AR112481A1 - Agentes antivirales contra la hepatitis b - Google Patents
Agentes antivirales contra la hepatitis bInfo
- Publication number
- AR112481A1 AR112481A1 ARP180102433A AR112481A1 AR 112481 A1 AR112481 A1 AR 112481A1 AR P180102433 A ARP180102433 A AR P180102433A AR 112481 A1 AR112481 A1 AR 112481A1
- Authority
- AR
- Argentina
- Prior art keywords
- optionally substituted
- alkyl
- occurrence
- group
- independently selected
- Prior art date
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/426—1,3-Thiazoles
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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Abstract
Reivindicación 1: Un compuesto representado por la fórmula (1), (2), (3) ó (4), o una sal de uso farmacéutico aceptable del mismo, donde n en cada aparición es independientemente 0, 1, 2 ó 3; m1 en cada aparición es independientemente 1, 2 ó 3; m2 en cada aparición es independientemente 0, 1 ó 2; m4 en cada aparición es independientemente 0, 1 ó 2; E en cada aparición es seleccionado independientemente de -C(R¹⁰)₂-, -N(R¹⁰)-, O, S, S(O) y S(O)₂; R¹⁰ en cada aparición es seleccionado independientemente de grupo que comprende hidrógeno, halo, -CN, -NO₂, alquilo C₁₋₆ opcionalmente sustituido, alquenilo C₂₋₈ opcionalmente sustituido, alquinilo C₂₋₈ opcionalmente sustituido, cicloalquilo C₃₋₈ opcionalmente sustituido, anillo heterocíclico de 3- a 8- miembros opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido y -L¹-R¹; donde L¹ es -O-, -S-, -NR¹-, -C(O)-, -C(O)O-, -OC(O)-, -C(O)N(R¹)-, -N(R¹)C(O)-, -OC(O)N(R¹)-, -N(R¹)C(O)O-, -N(R¹)C(O)N(R¹)-, -S(O)-, -S(O)₂-, -S(O)₂N(R¹)-, -N(R¹)S(O)₂-; R¹ en cada aparición es seleccionado independientemente del grupo que comprende hidrógeno, alquilo C₁₋₆ opcionalmente sustituido, alquenilo C₂₋₈ opcionalmente sustituido, alquinilo C₂₋₈ opcionalmente sustituido, cicloalquilo C₃₋₈ opcionalmente sustituido, anillo heterocíclico de 3- a 8- miembros opcionalmente sustituido, arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R¹¹ en cada aparición es seleccionado independientemente del grupo que comprende hidrógeno, halógeno, hidroxi, hidroxi protegido, -CN, amino, amino protegido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, alquilo C₁₋₆ opcionalmente sustituido, alquenilo C₂₋₈ opcionalmente sustituido, alquinilo C₂₋₈ opcionalmente sustituido, cicloalquilo C₃₋₈ opcionalmente sustituido, anillo heterocíclico de 3- a 8- miembros opcionalmente sustituido, alcoxi C₁₋₆ opcionalmente sustituido, -NH-alquilo C₁₋₆ opcionalmente sustituido, -N(alquilo C₁₋₆)₂, -CO₂H, -C(O)₂-alquilo C₁₋₆ opcionalmente sustituido, -C(O)NH-alquilo C₁₋₆ opcionalmente sustituido y -C(O)-alquilo C₁₋₆ opcionalmente sustituido; R²¹ en cada aparición es seleccionado independientemente del grupo que comprende halógeno, CN, alquilo C₁₋₆ opcionalmente sustituido, alcoxi C₁₋₆ opcionalmente sustituido y cicloalquilo C₃₋₈ opcionalmente sustituido; R²² en cada aparición es seleccionado independientemente del grupo que comprende halógeno, CN, alquilo C₁₋₆ opcionalmente sustituido, alcoxi C₁₋₆ opcionalmente sustituido, arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R³⁰ es hidrógeno, alquilo C₁₋₆ opcionalmente sustituido, un grupo protector de oxhidrilos o un grupo hidroxi de profármaco; R³¹ es seleccionado independientemente del grupo que comprende hidrógeno, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, alquilo C₁₋₆ opcionalmente sustituido, alquenilo C₂₋₈ opcionalmente sustituido, alquinilo C₂₋₈ opcionalmente sustituido, cicloalquilo C₃₋₈ opcionalmente sustituido y anillo heterocíclico de 3- a 8- miembros opcionalmente sustituido.
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Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109069488B (zh) * | 2016-03-07 | 2021-09-07 | 英安塔制药有限公司 | 乙型肝炎抗病毒剂 |
CA3073986A1 (en) * | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
US10865211B2 (en) | 2018-09-21 | 2020-12-15 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
US11198693B2 (en) | 2018-11-21 | 2021-12-14 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
WO2020247444A1 (en) | 2019-06-03 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
WO2020247575A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
WO2020247561A1 (en) | 2019-06-04 | 2020-12-10 | Enanta Pharmaceuticals, Inc, | Hepatitis b antiviral agents |
WO2021007488A1 (en) | 2019-07-11 | 2021-01-14 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
WO2021046286A1 (en) * | 2019-09-04 | 2021-03-11 | Taigen Biotechnology Co., Ltd. | Hepatitis b antiviral agents |
US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
US11802125B2 (en) | 2020-03-16 | 2023-10-31 | Enanta Pharmaceuticals, Inc. | Functionalized heterocyclic compounds as antiviral agents |
CN113105350B (zh) * | 2021-04-06 | 2023-11-24 | 利尔化学股份有限公司 | 制备2-氨基-3-烷基-5-氯苯甲酸的方法 |
Family Cites Families (148)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3385756A (en) | 1965-06-07 | 1968-05-28 | Monsanto Co | Methods of destroying insects with nitro-substituted salicylanilides |
US3975532A (en) | 1973-06-14 | 1976-08-17 | Ici United States Inc. | Hexahydro-1H-furo(3,4-c) pyrrole compounds for treating pain |
DE2853220A1 (de) | 1978-12-09 | 1980-07-03 | Hoechst Ag | Neue amino-pyrimidin-carbanilide, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung |
US4507481A (en) | 1983-07-29 | 1985-03-26 | Pennwalt Corporation | Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines |
US4917826A (en) | 1985-10-18 | 1990-04-17 | The Upjohn Company | Cyclic hydrocarbons with an aminoalkyl sidechain |
US5656644A (en) | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
EP0630644A4 (en) | 1992-11-16 | 1996-02-28 | Leonidov Nikolai B | ANTIMICROBIAL AND INTERFERON INDUCING PHARMACEUTICAL COMPOUND. |
GB9315595D0 (en) | 1993-07-28 | 1993-09-08 | Res Inst Medicine Chem | New compounds |
FR2765577A1 (fr) | 1997-07-02 | 1999-01-08 | Hoechst Schering Agrevo Sa | Nouveaux amides aromatiques, leur procede de preparation et leur application comme pesticides |
GB9805520D0 (en) | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
DE19817262A1 (de) | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
US6525069B1 (en) | 1998-12-18 | 2003-02-25 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
ATE556713T1 (de) | 1999-01-13 | 2012-05-15 | Bayer Healthcare Llc | Omega-carboxyarylsubstituierte-diphenyl- harnstoffe als p38-kinasehemmer |
DE60006541D1 (de) | 1999-06-30 | 2003-12-18 | Merck & Co Inc | Src-kinase hemmende verbindungen |
DE10012549A1 (de) | 2000-03-15 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10012823A1 (de) | 2000-03-16 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
DE10013126A1 (de) | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
JP4137636B2 (ja) | 2000-12-28 | 2008-08-20 | 塩野義製薬株式会社 | カンナビノイド2型受容体親和作用を有するピリドン誘導体 |
DE10109856A1 (de) | 2001-03-01 | 2002-09-05 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
WO2003099276A1 (en) | 2002-05-10 | 2003-12-04 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
AU2003244632A1 (en) | 2002-07-25 | 2004-02-25 | Pharmacia Italia S.P.A. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
US20050113450A1 (en) | 2002-08-23 | 2005-05-26 | Atli Thorarensen | Antibacterial agents |
US20040209930A1 (en) | 2002-10-02 | 2004-10-21 | Carboni Joan M. | Synergistic methods and compositions for treating cancer |
DE10257358A1 (de) | 2002-12-09 | 2004-07-08 | Bayer Healthcare Ag | Substituierte Pyrrole |
US7232825B2 (en) | 2003-05-02 | 2007-06-19 | Guoqing P Chen | Phenylaminopyrimidine derivatives and methods of use |
TW200519091A (en) | 2003-09-10 | 2005-06-16 | Synta Pharmaceuticals Corp | Dihydropyridine compounds for treating or preventing metabolic disorders |
EP1696898B1 (en) | 2003-12-02 | 2015-11-18 | The Ohio State University Research Foundation | Zn 2+ -chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors |
BRPI0511834A (pt) | 2004-07-14 | 2008-01-08 | Ptc Therapeutics Inc | métodos por tratar hepatite c |
WO2006033995A2 (en) | 2004-09-16 | 2006-03-30 | Valeant Research And Development | Thiazolidin-4-ones having anti-hepatitis b activity |
WO2007011626A2 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
JP5261176B2 (ja) | 2005-08-16 | 2013-08-14 | アイカジェン, インコーポレイテッド | 電位作動型ナトリウムチャンネル阻害剤 |
US20070219239A1 (en) | 2006-02-10 | 2007-09-20 | Mjalli Adnan M | Nitrogen-containing heterocycle derivatives, pharmaceutical compositions, and methods of use thereof as antiviral agents |
CA2663366C (en) | 2006-10-02 | 2012-02-07 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
US20080120759A1 (en) | 2006-11-27 | 2008-05-29 | Tolton Gary A | Waterproof cuff assembly for outer wear garment |
WO2008120759A1 (ja) | 2007-03-30 | 2008-10-09 | Japan Tobacco Inc. | ウレア化合物およびその用途 |
CA2686382C (en) | 2007-05-04 | 2013-09-17 | Irm Llc | Phenylaminopyrimidine derivatives and compositions thereof as c-kit and pdgfr kinase inhibitors |
TWI394575B (zh) | 2007-07-09 | 2013-05-01 | Golden Biotechnology Corp | Application of Cynanchum auranthone Cyclohexenone Compounds in the Preparation of Drugs for the Suppression of Hepatitis B Virus |
CA2693588C (en) | 2007-07-13 | 2015-11-17 | Icagen, Inc. | Sodium channel inhibitors |
JP2010535172A (ja) | 2007-08-02 | 2010-11-18 | エフ.ホフマン−ラ ロシュ アーゲー | Cns障害の処置のためのベンズアミド誘導体の使用 |
MX2010005356A (es) | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
JP5501226B2 (ja) | 2008-04-24 | 2014-05-21 | Msd株式会社 | アリールスルホニル誘導体を有効成分とする長鎖脂肪酸伸長酵素阻害剤 |
US8071595B2 (en) | 2008-06-25 | 2011-12-06 | Envivo Pharmaceuticals, Inc. | 1,2-disubstituted heterocyclic compounds |
JP2010030970A (ja) | 2008-07-31 | 2010-02-12 | Bayer Cropscience Ag | 殺虫性ベンゼンジカルボキサミド誘導体 |
US8101643B2 (en) | 2009-02-27 | 2012-01-24 | Enanta Pharmaceuticals, Inc. | Benzimidazole derivatives |
WO2010123139A1 (ja) | 2009-04-24 | 2010-10-28 | 持田製薬株式会社 | スルファモイル基を有するアリールカルボキサミド誘導体 |
JP5918124B2 (ja) | 2009-05-12 | 2016-05-18 | ロマーク ラボラトリーズ エル.シー. | ハロアルキルヘテロアリールベンズアミド化合物 |
US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
US20110281950A1 (en) | 2010-05-11 | 2011-11-17 | Baiocchi Robert A | Compositions and methods for reducing proliferation and viability of lymphoblastoid cells |
WO2013006394A1 (en) | 2011-07-01 | 2013-01-10 | Institute For Hepatitis And Virus Research | Sulfamoylbenzamide derivatives as antiviral agents against hbv infection |
CA2857344C (en) | 2011-12-21 | 2019-02-12 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
EP2800742B1 (en) | 2012-01-06 | 2016-04-06 | Janssen Sciences Ireland UC | 4,4-disubstituted-1,4-dihydropyrimidines and the use thereof as medicaments for the treatment of hepatitis b |
PL2803662T3 (pl) | 2012-01-13 | 2017-09-29 | Nippon Chemiphar Co., Ltd. | Antagonista receptora p2x4 |
EP2819671A4 (en) | 2012-02-29 | 2016-05-11 | Baruch S Blumberg Inst | INHIBITORS OF HEPATITIS B VIRUS WITH COVALENT CLOSED CIRCULAR DNA PREPARATION AND ITS USE METHOD |
MX2014011749A (es) | 2012-03-31 | 2015-01-22 | Hoffmann La Roche | 4-metil-dihidropirimidinas novedosas para el tratamiento y la prolifaxis de la infeccion por el virus de la hepatitis b. |
US20130267517A1 (en) | 2012-03-31 | 2013-10-10 | Hoffmann-La Roche Inc. | Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
WO2013163404A1 (en) | 2012-04-27 | 2013-10-31 | The Uab Research Foundation | TREATING VIRAL INFECTIONS HAVING VIRAL RNAs TRANSLATED BY A NON-IRES MEDIATED MECHANISM |
KR101945578B1 (ko) | 2012-06-01 | 2019-02-07 | 드렉셀유니버시티 | B형 간염 바이러스 cccdna 전사의 조절 |
AU2013305390C1 (en) | 2012-08-24 | 2015-12-24 | Ruyuan Wei Xiang Technology Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
NZ743499A (en) | 2012-08-28 | 2019-09-27 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
CA2881322A1 (en) | 2012-09-10 | 2014-03-13 | F. Hoffmann-La Roche Ag | 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
BR112015009168B1 (pt) | 2012-10-25 | 2022-09-27 | Tetra Discovery Partners, LLC | Composto de fórmula estrutural xi ou um sal do mesmo, uso de um composto e composição farmacêutica |
CA2896554C (en) * | 2012-12-27 | 2019-11-05 | Drexel University | Novel antiviral agents against hbv infection |
WO2014184328A1 (en) | 2013-05-17 | 2014-11-20 | F. Hoffmann-La Roche Ag | 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
EP2997019B1 (en) | 2013-05-17 | 2018-08-08 | Janssen Sciences Ireland UC | Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
WO2015005295A1 (ja) | 2013-07-12 | 2015-01-15 | 株式会社アイ・イー・ジェー | 抗菌剤、袋入り抗菌剤およびシート型抗菌剤 |
UY35834A (es) | 2013-11-14 | 2015-05-29 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Piperazinas de pirazolo sustituido como inhibidores de caseína quinasa 1 delta y epsilon |
RU2678990C1 (ru) | 2013-11-19 | 2019-02-05 | Саншайн Лейк Фарма Ко., Лтд. | Соединения дигидропиримидина и их применение в фармацевтических препаратах |
AU2014356984B2 (en) | 2013-11-27 | 2018-01-04 | Sunshine Lake Pharma Co., Ltd. | Processes for preparing dihydropyrimidine derivatives and intermediates thereof |
US9435197B2 (en) | 2014-01-14 | 2016-09-06 | Baker Hughes Incorporated | Distributed marinized borehole system |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
PE20160686A1 (es) | 2014-01-30 | 2016-07-23 | Hoffmann La Roche | Nuevas dihidroquinolizinonas para el tratamiento y profilaxis de la infeccion por virus de la hepatitis b |
JP6306750B2 (ja) | 2014-03-07 | 2018-04-04 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B型肝炎ウイルス感染症の治療および予防のための新規な6−縮合ヘテロアリールジヒドロピリミジン |
SG11201605896WA (en) | 2014-03-28 | 2016-08-30 | Sunshine Lake Pharma Co Ltd | Dihydropyrimidine compounds and their application in pharmaceuticals |
RU2016146365A (ru) | 2014-05-13 | 2018-06-19 | Ф. Хоффманн-Ля Рош Аг | Новые дигидрохинолизиноны для лечения и профилактики заражения вирусом гепатита b |
BR112016028000B1 (pt) | 2014-05-30 | 2022-05-17 | Qilu Pharmaceutical Co., Ltd | Derivado de alça de di-hidropirimido como um inibidor de hbv |
EP3174859B1 (en) | 2014-07-31 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Flt3 receptor antagonists |
CN106573898B (zh) | 2014-08-14 | 2018-11-09 | 豪夫迈·罗氏有限公司 | 治疗和预防乙型肝炎病毒感染的新的哒嗪酮和三嗪酮 |
WO2016025933A2 (en) | 2014-08-15 | 2016-02-18 | Ptc Therapeutics, Inc. | Substituted polycyclic antibacterial compounds |
US9637485B2 (en) | 2014-11-03 | 2017-05-02 | Hoffmann-La Roche Inc. | 6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection |
AU2015358561A1 (en) | 2014-12-02 | 2017-06-08 | Novira Therapeutics, Inc. | Sulfide alkyl and pyridyl reverse sulfonamide compounds for HBV treatment |
EP3240537B1 (en) | 2014-12-30 | 2020-09-09 | F. Hoffmann-La Roche AG | Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection |
US9518057B2 (en) | 2014-12-30 | 2016-12-13 | Novira Therapeutics, Inc. | Derivatives and methods of treating hepatitis B infections |
CN107207505B (zh) | 2015-02-11 | 2018-12-14 | 豪夫迈·罗氏有限公司 | 治疗和预防乙型肝炎病毒感染的 2-氧代-6,7-二氢苯并[a]喹嗪-3-甲酸衍生物 |
WO2016161268A1 (en) | 2015-04-01 | 2016-10-06 | Enanta Pharmaceuticals, Inc. | Hepatitis b antviral agents |
CN107624113B (zh) | 2015-05-04 | 2020-10-23 | 豪夫迈·罗氏有限公司 | 作为HBsAg (HBV 表面抗原)和HBV DNA 生成的抑制剂用于治疗乙型肝炎病毒感染的四氢吡啶并嘧啶和四氢吡啶并吡啶类化合物 |
WO2016183266A1 (en) | 2015-05-13 | 2016-11-17 | Enanta Pharmaceuticals, Inc. | Ehpatitis b antiviral agents |
US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
WO2017013046A1 (en) | 2015-07-21 | 2017-01-26 | F. Hoffmann-La Roche Ag | Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
US10301255B2 (en) | 2015-07-22 | 2019-05-28 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
EP3328855B1 (en) | 2015-07-27 | 2019-05-15 | H. Hoffnabb-La Roche Ag | Novel tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection |
WO2017017043A1 (en) | 2015-07-28 | 2017-02-02 | F. Hoffmann-La Roche Ag | Novel 6,7-dihydropyrido[2,1-a]phthalazin-2-ones for the treatment and prophylaxis of hepatitis b virus infection |
CN108135891B (zh) | 2015-10-05 | 2021-07-20 | 富士胶片富山化学株式会社 | 抗乙型肝炎病毒药 |
WO2017076286A1 (zh) | 2015-11-04 | 2017-05-11 | 南京明德新药研发股份有限公司 | 二氢吡啶并环化合物的晶型、制备方法和中间体 |
EP3637728A1 (en) | 2015-12-24 | 2020-04-15 | Samsung Electronics Co., Ltd. | Method and terminal for implementing communication |
US10280175B2 (en) | 2016-02-02 | 2019-05-07 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
ES2897913T3 (es) | 2016-02-19 | 2022-03-03 | Novartis Ag | Compuestos de piridona tetracíclicos como antivirales |
CN109069488B (zh) | 2016-03-07 | 2021-09-07 | 英安塔制药有限公司 | 乙型肝炎抗病毒剂 |
US10858366B2 (en) | 2016-03-08 | 2020-12-08 | Novartis Ag | Tricyclic compounds useful to treat orthomyxovirus infections |
FI3442947T3 (fi) | 2016-04-15 | 2023-08-24 | Epizyme Inc | Amiinisubstituoituja aryyli- tai heteroaryyliyhdisteitä EHMT1- ja EHMT2-inhibiittoreina |
BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
WO2017214395A1 (en) | 2016-06-10 | 2017-12-14 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
TN2018000395A1 (en) | 2016-06-10 | 2020-06-15 | Servier Lab | New (hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them |
CR20180581A (es) | 2016-06-10 | 2019-02-11 | Bayer Pharma AG | Complejos radio-farmacéuticos |
AR108586A1 (es) | 2016-06-10 | 2018-09-05 | Lilly Co Eli | Compuestos de 2,3-dihidro-1h-indol |
FR3052452B1 (fr) | 2016-06-10 | 2018-06-22 | Les Laboratoires Servier | Nouveaux derives de piperidinyle, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2017216686A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals |
WO2017216685A1 (en) | 2016-06-16 | 2017-12-21 | Novartis Ag | Pentacyclic pyridone compounds as antivirals |
MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
EP3478680B1 (en) | 2016-06-29 | 2020-04-22 | H. Hoffnabb-La Roche Ag | Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hbv infection |
JP6821716B2 (ja) | 2016-06-29 | 2021-01-27 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | B型肝炎ウイルス感染の処置および予防のための新規のジヒドロピロロピリミジン |
WO2018019297A1 (zh) | 2016-07-29 | 2018-02-01 | 银杏树药业(苏州)有限公司 | 异喹啉酮类化合物及其制备抗病毒药物的应用 |
CN110156774A (zh) | 2016-07-29 | 2019-08-23 | 新波制药有限公司 | 用于治疗hbv感染的新颖治疗剂 |
WO2018047109A1 (en) | 2016-09-09 | 2018-03-15 | Novartis Ag | Polycyclic pyridone compounds as antivirals |
TW201819380A (zh) | 2016-10-18 | 2018-06-01 | 瑞士商諾華公司 | 作為抗病毒劑之稠合四環吡啶酮化合物 |
EP3535262B1 (en) | 2016-11-03 | 2020-08-05 | F. Hoffmann-La Roche AG | Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
WO2018083136A1 (en) | 2016-11-03 | 2018-05-11 | F. Hoffmann-La Roche Ag | Novel tetrahydroisoquinolines and terahydronaphthyridines for the treatment and prophylaxis of hepatitis b virus infection |
JP7019691B2 (ja) | 2016-11-03 | 2022-02-15 | エフ.ホフマン-ラ ロシュ アーゲー | B型肝炎ウイルス感染症の処置及び予防のための新規なテトラヒドロピリドピリミジン |
CN116751200A (zh) | 2016-11-07 | 2023-09-15 | 爱彼特生物制药公司 | 含有取代的吡啶酮的三环化合物以及使用其的方法 |
WO2018087345A1 (en) | 2016-11-14 | 2018-05-17 | F. Hoffmann-La Roche Ag | COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON |
US10085126B2 (en) | 2016-11-15 | 2018-09-25 | Hank Technology Llc | Inmate text communication via Wi-Fi radio |
CN117024351A (zh) | 2017-01-06 | 2023-11-10 | 里维斯制药股份有限公司 | 新型苯基衍生物 |
CN109369640B (zh) | 2017-01-13 | 2020-03-27 | 苏州爱科百发生物医药技术有限公司 | 一种二氢异喹啉类化合物的制备方法 |
JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
WO2018154466A1 (en) | 2017-02-21 | 2018-08-30 | Glaxosmithkline Intellectual Property Development Limited | Dihydroquinolizinones as antivirals |
CN106928245B (zh) | 2017-03-06 | 2019-06-11 | 河南春风医药科技有限公司 | 一种喹嗪酮类化合物及其制备方法和应用 |
CN106928215B (zh) | 2017-03-06 | 2019-03-22 | 河南春风医药科技有限公司 | 一种喹嗪酮类化合物的制备方法 |
ES2879930T3 (es) | 2017-03-09 | 2021-11-23 | Fujian Cosunter Pharmaceutical Co Ltd | Inhibidor del antígeno de superficie del virus de la hepatitis B |
RU2019130519A (ru) | 2017-03-31 | 2021-04-30 | Фуджифилм Корпорэйшн | 4-пиридоновое соединение или его соль, фармацевтическая композиция и содержащий их состав |
CN108727378A (zh) | 2017-04-19 | 2018-11-02 | 银杏树药业(苏州)有限公司 | 新型异喹啉类化合物及其医药用途 |
AR111419A1 (es) | 2017-04-27 | 2019-07-10 | Novartis Ag | Compuestos fusionados de indazol piridona como antivirales |
CN108794481A (zh) | 2017-04-28 | 2018-11-13 | 齐鲁制药有限公司 | 化合物的多晶型、其制备方法和用途 |
CN110066278B (zh) | 2017-06-01 | 2021-06-08 | 广东东阳光药业有限公司 | 稠合三环类化合物及其在药物中的应用 |
CA3073986A1 (en) | 2017-08-28 | 2019-03-07 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
DK3692040T3 (da) | 2017-10-05 | 2023-03-13 | Glaxosmithkline Ip Dev Ltd | Kemiske forbindelser |
EP3710455A1 (en) | 2017-11-17 | 2020-09-23 | Novartis AG | Novel dihydroisoxazole compounds and their use for the treatment of hepatitis b |
EP3694856B1 (en) | 2017-11-22 | 2023-10-25 | Sunshine Lake Pharma Co., Ltd. | Fused tricyclic compounds and uses thereof in medicine |
GB201720163D0 (en) | 2017-12-04 | 2018-01-17 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of hepatitis B |
TW201927789A (zh) | 2017-12-06 | 2019-07-16 | 美商因那塔製藥公司 | B型肝炎抗病毒試劑 |
WO2019113175A1 (en) | 2017-12-06 | 2019-06-13 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
WO2019123285A1 (en) | 2017-12-20 | 2019-06-27 | Novartis Ag | Fused tricyclic pyrazolo-dihydropyrazinyl-pyridone compounds as antivirals |
CN111511739B (zh) | 2017-12-28 | 2023-09-15 | 豪夫迈·罗氏有限公司 | 用于治疗和预防乙型肝炎病毒感染的二氢嘧啶基噻唑 |
US11058678B2 (en) | 2018-01-22 | 2021-07-13 | Enanta Pharmaceuticals, Inc. | Substituted heterocycles as antiviral agents |
CN111801331A (zh) | 2018-02-28 | 2020-10-20 | 诺华股份有限公司 | 吲哚-2-羰基化合物及其用于治疗乙型肝炎的用途 |
US10729688B2 (en) | 2018-03-29 | 2020-08-04 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
US10865211B2 (en) | 2018-09-21 | 2020-12-15 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
US11198693B2 (en) | 2018-11-21 | 2021-12-14 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
US11236108B2 (en) | 2019-09-17 | 2022-02-01 | Enanta Pharmaceuticals, Inc. | Functionalized heterocycles as antiviral agents |
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SG11202001685TA (en) | 2020-03-30 |
TW201920095A (zh) | 2019-06-01 |
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KR102556744B1 (ko) | 2023-07-18 |
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PH12020550065A1 (en) | 2021-02-15 |
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BR112020004112A2 (pt) | 2020-09-24 |
IL272941B (en) | 2022-11-01 |
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