性剤によるタンパク質の精製
FR2902799B1 (fr) 2006-06-27 2012-10-26 Millipore Corp Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
AR062069A1 (es) 2006-07-14 2008-10-15 Genentech Inc Replegado de proteinas recombinantes
US8362217B2 (en) 2006-12-21 2013-01-29 Emd Millipore Corporation Purification of proteins
US8569464B2 (en) 2006-12-21 2013-10-29 Emd Millipore Corporation Purification of proteins
WO2008079302A2 (en) * 2006-12-21 2008-07-03 Millipore Corporation Purification of proteins
WO2008140615A2 (en) * 2006-12-21 2008-11-20 Novozymes, Inc. Modified messenger rna stabilizing sequences for expressing genes in bacterial cells
RU2474585C2 (ru) * 2007-01-22 2013-02-10 Дженентек, Инк. Осаждение и очистка белков полиэлектролитами
KR102055873B1 (ko) 2007-07-09 2019-12-13 제넨테크, 인크. 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지
US7887821B2 (en) * 2007-12-20 2011-02-15 Alk-Abello A/S Process for producing an allergen extract
US8999702B2 (en) 2008-06-11 2015-04-07 Emd Millipore Corporation Stirred tank bioreactor
WO2010043701A1 (en) * 2008-10-17 2010-04-22 Dsm Ip Assets B.V. Clarification process
JP2012511929A (ja) 2008-12-16 2012-05-31 イー・エム・デイー・ミリポア・コーポレイシヨン 攪拌タンク反応器及び方法
US9377454B2 (en) 2009-06-25 2016-06-28 Crealta Pharmaceuticals Llc Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
CN102869767B (zh) * 2010-02-01 2016-03-09 迪格纳生物技术公司 干扰素α5的制备方法
MX2012009267A (es) * 2010-02-12 2013-02-07 Leti Sl Lab Proceso para producir un extracto alergenico.
WO2011110598A1 (en) * 2010-03-10 2011-09-15 F. Hoffmann-La Roche Ag Method for purifying immunoglobulin solutions
JO3131B1 (ar) 2010-04-27 2017-09-20 Glaxosmithkline Llc مركبات كيميائية
WO2011146394A1 (en) 2010-05-17 2011-11-24 Millipore Corporation Stimulus responsive polymers for the purification of biomolecules
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
DE102011001743A1 (de) * 2011-04-01 2012-10-04 Technische Universität Dortmund Verfahren zur Trennung/Reinigung von Biomolekühlen
RU2654567C2 (ru) 2011-10-11 2018-05-21 Дженентек, Инк. Улучшенная сборка биспецифических антител
CN102443055B (zh) * 2011-10-26 2017-07-28 浙江海正药业股份有限公司 一种重组人肿瘤坏死因子相关凋亡诱导配体的纯化工艺
CN102701501A (zh) * 2012-06-26 2012-10-03 天津市津华盛生物科技有限公司 工业乳酸链球菌素废水综合利用的方法
EP2992021B1 (en) * 2013-04-30 2020-07-22 Intas Pharmaceuticals Limited Novel cloning, expression & purification method for the preparation of ranibizumab
DK3137483T3 (en) 2014-04-30 2019-04-23 Novozymes As Method of reducing the DNA content of a fermentation broth
CN116637177A (zh) 2016-11-11 2023-08-25 好利恩治疗美国公司 泼尼松和尿酸酶分子的组合疗法及其用途
CN108333263A (zh) * 2017-01-20 2018-07-27 北京蛋白质组研究中心 一种尿蛋白制备方法及尿蛋白质组的检测方法
TW201927335A (zh) * 2017-10-02 2019-07-16 美商拜耳保健有限責任公司 防止雙硫鍵於細胞培養收集物中還原之方法
MX2020006639A (es) * 2017-12-22 2020-09-14 Regeneron Pharma Sistema y metodo para caracterizar las impurezas de un producto farmaceutico.
CN111363024A (zh) * 2018-12-26 2020-07-03 深圳翰宇药业股份有限公司 多肽的纯化方法
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
EP3980349A4 (en) * 2019-06-05 2023-07-12 Viome Life Sciences, Inc. SAMPLE COLLECTION METHODS AND DEVICES
WO2021211493A1 (en) 2020-04-15 2021-10-21 Genentech, Inc. Copper loss mitigation
CN112708566A (zh) * 2021-01-25 2021-04-27 西南林业大学 一种黑曲霉生产胞外多聚物的优化培养基及培养方法
CN114774500A (zh) * 2022-04-26 2022-07-22 成都蜀星饲料有限公司 多肽及制备方法、有机复合微量元素及制备方法
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Citations (1)

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JPS5515444B1 (https=) * 1969-04-01 1980-04-23

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012504586A (ja) * 2008-10-06 2012-02-23 フジフィルム・ダイオシンス・バイオテクノロジーズ ・ユーケイ・リミテッド 断片抗体のための精製方法
JP2015525213A (ja) * 2012-05-31 2015-09-03 エイジェンシー フォー サイエンス，テクノロジー アンド リサーチ タンパク質製剤中の凝集物含量を低減するために混合型多官能表面を使用する方法
US9920125B2 (en) 2012-05-31 2018-03-20 Agency For Science, Technology And Research Methods for use of mixed multifunctional surfaces for reducing aggregate content in protein preparations
JP2016506953A (ja) * 2013-02-06 2016-03-07 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ タンパク質精製方法
JP2016507588A (ja) * 2013-02-26 2016-03-10 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマーおよび電気陽性表面の存在下でのタンパク質精製
US10112971B2 (en) 2013-02-26 2018-10-30 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers and electropositive surfaces
JP2016509069A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ 非イオン性有機ポリマー存在下、高導電率でのタンパク質精製
JP2016509068A (ja) * 2013-02-28 2016-03-24 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ クロマチン欠損細胞培養採取物からの抗体のクロマトグラフィー精製
US10253063B2 (en) 2013-02-28 2019-04-09 Agency For Science, Technology And Research Protein purification in the presence of nonionic organic polymers at elevated conductivity

Also Published As

Publication number Publication date
PL377653A1 (pl) 2006-02-06
MXPA05007378A (es) 2005-11-23
RU2337968C2 (ru) 2008-11-10
DE602004006831D1 (de) 2007-07-19
NZ540895A (en) 2007-03-30
ES2287687T3 (es) 2007-12-16
US7579448B2 (en) 2009-08-25
KR20050095605A (ko) 2005-09-29
BRPI0406470A (pt) 2005-12-06
CA2511946A1 (en) 2004-10-28
DK1581644T3 (da) 2007-10-08
ATE364092T1 (de) 2007-06-15
ZA200504990B (en) 2006-08-30
RU2005125210A (ru) 2006-01-10
DE602004006831T2 (de) 2008-02-14
EP1581644A1 (en) 2005-10-05
WO2004092393A1 (en) 2004-10-28
CN100467611C (zh) 2009-03-11
AU2004230670B2 (en) 2010-11-25
CN1759186A (zh) 2006-04-12
US20050037456A1 (en) 2005-02-17
AU2004230670A1 (en) 2004-10-28
US20070077625A1 (en) 2007-04-05
EP1581644B1 (en) 2007-06-06
US7169908B2 (en) 2007-01-30

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