ZA83328B - 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative - Google Patents

5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative

Info

Publication number
ZA83328B
ZA83328B ZA83328A ZA83328A ZA83328B ZA 83328 B ZA83328 B ZA 83328B ZA 83328 A ZA83328 A ZA 83328A ZA 83328 A ZA83328 A ZA 83328A ZA 83328 B ZA83328 B ZA 83328B
Authority
ZA
South Africa
Prior art keywords
carbon atoms
hydrogen
itner
trinor
derivative
Prior art date
Application number
ZA83328A
Other languages
English (en)
Inventor
Ohno Kiyotaka
Nagase Hiroshi
Matsumoto Kazuhisa
Nishio Shintaro
Original Assignee
Toray Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11630492&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA83328(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Toray Industries filed Critical Toray Industries
Publication of ZA83328B publication Critical patent/ZA83328B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/12—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids
    • C07C29/124—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of mineral acids of halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/56—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by isomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015—Esters of acyclic unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
ZA83328A 1982-01-20 1983-01-18 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative ZA83328B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57006150A JPS58124778A (ja) 1982-01-20 1982-01-20 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体

Publications (1)

Publication Number Publication Date
ZA83328B true ZA83328B (en) 1983-10-26

Family

ID=11630492

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA83328A ZA83328B (en) 1982-01-20 1983-01-18 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative

Country Status (8)

Country Link
US (1) US4474802A (OSRAM)
EP (1) EP0084856B2 (OSRAM)
JP (1) JPS58124778A (OSRAM)
AT (1) ATE23716T1 (OSRAM)
AU (1) AU556348B2 (OSRAM)
CA (1) CA1226280A (OSRAM)
DE (1) DE3367774D1 (OSRAM)
ZA (1) ZA83328B (OSRAM)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
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CA1275287C (en) * 1986-01-24 1990-10-16 Kiyotaka Ohno 2,5,6,7-tetranor-4,8-inter-m-phanylene pgi derivatives
US4880939A (en) * 1986-12-11 1989-11-14 Toray Industries 2,5,6,7-tetranor-18,18,19,19-tetradehydro-4,8-inter-m-phenylene PGI2 derivatives
JP2527277B2 (ja) * 1989-02-27 1996-08-21 東レ株式会社 ５，６，７―トリノル―４，８―インタ―ｍ―フェニレンＰＧＩ２誘導体の製造方法
DK0389162T3 (da) * 1989-03-14 1994-02-14 Toray Industries 2,5,6,7-Tetranor-4,8-inter-m-phenylen PGI2 derivater
JP2608135B2 (ja) * 1989-03-31 1997-05-07 科研製薬株式会社 糖尿病性神経障害治療剤
DE4104607A1 (de) * 1991-02-12 1992-08-13 Schering Ag Prostacyclin- und carbacyclinderivate als mittel zur behandlung von fiebrigen erkrankungen
JP3230246B2 (ja) * 1991-04-11 2001-11-19 東レ株式会社 悪性腫瘍転移抑制剤
US5496850A (en) * 1991-04-11 1996-03-05 Toray Industries, Inc. Antimetastasis agent of malignant tumors
US5233059A (en) * 1991-07-25 1993-08-03 Iowa State University Research Foundation, Inc. Synthesis of benzoprostacyclins using palladium catalysis
US5169959A (en) * 1991-09-23 1992-12-08 Iowa State University Research Foundation, Inc. Free radical-catalyzed synthesis of benzoprostacyclins
WO1993007876A1 (en) * 1991-10-25 1993-04-29 Toray Industries, Inc. Remedy for hepatic disease
JP3102141B2 (ja) * 1992-05-29 2000-10-23 東レ株式会社 養毛育毛剤
ES2101333T3 (es) * 1992-08-07 1997-07-01 Schering Ag Utilizacion de derivados de prostano para la preparacion de un medicamento destinado al tratamiento de la poliartritis cronica.
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
WO1994006785A1 (en) * 1992-09-18 1994-03-31 Toray Industries, Inc. Novel sulfonic acide derivative and medicinal use thereof
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
JP3541417B2 (ja) * 1994-02-24 2004-07-14 日産化学工業株式会社 フェニル置換ヒドロキシシクロペンテノン類、ペンタノン類及びフェニル置換プロスタグランジンｉ２類中間体並びにその製造法及び光学分割法
ES2180658T3 (es) * 1994-11-17 2003-02-16 Toray Industries Preparado para absorcion percutanea.
JP4062743B2 (ja) * 1995-02-27 2008-03-19 東レ株式会社 「肺性心治療剤」
CZ168896A3 (en) * 1995-06-27 1997-01-15 Egyt Gyogyszervegyeszeti Gyar Oxaindene derivatives and process for preparing thereof
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
AU734650B2 (en) 1996-05-07 2001-06-21 Toray Industries, Inc. Ophthalmic preparations
DE69713271T2 (de) * 1996-09-17 2002-09-26 Toray Industries, Inc. Verstärker der blutplättchenfunktionund verfahren zur behandlung der blut plättchenfunktionsstörung
CA2253717A1 (en) * 1997-02-27 1998-09-03 Toray Industries Inc. Drugs for ameliorating pulmonary circulation
CA2254925A1 (en) * 1997-03-13 1998-09-17 Shigeyasu Annoh Drugs for relieving diabetic vascular lesion
AU6310898A (en) * 1997-03-14 1998-10-12 Toray Industries, Inc. Sustained-release prostaglandin i derivative preparation
US6653345B2 (en) 1997-09-16 2003-11-25 Toray Industries, Inc. C-C chemokine synthesis inhibitor
EP1043031A4 (en) 1997-12-26 2007-05-02 Astellas Pharma Inc MEDICINAL COMPOSITIONS WITH PROLONGED RELEASE
JP4019481B2 (ja) 1998-01-23 2007-12-12 ソニー株式会社 情報処理装置および方法、情報処理システム、並びに提供媒体
CA2306567A1 (en) * 1998-08-12 2000-02-24 Sho-Ichi Yamagishi Plasminogen activator inhibitor-1 production inhibitor
WO2000009135A1 (en) * 1998-08-14 2000-02-24 Toray Industries, Inc. Peridermal cell protecting agents
US20030092760A1 (en) * 2001-03-12 2003-05-15 Toray Industries, Inc. Therapeutic agent for renal failure
HU227157B1 (en) * 2001-07-30 2010-09-28 Chinoin Gyogyszer Es Vegyeszet Production of beraprost ester by selective oxidation
JP3340732B1 (ja) * 2001-10-05 2002-11-05 日本医薬品工業株式会社 シクロペンタベンゾフラン誘導体の製造方法及びその製造原料となる新規化合物
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
JP4702054B2 (ja) 2003-05-09 2011-06-15 東レ株式会社 増強剤
AU2003243972A1 (en) * 2003-06-25 2005-01-13 Cardiovascular Institute, Ltd. External preparation for improving coital function
CN101217960B (zh) 2005-07-08 2010-12-15 东丽株式会社 用于改善尿毒症的治疗药和处置方法
JP5424291B2 (ja) * 2006-03-03 2014-02-26 独立行政法人国立循環器病研究センター 骨髄細胞の動員剤および動員方法
CA2669763C (en) * 2006-11-16 2015-02-17 Bayer Schering Pharma Aktiengesellschaft Ep2 and ep4 agonists as agents for the treatment of influenza a viral infection
US8809334B2 (en) 2008-08-13 2014-08-19 Actelion Pharmaceuticals Ltd. Therapeutic compositions containing macitentan
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US8779170B2 (en) * 2011-06-16 2014-07-15 Lung Biotechnology Inc. Method of producing beraprost
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
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CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
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CN106632372B (zh) * 2016-09-26 2019-04-02 上海北卡医药技术有限公司 一种中间体及其制备方法和用途
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CN107325122B (zh) * 2017-01-06 2020-05-01 常州博海威医药科技股份有限公司 制备贝前列腺素的新中间体及其制备方法
CA3070805A1 (en) 2017-07-27 2019-01-31 Allergan, Inc. Prostacyclin receptor agonists for reduction of body fat
CN109305986B (zh) * 2018-11-13 2021-02-19 济南康和医药科技有限公司 一种贝前列素钠中间体的合成方法
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
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CN112569181B (zh) * 2019-09-27 2023-03-21 中国科学院上海高等研究院 一种快速增溶肾上腺素的方法
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DE2734791A1 (de) * 1977-07-29 1979-02-15 Schering Ag Neue prostaglandin-i tief 2 -derivate und verfahren zu ihrer herstellung
JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative

Also Published As

Publication number Publication date
EP0084856B2 (en) 1994-05-04
US4474802A (en) 1984-10-02
JPS58124778A (ja) 1983-07-25
EP0084856A1 (en) 1983-08-03
EP0084856B1 (en) 1986-11-20
DE3367774D1 (de) 1987-01-08
JPH0153672B2 (OSRAM) 1989-11-15
AU556348B2 (en) 1986-10-30
ATE23716T1 (de) 1986-12-15
CA1226280A (en) 1987-09-01
AU1060983A (en) 1983-07-28

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