ATE234834T1 - Verbesserte verfahren zur herstellung von thiazolidin-2,4-dion derivaten - Google Patents
Verbesserte verfahren zur herstellung von thiazolidin-2,4-dion derivatenInfo
- Publication number
- ATE234834T1 ATE234834T1 AT99940422T AT99940422T ATE234834T1 AT E234834 T1 ATE234834 T1 AT E234834T1 AT 99940422 T AT99940422 T AT 99940422T AT 99940422 T AT99940422 T AT 99940422T AT E234834 T1 ATE234834 T1 AT E234834T1
- Authority
- AT
- Austria
- Prior art keywords
- formula
- compound
- acid
- improved methods
- thiazolidine
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001473 2,4-thiazolidinediones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 238000007796 conventional method Methods 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- IETKPTYAGKZLKY-UHFFFAOYSA-N 5-[[4-[(3-methyl-4-oxoquinazolin-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound N=1C2=CC=CC=C2C(=O)N(C)C=1COC(C=C1)=CC=C1CC1SC(=O)NC1=O IETKPTYAGKZLKY-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
- KIMWOULVHFLJIU-UHFFFAOYSA-N N-Methylanthranilamide Chemical compound CNC(=O)C1=CC=CC=C1N KIMWOULVHFLJIU-UHFFFAOYSA-N 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052749 magnesium Inorganic materials 0.000 abstract 1
- 239000011777 magnesium Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2060MA1998 IN187716B (instruction) | 1998-09-14 | 1998-09-14 | |
| PCT/IB1999/001530 WO2000015638A1 (en) | 1998-09-14 | 1999-09-10 | An improved process for the preparation of thiazolidine-2,4-dione derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE234834T1 true ATE234834T1 (de) | 2003-04-15 |
Family
ID=11096874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99940422T ATE234834T1 (de) | 1998-09-14 | 1999-09-10 | Verbesserte verfahren zur herstellung von thiazolidin-2,4-dion derivaten |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6469167B1 (instruction) |
| EP (1) | EP1114047B1 (instruction) |
| JP (2) | JP2002524563A (instruction) |
| KR (1) | KR100448179B1 (instruction) |
| CN (2) | CN1295222C (instruction) |
| AT (1) | ATE234834T1 (instruction) |
| AU (1) | AU762353B2 (instruction) |
| BR (1) | BR9914493A (instruction) |
| CA (1) | CA2343883C (instruction) |
| CZ (1) | CZ300933B6 (instruction) |
| DE (1) | DE69906100T2 (instruction) |
| DK (1) | DK1114047T3 (instruction) |
| ES (1) | ES2195600T3 (instruction) |
| HU (1) | HU229519B1 (instruction) |
| IL (1) | IL141737A0 (instruction) |
| IN (2) | IN187716B (instruction) |
| NO (1) | NO317383B1 (instruction) |
| NZ (1) | NZ510316A (instruction) |
| PL (1) | PL195617B1 (instruction) |
| PT (1) | PT1114047E (instruction) |
| RU (1) | RU2223961C2 (instruction) |
| UA (1) | UA70962C2 (instruction) |
| WO (1) | WO2000015638A1 (instruction) |
| ZA (1) | ZA200101699B (instruction) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1623984B1 (en) * | 2002-03-15 | 2011-11-02 | Dr. Reddy's Laboratories Limited | Polymorphic form I of 5-[4-[[3-methyl-4-oxo-3,4-dihydroquinazolin-2yl]methoxy]benzyl] thiazolidine-2,4-dione potassium salt |
| CN103288757B (zh) * | 2013-05-16 | 2015-07-01 | 苏州明锐医药科技有限公司 | 6-氨基-7-羟基-3,4-二氢喹唑啉-4-酮的制备方法 |
| KR101677340B1 (ko) | 2014-11-28 | 2016-11-29 | 이청주 | 광고용 열기구 |
| KR20160134615A (ko) | 2016-11-11 | 2016-11-23 | 이청주 | 광고용 열기구 |
| CN109867765A (zh) * | 2019-02-28 | 2019-06-11 | 中山大学惠州研究院 | 一种长效缓释可降解防污聚氨酯及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB306228A (en) * | 1927-12-15 | 1929-02-21 | Bohn Aluminium & Brass Corp | Improvements in pistons |
| ES2137915T3 (es) * | 1987-09-04 | 2000-01-01 | Beecham Group Plc | Derivados de tiazolidindiona sustituida. |
| ATE205206T1 (de) * | 1990-04-27 | 2001-09-15 | Sankyo Co | Benzylidenthiazolidinderivate, ihre herstellung und ihre anwendung als lipidperoxid-inhibitoren |
| ES2139633T3 (es) * | 1992-08-31 | 2000-02-16 | Sankyo Co | Derivados de oxazolidina con propiedades anti-diabetica y anti-obesidad, su preparacion y su utilizacion terapeutica. |
| FR2696743B1 (fr) * | 1992-10-12 | 1994-12-23 | Adir | Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant. |
| TW399051B (en) * | 1996-01-31 | 2000-07-21 | Ssp Co Ltd | A novel benzoazine thiazolidinedione derivative and pharmaceutical composition for reducing blood glucose |
| KR100579765B1 (ko) * | 1996-07-01 | 2006-12-28 | 닥터 레디스 레보러터리즈 리미티드 | 신규헤테로고리형화합물의제조방법,이를함유하는약제조성물및당뇨병및이와관련된질병의치료에있어서그의용도 |
| US5885997A (en) * | 1996-07-01 | 1999-03-23 | Dr. Reddy's Research Foundation | Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases |
| JP4339402B2 (ja) * | 1996-12-31 | 2009-10-07 | ドクター・レディーズ・ラボラトリーズ・リミテッド | 新規なヘテロ環化合物、これらの製造方法及びこれらを含有する薬学的組成物、並びに糖尿病及び関連疾患の治療におけるこれらの使用 |
-
1998
- 1998-09-14 IN IN2060MA1998 patent/IN187716B/en unknown
-
1999
- 1999-09-10 PL PL346532A patent/PL195617B1/pl unknown
- 1999-09-10 HU HU0103517A patent/HU229519B1/hu not_active IP Right Cessation
- 1999-09-10 DE DE69906100T patent/DE69906100T2/de not_active Expired - Lifetime
- 1999-09-10 BR BR9914493-0A patent/BR9914493A/pt not_active IP Right Cessation
- 1999-09-10 JP JP2000570176A patent/JP2002524563A/ja not_active Withdrawn
- 1999-09-10 KR KR10-2001-7003251A patent/KR100448179B1/ko not_active Expired - Fee Related
- 1999-09-10 CA CA2343883A patent/CA2343883C/en not_active Expired - Lifetime
- 1999-09-10 CN CNB2004100826925A patent/CN1295222C/zh not_active Expired - Fee Related
- 1999-09-10 DK DK99940422T patent/DK1114047T3/da active
- 1999-09-10 ES ES99940422T patent/ES2195600T3/es not_active Expired - Lifetime
- 1999-09-10 IL IL14173799A patent/IL141737A0/xx not_active IP Right Cessation
- 1999-09-10 CZ CZ20010825A patent/CZ300933B6/cs not_active IP Right Cessation
- 1999-09-10 RU RU2001110171/04A patent/RU2223961C2/ru not_active IP Right Cessation
- 1999-09-10 NZ NZ510316A patent/NZ510316A/xx not_active IP Right Cessation
- 1999-09-10 WO PCT/IB1999/001530 patent/WO2000015638A1/en active IP Right Grant
- 1999-09-10 AU AU54399/99A patent/AU762353B2/en not_active Ceased
- 1999-09-10 EP EP99940422A patent/EP1114047B1/en not_active Expired - Lifetime
- 1999-09-10 UA UA2001042425A patent/UA70962C2/uk unknown
- 1999-09-10 PT PT99940422T patent/PT1114047E/pt unknown
- 1999-09-10 US US09/763,940 patent/US6469167B1/en not_active Expired - Lifetime
- 1999-09-10 AT AT99940422T patent/ATE234834T1/de active
- 1999-09-10 CN CNB99811992XA patent/CN1231481C/zh not_active Expired - Fee Related
- 1999-11-29 IN IN1150MA1999 patent/IN189187B/en unknown
-
2001
- 2001-02-28 ZA ZA200101699A patent/ZA200101699B/en unknown
- 2001-03-13 NO NO20011265A patent/NO317383B1/no not_active IP Right Cessation
-
2011
- 2011-02-14 JP JP2011028783A patent/JP2011144179A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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