FI812876L - Foerfarande foer framstaellning av nya amidinfoereningar - Google Patents

Foerfarande foer framstaellning av nya amidinfoereningar

Info

Publication number
FI812876L
FI812876L FI812876A FI812876A FI812876L FI 812876 L FI812876 L FI 812876L FI 812876 A FI812876 A FI 812876A FI 812876 A FI812876 A FI 812876A FI 812876 L FI812876 L FI 812876L
Authority
FI
Finland
Prior art keywords
amidinfoereningar
nya
amidino
foerfarande foer
foer framstaellning
Prior art date
Application number
FI812876A
Other languages
English (en)
Other versions
FI73975C (fi
FI73975B (fi
Inventor
Setsuro Fujii
Toshiyuki Okutome
Toyoo Nakayama
Takashi Yaegashi
Masateru Kurumi
Original Assignee
Torii & Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP12826980A external-priority patent/JPS5753454A/ja
Priority claimed from JP6494281A external-priority patent/JPS57179146A/ja
Application filed by Torii & Co Ltd filed Critical Torii & Co Ltd
Publication of FI812876L publication Critical patent/FI812876L/fi
Application granted granted Critical
Publication of FI73975B publication Critical patent/FI73975B/fi
Publication of FI73975C publication Critical patent/FI73975C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
FI812876A 1980-09-16 1981-09-15 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara amidinoderivat. FI73975C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP12826980A JPS5753454A (en) 1980-09-16 1980-09-16 Guanidinobenzoate and anticomplementary agent
JP12826980 1980-09-16
JP6494281A JPS57179146A (en) 1981-04-28 1981-04-28 Amidine compound
JP6494281 1981-04-28

Publications (3)

Publication Number Publication Date
FI812876L true FI812876L (fi) 1982-03-17
FI73975B FI73975B (fi) 1987-08-31
FI73975C FI73975C (fi) 1987-12-10

Family

ID=26406084

Family Applications (1)

Application Number Title Priority Date Filing Date
FI812876A FI73975C (fi) 1980-09-16 1981-09-15 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara amidinoderivat.

Country Status (17)

Country Link
US (2) US4454338A (fi)
EP (1) EP0048433B1 (fi)
KR (1) KR860000264B1 (fi)
AT (1) ATE20051T1 (fi)
AU (1) AU527371B2 (fi)
CA (1) CA1177488A (fi)
CS (1) CS228534B2 (fi)
DD (1) DD201779A5 (fi)
DE (1) DE3174717D1 (fi)
DK (1) DK155003C (fi)
ES (1) ES8206443A1 (fi)
FI (1) FI73975C (fi)
GB (1) GB2083818B (fi)
HU (1) HU185956B (fi)
NO (1) NO153568C (fi)
PH (1) PH18109A (fi)
SU (1) SU1176832A3 (fi)

Families Citing this family (60)

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AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
FR2500825B1 (fr) * 1981-02-27 1985-08-23 Torii & Co Ltd Nouveau carboxylate de 4-amidino-phenyle substitue, son procede de preparation et agent anti-complement en comprenant
JPS57179147A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine derivative
JPS59139357A (ja) * 1983-01-28 1984-08-10 Torii Yakuhin Kk アミジン誘導体
US4818273A (en) * 1983-11-14 1989-04-04 The Dow Chemical Company Substituted 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonamides, compositions containing them, and their utility as herbicides
US4563527A (en) * 1984-07-19 1986-01-07 Torii & Co., Ltd. Amidine compounds
JPS6133173A (ja) * 1984-07-25 1986-02-17 Torii Yakuhin Kk アミジン化合物
FR2568253B1 (fr) * 1984-07-26 1987-01-30 Torii Co Nouvelle amidine
GB2162171B (en) * 1984-07-26 1988-01-27 Torii & Co Ltd Amidine compounds
DE3427865A1 (de) * 1984-07-27 1986-02-06 Torii & Co., Tokio/Tokyo Amidinoverbindungen, verfahren zu deren herstellung und diese verbindungen enthaltende pharmazeutische mittel
US4709082A (en) * 1984-10-25 1987-11-24 Nissan Chemical Industries, Ltd. 2-phenylpropionic acid esters, method for optical resolution thereof and optically active substance thereof
AU584502B2 (en) * 1987-03-30 1989-05-25 Shosuke Okamoto Phenylalanine derivatives and proteinase inhibitor
US4990537A (en) * 1988-07-11 1991-02-05 Banyu Pharmaceutical Co., Ltd. Anti influenza agent
US5116985A (en) * 1989-12-28 1992-05-26 Snow Brand Milk Products Co., Ltd. Isoquinoline derivatives and salts thereof
DE69017627T2 (de) * 1989-12-28 1995-10-26 Snow Brand Milk Products Co Ltd Isochinolinderivate und ihre Salze als Proteasehemmer.
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
JPH078789B2 (ja) * 1990-04-05 1995-02-01 鳥居薬品株式会社 脳血管攣縮治療剤
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
ATE178589T1 (de) * 1994-09-20 1999-04-15 Ono Pharmaceutical Co Amidinophenol-derivate als protease-hemmende verbindungen
RU2154633C2 (ru) * 1994-12-02 2000-08-20 Яманоути Фармасьютикал Ко., Лтд. Производные амидинонафтила и фармацевтическая композиция
WO1996020917A1 (fr) * 1995-01-05 1996-07-11 Torii Pharmaceutical Co., Ltd. Derives d'ester d'amidinonaphtyle substitues
EP0893437A4 (en) 1996-04-10 2000-12-27 Ono Pharmaceutical Co GUANIDINO TRYPTASE INHIBITOR
WO1998055471A1 (en) 1997-06-03 1998-12-10 Biocryst Pharmaceuticals, Inc. Novel compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
AU1208999A (en) * 1997-11-10 1999-05-31 Array Biopharma, Inc. Compounds which inhibit tryptase activity
US6066673A (en) 1998-03-12 2000-05-23 The Procter & Gamble Company Enzyme inhibitors
EA003101B1 (ru) 1998-03-19 2002-12-26 Бристол-Майерз Сквибб Компани Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ лечения диабета с помощью этой системы
EP1066272A4 (en) * 1998-03-27 2002-03-13 Biocryst Pharm Inc NEW CONNECTIONS USEFUL IN THE COMPLEMENT, COAGULATE AND KALLIKREIN REACTION WAY AND METHOD FOR THEIR PRODUCTION
AU3620099A (en) * 1998-04-24 1999-11-16 Proteus Molecular Design Limited Aminomethyl-benzoic ester derivatives as tryptase inhibitors
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
AR037097A1 (es) 2001-10-05 2004-10-20 Novartis Ag Compuestos acilsulfonamidas, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
EP1572115B1 (en) * 2002-11-27 2015-01-21 Ampio Pharmaceuticals, Inc. Treatment of diseases and conditions mediated by increased phosphorylation
US20050192348A1 (en) * 2003-09-25 2005-09-01 David Bar-Or Methods and products which utilize N-acyl-L-aspartic acid
EP2119439A3 (en) * 2005-05-17 2010-01-27 Santen Pharmaceutical Co., Ltd. Angiogenesis inhibitor for treating macular degeneration
EP2119440A1 (en) * 2005-05-17 2009-11-18 Santen Pharmaceutical Co., Ltd. Amidino derivatives for use in the prevention or treatment of retinitis pigmentosa and Leber's disease
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
WO2010005087A1 (ja) * 2008-07-11 2010-01-14 味の素株式会社 アミジン誘導体
JP5706825B2 (ja) 2008-10-17 2015-04-22 シグネーチャー セラピューティクス, インク.Signature Therapeutics, Inc. フェノール性オピオイドの放出が減弱された医薬組成物
MX348262B (es) 2009-09-08 2017-06-05 Signature Therapeutics Inc * Composiciones que comprenden profarmacos opioides con una cetona modificada que se pueden escindir enzimaticamente e inhibidores opcionales de estos.
US9238020B2 (en) 2010-04-21 2016-01-19 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug
US20110262355A1 (en) 2010-04-21 2011-10-27 Jenkins Thomas E Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
ES2710617T3 (es) 2010-04-21 2019-04-26 Signature Therapeutics Inc Composiciones que comprenden profármacos de anfetamina escindibles enzimáticamente e inhibidores de los mismos
MX342120B (es) 2010-07-09 2016-09-14 William Owen Wilkison Combinación de sistema de liberación prolongada/inmediata para productos farmacéuticos de vida media corta como el remogliflozin.
US8497237B2 (en) 2011-01-11 2013-07-30 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
CA2814763C (en) 2011-01-11 2019-05-28 Signature Therapeutics, Inc. Compositions comprising enzyme-cleavable oxycodone prodrug
US8685916B2 (en) 2011-03-09 2014-04-01 Signature Therapeutics, Inc. Opioid prodrugs with heterocyclic linkers
EP2683394B1 (en) 2011-03-09 2021-01-06 Signature Therapeutics, Inc. Active agent prodrugs with heterocyclic linkers
PL2757093T3 (pl) 2011-09-15 2017-06-30 Astellas Pharma Inc. Związek, kwas guanidynobenzoesowy
CN103012214A (zh) * 2011-09-28 2013-04-03 南京长澳医药科技有限公司 一种萘莫司他盐酸盐及萘莫司他甲磺酸盐的制备方法
AU2014230583B2 (en) 2013-03-13 2017-09-28 Takeda Pharmaceutical Company Limited Guanidinobenzoic acid ester compound
CN103641749B (zh) * 2013-12-02 2016-02-10 山东永泰化工有限公司 一种甲磺酸萘莫司他的制备方法
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
CN110330447B (zh) * 2019-07-16 2022-04-15 北京赛升药业股份有限公司 一种甲磺酸萘莫司他中间体的制备方法及其应用
EP4094758A4 (en) * 2020-01-21 2024-02-21 Acad Of Military Medical Sciences USE OF BENZOATE COMPOUNDS TO TREAT SARS-COV-2 INFECTIONS
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN111574409A (zh) * 2020-05-14 2020-08-25 河北省医疗器械与药品包装材料检验研究院(河北省医疗器械技术审评中心) 一种甲磺酸萘莫司他的重结晶工艺方法
CN113999145B (zh) * 2021-11-12 2023-02-03 开封明仁药业有限公司 一种甲磺酸萘莫司他的合成方法
WO2023118896A1 (en) 2021-12-23 2023-06-29 Subintro Limited Novel antiviral compositions comprising oleic acid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD89611A (fi) *
DE1905813A1 (de) * 1968-07-04 1970-03-05 Akad Wissenschaften Ddr 3- oder 4-Guanidobenzoesaeurebenzyl- oder -phenylestern und deren Verwendung als Inhibitoren
GB1472700A (en) * 1974-11-01 1977-05-04 Ono Pharmaceutical Co Guanidinobehzoic acid derivatives and process for preparing the same
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine

Also Published As

Publication number Publication date
US4532255A (en) 1985-07-30
NO153568C (no) 1986-05-21
AU7506281A (en) 1982-03-25
KR860000264B1 (ko) 1986-03-22
EP0048433A2 (en) 1982-03-31
EP0048433A3 (en) 1982-07-21
US4454338A (en) 1984-06-12
FI73975C (fi) 1987-12-10
DK410681A (da) 1982-03-17
DK155003B (da) 1989-01-23
SU1176832A3 (ru) 1985-08-30
CA1177488A (en) 1984-11-06
GB2083818B (en) 1984-05-10
FI73975B (fi) 1987-08-31
ES505460A0 (es) 1982-08-16
KR830007527A (ko) 1983-10-21
GB2083818A (en) 1982-03-31
CS228534B2 (en) 1984-05-14
DE3174717D1 (en) 1986-07-03
ES8206443A1 (es) 1982-08-16
DD201779A5 (de) 1983-08-10
EP0048433B1 (en) 1986-05-28
NO153568B (no) 1986-01-06
ATE20051T1 (de) 1986-06-15
PH18109A (en) 1985-03-22
NO813138L (no) 1982-03-17
HU185956B (en) 1985-04-28
AU527371B2 (en) 1983-03-03
DK155003C (da) 1989-05-29

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MA Patent expired

Owner name: TORII & CO., LTD.