DK3183359T3 - Effektiv valg af rekombinante proteiner - Google Patents

Effektiv valg af rekombinante proteiner Download PDF

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Publication number
DK3183359T3
DK3183359T3 DK15833421.9T DK15833421T DK3183359T3 DK 3183359 T3 DK3183359 T3 DK 3183359T3 DK 15833421 T DK15833421 T DK 15833421T DK 3183359 T3 DK3183359 T3 DK 3183359T3
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DK
Denmark
Prior art keywords
recombinant proteins
efficient choice
choice
efficient
recombinant
Prior art date
Application number
DK15833421.9T
Other languages
English (en)
Inventor
Dipali Deshpande
Darya Burakov
Gang Chen
James Fandl
Original Assignee
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regeneron Pharma filed Critical Regeneron Pharma
Application granted granted Critical
Publication of DK3183359T3 publication Critical patent/DK3183359T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK15833421.9T 2014-08-19 2015-08-19 Effektiv valg af rekombinante proteiner DK3183359T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462039416P 2014-08-19 2014-08-19
PCT/US2015/045793 WO2016028838A1 (en) 2014-08-19 2015-08-19 Efficient selectivity of recombinant proteins

Publications (1)

Publication Number Publication Date
DK3183359T3 true DK3183359T3 (da) 2021-02-01

Family

ID=55347784

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15833421.9T DK3183359T3 (da) 2014-08-19 2015-08-19 Effektiv valg af rekombinante proteiner

Country Status (27)

Country Link
US (4) US9732357B2 (da)
EP (2) EP3901274A1 (da)
JP (3) JP7115851B2 (da)
KR (2) KR102406976B1 (da)
CN (2) CN107075549B (da)
AR (1) AR102333A1 (da)
AU (3) AU2015305565B9 (da)
BR (1) BR112017003074A2 (da)
CA (1) CA2957036A1 (da)
CY (1) CY1124079T1 (da)
DK (1) DK3183359T3 (da)
EA (1) EA035340B1 (da)
ES (1) ES2849728T3 (da)
HR (1) HRP20210301T1 (da)
HU (1) HUE054069T2 (da)
IL (3) IL287020B (da)
LT (1) LT3183359T (da)
MA (1) MA40371B1 (da)
MX (2) MX2017002203A (da)
MY (1) MY191745A (da)
PL (1) PL3183359T3 (da)
PT (1) PT3183359T (da)
RS (1) RS61371B1 (da)
SG (2) SG10201707859RA (da)
SI (1) SI3183359T1 (da)
TW (3) TWI832364B (da)
WO (1) WO2016028838A1 (da)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR102333A1 (es) * 2014-08-19 2017-02-22 Regeneron Pharma Selectividad eficiente de proteínas recombinadas
WO2019157395A1 (en) * 2018-02-08 2019-08-15 Applied Stemcells, Inc Methods for screening variant of target gene
WO2021079909A1 (ja) 2019-10-23 2021-04-29 キヤノン株式会社 セラミックス物品の製造方法およびセラミックス物品

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6077835A (en) 1994-03-23 2000-06-20 Case Western Reserve University Delivery of compacted nucleic acid to cells
KR970029803A (ko) 1995-11-03 1997-06-26 김광호 반도체 메모리장치의 프리차지 회로
US5972650A (en) 1997-06-26 1999-10-26 Brigham And Women's Hospital Tetracycline repressor regulated mammalian cell transcription and viral replication switch
US6281005B1 (en) 1999-05-14 2001-08-28 Copernicus Therapeutics, Inc. Automated nucleic acid compaction device
DE60211329T2 (de) 2001-01-16 2007-05-24 Regeneron Pharmaceuticals, Inc. Isolierung von sezernierte proteine exprimierenden zellen
CA2492008C (en) 2002-03-29 2012-06-26 Xoma Technology Ltd. Multigenic vectors plasmids and methods for increasing expression of recombinant polypeptides
US8673589B2 (en) 2002-05-29 2014-03-18 Regeneron Pharmaceuticals, Inc. Inducible eukaryotic expression system
US7384744B2 (en) 2002-11-29 2008-06-10 Boehringer Ingelheim Pharma Gmbh & Co., Kg Expression vector, methods for the production of heterologous gene products and for the selection of recombinant cells producing high levels of such products
JP2005027599A (ja) * 2003-07-09 2005-02-03 Nara Institute Of Science & Technology 植物由来遺伝子を用いた遺伝子導入植物の選抜法
EP1586585A1 (de) * 2004-04-14 2005-10-19 F. Hoffmann-La Roche Ag Expressionssystem zur Herstellung von IL-15/Fc-Fusionsproteinen und ihre Verwendung
CN106987561A (zh) 2006-12-07 2017-07-28 陶氏益农公司 新型选择性标记基因
EP2150617B1 (en) 2007-06-04 2014-10-22 Regeneron Pharmaceuticals, Inc. Enhanced expression and stability regions
KR100927803B1 (ko) * 2007-11-23 2009-11-23 한국생명공학연구원 식물 형질전환체를 선별하기 위한 마커로서 gpt 유전자
EP2796466B1 (en) * 2007-12-07 2017-11-22 ZymoGenetics, Inc. Humanized antibody molecules specific for IL-31
CA2722423A1 (en) * 2008-04-22 2009-10-29 Rutgers, The State University Hcv e2 construct compositions and methods
CN102307993B (zh) * 2008-12-09 2014-06-25 哈洛齐梅公司 延长的可溶性ph20多肽及其用途
EP2674495A1 (en) 2012-06-14 2013-12-18 Sanofi CHO expression system
AR102333A1 (es) * 2014-08-19 2017-02-22 Regeneron Pharma Selectividad eficiente de proteínas recombinadas

Also Published As

Publication number Publication date
AU2020205336B2 (en) 2022-11-10
EP3183359A1 (en) 2017-06-28
IL287020A (en) 2021-12-01
CN113293139A (zh) 2021-08-24
JP7115851B2 (ja) 2022-08-09
ES2849728T3 (es) 2021-08-20
AU2023200752A1 (en) 2023-03-09
US10457959B2 (en) 2019-10-29
KR102556383B1 (ko) 2023-07-17
IL295361A (en) 2022-10-01
PL3183359T3 (pl) 2021-08-02
MA40371B1 (fr) 2021-03-31
PT3183359T (pt) 2021-02-03
BR112017003074A2 (pt) 2018-03-06
AR102333A1 (es) 2017-02-22
AU2015305565A1 (en) 2017-03-09
MX2021009154A (es) 2021-09-10
EP3901274A1 (en) 2021-10-27
US20170335341A1 (en) 2017-11-23
MA40371A (fr) 2017-06-28
KR20170055481A (ko) 2017-05-19
WO2016028838A1 (en) 2016-02-25
HRP20210301T1 (hr) 2021-04-02
CN107075549B (zh) 2021-04-20
TWI832364B (zh) 2024-02-11
IL250531A0 (en) 2017-03-30
TW201615833A (zh) 2016-05-01
JP7260510B2 (ja) 2023-04-18
US20210340564A1 (en) 2021-11-04
EA201790241A1 (ru) 2017-06-30
TW202246506A (zh) 2022-12-01
US11085053B2 (en) 2021-08-10
JP2020174681A (ja) 2020-10-29
SG10201707859RA (en) 2017-10-30
AU2023200752B2 (en) 2024-02-29
KR20220080215A (ko) 2022-06-14
TWI777374B (zh) 2022-09-11
TWI719945B (zh) 2021-03-01
TW202124716A (zh) 2021-07-01
US9732357B2 (en) 2017-08-15
AU2020205336A1 (en) 2020-08-06
JP2023076667A (ja) 2023-06-01
SG11201701121UA (en) 2017-03-30
AU2015305565B2 (en) 2020-04-30
MX2017002203A (es) 2017-05-22
HUE054069T2 (hu) 2021-08-30
RS61371B1 (sr) 2021-02-26
CY1124079T1 (el) 2022-05-27
LT3183359T (lt) 2021-02-25
KR102406976B1 (ko) 2022-06-10
US20160053280A1 (en) 2016-02-25
US20200063159A1 (en) 2020-02-27
SI3183359T1 (sl) 2021-03-31
EA035340B1 (ru) 2020-05-29
EP3183359A4 (en) 2018-04-04
JP2017525368A (ja) 2017-09-07
IL287020B (en) 2022-09-01
IL295361B2 (en) 2023-08-01
IL295361B1 (en) 2023-04-01
CA2957036A1 (en) 2016-02-25
MY191745A (en) 2022-07-13
CN107075549A (zh) 2017-08-18
EP3183359B1 (en) 2020-12-16
IL250531B (en) 2021-10-31
AU2015305565B9 (en) 2020-05-21

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