AR102333A1 - Selectividad eficiente de proteínas recombinadas - Google Patents

Selectividad eficiente de proteínas recombinadas

Info

Publication number
AR102333A1
AR102333A1 ARP150102631A ARP150102631A AR102333A1 AR 102333 A1 AR102333 A1 AR 102333A1 AR P150102631 A ARP150102631 A AR P150102631A AR P150102631 A ARP150102631 A AR P150102631A AR 102333 A1 AR102333 A1 AR 102333A1
Authority
AR
Argentina
Prior art keywords
mammalian
protein
expression
selection marker
gpt
Prior art date
Application number
ARP150102631A
Other languages
English (en)
Spanish (es)
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Publication of AR102333A1 publication Critical patent/AR102333A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
ARP150102631A 2014-08-19 2015-08-14 Selectividad eficiente de proteínas recombinadas AR102333A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462039416P 2014-08-19 2014-08-19

Publications (1)

Publication Number Publication Date
AR102333A1 true AR102333A1 (es) 2017-02-22

Family

ID=55347784

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150102631A AR102333A1 (es) 2014-08-19 2015-08-14 Selectividad eficiente de proteínas recombinadas

Country Status (27)

Country Link
US (4) US9732357B2 (enExample)
EP (2) EP3183359B1 (enExample)
JP (4) JP7115851B2 (enExample)
KR (2) KR102556383B1 (enExample)
CN (2) CN113293139B (enExample)
AR (1) AR102333A1 (enExample)
AU (3) AU2015305565B9 (enExample)
CA (1) CA2957036A1 (enExample)
CY (1) CY1124079T1 (enExample)
DK (1) DK3183359T3 (enExample)
EA (1) EA035340B1 (enExample)
ES (1) ES2849728T3 (enExample)
HR (1) HRP20210301T1 (enExample)
HU (1) HUE054069T2 (enExample)
IL (3) IL287020B (enExample)
LT (1) LT3183359T (enExample)
MA (1) MA40371B1 (enExample)
MX (2) MX384990B (enExample)
MY (1) MY191745A (enExample)
PL (1) PL3183359T3 (enExample)
PT (1) PT3183359T (enExample)
RS (1) RS61371B1 (enExample)
SG (2) SG10201707859RA (enExample)
SI (1) SI3183359T1 (enExample)
SM (1) SMT202100054T1 (enExample)
TW (3) TWI832364B (enExample)
WO (1) WO2016028838A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102333A1 (es) * 2014-08-19 2017-02-22 Regeneron Pharma Selectividad eficiente de proteínas recombinadas
CN111712566A (zh) 2018-02-08 2020-09-25 应用干细胞有限公司 用于筛选靶基因变体的方法
WO2021079909A1 (ja) 2019-10-23 2021-04-29 キヤノン株式会社 セラミックス物品の製造方法およびセラミックス物品

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
WO2001053312A1 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002057423A2 (en) 2001-01-16 2002-07-25 Regeneron Pharmaceuticals, Inc. Isolating cells expressing secreted proteins
ATE496134T1 (de) 2002-03-29 2011-02-15 Xoma Technology Ltd Multigene vectoren und methoden für eine erhöhte expression von rekombinanten polypeptiden
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
US7384744B2 (en) * 2002-11-29 2008-06-10 Boehringer Ingelheim Pharma Gmbh & Co., Kg Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
JP2005027599A (ja) * 2003-07-09 2005-02-03 Nara Institute Of Science & Technology 植物由来遺伝子を用いた遺伝子導入植物の選抜法
EP1586585A1 (de) * 2004-04-14 2005-10-19 F. Hoffmann-La Roche Ag Expressionssystem zur Herstellung von IL-15/Fc-Fusionsproteinen und ihre Verwendung
DK2610334T3 (en) 2006-12-07 2017-01-30 Dow Agrosciences Llc HAVE UNKNOWN SELECTABLE MARKET GENERATIONS
ES2522615T3 (es) 2007-06-04 2014-11-17 Regeneron Pharmaceuticals, Inc. Regiones de expresión y estabilidad potenciadas
KR100927803B1 (ko) * 2007-11-23 2009-11-23 한국생명공학연구원 식물 형질전환체를 선별하기 위한 마커로서 ｇｐｔ 유전자
LT2796466T (lt) * 2007-12-07 2018-02-26 Zymogenetics, Inc. Humanizuotų antikūnų molekulės, specifinės il-31 atžvilgiu
CA2722423A1 (en) * 2008-04-22 2009-10-29 Rutgers, The State University Hcv e2 construct compositions and methods
EA036569B1 (ru) * 2008-12-09 2020-11-24 Галозим, Инк. Способ получения полипептида гиалуронидазы ph20
EP2674495A1 (en) 2012-06-14 2013-12-18 Sanofi CHO expression system
AR102333A1 (es) 2014-08-19 2017-02-22 Regeneron Pharma Selectividad eficiente de proteínas recombinadas

Also Published As

Publication number Publication date
AU2015305565A1 (en) 2017-03-09
IL287020B (en) 2022-09-01
CN113293139B (zh) 2025-04-29
DK3183359T3 (da) 2021-02-01
IL287020A (en) 2021-12-01
SG10201707859RA (en) 2017-10-30
CA2957036A1 (en) 2016-02-25
AU2015305565B9 (en) 2020-05-21
US20160053280A1 (en) 2016-02-25
KR20220080215A (ko) 2022-06-14
MA40371B1 (fr) 2021-03-31
TWI832364B (zh) 2024-02-11
TWI719945B (zh) 2021-03-01
MX2017002203A (es) 2017-05-22
SMT202100054T1 (it) 2021-03-15
RS61371B1 (sr) 2021-02-26
KR102556383B1 (ko) 2023-07-17
SG11201701121UA (en) 2017-03-30
KR102406976B1 (ko) 2022-06-10
IL295361B1 (en) 2023-04-01
JP7561232B2 (ja) 2024-10-03
TW201615833A (zh) 2016-05-01
US20200063159A1 (en) 2020-02-27
IL295361B2 (en) 2023-08-01
BR112017003074A2 (pt) 2018-03-06
EA035340B1 (ru) 2020-05-29
LT3183359T (lt) 2021-02-25
PL3183359T3 (pl) 2021-08-02
HRP20210301T1 (hr) 2021-04-02
AU2020205336A1 (en) 2020-08-06
TW202246506A (zh) 2022-12-01
MA40371A (fr) 2017-06-28
IL295361A (en) 2022-10-01
MX384990B (es) 2025-03-14
AU2023200752B2 (en) 2024-02-29
IL250531B (en) 2021-10-31
ES2849728T3 (es) 2021-08-20
MX2021009154A (es) 2021-09-10
CN107075549A (zh) 2017-08-18
JP7115851B2 (ja) 2022-08-09
JP2017525368A (ja) 2017-09-07
KR20170055481A (ko) 2017-05-19
IL250531A0 (en) 2017-03-30
CN107075549B (zh) 2021-04-20
AU2015305565B2 (en) 2020-04-30
TWI777374B (zh) 2022-09-11
EP3901274A1 (en) 2021-10-27
JP2024166420A (ja) 2024-11-28
JP2020174681A (ja) 2020-10-29
EP3183359A1 (en) 2017-06-28
JP2023076667A (ja) 2023-06-01
US11085053B2 (en) 2021-08-10
US20210340564A1 (en) 2021-11-04
AU2023200752A1 (en) 2023-03-09
US10457959B2 (en) 2019-10-29
WO2016028838A1 (en) 2016-02-25
AU2020205336B2 (en) 2022-11-10
CY1124079T1 (el) 2022-05-27
US9732357B2 (en) 2017-08-15
PT3183359T (pt) 2021-02-03
JP7260510B2 (ja) 2023-04-18
EP3183359A4 (en) 2018-04-04
EP3183359B1 (en) 2020-12-16
EA201790241A1 (ru) 2017-06-30
TW202124716A (zh) 2021-07-01
HUE054069T2 (hu) 2021-08-30
CN113293139A (zh) 2021-08-24
SI3183359T1 (sl) 2021-03-31
US20170335341A1 (en) 2017-11-23
MY191745A (en) 2022-07-13

Similar Documents

Publication Publication Date Title
MX2017008817A (es) Composiciones y metodos para la glicosilacion de proteinas.
AR118723A2 (es) Proteínas tóxicas para especies de insectos hemípteros
BR112018067536A2 (pt) sistema de transpóson e métodos de uso
EP4303314A3 (en) Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection
BR112018008051A2 (pt) vacinas de ácido nucleico para vírus de varicella zoster (vzv)
CO2020003882A2 (es) Anticuerpo multiespecifico
MX387336B (es) Enzimas de clostridium histolyticum y metodos para el uso de los mismos.
BR112018076259A2 (pt) tagmentação usando transposomas imobilizados com ligantes
BR112019000195A2 (pt) composições e métodos relacionados a sistemas celulares terapêuticos que expressam rna exógeno
BR112019010565A2 (pt) aplicação viral de neoantígenos
BR112017008082A2 (pt) composições e métodos para detectar um vírus de rna
MX2018004263A (es) Edición genómica multiplexada.
WO2014145820A3 (en) Multiple tagging of long dna fragments
MX385926B (es) Proteínas de fusión de citoquinas.
BR102014027466A8 (pt) Sequência recombinante, uso de uma planta, uma parte de planta, ou uma célula de planta de soja, método para preparação de uma célula de planta transgênica, e loci genômicos de soja não gênicos purificados
ES2690386T3 (es) Composición para escindir un ADN diana que comprende un ARN guía específico para el ADN diana y el ácido nucleico que codifica la proteína Cas o la propia proteína Cas, y sus usos
BR112017018770A2 (pt) redução da tolerância imunológica induzida por pd-l1
AR092712A1 (es) Una proteina con actividad cetosa 3-epimerasa
ES2721309T3 (es) Composición para preparar tagatosa y método para preparar tagatosa a partir de fructosa
BR112015023398A8 (pt) Métodos para amplificar ácidos nucléicos
MX2022001085A (es) Anticuerpos anti-c1s humanizados y metodos para usarlos.
AR091418A1 (es) Sistema de expresion en una linea celular de ovario de hamster chino (cho)
CL2018000164A1 (es) Vector recombinante del virus orf.
PE20170955A1 (es) Nuevas proteinas inhibidoras de insectos
CL2020002373A1 (es) Composición de vacuna que comprende un péptido aislado de piojo de mar; uso de la vacuna para para prevenir o controlar una infestación de piojos de mar en un salmónido; vector; célula hospedadora (divisional de la solicitud no. 201900422).

Legal Events

Date Code Title Description
FG Grant, registration