DK410681A - Fremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf - Google Patents

Fremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf

Info

Publication number
DK410681A
DK410681A DK410681A DK410681A DK410681A DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A DK 410681 A DK410681 A DK 410681A
Authority
DK
Denmark
Prior art keywords
addition salts
acid addition
acceptable acid
procedure
preparation
Prior art date
Application number
DK410681A
Other languages
English (en)
Other versions
DK155003C (da
DK155003B (da
Inventor
S Fujii
T Okutome
T Nakayama
T Yaegashi
M Kurumi
Original Assignee
Torii & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12826980A external-priority patent/JPS5753454A/ja
Priority claimed from JP6494281A external-priority patent/JPS57179146A/ja
Application filed by Torii & Co Ltd filed Critical Torii & Co Ltd
Publication of DK410681A publication Critical patent/DK410681A/da
Publication of DK155003B publication Critical patent/DK155003B/da
Application granted granted Critical
Publication of DK155003C publication Critical patent/DK155003C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Heat Treatment Of Sheet Steel (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Power Steering Mechanism (AREA)
DK410681A 1980-09-16 1981-09-15 Analogifremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf DK155003C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP12826980A JPS5753454A (en) 1980-09-16 1980-09-16 Guanidinobenzoate and anticomplementary agent
JP12826980 1980-09-16
JP6494281 1981-04-28
JP6494281A JPS57179146A (en) 1981-04-28 1981-04-28 Amidine compound

Publications (3)

Publication Number Publication Date
DK410681A true DK410681A (da) 1982-03-17
DK155003B DK155003B (da) 1989-01-23
DK155003C DK155003C (da) 1989-05-29

Family

ID=26406084

Family Applications (1)

Application Number Title Priority Date Filing Date
DK410681A DK155003C (da) 1980-09-16 1981-09-15 Analogifremgangsmaade til fremstilling af amidin-derivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (17)

Country Link
US (2) US4454338A (da)
EP (1) EP0048433B1 (da)
KR (1) KR860000264B1 (da)
AT (1) ATE20051T1 (da)
AU (1) AU527371B2 (da)
CA (1) CA1177488A (da)
CS (1) CS228534B2 (da)
DD (1) DD201779A5 (da)
DE (1) DE3174717D1 (da)
DK (1) DK155003C (da)
ES (1) ES8206443A1 (da)
FI (1) FI73975C (da)
GB (1) GB2083818B (da)
HU (1) HU185956B (da)
NO (1) NO153568C (da)
PH (1) PH18109A (da)
SU (1) SU1176832A3 (da)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
FR2500825B1 (fr) * 1981-02-27 1985-08-23 Torii & Co Ltd Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant
JPS57179147A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine derivative
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US4818273A (en) * 1983-11-14 1989-04-04 The Dow Chemical Company Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds
JPS6133173A (ja) * 1984-07-25 1986-02-17 Torii Yakuhin Kk アミジン化合物
GB2162171B (en) * 1984-07-26 1988-01-27 Torii & Co Ltd Amidine compounds
FR2568253B1 (fr) * 1984-07-26 1987-01-30 Torii Co Nouvelle amidine
DE3427865A1 (de) * 1984-07-27 1986-02-06 Torii & Co., Tokio/Tokyo Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
US4709082A (en) * 1984-10-25 1987-11-24 Nissan Chemical Industries, Ltd. 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof
US4873253A (en) * 1987-03-30 1989-10-10 Shosuke Okamoto Phenylalanine derivative and proteinase inhibitor
US4990537A (en) * 1988-07-11 1991-02-05 Banyu Pharmaceutical Co., Ltd. Anti influenza agent
ES2073502T3 (es) * 1989-12-28 1995-08-16 Snow Brand Milk Products Co Ltd Derivados de isoquinolina y sus sales como inhibidores de la proteasa.
US5116985A (en) * 1989-12-28 1992-05-26 Snow Brand Milk Products Co., Ltd. Isoquinoline derivatives and salts thereof
JPH078789B2 (ja) * 1990-04-05 1995-02-01 鳥居薬品株式会社 脳血管攣縮治療剤
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
EP0703216B1 (en) * 1994-09-20 1999-04-07 Ono Pharmaceutical Co., Ltd. Amidinophenol derivatives as protease inhibitors
NZ296210A (en) * 1994-12-02 1998-05-27 Yamanouchi Pharma Co Ltd Amidinonaphthyl derivatives to inhibit activated blood coagulation factor x
CA2208032C (en) * 1995-01-05 2003-12-23 Torii Pharmaceutical Co., Ltd. Substituted amidinonaphthyl ester derivative
WO1997037969A1 (fr) 1996-04-10 1997-10-16 Ono Pharmaceutical Co., Ltd. Inhibiteur de tryptase derives de guanidino
AU7808198A (en) 1997-06-03 1998-12-21 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
AU1208999A (en) * 1997-11-10 1999-05-31 Array Biopharma, Inc. Compounds which inhibit tryptase activity
US6066673A (en) 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
CN1203846C (zh) 1998-03-19 2005-06-01 布里斯托尔-迈尔斯斯奎布公司 高溶解性药物的双相控释递送系统和方法
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
EP1073624A1 (en) * 1998-04-24 2001-02-07 Proteus Molecular Design Limited Aminomethyl-benzoic ester derivatives as tryptase inhibitors
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
CN1980948B (zh) 2002-11-27 2011-08-10 Dmi生物科学公司 治疗由增强磷酸化介导的疾病和病况
CN1886126A (zh) * 2003-09-25 2006-12-27 Dmi生物科学公司 利用n－酰基－l－天冬氨酸的方法和产品
US20090088472A1 (en) * 2005-05-17 2009-04-02 Kouji Oohashi Protective Agent for Neuronal Cell Comprising Amidino Derivative as Active Ingredient
DE602006020434D1 (de) * 2005-05-17 2011-04-14 Santen Pharmaceutical Co Ltd Ein aminderivat als wirkstoff enthaltender angiogeneseinhibitor
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
EP2311810A4 (en) * 2008-07-11 2012-04-04 Ajinomoto Kk AMIDINE DERIVATIVE
KR20110081852A (ko) 2008-10-17 2011-07-14 파마코포어, 인크. 페놀성 오피오이드를 약독화시켜 방출하는 약제학적 조성물
CN102695545B (zh) 2009-09-08 2016-08-17 特色疗法股份有限公司 包括酶可剪切的酮改性的阿片样物质药物前体以及其可任选的抑制剂的组合物
ES2710617T3 (es) 2010-04-21 2019-04-26 Signature Therapeutics Inc Composiciones que comprenden profármacos de anfetamina escindibles enzimáticamente e inhibidores de los mismos
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US20110262355A1 (en) 2010-04-21 2011-10-27 Jenkins Thomas E Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
CA2804926C (en) 2010-07-09 2019-01-08 James Trinca Green Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin
WO2012096886A1 (en) 2011-01-11 2012-07-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
EP2663187B1 (en) 2011-01-11 2016-06-01 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
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RU2608305C2 (ru) 2011-03-09 2017-01-17 Сигничер Терапьютикс, Инк. Пролекарства действующих веществ гетероциклическими линкерами
WO2013039187A1 (ja) 2011-09-15 2013-03-21 アステラス製薬株式会社 グアニジノ安息香酸化合物
CN103012214A (zh) * 2011-09-28 2013-04-03 南京长澳医药科技有限公司 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法
BR112015022762B1 (pt) * 2013-03-13 2022-08-16 Takeda Pharmaceutical Company Limited Composto de éster do ácido guanidinobenzóico, composição farmacêutica, e, uso do composto
CN103641749B (zh) * 2013-12-02 2016-02-10 山东永泰化工有限公司 一种甲磺酸萘莫司他的制备方法
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
CN110330447B (zh) * 2019-07-16 2022-04-15 北京赛升药业股份有限公司 一种甲磺酸萘莫司他中间体的制备方法及其应用
US20230210807A1 (en) * 2020-01-21 2023-07-06 Academy Of Military Medical Sciences Use of benzoate compound in treatment of sars-cov-2 infections
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN111574409A (zh) * 2020-05-14 2020-08-25 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) 一种甲磺酸萘莫司他的重结晶工艺方法
CN113999145B (zh) * 2021-11-12 2023-02-03 开封明仁药业有限公司 一种甲磺酸萘莫司他的合成方法
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD89611A (da) *
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
GB1472700A (en) * 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine

Also Published As

Publication number Publication date
DK155003C (da) 1989-05-29
US4532255A (en) 1985-07-30
KR860000264B1 (ko) 1986-03-22
FI812876L (fi) 1982-03-17
GB2083818A (en) 1982-03-31
EP0048433B1 (en) 1986-05-28
KR830007527A (ko) 1983-10-21
AU527371B2 (en) 1983-03-03
CA1177488A (en) 1984-11-06
NO153568B (no) 1986-01-06
DD201779A5 (de) 1983-08-10
DK155003B (da) 1989-01-23
AU7506281A (en) 1982-03-25
GB2083818B (en) 1984-05-10
EP0048433A2 (en) 1982-03-31
US4454338A (en) 1984-06-12
FI73975C (fi) 1987-12-10
NO813138L (no) 1982-03-17
EP0048433A3 (en) 1982-07-21
FI73975B (fi) 1987-08-31
PH18109A (en) 1985-03-22
CS228534B2 (en) 1984-05-14
DE3174717D1 (en) 1986-07-03
HU185956B (en) 1985-04-28
ATE20051T1 (de) 1986-06-15
SU1176832A3 (ru) 1985-08-30
NO153568C (no) 1986-05-21
ES505460A0 (es) 1982-08-16
ES8206443A1 (es) 1982-08-16

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