AR240824A2 - Procedimiento para preparar derivados de 3-propenil-cefalosporinas, que poseen configuracion (z) con respecto al doble enlace exociclico y sus sales farmaceuticamente aceptables - Google Patents

Procedimiento para preparar derivados de 3-propenil-cefalosporinas, que poseen configuracion (z) con respecto al doble enlace exociclico y sus sales farmaceuticamente aceptables

Info

Publication number
AR240824A2
AR240824A2 AR29553584A AR29553584A AR240824A2 AR 240824 A2 AR240824 A2 AR 240824A2 AR 29553584 A AR29553584 A AR 29553584A AR 29553584 A AR29553584 A AR 29553584A AR 240824 A2 AR240824 A2 AR 240824A2
Authority
AR
Argentina
Prior art keywords
group
formula
phosphony
mis
salt
Prior art date
Application number
AR29553584A
Other languages
English (en)
Other versions
AR240824A1 (es
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27040143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR240824(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of AR240824A1 publication Critical patent/AR240824A1/es
Publication of AR240824A2 publication Critical patent/AR240824A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER DERIVADOS DE 3-(Z)-PROPENIL-CEFALOSPORINAS, QUE POSEEN LA CONFIGURACION (Z) CON RESPECTO AL DOBLE ENLACE EXOCICLICO, DE FORMULA (I), EN LA QUE: R1 ES H, OH, O CL, R2 REPRESENTA ALCOXI, H O OH Y ADEMAS LOS DERIVADOS DE LOS MISMOS PROVENIENTES DE LA PROTECCION DEL GRUPO AMINO CON UN GRUPO T-BUTILOXICARBONILO Y DEL GRUPO CARBOXILO CON UN GRUPO BENZHIDRILO, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS, QUE COMPRENDE: A) HACER REACCIONAR EN UN MEDIO DE REACCION ORGANICO INERTE LIQUIDO, ENTRE 20 Y 150 C HALUROS REACTIVOS DE FORMULA QCH2X EN LA QUE X ES HALOGENO CON TRIFENILFORSFINA, FORMANDO LA SAL DE FOSFONIO; B) CONVERTIR LA SAL DE FOSFONIO CON UNA BASE ACUOSA Y EN UN MEDIO SOLVENTE LIQUIDO ORGANICO E INERTE, AL CORRESPONDIENTE COMPUESTO DE FOSFORANILO DE FORMULA QCH=P(PH)3; C) HACER REACCIONAR DICHOS COMPUESTOS DE FOSFORANILO BAJO CONDICIONES ANHIDRAS Y ENTRE -40 C Y +50 C, CON ACETALDEHIDO INSOLUBLE EN AGUA; Y SI ES NECESARIO SE ELIMINAN DICHOSGRUPOS PROTECTORES CON ACIDO TRIFLUORACETICO.
AR295535A 1983-01-28 1984-01-26 Procedimiento para preparar derivados de 3-propenil-cefalosporinas, que poseen configuracion (z) con respecto al doble enlace exociclico y sus sales farmaceuticamente aceptables AR240824A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46183383A 1983-01-28 1983-01-28
US06/564,604 US4520022A (en) 1983-01-28 1983-12-28 Substituted vinyl cephalosporins

Publications (2)

Publication Number Publication Date
AR240824A1 AR240824A1 (es) 1991-02-28
AR240824A2 true AR240824A2 (es) 1991-02-28

Family

ID=27040143

Family Applications (1)

Application Number Title Priority Date Filing Date
AR295535A AR240824A1 (es) 1983-01-28 1984-01-26 Procedimiento para preparar derivados de 3-propenil-cefalosporinas, que poseen configuracion (z) con respecto al doble enlace exociclico y sus sales farmaceuticamente aceptables

Country Status (32)

Country Link
US (1) US4520022A (es)
AR (1) AR240824A1 (es)
AT (1) AT383351B (es)
BE (1) BE898778A (es)
CA (3) CA1233815A (es)
CH (1) CH661731A5 (es)
CY (1) CY1528A (es)
CZ (1) CZ280411B6 (es)
DD (2) DD222029A5 (es)
DE (1) DE3402642A1 (es)
DK (1) DK162052C (es)
ES (2) ES529171A0 (es)
FI (2) FI79540C (es)
FR (1) FR2540117B1 (es)
GB (1) GB2135305B (es)
GR (1) GR79791B (es)
HK (1) HK73690A (es)
HU (1) HU191990B (es)
IE (1) IE56784B1 (es)
IL (1) IL70773A (es)
IT (1) IT1218842B (es)
LU (1) LU85184A1 (es)
NL (1) NL190581C (es)
NO (1) NO165027C (es)
NZ (1) NZ206973A (es)
OA (1) OA07643A (es)
PT (1) PT78020B (es)
SE (2) SE458611B (es)
SK (1) SK278845B6 (es)
SU (1) SU1407400A3 (es)
YU (1) YU44393B (es)
ZW (1) ZW1184A1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA84584B (en) * 1983-01-28 1984-09-26 Bristol Myers Co Substituted vinyl cephalosporins
GB8411954D0 (en) * 1984-05-10 1984-06-13 Glaxo Group Ltd Cephalosporin antibiotics
US4699979A (en) * 1985-04-22 1987-10-13 Bristol-Meyers Company 7-amino-3-propenylcephalosporanic acid and esters thereof
FR2580652B1 (fr) * 1985-04-22 1989-01-06 Bristol Myers Co Acide 7-amino-3-propenylcephalosporanique et ses esters
US4708955A (en) * 1985-06-24 1987-11-24 Bristol-Myers Company 3-(substituted)propenyl-7-aminothiazol-ylcephalosporanic acids and esters thereof
US4694079A (en) * 1985-07-29 1987-09-15 Bristol-Myers Company 3-propenyl cephalosporin solvates
US4619925A (en) * 1985-11-08 1986-10-28 Bristol-Myers Company 3-Propenyl cephalosporin derivatives
US4727070A (en) * 1985-11-25 1988-02-23 Bristol-Myers Company 3-Propenzl cephalosporin isomer separation process and derivative
US4847373A (en) * 1987-02-26 1989-07-11 Bristol-Myers Company Production of 3-allyl- and 3-butenyl-3-cephems
DE3734004A1 (de) * 1987-05-26 1988-12-15 Bayer Ag Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3734005A1 (de) * 1987-05-26 1988-12-15 Bayer Ag Substituierte vinylcephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5128336A (en) * 1988-03-23 1992-07-07 Eli Lilly And Company 3-(substituted)-1-carba(dethia)-3-cephems
US5245027A (en) * 1989-11-21 1993-09-14 Bristol-Myers Squibb Company 3-fluorosulfonyloxyceph-3-em compounds
SG48415A1 (en) 1992-02-05 1998-04-17 Biochemie Gmbh Process for the purification of a 3-cephem-4-carboxylic acid derivative
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US7230097B2 (en) * 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
WO2004110399A2 (en) * 2003-06-19 2004-12-23 Ranbaxy Laboratories Limited Solvates of cefprozil
EP1678186A4 (en) 2003-10-30 2007-04-25 Cj Corp PROCESS FOR THE PREPARATION OF CEPHEM DERIVATIVES
US20070072945A1 (en) * 2004-03-31 2007-03-29 Pohoreski Anton Sulphur-containing oils for controlling plant pathogens and stimulating nutrient uptake
ATE457990T1 (de) * 2004-11-01 2010-03-15 Hetero Drugs Ltd Neues verfahren zur herstellung eines cefprozil- zwischenprodukts
JP5733856B2 (ja) 2007-10-09 2015-06-10 ソファーミア，インコーポレイテッド 広帯域β−ラクタマーゼ阻害薬
TR201000689A1 (tr) 2010-01-29 2011-08-22 Bi̇lgi̇ç Mahmut Sefprozil içeren katı dozaj formlar.
WO2013109201A1 (en) 2012-01-18 2013-07-25 Mahmut Bilgic Pharmaceutical compositions comprising cefprozil and clavulanic acid
ES2700575T3 (es) 2013-03-12 2019-02-18 Gladius Pharmaceuticals Corp 3-Estiril-cefalosporinas derivadas

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507861A (en) * 1966-09-14 1970-04-21 Lilly Co Eli Certain 3-methyl-cephalosporin compounds
US3351596A (en) * 1966-09-21 1967-11-07 Lilly Co Eli 3-formyl cephalosporins
US3489751A (en) * 1967-09-05 1970-01-13 Bristol Myers Co 7-amino-cephalosporanic and decephalosporanic acid derivatives
US3485819A (en) * 1968-07-02 1969-12-23 Squibb & Sons Inc Alpha-amino-cyclohexadienylalkylene-penicillins and cephalosporins
GB1342241A (en) * 1970-01-23 1974-01-03 Glaxo Lab Ltd Cephalosporin compounds
US3994884A (en) * 1970-01-23 1976-11-30 Glaxo Laboratories Limited 3-Vinyl-7β-(2,2-disubstituted acetamido)-cephalosporins
US4107431A (en) * 1970-01-23 1978-08-15 Glaxo Laboratories Limited Δ3 -3-Vinyl or substituted vinyl-4-carboxy cephalosporins
US3769277A (en) 1970-01-23 1973-10-30 Glaxo Lab Ltd Preparation of delta3-4 carboxy cephalosporins having a 3-vinyl or substituted 3-vinyl group
US3674784A (en) * 1970-07-27 1972-07-04 Lilly Co Eli 3-formyl cephalosporin sulfoxides
US4065620A (en) * 1971-06-14 1977-12-27 Eli Lilly And Company 3-(Substituted) vinyl cephalosporins
BE789817A (fr) 1971-10-07 1973-04-06 Glaxo Lab Ltd Perfectionnements aux composes de cephalosporine
US3925372A (en) * 1973-02-23 1975-12-09 Lilly Co Eli Alpha-aminoacyl-3-halo cephalosporins
GB1472174A (en) * 1973-09-22 1977-05-04 Beecham Group Ltd Dihydroxy amino cephalosporins
FR2264021A1 (en) * 1974-03-13 1975-10-10 Aries Robert Cephalosporanic acid antibiotics - from alpha amino phenyl acetic acids and phosphorus trihalide then a 7-amino cepheme
JPS5129492A (en) * 1974-09-04 1976-03-12 Sankyo Co Sefuarosuhorinjudotai no seiho
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US3983113A (en) * 1975-08-15 1976-09-28 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US4094978A (en) * 1976-07-29 1978-06-13 Syntex (U.S.A.) Inc. 3-propenyl derivatives of cephalosporin, compositions and their use
US4112087A (en) * 1976-11-04 1978-09-05 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials having a substituted propenyl group in the 3-position
US4255423A (en) * 1977-07-27 1981-03-10 Merck & Co., Inc. Cephalosporin compounds
FR2457297A1 (fr) * 1979-05-23 1980-12-19 Rhone Poulenc Ind Nouvelles vinyl-3 cephalosporines, et leur preparation
US4409214A (en) * 1979-11-19 1983-10-11 Fujisawa Pharmaceutical, Co., Ltd. 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof

Also Published As

Publication number Publication date
IT1218842B (it) 1990-04-24
DD222029A5 (de) 1985-05-08
IL70773A0 (en) 1984-04-30
FI81356B (fi) 1990-06-29
BE898778A (fr) 1984-07-27
FI79540C (fi) 1990-01-10
SK61684A3 (en) 1998-03-04
IT8419346A0 (it) 1984-01-27
DE3402642C2 (es) 1989-11-09
SE466204B (sv) 1992-01-13
AU2357584A (en) 1984-08-02
NO840334L (no) 1984-07-30
DK162052C (da) 1992-02-10
ES535953A0 (es) 1985-10-01
SE8400419D0 (sv) 1984-01-27
ES8505206A1 (es) 1985-05-16
SE8703153L (sv) 1987-08-13
LU85184A1 (fr) 1984-10-24
FI840300A (fi) 1984-07-29
FR2540117B1 (fr) 1987-03-20
FI840300A0 (fi) 1984-01-25
SE8703153D0 (sv) 1987-08-13
PT78020A (en) 1984-02-01
CZ280411B6 (cs) 1996-01-17
YU44393B (en) 1990-06-30
IL70773A (en) 1988-09-30
DK162052B (da) 1991-09-09
YU14084A (en) 1987-06-30
DK35384A (da) 1984-07-29
OA07643A (fr) 1985-05-23
AR240824A1 (es) 1991-02-28
DE3402642A1 (de) 1984-08-02
AT383351B (de) 1987-06-25
DK35384D0 (da) 1984-01-26
NL8400229A (nl) 1984-08-16
GB8402255D0 (en) 1984-02-29
GR79791B (es) 1984-10-31
NZ206973A (en) 1987-03-06
NO165027B (no) 1990-09-03
PT78020B (en) 1986-06-02
FR2540117A1 (fr) 1984-08-03
SU1407400A3 (ru) 1988-06-30
ZW1184A1 (en) 1984-08-29
SE8400419L (sv) 1984-07-29
AU566112B2 (en) 1987-10-08
CA1233815A (en) 1988-03-08
ES8600310A1 (es) 1985-10-01
FI81356C (fi) 1990-10-10
ATA29984A (de) 1986-11-15
US4520022A (en) 1985-05-28
HUT34492A (en) 1985-03-28
FI881929A (fi) 1988-04-25
GB2135305A (en) 1984-08-30
IE840026L (en) 1984-07-28
CA1241948A (en) 1988-09-13
DD228261A5 (de) 1985-10-09
SE458611B (sv) 1989-04-17
NO165027C (no) 1990-12-12
GB2135305B (en) 1987-03-04
NL190581C (nl) 1994-05-02
FI79540B (fi) 1989-09-29
CY1528A (en) 1990-11-16
CA1225084A (en) 1987-08-04
NL190581B (nl) 1993-12-01
CH661731A5 (de) 1987-08-14
ES529171A0 (es) 1985-05-16
FI881929A0 (fi) 1988-04-25
HK73690A (en) 1990-09-28
HU191990B (en) 1987-04-28
IE56784B1 (en) 1991-12-18
SK278845B6 (sk) 1998-03-04

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