AR110977A2 - Compuestos de cicloalquiloxi- y heterocicloalquiloxipiridina como moduladores del receptor de histamina h₃ - Google Patents
Compuestos de cicloalquiloxi- y heterocicloalquiloxipiridina como moduladores del receptor de histamina h₃Info
- Publication number
- AR110977A2 AR110977A2 ARP180100346A ARP180100346A AR110977A2 AR 110977 A2 AR110977 A2 AR 110977A2 AR P180100346 A ARP180100346 A AR P180100346A AR P180100346 A ARP180100346 A AR P180100346A AR 110977 A2 AR110977 A2 AR 110977A2
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- heterocicloalquyloxypyridine
- cyclalquyloxy
- modulators
- compounds
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1), en donde R¹ es -alquilo C₁₋₅ o un grupo cicloalquilo saturado; m es 1 ó 2; R² es -H o -OCHR³R⁴; donde R³ es -H; y R⁴ es un anillo cicloalquilo o heterocicloalquilo, no sustituido o sustituido con -alquilo C₁₋₄ o acetilo; o R³ y R⁴, tomados junto con el carbono al cual están unidos, forman un anillo cicloalquilo o heterocicloalquilo, no sustituido o sustituido con -alquilo C₁₋₄ o acetilo; X es N o CH; e Y es N o CRᵃ; donde Rᵃ es -H, -OCHR³R⁴, -CH₂NRᵇRᶜ, -CN, -CO₂-alquilo C₁₋₄, -CO₂H o -CONRᵇRᶜ; Rᵇ y Rᶜ son cada uno independientemente -H o -alquilo C₁₋₄; con la condición de que uno de X e Y sea N y uno de R² y Rᵃ sea -OCHR³R⁴; o una sal farmacéuticamente aceptable, una prodroga farmacéuticamente aceptable o un metabolito farmacéuticamente activo de dicho compuesto.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98924607P | 2007-11-20 | 2007-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR110977A2 true AR110977A2 (es) | 2019-05-22 |
Family
ID=40297867
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080105055A AR069387A1 (es) | 2007-11-20 | 2008-11-20 | Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3 |
ARP180100346A AR110977A2 (es) | 2007-11-20 | 2018-02-14 | Compuestos de cicloalquiloxi- y heterocicloalquiloxipiridina como moduladores del receptor de histamina h₃ |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080105055A AR069387A1 (es) | 2007-11-20 | 2008-11-20 | Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3 |
Country Status (23)
Country | Link |
---|---|
US (1) | US8883776B2 (es) |
EP (1) | EP2222664B1 (es) |
JP (1) | JP5498390B2 (es) |
KR (1) | KR101546712B1 (es) |
CN (2) | CN101868454A (es) |
AR (2) | AR069387A1 (es) |
AU (1) | AU2008326561B2 (es) |
BR (1) | BRPI0820481A2 (es) |
CA (1) | CA2706328C (es) |
CL (1) | CL2008003465A1 (es) |
CO (1) | CO6210700A2 (es) |
CR (1) | CR11529A (es) |
EA (1) | EA018582B1 (es) |
EC (1) | ECSP10010190A (es) |
HK (1) | HK1147994A1 (es) |
MX (1) | MX2010005488A (es) |
MY (1) | MY158253A (es) |
NI (1) | NI201000086A (es) |
NZ (1) | NZ584998A (es) |
TW (1) | TWI491604B (es) |
UA (1) | UA103468C2 (es) |
WO (1) | WO2009067401A1 (es) |
ZA (1) | ZA201004334B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0324159D0 (en) | 2003-10-15 | 2003-11-19 | Glaxo Group Ltd | Novel compounds |
KR20100059944A (ko) * | 2007-09-06 | 2010-06-04 | 글락소 그룹 리미티드 | 히스타민 h3 수용체에 대해 친화성을 갖는 피페라진 유도체 |
US20090318380A1 (en) | 2007-11-20 | 2009-12-24 | Pharmasset, Inc. | 2',4'-substituted nucleosides as antiviral agents |
CA2721303C (en) * | 2008-05-08 | 2016-06-28 | Evotec Ag | Azetidines and cyclobutanes as histamine h3 receptor antagonists |
MX2011009784A (es) * | 2009-03-18 | 2011-09-30 | Janssen Pharmaceutica Nv | Proceso para la preparacion de moduladores del receptor h3 de histamina. |
US20110183980A1 (en) * | 2009-09-21 | 2011-07-28 | Conn P Jeffrey | O-benzyl nicotinamide analogs as mglur5 positive allosteric modulators |
CN103826616B (zh) | 2011-07-07 | 2016-08-10 | 爱尔兰詹森科学公司 | 地瑞纳韦组合配制品 |
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2008
- 2008-11-17 EA EA201070637A patent/EA018582B1/ru unknown
- 2008-11-17 CN CN200880117055A patent/CN101868454A/zh active Pending
- 2008-11-17 KR KR1020107013252A patent/KR101546712B1/ko active IP Right Grant
- 2008-11-17 NZ NZ584998A patent/NZ584998A/xx not_active IP Right Cessation
- 2008-11-17 BR BRPI0820481-0A patent/BRPI0820481A2/pt not_active IP Right Cessation
- 2008-11-17 US US12/272,268 patent/US8883776B2/en not_active Expired - Fee Related
- 2008-11-17 UA UAA201007603A patent/UA103468C2/ru unknown
- 2008-11-17 CN CN201610094782.9A patent/CN105712977B/zh not_active Expired - Fee Related
- 2008-11-17 CA CA2706328A patent/CA2706328C/en not_active Expired - Fee Related
- 2008-11-17 JP JP2010535014A patent/JP5498390B2/ja not_active Expired - Fee Related
- 2008-11-17 MX MX2010005488A patent/MX2010005488A/es active IP Right Grant
- 2008-11-17 MY MYPI2010002288A patent/MY158253A/en unknown
- 2008-11-17 EP EP08852442.6A patent/EP2222664B1/en not_active Not-in-force
- 2008-11-17 AU AU2008326561A patent/AU2008326561B2/en not_active Ceased
- 2008-11-17 WO PCT/US2008/083764 patent/WO2009067401A1/en active Application Filing
- 2008-11-19 TW TW097144606A patent/TWI491604B/zh not_active IP Right Cessation
- 2008-11-20 CL CL2008003465A patent/CL2008003465A1/es unknown
- 2008-11-20 AR ARP080105055A patent/AR069387A1/es not_active Application Discontinuation
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2010
- 2010-05-18 NI NI201000086A patent/NI201000086A/es unknown
- 2010-05-19 EC EC2010010190A patent/ECSP10010190A/es unknown
- 2010-05-20 CO CO10060285A patent/CO6210700A2/es active IP Right Grant
- 2010-06-18 ZA ZA2010/04334A patent/ZA201004334B/en unknown
- 2010-06-21 CR CR11529A patent/CR11529A/es not_active Application Discontinuation
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2011
- 2011-02-28 HK HK11101993.2A patent/HK1147994A1/xx not_active IP Right Cessation
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AU2008326561B2 (en) | 2013-12-05 |
BRPI0820481A2 (pt) | 2015-06-16 |
HK1147994A1 (en) | 2011-08-26 |
CN101868454A (zh) | 2010-10-20 |
CL2008003465A1 (es) | 2009-03-06 |
KR101546712B1 (ko) | 2015-08-24 |
JP2011503233A (ja) | 2011-01-27 |
UA103468C2 (ru) | 2013-10-25 |
EA201070637A1 (ru) | 2010-12-30 |
NZ584998A (en) | 2012-08-31 |
TWI491604B (zh) | 2015-07-11 |
JP5498390B2 (ja) | 2014-05-21 |
MY158253A (en) | 2016-09-30 |
US8883776B2 (en) | 2014-11-11 |
ECSP10010190A (es) | 2010-06-29 |
CN105712977A (zh) | 2016-06-29 |
AU2008326561A1 (en) | 2009-05-28 |
TW200936579A (en) | 2009-09-01 |
KR20100098636A (ko) | 2010-09-08 |
CN105712977B (zh) | 2021-06-29 |
WO2009067401A1 (en) | 2009-05-28 |
EP2222664B1 (en) | 2014-10-29 |
CR11529A (es) | 2012-10-25 |
NI201000086A (es) | 2011-03-17 |
CO6210700A2 (es) | 2010-10-20 |
EP2222664A1 (en) | 2010-09-01 |
EA018582B1 (ru) | 2013-09-30 |
ZA201004334B (en) | 2011-10-26 |
CA2706328A1 (en) | 2009-05-28 |
MX2010005488A (es) | 2010-06-01 |
AR069387A1 (es) | 2010-01-20 |
US20090131415A1 (en) | 2009-05-21 |
CA2706328C (en) | 2016-04-19 |
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