ES8401008A1 - Procedimiento para la preparacion de derivados de carbaciclina. - Google Patents
Procedimiento para la preparacion de derivados de carbaciclina.Info
- Publication number
- ES8401008A1 ES8401008A1 ES520537A ES520537A ES8401008A1 ES 8401008 A1 ES8401008 A1 ES 8401008A1 ES 520537 A ES520537 A ES 520537A ES 520537 A ES520537 A ES 520537A ES 8401008 A1 ES8401008 A1 ES 8401008A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- residue
- image
- hydrogen atom
- atoms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4018—Esters of cycloaliphatic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE CARBACICLINA.CONSISTE EN: A) LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN REACTIVO DE WITTING DE FORMULA (III), O B) LA ETERIFICACION EN PRESENCIA DE UNA BASE DE UN COMPUESTO DE FORMULA (IV) CON UN DERIVADO DE ACIDO HALOGENOACETICO DE FORMULA (V), PARA OBTENERSE UN COMPUESTO DE FORMULA (I). LOS RADICALES TIENEN EL SIGUIENTE SIGNIFICADO: R1, ES -CH2OH O AA4-COBOR2 O -ILCO-NHR3; R2 ES HIDROGENO CON UN RADICAL ALCOHILO, CICLOALCOHILO O ARILO; R3 ES UN RADICAL ALCANOILO O ALCANSULFONILO; X ES OXIGENO O UN GRUPO-CH2; A ES UN GRUPO TRANS-CHFCH O -CFC; W ES UN GRUPO HIDROXIMETILENO; D, ES UN GRUPO ALCOHILENO DE CADENA RECTA CON C 1 A 5; E, REPRESENTA UN ENLACE -CFC-; B ES UN DOBLE ENLACE O UN GRUPO -CHFCBR-; R4 ES UN GRUPO ALCOHILO, CICLOALCOHILO O ARILO; R5, ES UN GRUPO HIDROXI; N PUEDE SER 1, 2 O 3; Y M, 1 O 2.DE APLICACION FARMACOLOGICA POR SUS EFECTOS HIPOTENSORES Y BRONCODILATADORES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823209702 DE3209702A1 (de) | 1982-03-12 | 1982-03-12 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3306125A DE3306125A1 (de) | 1983-02-18 | 1983-02-18 | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8401008A1 true ES8401008A1 (es) | 1983-12-16 |
ES520537A0 ES520537A0 (es) | 1983-12-16 |
Family
ID=25800399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES520537A Granted ES520537A0 (es) | 1982-03-12 | 1983-03-11 | Procedimiento para la preparacion de derivados de carbaciclina. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0105288B1 (es) |
JP (1) | JPS59500471A (es) |
AU (1) | AU563881B2 (es) |
CA (1) | CA1220471A (es) |
DE (1) | DE3361463D1 (es) |
DK (1) | DK506183A (es) |
ES (1) | ES520537A0 (es) |
GR (1) | GR77976B (es) |
IT (1) | IT1194158B (es) |
WO (1) | WO1983003248A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3221193A1 (de) * | 1982-05-28 | 1983-12-01 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3225287A1 (de) * | 1982-07-02 | 1984-01-05 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3226550A1 (de) * | 1982-07-13 | 1984-01-19 | Schering AG, 1000 Berlin und 4709 Bergkamen | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
HU191110B (en) * | 1982-10-01 | 1987-01-28 | Farmitala Carlo Erba Spa,It | Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines |
JPS59141536A (ja) * | 1983-02-01 | 1984-08-14 | Sumitomo Chem Co Ltd | 新規ビシクロオクタン誘導体 |
GB2192395B (en) * | 1986-07-08 | 1990-11-14 | Kotobuki Seiyaku Co Ltd | Carbacyclin derivatives |
CN1377263A (zh) * | 1999-08-05 | 2002-10-30 | 帝人株式会社 | 含有含氮化合物作为活性成分的神经损伤治疗剂 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5823393B2 (ja) * | 1974-03-14 | 1983-05-14 | オノヤクヒンコウギヨウ カブシキガイシヤ | プロスタグランジンルイジカゴウブツ ノ セイゾウホウホウ |
GB2013661B (en) * | 1978-01-26 | 1982-11-10 | Erba Farmitalia | 9-deoxy-9 -methylene isosteres of pgi2 |
-
1983
- 1983-03-10 GR GR70744A patent/GR77976B/el unknown
- 1983-03-11 AU AU13364/83A patent/AU563881B2/en not_active Ceased
- 1983-03-11 IT IT20023/83A patent/IT1194158B/it active
- 1983-03-11 DE DE8383900905T patent/DE3361463D1/de not_active Expired
- 1983-03-11 CA CA000423413A patent/CA1220471A/en not_active Expired
- 1983-03-11 JP JP58501046A patent/JPS59500471A/ja active Granted
- 1983-03-11 WO PCT/DE1983/000045 patent/WO1983003248A1/en active IP Right Grant
- 1983-03-11 EP EP83900905A patent/EP0105288B1/de not_active Expired
- 1983-03-11 ES ES520537A patent/ES520537A0/es active Granted
- 1983-11-04 DK DK506183A patent/DK506183A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1983003248A1 (en) | 1983-09-29 |
GR77976B (es) | 1984-09-25 |
IT8320023A0 (it) | 1983-03-11 |
IT1194158B (it) | 1988-09-14 |
AU1336483A (en) | 1983-10-24 |
IT8320023A1 (it) | 1984-09-11 |
JPH0446256B2 (es) | 1992-07-29 |
DK506183D0 (da) | 1983-11-04 |
AU563881B2 (en) | 1987-07-23 |
EP0105288A1 (de) | 1984-04-18 |
DK506183A (da) | 1983-11-04 |
ES520537A0 (es) | 1983-12-16 |
DE3361463D1 (en) | 1986-01-23 |
CA1220471A (en) | 1987-04-14 |
JPS59500471A (ja) | 1984-03-22 |
EP0105288B1 (de) | 1985-12-11 |
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