AU1336483A - Carbacycline, preparation and utilization thereof - Google Patents

Carbacycline, preparation and utilization thereof

Info

Publication number
AU1336483A
AU1336483A AU13364/83A AU1336483A AU1336483A AU 1336483 A AU1336483 A AU 1336483A AU 13364/83 A AU13364/83 A AU 13364/83A AU 1336483 A AU1336483 A AU 1336483A AU 1336483 A AU1336483 A AU 1336483A
Authority
AU
Australia
Prior art keywords
carbacycline
utilization
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU13364/83A
Other versions
AU563881B2 (en
Inventor
Jorge Casals-Stenzel
Gerda Mannesmann
Bernd Raduchel
Norbert Schwarz
Werner Skuballa
Michael-Harold Town
Helmut Vorbruggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19823209702 external-priority patent/DE3209702A1/en
Priority claimed from DE3306125A external-priority patent/DE3306125A1/en
Application filed by Schering AG filed Critical Schering AG
Publication of AU1336483A publication Critical patent/AU1336483A/en
Application granted granted Critical
Publication of AU563881B2 publication Critical patent/AU563881B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/26—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4018—Esters of cycloaliphatic acids
AU13364/83A 1982-02-18 1983-03-11 Carbacycline, preparation and utilization thereof Ceased AU563881B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3306125 1982-02-18
DE19823209702 DE3209702A1 (en) 1982-03-12 1982-03-12 Novel carbacyclins, process for their preparation and their use as medicaments
DE3209702 1982-03-12
DE3306125A DE3306125A1 (en) 1983-02-18 1983-02-18 Novel carbacyclins, process for their preparation and their use as medicaments

Publications (2)

Publication Number Publication Date
AU1336483A true AU1336483A (en) 1983-10-24
AU563881B2 AU563881B2 (en) 1987-07-23

Family

ID=25800399

Family Applications (1)

Application Number Title Priority Date Filing Date
AU13364/83A Ceased AU563881B2 (en) 1982-02-18 1983-03-11 Carbacycline, preparation and utilization thereof

Country Status (10)

Country Link
EP (1) EP0105288B1 (en)
JP (1) JPS59500471A (en)
AU (1) AU563881B2 (en)
CA (1) CA1220471A (en)
DE (1) DE3361463D1 (en)
DK (1) DK506183A (en)
ES (1) ES520537A0 (en)
GR (1) GR77976B (en)
IT (1) IT1194158B (en)
WO (1) WO1983003248A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU567911B2 (en) * 1983-02-01 1987-12-10 Sumitomo Chemical Company, Limited Bicyclooctane derivatives
AU571443B2 (en) * 1982-07-02 1988-04-21 Schering Aktiengesellschaft Carbacyclin amides

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3221193A1 (en) * 1982-05-28 1983-12-01 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINESTERS, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICINAL PRODUCTS
DE3226550A1 (en) * 1982-07-13 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen NEW CARBACYCLINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
HU191110B (en) * 1982-10-01 1987-01-28 Farmitala Carlo Erba Spa,It Process for the production of the 15-cycloaliphatic derivatives 13,14-didehydro-carbaprostacyclines
GB2192395B (en) * 1986-07-08 1990-11-14 Kotobuki Seiyaku Co Ltd Carbacyclin derivatives
DE60023144T2 (en) 1999-08-05 2006-07-06 Teijin Ltd. MEANS FOR IMPROVING NEUROPATHY, CONTAINING NITROGEN-CONTAINING COMPOUNDS AS ACTIVE INGREDIENTS

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5823393B2 (en) * 1974-03-14 1983-05-14 オノヤクヒンコウギヨウ カブシキガイシヤ prostaglandin
GB2013661B (en) * 1978-01-26 1982-11-10 Erba Farmitalia 9-deoxy-9 -methylene isosteres of pgi2

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU571443B2 (en) * 1982-07-02 1988-04-21 Schering Aktiengesellschaft Carbacyclin amides
AU567911B2 (en) * 1983-02-01 1987-12-10 Sumitomo Chemical Company, Limited Bicyclooctane derivatives

Also Published As

Publication number Publication date
IT1194158B (en) 1988-09-14
AU563881B2 (en) 1987-07-23
WO1983003248A1 (en) 1983-09-29
ES8401008A1 (en) 1983-12-16
CA1220471A (en) 1987-04-14
JPS59500471A (en) 1984-03-22
DK506183D0 (en) 1983-11-04
IT8320023A1 (en) 1984-09-11
IT8320023A0 (en) 1983-03-11
JPH0446256B2 (en) 1992-07-29
ES520537A0 (en) 1983-12-16
EP0105288B1 (en) 1985-12-11
GR77976B (en) 1984-09-25
DK506183A (en) 1983-11-04
EP0105288A1 (en) 1984-04-18
DE3361463D1 (en) 1986-01-23

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