ATE23716T1 - 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate. - Google Patents
5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate.Info
- Publication number
- ATE23716T1 ATE23716T1 AT83100449T AT83100449T ATE23716T1 AT E23716 T1 ATE23716 T1 AT E23716T1 AT 83100449 T AT83100449 T AT 83100449T AT 83100449 T AT83100449 T AT 83100449T AT E23716 T1 ATE23716 T1 AT E23716T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- hydrogen
- trinor
- prostaglandin
- phenylene
- Prior art date
Links
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003435 aroyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 230000002959 anti-hypotensive effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
- C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
- C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57006150A JPS58124778A (ja) | 1982-01-20 | 1982-01-20 | ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体 |
| EP83100449A EP0084856B2 (en) | 1982-01-20 | 1983-01-19 | 5,6,7-Trinor-4, 8-inter-m-phenylene prostaglandin I2 derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE23716T1 true ATE23716T1 (de) | 1986-12-15 |
Family
ID=11630492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83100449T ATE23716T1 (de) | 1982-01-20 | 1983-01-19 | 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4474802A (OSRAM) |
| EP (1) | EP0084856B2 (OSRAM) |
| JP (1) | JPS58124778A (OSRAM) |
| AT (1) | ATE23716T1 (OSRAM) |
| AU (1) | AU556348B2 (OSRAM) |
| CA (1) | CA1226280A (OSRAM) |
| DE (1) | DE3367774D1 (OSRAM) |
| ZA (1) | ZA83328B (OSRAM) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3765646D1 (de) * | 1986-01-24 | 1990-11-29 | Toray Industries | 2,5,6,7-tetranor-4,8-inter-m-phenylen-pgi2-derivate. |
| US4880939A (en) * | 1986-12-11 | 1989-11-14 | Toray Industries | 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives |
| DE69008851T2 (de) * | 1989-02-27 | 1994-08-18 | Toray Industries | VERFAHREN ZUR HERSTELLUNG VON 5,6,7, -TRINOR- 4,8,-INTER-m-PHENYLEN PGI,2 Abkömmlingen. |
| CA2012081C (en) * | 1989-03-14 | 2000-08-29 | Shigeki Itou | 2,5,6,7-tetranor-4,8-inter-m-phenylene pgi 2 derivatives |
| JP2608135B2 (ja) * | 1989-03-31 | 1997-05-07 | 科研製薬株式会社 | 糖尿病性神経障害治療剤 |
| DE4104607A1 (de) * | 1991-02-12 | 1992-08-13 | Schering Ag | Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen |
| US5496850A (en) * | 1991-04-11 | 1996-03-05 | Toray Industries, Inc. | Antimetastasis agent of malignant tumors |
| JP3230246B2 (ja) * | 1991-04-11 | 2001-11-19 | 東レ株式会社 | 悪性腫瘍転移抑制剤 |
| US5233059A (en) * | 1991-07-25 | 1993-08-03 | Iowa State University Research Foundation, Inc. | Synthesis of benzoprostacyclins using palladium catalysis |
| US5169959A (en) * | 1991-09-23 | 1992-12-08 | Iowa State University Research Foundation, Inc. | Free radical-catalyzed synthesis of benzoprostacyclins |
| WO1993007876A1 (en) * | 1991-10-25 | 1993-04-29 | Toray Industries, Inc. | Remedy for hepatic disease |
| JP3102141B2 (ja) * | 1992-05-29 | 2000-10-23 | 東レ株式会社 | 養毛育毛剤 |
| EP0686036B1 (de) * | 1992-08-07 | 1997-03-12 | Schering Aktiengesellschaft | Verwendung von prostanderivaten zur herstellung eines arzneimittels zur behandlung der chronischen polyarthritis |
| DE4226615C1 (de) * | 1992-08-07 | 1994-05-19 | Schering Ag | Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis |
| DE69322496T2 (de) * | 1992-09-18 | 1999-05-06 | Toray Industries, Inc., Tokio/Tokyo | Sulfonsäure derivat und deren pharmazeutische verwendung |
| JPH07126161A (ja) * | 1993-10-29 | 1995-05-16 | Toray Ind Inc | 心不全治療剤 |
| JP3541417B2 (ja) * | 1994-02-24 | 2004-07-14 | 日産化学工業株式会社 | フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法 |
| FI962869A7 (fi) * | 1994-11-17 | 1996-09-16 | Toray Industries | Ihon läpi absorboituvissa oleva preparaatti |
| FI964303L (fi) * | 1995-02-27 | 1996-10-25 | Toray Industries | Keuhkosydänvian hoitamiseen tarkoitettu aine |
| CZ168896A3 (en) * | 1995-06-27 | 1997-01-15 | Egyt Gyogyszervegyeszeti Gyar | Oxaindene derivatives and process for preparing thereof |
| DE19530884C2 (de) * | 1995-08-11 | 1997-07-31 | Schering Ag | Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis |
| AU734650B2 (en) | 1996-05-07 | 2001-06-21 | Toray Industries, Inc. | Ophthalmic preparations |
| WO1998011899A1 (fr) * | 1996-09-17 | 1998-03-26 | Toray Industries, Inc. | Agent de potentialisation de la fonction plaquettaire et procede de traitement du dysfonctionnement plaquettaire |
| CA2253717A1 (en) * | 1997-02-27 | 1998-09-03 | Toray Industries Inc. | Drugs for ameliorating pulmonary circulation |
| CA2254925A1 (en) * | 1997-03-13 | 1998-09-17 | Shigeyasu Annoh | Drugs for relieving diabetic vascular lesion |
| PT947196E (pt) | 1997-03-14 | 2009-09-24 | Toray Industries | Preparação de derivado de prostaglandina i de libertação prolongada |
| US6653345B2 (en) | 1997-09-16 | 2003-11-25 | Toray Industries, Inc. | C-C chemokine synthesis inhibitor |
| AU742250B2 (en) | 1997-12-26 | 2001-12-20 | Astellas Pharma Inc. | Sustained release medicinal compositions |
| JP4019481B2 (ja) | 1998-01-23 | 2007-12-12 | ソニー株式会社 | 情報処理装置および方法、情報処理システム、並びに提供媒体 |
| WO2000009161A1 (fr) * | 1998-08-12 | 2000-02-24 | Toray Industries, Inc. | Agents qui regulent la production de l'inhibiteur 1 des activateurs du plasminogene |
| WO2000009135A1 (en) * | 1998-08-14 | 2000-02-24 | Toray Industries, Inc. | Peridermal cell protecting agents |
| US20030092760A1 (en) * | 2001-03-12 | 2003-05-15 | Toray Industries, Inc. | Therapeutic agent for renal failure |
| HU227157B1 (en) * | 2001-07-30 | 2010-09-28 | Chinoin Gyogyszer Es Vegyeszet | Production of beraprost ester by selective oxidation |
| JP3340732B1 (ja) * | 2001-10-05 | 2002-11-05 | 日本医薬品工業株式会社 | シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物 |
| GB0215757D0 (en) * | 2002-07-08 | 2002-08-14 | Cascade Biochem Ltd | Benzoprostacyclin intermediates methods for their preparation and products derived therefrom |
| US20060217421A1 (en) | 2003-05-09 | 2006-09-28 | Hajimu Kurumatani | Fortifier |
| AU2003243972A1 (en) * | 2003-06-25 | 2005-01-13 | Cardiovascular Institute, Ltd. | External preparation for improving coital function |
| CA2618708C (en) | 2005-07-08 | 2013-11-12 | Toray Industries, Inc. | Therapeutic agent and treatment method for ameliorating uremia |
| JP5424291B2 (ja) * | 2006-03-03 | 2014-02-26 | 独立行政法人国立循環器病研究センター | 骨髄細胞の動員剤および動員方法 |
| JP5271272B2 (ja) | 2006-11-16 | 2013-08-21 | ジェンムス ファーマ インコーポレイティド | Ａ型インフルエンザウィルス感染の治療のための薬剤としてのｅｐ２およびｅｐ４作動薬 |
| HUE047767T2 (hu) | 2008-08-13 | 2020-05-28 | Actelion Pharmaceuticals Ltd | Macitentánt tartalmazó terápiás készítmények |
| NZ599128A (en) | 2009-10-14 | 2014-02-28 | Gemmus Pharma Inc | Combination therapy treatment for viral infections |
| ES2525748T3 (es) | 2009-11-13 | 2014-12-29 | Toray Industries, Inc. | Agente terapéutico o profiláctico para la diabetes |
| ES2717226T3 (es) | 2011-06-16 | 2019-06-19 | Lung Biotechnology Inc | Método de producción de beraprost |
| CN103509044A (zh) * | 2012-06-21 | 2014-01-15 | 上海天伟生物制药有限公司 | 贝前列素钠中间体及其制备方法 |
| CN107802623B (zh) | 2012-07-19 | 2020-10-30 | 开曼化学股份有限公司 | 用于ep4介导的骨相关疾病和病症的二氟内酰胺组合物 |
| CN103242274B (zh) * | 2013-05-22 | 2014-11-05 | 孙威 | 一种贝前列素钠化合物及其制备方法 |
| US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
| KR101986966B1 (ko) | 2015-08-12 | 2019-06-07 | 유나이티드 쎄러퓨틱스 코포레이션 | 베라프로스트의 제조 방법 |
| CN106632372B (zh) * | 2016-09-26 | 2019-04-02 | 上海北卡医药技术有限公司 | 一种中间体及其制备方法和用途 |
| CN110381951A (zh) | 2016-12-14 | 2019-10-25 | 瑞必治公司 | 用于治疗肺性高血压和其他肺病症的方法及组合物 |
| CN107325122B (zh) * | 2017-01-06 | 2020-05-01 | 常州博海威医药科技股份有限公司 | 制备贝前列腺素的新中间体及其制备方法 |
| CN111093704A (zh) | 2017-07-27 | 2020-05-01 | 阿勒根公司 | 用于减少身体脂肪的前列环素受体激动剂 |
| CN109305986B (zh) * | 2018-11-13 | 2021-02-19 | 济南康和医药科技有限公司 | 一种贝前列素钠中间体的合成方法 |
| US10577340B1 (en) * | 2018-11-26 | 2020-03-03 | Chirogate International Inc. | Beraprost-314d crystals and methods for preparation thereof |
| EP3972599B1 (en) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| CN110746450A (zh) * | 2019-09-17 | 2020-02-04 | 济南康和医药科技有限公司 | 一种贝前列素钠关键中间体的合成方法 |
| CN112569181B (zh) * | 2019-09-27 | 2023-03-21 | 中国科学院上海高等研究院 | 一种快速增溶肾上腺素的方法 |
| CA3167058A1 (en) | 2020-02-12 | 2021-08-19 | Cytoagents, Inc. | Compositions and methods for treating coronavirus infections |
| TW202317089A (zh) | 2021-06-16 | 2023-05-01 | 日商東麗股份有限公司 | 罹患慢性腎臟病的貓的治療方法 |
| WO2023276983A1 (ja) * | 2021-06-28 | 2023-01-05 | 大内新興化学工業株式会社 | ベラプロストまたは光学活性体の合成中間体およびその製造方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2734791A1 (de) * | 1977-07-29 | 1979-02-15 | Schering Ag | Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung |
| JPS5931510B2 (ja) * | 1979-09-03 | 1984-08-02 | 東レ株式会社 | ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体 |
| JPS57144276A (en) * | 1981-03-03 | 1982-09-06 | Toray Ind Inc | 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative |
-
1982
- 1982-01-20 JP JP57006150A patent/JPS58124778A/ja active Granted
-
1983
- 1983-01-18 ZA ZA83328A patent/ZA83328B/xx unknown
- 1983-01-19 AU AU10609/83A patent/AU556348B2/en not_active Expired
- 1983-01-19 AT AT83100449T patent/ATE23716T1/de not_active IP Right Cessation
- 1983-01-19 US US06/459,226 patent/US4474802A/en not_active Expired - Lifetime
- 1983-01-19 EP EP83100449A patent/EP0084856B2/en not_active Expired - Lifetime
- 1983-01-19 DE DE8383100449T patent/DE3367774D1/de not_active Expired
- 1983-01-20 CA CA000419895A patent/CA1226280A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ZA83328B (en) | 1983-10-26 |
| JPH0153672B2 (OSRAM) | 1989-11-15 |
| AU556348B2 (en) | 1986-10-30 |
| EP0084856B2 (en) | 1994-05-04 |
| DE3367774D1 (de) | 1987-01-08 |
| US4474802A (en) | 1984-10-02 |
| CA1226280A (en) | 1987-09-01 |
| EP0084856B1 (en) | 1986-11-20 |
| JPS58124778A (ja) | 1983-07-25 |
| EP0084856A1 (en) | 1983-08-03 |
| AU1060983A (en) | 1983-07-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE23716T1 (de) | 5,6,7-trinor-4,8-inter-m-phenylen-prostaglandin i2-derivate. | |
| ES527954A1 (es) | Un procedimiento para preparar isoxazoles | |
| IL56288A (en) | 15-deoxy-16-hydroxy-2-decarboxy-2-hydroxymethylprostaglandin derivatives and their preparation | |
| ES8503667A1 (es) | Un procedimiento para la preparacion de nuevos derivados de 2-oxo-imidazolina. | |
| ES8401961A1 (es) | Procedimiento para la preparacion de nuevas n-(4-indolil-piperidino-alcohil-bencimidazolonas sustituidas. | |
| ES8304567A1 (es) | "un procedimiento para preparar nuevos derivados de la n-dihidrotiazolil-3-quinolein-carboxamida". | |
| ES8609225A1 (es) | Un procedimiento para preparar un derivado de semicarbazida | |
| DE3477488D1 (en) | Polymethoxybenzyl piperazine derivatives, processes for their preparation and pharmaceutical compositions containing said derivatives | |
| MX9206127A (es) | Compuestos de acetileno | |
| JPS5750989A (en) | Imidazole compound | |
| IL77124A (en) | 5-alkyl-1-phenyl-2-piperazinoalkylpyrazolin-3-one compoundds,their preparation and pharmaceutical compositions containing them | |
| AU550340B2 (en) | Dibenzazepine derivatives | |
| DE3266845D1 (en) | Hydrocortisone derivatives, their preparation and their utilization | |
| ES8500953A1 (es) | Procedimiento para preparar derivados de tieno-tiazol | |
| ES8305758A1 (es) | "un procedimiento para la preparacion de 2-(1,4-benzodioxan-2-il-metil)-imidazolina". | |
| CA1273946C (en) | ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES | |
| ES8200648A2 (es) | Procedimiento de preparacion de compuestos opacificantes para radiografia y similares | |
| ES8401008A1 (es) | Procedimiento para la preparacion de derivados de carbaciclina. | |
| PH22282A (en) | Monobasic disobutamide derivatives | |
| JPS52100470A (en) | Synthesis of hydantoin derivatives | |
| DE3363575D1 (en) | Furyloxazolylacetic acid derivatives, process for preparing same and pharmaceutical compositions containing same | |
| DE3264556D1 (en) | Sulfimines, their salts and their preparation, and pharmaceutical compositions containing them | |
| ES8103742A2 (es) | Un procedimiento de preparacion de nuevos derivados de 1,3-benzodioxina | |
| ES459705A1 (es) | Procedimiento para la preparacion de derivados de hidracina-piridacina. | |
| IL70103A0 (en) | Semicarbazides,their preparation and pharmaceutical compositions containing them |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |