EA202190359A1 - Способы лечения нейродегенеративных расстройств - Google Patents
Способы лечения нейродегенеративных расстройствInfo
- Publication number
- EA202190359A1 EA202190359A1 EA202190359A EA202190359A EA202190359A1 EA 202190359 A1 EA202190359 A1 EA 202190359A1 EA 202190359 A EA202190359 A EA 202190359A EA 202190359 A EA202190359 A EA 202190359A EA 202190359 A1 EA202190359 A1 EA 202190359A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- methods
- neurodegenerative disorders
- amyloid
- disease
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
В изобретении предложено применение соединения формулы (I)или его фармацевтически приемлемой соли для лечения заболевания, характеризующегося амилоидом и амилоидоподобными агрегатами, например болезни Альцгеймера.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862713056P | 2018-08-01 | 2018-08-01 | |
| PCT/US2019/044114 WO2020028348A1 (en) | 2018-08-01 | 2019-07-30 | Sulfopropanoic acid derivatives for treating neurodegenerative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA202190359A1 true EA202190359A1 (ru) | 2021-09-27 |
Family
ID=67587959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA202190359A EA202190359A1 (ru) | 2018-08-01 | 2019-07-30 | Способы лечения нейродегенеративных расстройств |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20220087967A1 (ru) |
| EP (2) | EP4296670A3 (ru) |
| JP (1) | JP7466520B2 (ru) |
| KR (1) | KR20210039416A (ru) |
| CN (1) | CN112867487A (ru) |
| AU (1) | AU2019314323A1 (ru) |
| BR (1) | BR112021001718A2 (ru) |
| CA (1) | CA3108182A1 (ru) |
| DK (1) | DK3829568T3 (ru) |
| EA (1) | EA202190359A1 (ru) |
| ES (1) | ES2969887T3 (ru) |
| FI (1) | FI3829568T3 (ru) |
| HR (1) | HRP20231576T1 (ru) |
| HU (1) | HUE064501T2 (ru) |
| IL (1) | IL280441A (ru) |
| LT (1) | LT3829568T (ru) |
| MX (1) | MX2021001273A (ru) |
| PL (1) | PL3829568T3 (ru) |
| PT (1) | PT3829568T (ru) |
| RS (1) | RS65022B1 (ru) |
| SG (1) | SG11202100761PA (ru) |
| SI (1) | SI3829568T1 (ru) |
| WO (1) | WO2020028348A1 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114315655A (zh) * | 2021-12-18 | 2022-04-12 | 青岛科技大学 | 一种吸电子基团的不饱和烷烃的磺化方法 |
| WO2024119183A1 (en) | 2022-12-02 | 2024-06-06 | Alzheon, Inc. | Methods for treating neurodegenerative disorders with tramiprosate |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840294A (en) * | 1993-03-29 | 1998-11-24 | Queen's University At Kingston | Method for treating amyloidosis |
| CN100571701C (zh) * | 2002-12-24 | 2009-12-23 | 贝卢斯健康(国际）有限公司 | 治疗β淀粉样蛋白相关疾病的治疗性制品 |
| US10471029B2 (en) * | 2014-03-21 | 2019-11-12 | Alzheon, Inc. | Methods for treating neurological disorders |
| JP6789579B2 (ja) * | 2015-09-10 | 2020-11-25 | アルジオン， インコーポレイテッド | 特定の患者集団において神経変性障害を処置する方法 |
-
2019
- 2019-07-30 ES ES19752609T patent/ES2969887T3/es active Active
- 2019-07-30 HR HRP20231576TT patent/HRP20231576T1/hr unknown
- 2019-07-30 PL PL19752609.8T patent/PL3829568T3/pl unknown
- 2019-07-30 CA CA3108182A patent/CA3108182A1/en active Pending
- 2019-07-30 EP EP23188362.0A patent/EP4296670A3/en active Pending
- 2019-07-30 AU AU2019314323A patent/AU2019314323A1/en active Pending
- 2019-07-30 SG SG11202100761PA patent/SG11202100761PA/en unknown
- 2019-07-30 JP JP2021505732A patent/JP7466520B2/ja active Active
- 2019-07-30 PT PT197526098T patent/PT3829568T/pt unknown
- 2019-07-30 EA EA202190359A patent/EA202190359A1/ru unknown
- 2019-07-30 RS RS20231168A patent/RS65022B1/sr unknown
- 2019-07-30 US US17/264,478 patent/US20220087967A1/en active Pending
- 2019-07-30 KR KR1020217005804A patent/KR20210039416A/ko unknown
- 2019-07-30 DK DK19752609.8T patent/DK3829568T3/da active
- 2019-07-30 MX MX2021001273A patent/MX2021001273A/es unknown
- 2019-07-30 CN CN201980064442.3A patent/CN112867487A/zh active Pending
- 2019-07-30 SI SI201930675T patent/SI3829568T1/sl unknown
- 2019-07-30 BR BR112021001718-6A patent/BR112021001718A2/pt unknown
- 2019-07-30 EP EP19752609.8A patent/EP3829568B1/en active Active
- 2019-07-30 FI FIEP19752609.8T patent/FI3829568T3/fi active
- 2019-07-30 LT LTEPPCT/US2019/044114T patent/LT3829568T/lt unknown
- 2019-07-30 HU HUE19752609A patent/HUE064501T2/hu unknown
- 2019-07-30 WO PCT/US2019/044114 patent/WO2020028348A1/en active Application Filing
-
2021
- 2021-01-27 IL IL280441A patent/IL280441A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020028348A1 (en) | 2020-02-06 |
| FI3829568T3 (fi) | 2023-12-04 |
| JP7466520B2 (ja) | 2024-04-12 |
| EP3829568A1 (en) | 2021-06-09 |
| JP2021534086A (ja) | 2021-12-09 |
| SG11202100761PA (en) | 2021-02-25 |
| MX2021001273A (es) | 2021-07-15 |
| US20220087967A1 (en) | 2022-03-24 |
| LT3829568T (lt) | 2023-12-27 |
| DK3829568T3 (en) | 2023-12-18 |
| ES2969887T3 (es) | 2024-05-23 |
| SI3829568T1 (sl) | 2024-02-29 |
| EP3829568B1 (en) | 2023-09-06 |
| AU2019314323A1 (en) | 2021-03-18 |
| IL280441A (en) | 2021-03-01 |
| HUE064501T2 (hu) | 2024-03-28 |
| EP4296670A3 (en) | 2024-03-13 |
| PL3829568T3 (pl) | 2024-03-25 |
| KR20210039416A (ko) | 2021-04-09 |
| BR112021001718A2 (pt) | 2021-04-27 |
| HRP20231576T1 (hr) | 2024-03-15 |
| CA3108182A1 (en) | 2020-02-06 |
| PT3829568T (pt) | 2023-12-14 |
| EP4296670A2 (en) | 2023-12-27 |
| CN112867487A (zh) | 2021-05-28 |
| RS65022B1 (sr) | 2024-01-31 |
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