AR069387A1 - Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3 - Google Patents

Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3

Info

Publication number
AR069387A1
AR069387A1 ARP080105055A ARP080105055A AR069387A1 AR 069387 A1 AR069387 A1 AR 069387A1 AR P080105055 A ARP080105055 A AR P080105055A AR P080105055 A ARP080105055 A AR P080105055A AR 069387 A1 AR069387 A1 AR 069387A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocicloalquyloxypyridine
cyclalquyloxy
modulators
compounds
Prior art date
Application number
ARP080105055A
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English (en)
Original Assignee
Janssen Pharmaceutica Nv
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40297867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069387(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR069387A1 publication Critical patent/AR069387A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composicion farmacéutica y usos. Reivindicacion 1: Un compuesto de formula (1) en donde R1 es -alquilo C1-5 o un grupo cicloalquilo saturado; m es 1 o 2; R2 es -H o -OCHR3R4 donde R3 es -H; y R4 es un anillo cicloalquilo o heterocicloalquilo, no sustituido o sustituido con -alquilo C1-4 o acetilo; o R3 y R4, tomados junto con el carbono al cual están unidos, forman un anillo cicloalquilo o heterocicloalquilo, no sustituido o sustituido con -alquilo C1-4 o acetilo; X es N o CH; e Y es N o CRa; donde Ra es -H, -OCHR3R4, -CH2NRbRc, -CN, -CO2-alquilo C1-4 -CO2H o -CONRbRc; Rb y Rc son cada uno independientemente -H o -alquilo C1-4; con la condicion de que uno de X e Y sea N y uno de R2 y Ra sea -OCHR3R4; o una sal farmacéuticamente aceptable, una prodroga farmacéuticamente aceptable o un metabolito farmacéuticamente activo de dicho compuesto.
ARP080105055A 2007-11-20 2008-11-20 Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3 AR069387A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98924607P 2007-11-20 2007-11-20

Publications (1)

Publication Number Publication Date
AR069387A1 true AR069387A1 (es) 2010-01-20

Family

ID=40297867

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP080105055A AR069387A1 (es) 2007-11-20 2008-11-20 Compuestos de cicloalquiloxi -y heterocicloalquiloxipiridina como moduladores del receptor de histamina h3
ARP180100346A AR110977A2 (es) 2007-11-20 2018-02-14 Compuestos de cicloalquiloxi- y heterocicloalquiloxipiridina como moduladores del receptor de histamina h₃

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP180100346A AR110977A2 (es) 2007-11-20 2018-02-14 Compuestos de cicloalquiloxi- y heterocicloalquiloxipiridina como moduladores del receptor de histamina h₃

Country Status (23)

Country Link
US (1) US8883776B2 (es)
EP (1) EP2222664B1 (es)
JP (1) JP5498390B2 (es)
KR (1) KR101546712B1 (es)
CN (2) CN105712977B (es)
AR (2) AR069387A1 (es)
AU (1) AU2008326561B2 (es)
BR (1) BRPI0820481A2 (es)
CA (1) CA2706328C (es)
CL (1) CL2008003465A1 (es)
CO (1) CO6210700A2 (es)
CR (1) CR11529A (es)
EA (1) EA018582B1 (es)
EC (1) ECSP10010190A (es)
HK (1) HK1147994A1 (es)
MX (1) MX2010005488A (es)
MY (1) MY158253A (es)
NI (1) NI201000086A (es)
NZ (1) NZ584998A (es)
TW (1) TWI491604B (es)
UA (1) UA103468C2 (es)
WO (1) WO2009067401A1 (es)
ZA (1) ZA201004334B (es)

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Also Published As

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UA103468C2 (ru) 2013-10-25
CN101868454A (zh) 2010-10-20
EA201070637A1 (ru) 2010-12-30
EP2222664B1 (en) 2014-10-29
MY158253A (en) 2016-09-30
CN105712977B (zh) 2021-06-29
WO2009067401A1 (en) 2009-05-28
AU2008326561B2 (en) 2013-12-05
NI201000086A (es) 2011-03-17
TW200936579A (en) 2009-09-01
CN105712977A (zh) 2016-06-29
TWI491604B (zh) 2015-07-11
HK1147994A1 (en) 2011-08-26
US8883776B2 (en) 2014-11-11
AR110977A2 (es) 2019-05-22
ECSP10010190A (es) 2010-06-29
EA018582B1 (ru) 2013-09-30
ZA201004334B (en) 2011-10-26
MX2010005488A (es) 2010-06-01
CL2008003465A1 (es) 2009-03-06
KR20100098636A (ko) 2010-09-08
CA2706328C (en) 2016-04-19
EP2222664A1 (en) 2010-09-01
JP2011503233A (ja) 2011-01-27
JP5498390B2 (ja) 2014-05-21
CO6210700A2 (es) 2010-10-20
KR101546712B1 (ko) 2015-08-24
BRPI0820481A2 (pt) 2015-06-16
US20090131415A1 (en) 2009-05-21
CR11529A (es) 2012-10-25
NZ584998A (en) 2012-08-31
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