CR20110268A - Moduladores de aril metil benzoquinazolinona alostéricos positivos del receptor m1 - Google Patents

Moduladores de aril metil benzoquinazolinona alostéricos positivos del receptor m1

Info

Publication number
CR20110268A
CR20110268A CR20110268A CR20110268A CR20110268A CR 20110268 A CR20110268 A CR 20110268A CR 20110268 A CR20110268 A CR 20110268A CR 20110268 A CR20110268 A CR 20110268A CR 20110268 A CR20110268 A CR 20110268A
Authority
CR
Costa Rica
Prior art keywords
benzoquinazolinona
metil
aril
modulators
receiver
Prior art date
Application number
CR20110268A
Other languages
English (en)
Inventor
Scott D Kuduk
Douglas C Beshore
Marco Christina Ng Di
Thomas J Greshock
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CR20110268A publication Critical patent/CR20110268A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
    • C07C53/19—Acids containing three or more carbon atoms
    • C07C53/21—Acids containing three or more carbon atoms containing fluorine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

El presente invento se refiere a nuevos compuestos de aril metil benzoquinazolinona de la fórmula genérica (I) o una sal farmacéuticamente aceptable de los mismos, que es útil com un modulador alostérico positivo del receptor M1.
CR20110268A 2008-11-20 2011-05-20 Moduladores de aril metil benzoquinazolinona alostéricos positivos del receptor m1 CR20110268A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19974008P 2008-11-20 2008-11-20

Publications (1)

Publication Number Publication Date
CR20110268A true CR20110268A (es) 2011-07-01

Family

ID=41565956

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110268A CR20110268A (es) 2008-11-20 2011-05-20 Moduladores de aril metil benzoquinazolinona alostéricos positivos del receptor m1

Country Status (37)

Country Link
US (4) US8557832B2 (es)
EP (1) EP2358686B1 (es)
JP (1) JP5102397B2 (es)
KR (1) KR101305590B1 (es)
CN (1) CN102292323B (es)
BR (1) BRPI0921924A2 (es)
CA (1) CA2743562C (es)
CO (1) CO6361928A2 (es)
CR (1) CR20110268A (es)
CY (1) CY1113665T1 (es)
DK (1) DK2358686T3 (es)
DO (1) DOP2011000135A (es)
EA (1) EA019098B1 (es)
EC (1) ECSP11011066A (es)
ES (1) ES2393694T3 (es)
GE (1) GEP20156348B (es)
GT (1) GT201100127A (es)
HK (1) HK1154587A1 (es)
HN (1) HN2011001358A (es)
HR (1) HRP20120992T1 (es)
IL (1) IL212573A (es)
MA (1) MA32898B1 (es)
MX (1) MX2011005284A (es)
MY (1) MY162502A (es)
NI (1) NI201100100A (es)
NZ (1) NZ592961A (es)
PE (1) PE20120031A1 (es)
PL (1) PL2358686T3 (es)
PT (1) PT2358686E (es)
RS (1) RS52528B (es)
SG (1) SG171769A1 (es)
SI (1) SI2358686T1 (es)
SV (1) SV2011003912A (es)
TN (1) TN2011000209A1 (es)
UA (1) UA100459C2 (es)
WO (1) WO2010059773A1 (es)
ZA (1) ZA201103612B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012003464B8 (pt) * 2009-08-31 2021-05-25 Merck Sharp & Dohme compostos de piranil aril metil benzoquinaozlinona, uso dos mesmos, e, composição farmacêutica
EP2490692B1 (en) 2009-10-21 2016-11-16 Merck Sharp & Dohme Corp. Quinolinone-pyrazolone m1 receptor positive allosteric modulators
EP2512245B1 (en) * 2009-12-14 2014-07-23 Merck Sharp & Dohme Corp. Pyridoquinazolinone m1 receptor positive allosteric modulators
US9199939B2 (en) 2009-12-17 2015-12-01 Merck Sharp & Dohme Corp. Quinoline amide M1 receptor positive allosteric modulators
US8383638B2 (en) * 2009-12-21 2013-02-26 Merck Sharp & Dohme Aminobenzoquinazolinone M1 receptor positive allosteric modulators
WO2011159553A1 (en) * 2010-06-15 2011-12-22 Merck Sharp & Dohme Corp. Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators
EP2588104B1 (en) 2010-07-01 2014-12-10 Merck Sharp & Dohme Corp. Isoindolone m1 receptor positive allosteric modulators
US8664234B2 (en) * 2010-10-04 2014-03-04 Merck Sharp & Dohme Corp. Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators
WO2012158473A1 (en) 2011-05-17 2012-11-22 Merck Sharp & Dohme Corp. N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators
AR088786A1 (es) 2011-08-12 2014-07-10 Basf Se Compuestos de antranilamida y sus usos como plaguicidas
EP2742022A1 (en) 2011-08-12 2014-06-18 Basf Se Anthranilamide compounds and their use as pesticides
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
IN2012DE00083A (es) * 2012-01-10 2015-05-01 Council Scient Ind Res
US9403802B2 (en) 2012-03-02 2016-08-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use therefor
US9777005B2 (en) 2012-11-19 2017-10-03 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound containing a substituted pyrrole ring
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
DE112015001835T5 (de) 2014-04-17 2016-12-29 Sumitomo Chemical Company, Limited Verfahren zur Herstellung einer Nitroverbindung
WO2016144727A1 (en) * 2015-03-06 2016-09-15 Chase Pharmaceuticals Corporation Peripheral-anticholinergic muscarinic agonist combination
EP3313836B1 (en) * 2015-06-26 2020-11-11 Takeda Pharmaceutical Company Limited 2,3-dihydro-4h-1,3-benzoxazin-4-one derivatives as modulators of cholinergic muscarinic m1 receptor
CA2996717A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
WO2017058691A1 (en) * 2015-09-30 2017-04-06 Merck Sharp & Dohme Corp. Process for making m1 receptor positive allosteric modulators
EP3356333A4 (en) * 2015-09-30 2019-03-27 Merck Sharp & Dohme Corp. CRYSTAL FORMS OF AN M1 RECEPTOR POSITIVE ALLOSTERIC MODULATOR
US10548899B2 (en) * 2015-10-20 2020-02-04 Takeda Pharmaceutical Company Limited Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity
AU2017251537B2 (en) 2016-04-15 2020-10-08 Abbvie Inc. Bromodomain inhibitors
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
UA125628C2 (uk) 2016-10-14 2022-05-04 Пі Індастріз Лтд Похідні 4-заміщеного феніламіну і їх використання для захисту культур від небажаних фітопатогенних мікроорганізмів
EP3535253A1 (en) 2016-11-01 2019-09-11 H. Hoffnabb-La Roche Ag 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases
WO2018212312A1 (ja) 2017-05-19 2018-11-22 武田薬品工業株式会社 スクリーニング方法
KR20210068025A (ko) 2018-09-28 2021-06-08 다케다 야쿠힌 고교 가부시키가이샤 헤테로시클릭 화합물
EP4308664A1 (de) 2021-03-18 2024-01-24 Merck Patent GmbH Heteroaromatische verbindungen für organische elektrolumineszenzvorrichtungen
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2180798T3 (es) * 1995-10-02 2003-02-16 Hoffmann La Roche Derivados de pirimidina como antagonistas del receptor de 5ht2c.
JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
JP4484368B2 (ja) * 1998-10-16 2010-06-16 大日本住友製薬株式会社 キナゾリノン誘導体
JP2005089298A (ja) * 2001-09-18 2005-04-07 Japan Tobacco Inc ナフタレン化合物及びその医薬用途
US20060233843A1 (en) 2003-02-19 2006-10-19 Conn P J Treatment of psychosis with a muscarinic m1 receptor ectopic activator
MX2007013606A (es) * 2005-05-04 2007-12-10 Hoffmann La Roche (3,4-dihidro-quinazolin2-il)-(2-ariloxi-etil)-aminas que tienen una actividad en el receptor 5-ht.
CA2655787A1 (en) * 2006-06-28 2008-01-03 Merck And Co., Inc. Benzyl-substituted quinolone m1 receptor positive allosteric modulators
US8664234B2 (en) * 2010-10-04 2014-03-04 Merck Sharp & Dohme Corp. Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators

Also Published As

Publication number Publication date
EP2358686B1 (en) 2012-09-26
SG171769A1 (en) 2011-07-28
US20140005182A1 (en) 2014-01-02
GEP20156348B (en) 2015-08-25
KR101305590B1 (ko) 2013-09-09
NZ592961A (en) 2012-09-28
PL2358686T3 (pl) 2013-02-28
IL212573A0 (en) 2011-06-30
MY162502A (en) 2017-06-15
RS52528B (en) 2013-04-30
ZA201103612B (en) 2012-01-25
HRP20120992T1 (hr) 2012-12-31
HK1154587A1 (en) 2012-04-27
US8883810B2 (en) 2014-11-11
EA019098B1 (ru) 2014-01-30
GT201100127A (es) 2014-02-10
UA100459C2 (en) 2012-12-25
MX2011005284A (es) 2011-06-17
EA201170705A1 (ru) 2011-12-30
AU2009316578A1 (en) 2011-06-23
US20160229813A1 (en) 2016-08-11
CA2743562A1 (en) 2010-05-27
WO2010059773A1 (en) 2010-05-27
ES2393694T3 (es) 2012-12-27
JP2012509343A (ja) 2012-04-19
US20110224198A1 (en) 2011-09-15
TN2011000209A1 (en) 2012-12-17
KR20110073596A (ko) 2011-06-29
SV2011003912A (es) 2011-10-13
IL212573A (en) 2015-01-29
BRPI0921924A2 (pt) 2015-12-29
CA2743562C (en) 2014-03-18
US8557832B2 (en) 2013-10-15
ECSP11011066A (es) 2011-06-30
SI2358686T1 (sl) 2013-05-31
EP2358686A1 (en) 2011-08-24
CO6361928A2 (es) 2012-01-20
JP5102397B2 (ja) 2012-12-19
CN102292323A (zh) 2011-12-21
CY1113665T1 (el) 2016-06-22
CN102292323B (zh) 2014-12-24
HN2011001358A (es) 2014-03-03
DOP2011000135A (es) 2011-07-31
NI201100100A (es) 2011-09-12
PT2358686E (pt) 2012-12-06
US9708273B2 (en) 2017-07-18
DK2358686T3 (da) 2013-01-07
PE20120031A1 (es) 2012-02-05
MA32898B1 (fr) 2011-12-01
US20150031713A1 (en) 2015-01-29

Similar Documents

Publication Publication Date Title
CR20110268A (es) Moduladores de aril metil benzoquinazolinona alostéricos positivos del receptor m1
UY31940A (es) Derivados sustituido del 4,5-(sustituido-piridin-3-il)-1-metil-1h-indol, sus sales farmacéuticamente aceptables, polimorfos, rotámeros, pro-fármacos, anantiómeros, hidratos, solvatos del mismo, composiciones conteniéndolos y aplicaciones
BRPI1012770B8 (pt) derivados de tiofeno
CR20130129A (es) Anàlogos de buprenorfina
EA201190021A1 (ru) Модуляторы toll-подобных рецепторов
CR11266A (es) Derivados de pirrolidin-2ona como moduladores del receptor de androgeno
CY1118093T1 (el) Φαρμακοτεχνικες μορφες που περιλαμβανουν παραγωγα 1-(bhta-d-γλυκοπυρανοζυλ)-2-θειενυλμεθυλβενζολιου ως αναστολεις sglt
CR20130415A (es) Derivados de heteroarilo como moduladores de nachr alfa 7
MA34644B1 (fr) Dérivés de pyrazole aminopyrimidine en tant que modulateurs du lrrk2
EA201590953A1 (ru) Пирролидиновые модуляторы gpr40
MX2012003389A (es) Moduladores de gpr40 de pirrolidina.
SV2010003472A (es) Compuestos de pirazol
CY1119826T1 (el) Θεραπευτικες συνθεσεις που περιεχουν μακιτεντανη
UY32481A (es) Derivados de benzofurano
EA201590951A1 (ru) Дигидропиразольные модуляторы gpr40
EA200901098A1 (ru) Производные тиазола в качестве модуляторов сопряженных с g-белком рецепторов
EA201591815A1 (ru) Бицикло [2.2.2] кислоты - модуляторы gpr120
CY1114689T1 (el) C7-φθορο υποκατεστημενες ενωσεις τετρακυκλινης
EA201590949A1 (ru) Дигидропиразольные модуляторы gpr40
EA201590954A1 (ru) Дигидропиразольные модуляторы gpr40
AR062211A1 (es) Derivados de 6-carboxi-normorfinano. composiciones farmaceuticas
ECSP14013296A (es) Derivados de etinilo
CO6321281A2 (es) Derivados de tetrazol como moduladores de receptores de glutamato metabotropicos (mglurs)
IN2014CN04960A (es)
CO6761304A2 (es) Nuevos compuestos de bezodioxol-piperazina