AR099019A1 - Módulos lanzadera monovalentes de la barrera hematocefálica - Google Patents
Módulos lanzadera monovalentes de la barrera hematocefálicaInfo
- Publication number
- AR099019A1 AR099019A1 ARP150100001A ARP150100001A AR099019A1 AR 099019 A1 AR099019 A1 AR 099019A1 AR P150100001 A ARP150100001 A AR P150100001A AR P150100001 A ARP150100001 A AR P150100001A AR 099019 A1 AR099019 A1 AR 099019A1
- Authority
- AR
- Argentina
- Prior art keywords
- seq
- blood
- brain barrier
- monovalent
- hematocephal
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2881—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD71
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Abstract
En la presente memoria se informa de un módulo lanzadera de barrera hematocefálica que comprende una entidad efectora cerebral, un conector y una entidad de unión monovalente que se une a un receptor de la barrera hematocefálica, en el que el conector acopla la entidad efectora con la entidad de unión monovalente, que se une al receptor de barrera hematocefálica, en el que la entidad de unión monovalente no comprende los dominios variables del anticuerpo 8D3 anti-receptor de transferrina (SEC ID nº 01 y SEC ID nº 02) o el anticuerpo variante 8D3v anti-receptor de transferrina (SEC ID nº 01 y SEC ID nº 03). Reivindicación 14: Utilización de un módulo lanzadera de barrera hematocefálica según cualquiera de las reivindicaciones 1 a 12 como medicamento. Reivindicación 15: Utilización según la reivindicación 14, en la que el medicamento está destinado al tratamiento de un trastorno neurológico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2014070183 | 2014-01-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR099019A1 true AR099019A1 (es) | 2016-06-22 |
Family
ID=52396646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP150100001A AR099019A1 (es) | 2014-01-06 | 2015-01-05 | Módulos lanzadera monovalentes de la barrera hematocefálica |
Country Status (13)
Country | Link |
---|---|
US (2) | US10364292B2 (es) |
EP (2) | EP3851452A1 (es) |
JP (1) | JP6557664B2 (es) |
KR (2) | KR20160105799A (es) |
CN (3) | CN105873947A (es) |
AR (1) | AR099019A1 (es) |
BR (1) | BR112016015589A2 (es) |
CA (1) | CA2932547C (es) |
ES (1) | ES2864160T3 (es) |
MX (3) | MX2016008190A (es) |
PL (1) | PL3092251T3 (es) |
RU (1) | RU2694659C2 (es) |
WO (1) | WO2015101588A1 (es) |
Families Citing this family (50)
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BR112016015589A2 (pt) | 2017-10-31 |
CN111057151A (zh) | 2020-04-24 |
EP3851452A1 (en) | 2021-07-21 |
US20200071413A1 (en) | 2020-03-05 |
CA2932547A1 (en) | 2015-07-09 |
MX2020013057A (es) | 2021-03-02 |
CN105873947A (zh) | 2016-08-17 |
KR20160105799A (ko) | 2016-09-07 |
CN111057147B (zh) | 2023-11-10 |
RU2016130707A3 (es) | 2018-08-15 |
JP2017509588A (ja) | 2017-04-06 |
KR20210108491A (ko) | 2021-09-02 |
US20170051071A1 (en) | 2017-02-23 |
MX2016008190A (es) | 2016-10-21 |
EP3092251A1 (en) | 2016-11-16 |
RU2694659C2 (ru) | 2019-07-16 |
CN111057147A (zh) | 2020-04-24 |
US10364292B2 (en) | 2019-07-30 |
KR102381685B1 (ko) | 2022-04-01 |
PL3092251T3 (pl) | 2021-08-02 |
MX2020013058A (es) | 2021-03-02 |
ES2864160T3 (es) | 2021-10-13 |
WO2015101588A1 (en) | 2015-07-09 |
JP6557664B2 (ja) | 2019-08-07 |
CA2932547C (en) | 2023-05-23 |
CN111057151B (zh) | 2022-05-03 |
EP3092251B1 (en) | 2021-01-20 |
RU2016130707A (ru) | 2018-02-12 |
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